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HIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGSPCAIGWVAGWLSAEFPARVVTGHALSRIS PRSIGRFGTSWAAQRADQILHAALVDAFGPDFRDLVWHPTGEQSEAARRSGLLNLPHIPGPHRRYAAQTS DIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWTINGKRPQAYPLMSRMVELGWICVSINYSKSP RCTWPAHIVDVKRAIAWVRENIADYGGDPDFITITGGSAGAHLAALAALSANDPALQPGFESADTAVQAA APYYGVYDLTNAENMHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYVHSEAPPFFVLHGEKDPMVPSAQ SRAFSAALRDAGAATVSYAELPNAHHAFDLAATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPAS *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2485c | lipQ | - | 100% (421) | PROBABLE CARBOXYLESTERASE LIPQ |
| M. tuberculosis H37Rv | Rv2284 | lipM | 2e-91 | 47.21% (394) | esterase LipM |
| M. tuberculosis H37Rv | Rv1426c | lipO | 1e-87 | 44.96% (387) | esterase LipO |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2510c | lipQ | 0.0 | 100.00% (421) | carboxylesterase LipQ |
| M. gilvum PYR-GCK | Mflv_0436 | - | 6e-81 | 40.98% (410) | alpha/beta hydrolase domain-containing protein |
| M. leprae Br4923 | MLBr_01243 | - | 1e-07 | 54.17% (48) | hypothetical protein MLBr_01243 |
| M. abscessus ATCC 19977 | MAB_0078 | - | 9e-15 | 27.81% (302) | putative lipase/esterase |
| M. marinum M | MMAR_3836 | lipQ | 0.0 | 76.13% (419) | carboxylesterase LipQ |
| M. avium 104 | MAV_1685 | - | 1e-170 | 71.15% (416) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0302 | - | 2e-77 | 52.94% (272) | peptidase, S9A/B/C families |
| M. thermoresistible (build 8) | TH_3835 | - | 7e-93 | 47.04% (389) | PUTATIVE alpha/beta hydrolase fold domain protein |
| M. ulcerans Agy99 | MUL_3766 | lipQ | 0.0 | 76.01% (421) | carboxylesterase LipQ |
| M. vanbaalenii PYR-1 | Mvan_0231 | - | 1e-81 | 45.24% (378) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2485c|M.tuberculosis_H37Rv --------MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGS
Mb2510c|M.bovis_AF2122/97 --------MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGS
MMAR_3836|M.marinum_M ----------MASVTSRCSRAGAEALRQGAQLAADARDAVRSGALLLRGS
MUL_3766|M.ulcerans_Agy99 --------MCMASVTSRCSRAGAEALRQGAQLAADARDAVRSGALLLRGS
MAV_1685|M.avium_104 -------MSVAGDLTSRCSWAGAQAAR----LAAEARDVYQLGNLVLRGG
MLBr_01243|M.leprae_Br4923 --------------------------------------------------
Mflv_0436|M.gilvum_PYR-GCK --------MPKPRPLLRAAAELLNAANGVQPLARDGYPTIPVFAFGWPTS
Mvan_0231|M.vanbaalenii_PYR-1 --------MPKRRPLLRAVAELLNAANGLRPLARDGYLTIPVFAFGWPTS
MSMEG_0302|M.smegmatis_MC2_155 ----------MAKPLLTASAEVLNAVNAVKPFGRKGYSTVVAFAFGWPTS
TH_3835|M.thermoresistible__bu MRDRIVHLARQIAAILAALLSLASTVNGYRPLFSKGYPSIFAWGFGLVVS
MAB_0078|M.abscessus_ATCC_1997 -----------------------------------------------MTL
Rv2485c|M.tuberculosis_H37Rv PCAIGWVAGWLSAEFPARVVTGH-------ALSRISPRSIGRFGTSWAAQ
Mb2510c|M.bovis_AF2122/97 PCAIGWVAGWLSAEFPARVVTGH-------ALSRISPRSIGRFGTSWAAQ
MMAR_3836|M.marinum_M PFALGWVAGWVSAEFPPHVLTGH-------ALSRVSPPAIGRYGTAWAAQ
MUL_3766|M.ulcerans_Agy99 PFALGWVAGWVSAEFPPHVLTGH-------ALSRVSPPAIGRYGTAWAAQ
MAV_1685|M.avium_104 PFALGCFAGWLFTEFPPHVLTGH-------ALSRVSHPSIGRVGKTLAAQ
MLBr_01243|M.leprae_Br4923 --------------------------------------------------
Mflv_0436|M.gilvum_PYR-GCK ELSPLYMAGSMADAVRRGIRGDFRGPRGRIALGLTAVAWALLYLIHRRNV
Mvan_0231|M.vanbaalenii_PYR-1 EVSPLYMAGSMLDAIRRGVRGDFRGARGRIALLLTAAAWALLYLIHRRNV
MSMEG_0302|M.smegmatis_MC2_155 ENGPLITTVSALDALRRAVRGDYRTTPGRISLLLKAVAWALLYIVHRRNR
TH_3835|M.thermoresistible__bu EF-PLQTLASQVGGLALTSRGLTRRVR-IFAWSAAAVSALGLLNFNRAGH
MAB_0078|M.abscessus_ATCC_1997 DPQLAALLPALNAGFPRVEKMTG----------AQARAAIRARYVPPARP
Rv2485c|M.tuberculosis_H37Rv RADQILHAALVDAFG--PDFRDLVWHPTGEQSE-AARRSGLLNLPHIPGP
Mb2510c|M.bovis_AF2122/97 RADQILHAALVDAFG--PDFRDLVWHPTGEQSE-AARRSGLLNLPHIPGP
MMAR_3836|M.marinum_M RADLTLTAALEESFG--SEFRDLVSHPSGDGSA-CATRGGLLP----SGP
MUL_3766|M.ulcerans_Agy99 RADLTLTAALEESFG--SQFRDLVSHPSGDGSA-CATRGGLLP----SGP
MAV_1685|M.avium_104 RADHTLTAALQESLG--PDFRDQVCHPTSVASV-CARRGGLLGR---PGP
MLBr_01243|M.leprae_Br4923 ---------------------------MVASCLPRKWEG-----------
Mflv_0436|M.gilvum_PYR-GCK ASQPHFEEPLRDVLG-----DDYQEIAEKAKSSRRRYFGVFPN----EVI
Mvan_0231|M.vanbaalenii_PYR-1 AAQPYFEDPLREALG-----ENYQRIAEAAKSSRRRRVGVFPP----DLV
MSMEG_0302|M.smegmatis_MC2_155 TSRRFFEEPLRSALG-----ADY-AVARRAR----RPGGVIRT----SWA
TH_3835|M.thermoresistible__bu RADRTLTAALDNGLGLHRRTDSEGLWRRPAGGGTAKTPGAVRM----LRI
MAB_0078|M.abscessus_ATCC_1997 LPMRSVTDECVYAFG--------GELPIR---------------------
Rv2485c|M.tuberculosis_H37Rv HRRYAAQTSDIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWTIN
Mb2510c|M.bovis_AF2122/97 HRRYAAQTSDIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWTIN
MMAR_3836|M.marinum_M RRRYAAQTSDISYGPGGREHLLDVWRRPDLAPGGRAPVLIQVPGGAWSVN
MUL_3766|M.ulcerans_Agy99 RRRYAAQTSDISYGPGGREHLLDVWRRPDLAPGGRAPVLIQVPGGAWSVN
MAV_1685|M.avium_104 HRRYAAQTSDISYGPGGRDNLLDIWRRDDLAPGCRAPVLIQVPGGAWALN
MLBr_01243|M.leprae_Br4923 --------------------------LPDVCLAVRSRCWYRFFVWHWSIN
Mflv_0436|M.gilvum_PYR-GCK RRRYVEKAGTVQYGPLR-VNRADIWRRPDLPRDGKAPVLLQVPGGAWAIG
Mvan_0231|M.vanbaalenii_PYR-1 RRRYVESV--VQYGPLR-VNRADIWRRADLPRDGKAPVLLQVPGGAWAIG
MSMEG_0302|M.smegmatis_MC2_155 RHRYATTT--VRYGPHR-ANLADIWMRPDLPRDGKAPVLLQVPGGAWMIG
TH_3835|M.thermoresistible__bu YRDYAHDG-DISYGPYGSANHLDIWRRPDLDRNGKAPVLFQIPGGAWTTG
MAB_0078|M.abscessus_ATCC_1997 ------------------------VYRPAVP--GPLPTVVFAHGGGFVFC
: :
Rv2485c|M.tuberculosis_H37Rv GKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDVKRAIAWVREN
Mb2510c|M.bovis_AF2122/97 GKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDVKRAIAWVREN
MMAR_3836|M.marinum_M GKRPQAYTLMSRMVELGWICVSINYSKSPRCKFPAHVVDVKRAIAWVREN
MUL_3766|M.ulcerans_Agy99 GKRPQAYTLMSRMVELGWICVSINYSKSPRCKFPAHVVDVKRAIAWVREN
MAV_1685|M.avium_104 GRRPQAYTLMSRMVQLGWICVSIDYSKSPRSTFPAHLIDVKRAIAWVREN
MLBr_01243|M.leprae_Br4923 IKRGQAYSLPNRGMELSGICVLVNGQQ-----------------------
Mflv_0436|M.gilvum_PYR-GCK MRKPQSYPLMSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEH
Mvan_0231|M.vanbaalenii_PYR-1 MRRPQAYPLLSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEH
MSMEG_0302|M.smegmatis_MC2_155 MRRPQSYPLMSHLAEQGWICVSIGYRISPKHSWPDHIVDVKQALAWVKAN
TH_3835|M.thermoresistible__bu NKRGQAHPLMSHLAELGWICVAINYRHSPRNTWPDHIIDVKRALAWVKEH
MAB_0078|M.abscessus_ATCC_1997 DLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHRWPTAAQDMFLAACWVTRN
: : * :.
Rv2485c|M.tuberculosis_H37Rv IADYGGDPDFITITGGSAGAHLAALAALSANDP--ALQPGFESADTAVQA
Mb2510c|M.bovis_AF2122/97 IADYGGDPDFITITGGSAGAHLAALAALSANDP--ALQPGFESADTAVQA
MMAR_3836|M.marinum_M IAAYGGNPDFIALTGGSAGAHLASLAALTPCDP--AFQPGFEHADTTVQA
MUL_3766|M.ulcerans_Agy99 IAAYGGNPDFIALTGGSAGAHLASLAALTPCDP--AFQPGFEHADTTVQA
MAV_1685|M.avium_104 IADYGGDPDFIAITGGSAGGHLASLAALTPNDP--AFQPGFENADTAVQA
MLBr_01243|M.leprae_Br4923 -----------------------------------GFALCLAGSHLRLKR
Mflv_0436|M.gilvum_PYR-GCK IAEYGGDPDFVAITGGSAGGHLSSLAALTADDP--QFQPGFEDADTSVVA
Mvan_0231|M.vanbaalenii_PYR-1 IAEYGGDPDFVAITGGSAGGHLSALAALTADDP--QFQPGFEDADTSVAA
MSMEG_0302|M.smegmatis_MC2_155 IADFGGDPESVCITGGSAGGHLTALAALTPNDP--KWQPGFEDADTSVVA
TH_3835|M.thermoresistible__bu IADYGGDPDFLAITGGSAGGHLSSLAALTPNDP--RFQPGFEDADTRVQA
MAB_0078|M.abscessus_ATCC_1997 APTLGGDPARVLVCGDSAGGNLAAVTTLMARDLGGPVLAGQILIYPVLDA
:
Rv2485c|M.tuberculosis_H37Rv AAPYYGVYDLTNAEN-MHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYV
Mb2510c|M.bovis_AF2122/97 AAPYYGVYDLTNAEN-MHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYV
MMAR_3836|M.marinum_M VAPYYGVYDFTDFDN-MHELMLPFLEHFVMKSRYADDPEPFTAASPISYV
MUL_3766|M.ulcerans_Agy99 VAPYYGVYDFTDFDN-MHELMLPFLEHFVMKSRYADDPEPFTAASPISYV
MAV_1685|M.avium_104 VAPYYGVYDFTDFEN-MHPLMVPFLEQFVLKARYADAPQRFAAASPISYV
MLBr_01243|M.leprae_Br4923 LSRGYAITLLT----------------------AAADSERFNAAAPISYT
Mflv_0436|M.gilvum_PYR-GCK AVPVYGRYDWVSAQGSGRREFLAFLQKFVVKKPVTRNRQVYVDASPTHRL
Mvan_0231|M.vanbaalenii_PYR-1 AVPIYGRYDWVSGRGSGRREFIAFLQEFVVKKPISGNRQLYVDASPRYRL
MSMEG_0302|M.smegmatis_MC2_155 AVPVYGRYDWYSTTGPGRTEFMEILERLIVKRPLDGNAELYRDASPIMLV
TH_3835|M.thermoresistible__bu AVPFYGVYDFTRFDDAMHPSMPELLERWVIKQPHSSNRETYASASPVNHI
MAB_0078|M.abscessus_ATCC_1997 DFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDHP----YAAPLRAD
. *:*
Rv2485c|M.tuberculosis_H37Rv HSEAPPFFVLHGE-KDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHA
Mb2510c|M.bovis_AF2122/97 HSEAPPFFVLHGE-KDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHA
MMAR_3836|M.marinum_M HREAPPFFVLHGE-RDELVPSGQARAFCAALRGAGADTVAYAELANAHHA
MUL_3766|M.ulcerans_Agy99 HREAPPFFVLHGE-RDELVPSGQARAFCAALRGAGADTVAYAELANAHHA
MAV_1685|M.avium_104 HADAPPFFVLHGQ-KDELVPSGQARAFCAALRAAGARTVGHAELSNAHHA
MLBr_01243|M.leprae_Br4923 QSEASSCLMLHGEEKNPLAPSAKAHAFCAALLTVGVRTGPCRHPRRD---
Mflv_0436|M.gilvum_PYR-GCK RADAPPFFILHGQ-DDSIIPVPEGREFAEALKEVSTSPVVYAEIPYAQHA
Mvan_0231|M.vanbaalenii_PYR-1 RADAPPFFILHGR-DDSIIPVPEGRAFAEALRNVSTSPVVYAEIPHAQHA
MSMEG_0302|M.smegmatis_MC2_155 RPDAPPFFVLHGT-NDSLIPVVEGRDFVAALREVSNSPVVYAEIPHAQHA
TH_3835|M.thermoresistible__bu SADAPPFFVLHGR-NDSLVPVEQGRDFVRRLREVSTQPVVYAELPLAQHA
MAB_0078|M.abscessus_ATCC_1997 LSGLPPAVVVTAR---YDPPCSEGEAYAAALREAG-VPVRYRRYDNAIHG
.. .:: . * :.. : * .. . .
Rv2485c|M.tuberculosis_H37Rv FDLA-ATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPAS
Mb2510c|M.bovis_AF2122/97 FDLA-ATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPAS
MMAR_3836|M.marinum_M FDIT-PTVRSRLAASAVSDFLGVVYGRWTSSVLGSLAFSANSAS
MUL_3766|M.ulcerans_Agy99 FDIT-PTVRSRLAASAVSDFLGVVYGRWTSSVLGSLAFSANSAS
MAV_1685|M.avium_104 FDIT-PTVRSRLAADAVADFLGVVYGRRVSSLVDSLPLSATSAS
MLBr_01243|M.leprae_Br4923 --------------------------------------------
Mflv_0436|M.gilvum_PYR-GCK FDFYYGSPRAHYTAQAIETFLSWVMATRRSESADRPTSPVRAS-
Mvan_0231|M.vanbaalenii_PYR-1 FDFYYGSPRAHYTAQAVEEFLSWVQGER---MLARKAG------
MSMEG_0302|M.smegmatis_MC2_155 FDFF-GSPHGHFTADAVEKFLNWVLAKR---GVAQNR-------
TH_3835|M.thermoresistible__bu FDIF-GSARAAHTAVAVEQFLAEIYANTVLGEGPRAQPAPR---
MAB_0078|M.abscessus_ATCC_1997 FMTMPGLELADAGIQRLCRDVGEMLG------------------