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MSVAGDLTSRCSWAGAQAARLAAEARDVYQLGNLVLRGGPFALGCFAGWLFTEFPPHVLTGHALSRVSHP SIGRVGKTLAAQRADHTLTAALQESLGPDFRDQVCHPTSVASVCARRGGLLGRPGPHRRYAAQTSDISYG PGGRDNLLDIWRRDDLAPGCRAPVLIQVPGGAWALNGRRPQAYTLMSRMVQLGWICVSIDYSKSPRSTFP AHLIDVKRAIAWVRENIADYGGDPDFIAITGGSAGGHLASLAALTPNDPAFQPGFENADTAVQAVAPYYG VYDFTDFENMHPLMVPFLEQFVLKARYADAPQRFAAASPISYVHADAPPFFVLHGQKDELVPSGQARAFC AALRAAGARTVGHAELSNAHHAFDITPTVRSRLAADAVADFLGVVYGRRVSSLVDSLPLSATSAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1685 | - | - | 100% (415) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_2146 | - | 2e-90 | 47.90% (405) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_3350 | - | 7e-90 | 54.66% (311) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2510c | lipQ | 1e-170 | 71.15% (416) | carboxylesterase LipQ |
| M. gilvum PYR-GCK | Mflv_0436 | - | 9e-78 | 47.55% (326) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv2485c | lipQ | 1e-170 | 71.15% (416) | carboxylesterase LipQ |
| M. leprae Br4923 | MLBr_01243 | - | 2e-08 | 52.00% (50) | hypothetical protein MLBr_01243 |
| M. abscessus ATCC 19977 | MAB_2814 | - | 2e-13 | 31.97% (147) | lipase LipH |
| M. marinum M | MMAR_3836 | lipQ | 0.0 | 77.24% (413) | carboxylesterase LipQ |
| M. smegmatis MC2 155 | MSMEG_0302 | - | 2e-75 | 48.23% (311) | peptidase, S9A/B/C families |
| M. thermoresistible (build 8) | TH_3835 | - | 1e-94 | 52.74% (347) | PUTATIVE alpha/beta hydrolase fold domain protein |
| M. ulcerans Agy99 | MUL_3766 | lipQ | 0.0 | 77.24% (413) | carboxylesterase LipQ |
| M. vanbaalenii PYR-1 | Mvan_0231 | - | 6e-78 | 43.67% (387) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3836|M.marinum_M ----------MASVTSRCSRAGAEALRQGAQLAADARDAVRSGALLLRGS
MUL_3766|M.ulcerans_Agy99 --------MCMASVTSRCSRAGAEALRQGAQLAADARDAVRSGALLLRGS
MAV_1685|M.avium_104 -------MSVAGDLTSRCSWAGAQAAR----LAAEARDVYQLGNLVLRGG
Mb2510c|M.bovis_AF2122/97 --------MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGS
Rv2485c|M.tuberculosis_H37Rv --------MHIASVTSRCSRAGAEALRQGAQLAADARDTCRAGALLLRGS
MLBr_01243|M.leprae_Br4923 --------------------------------------------------
Mflv_0436|M.gilvum_PYR-GCK --------MPKPRPLLRAAAELLNAANGVQPLARDGYPTIPVFAFGWPTS
Mvan_0231|M.vanbaalenii_PYR-1 --------MPKRRPLLRAVAELLNAANGLRPLARDGYLTIPVFAFGWPTS
MSMEG_0302|M.smegmatis_MC2_155 ----------MAKPLLTASAEVLNAVNAVKPFGRKGYSTVVAFAFGWPTS
TH_3835|M.thermoresistible__bu MRDRIVHLARQIAAILAALLSLASTVNGYRPLFSKGYPSIFAWGFGLVVS
MAB_2814|M.abscessus_ATCC_1997 ----------------------MTATAGIDPIIVKILEAVPIQLVSPDGP
MMAR_3836|M.marinum_M PFALGWVAGWVSAEFPPHVLTGH-------ALSRVSPPAIGRYGTAWAAQ
MUL_3766|M.ulcerans_Agy99 PFALGWVAGWVSAEFPPHVLTGH-------ALSRVSPPAIGRYGTAWAAQ
MAV_1685|M.avium_104 PFALGCFAGWLFTEFPPHVLTGH-------ALSRVSHPSIGRVGKTLAAQ
Mb2510c|M.bovis_AF2122/97 PCAIGWVAGWLSAEFPARVVTGH-------ALSRISPRSIGRFGTSWAAQ
Rv2485c|M.tuberculosis_H37Rv PCAIGWVAGWLSAEFPARVVTGH-------ALSRISPRSIGRFGTSWAAQ
MLBr_01243|M.leprae_Br4923 --------------------------------------------------
Mflv_0436|M.gilvum_PYR-GCK ELSPLYMAGSMADAVRRGIRGDFRGPRGRIALGLTAVAWALLYLIHRRNV
Mvan_0231|M.vanbaalenii_PYR-1 EVSPLYMAGSMLDAIRRGVRGDFRGARGRIALLLTAAAWALLYLIHRRNV
MSMEG_0302|M.smegmatis_MC2_155 ENGPLITTVSALDALRRAVRGDYRTTPGRISLLLKAVAWALLYIVHRRNR
TH_3835|M.thermoresistible__bu EF-PLQTLASQVGGLALTSRGLTRRVR-IFAWSAAAVSALGLLNFNRAGH
MAB_2814|M.abscessus_ATCC_1997 QASRDAYR----------------------AIATARPPWIEVANIEDR--
MMAR_3836|M.marinum_M RADLTLTAALEESFG--SEFRDLVSHPSGDGSA-CATRGGLLP----SGP
MUL_3766|M.ulcerans_Agy99 RADLTLTAALEESFG--SQFRDLVSHPSGDGSA-CATRGGLLP----SGP
MAV_1685|M.avium_104 RADHTLTAALQESLG--PDFRDQVCHPTSVASV-CARRGGLLGR---PGP
Mb2510c|M.bovis_AF2122/97 RADQILHAALVDAFG--PDFRDLVWHPTGEQSE-AARRSGLLNLPHIPGP
Rv2485c|M.tuberculosis_H37Rv RADQILHAALVDAFG--PDFRDLVWHPTGEQSE-AARRSGLLNLPHIPGP
MLBr_01243|M.leprae_Br4923 ---------------------------MVASCLPRKWEG-----------
Mflv_0436|M.gilvum_PYR-GCK ASQPHFEEPLRDVLG-----DDYQEIAEKAKSSRRRYFGVFPN----EVI
Mvan_0231|M.vanbaalenii_PYR-1 AAQPYFEDPLREALG-----ENYQRIAEAAKSSRRRRVGVFPP----DLV
MSMEG_0302|M.smegmatis_MC2_155 TSRRFFEEPLRSALG-----ADY-AVARRAR----RPGGVIRT----SWA
TH_3835|M.thermoresistible__bu RADRTLTAALDNGLGLHRRTDSEGLWRRPAGGGTAKTPGAVRM----LRI
MAB_2814|M.abscessus_ATCC_1997 --------TIPGPAG---------EIPVRIYSP-----------------
MMAR_3836|M.marinum_M RRRYAAQTSDISYGPGGREHLLDVWRRPDLAPGGRAPVLIQVPGGAWSVN
MUL_3766|M.ulcerans_Agy99 RRRYAAQTSDISYGPGGREHLLDVWRRPDLAPGGRAPVLIQVPGGAWSVN
MAV_1685|M.avium_104 HRRYAAQTSDISYGPGGRDNLLDIWRRDDLAPGCRAPVLIQVPGGAWALN
Mb2510c|M.bovis_AF2122/97 HRRYAAQTSDIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWTIN
Rv2485c|M.tuberculosis_H37Rv HRRYAAQTSDIPYGPGGRENLLDIWRRPDLAPGRRAPVLIQVPGGAWTIN
MLBr_01243|M.leprae_Br4923 --------------------------LPDVCLAVRSRCWYRFFVWHWSIN
Mflv_0436|M.gilvum_PYR-GCK RRRYVEKAGTVQYGPLR-VNRADIWRRPDLPRDGKAPVLLQVPGGAWAIG
Mvan_0231|M.vanbaalenii_PYR-1 RRRYVESV--VQYGPLR-VNRADIWRRADLPRDGKAPVLLQVPGGAWAIG
MSMEG_0302|M.smegmatis_MC2_155 RHRYATTT--VRYGPHR-ANLADIWMRPDLPRDGKAPVLLQVPGGAWMIG
TH_3835|M.thermoresistible__bu YRDYAHDG-DISYGPYGSANHLDIWRRPDLDRNGKAPVLFQIPGGAWTTG
MAB_2814|M.abscessus_ATCC_1997 ------------------------------AEGGVRPVFVLIHGGGWVIG
. * .
MMAR_3836|M.marinum_M GKRPQAYTLMSRMVELGWICVSINYSKSPRCKFPAHVVDVKRAIAWVREN
MUL_3766|M.ulcerans_Agy99 GKRPQAYTLMSRMVELGWICVSINYSKSPRCKFPAHVVDVKRAIAWVREN
MAV_1685|M.avium_104 GRRPQAYTLMSRMVQLGWICVSIDYSKSPRSTFPAHLIDVKRAIAWVREN
Mb2510c|M.bovis_AF2122/97 GKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDVKRAIAWVREN
Rv2485c|M.tuberculosis_H37Rv GKRPQAYPLMSRMVELGWICVSINYSKSPRCTWPAHIVDVKRAIAWVREN
MLBr_01243|M.leprae_Br4923 IKRGQAYSLPNRGMELSGICVLVNGQQ-----------------------
Mflv_0436|M.gilvum_PYR-GCK MRKPQSYPLMSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEH
Mvan_0231|M.vanbaalenii_PYR-1 MRRPQAYPLLSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEH
MSMEG_0302|M.smegmatis_MC2_155 MRRPQSYPLMSHLAEQGWICVSIGYRISPKHSWPDHIVDVKQALAWVKAN
TH_3835|M.thermoresistible__bu NKRGQAHPLMSHLAELGWICVAINYRHSPRNTWPDHIIDVKRALAWVKEH
MAB_2814|M.abscessus_ATCC_1997 DLDTHDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQWVHEH
: : . : * :.
MMAR_3836|M.marinum_M IAAYGGNPDFIALTGGSAGAHLASLAALTPCDPAFQPGFEHADTTVQAVA
MUL_3766|M.ulcerans_Agy99 IAAYGGNPDFIALTGGSAGAHLASLAALTPCDPAFQPGFEHADTTVQAVA
MAV_1685|M.avium_104 IADYGGDPDFIAITGGSAGGHLASLAALTPNDPAFQPGFENADTAVQAVA
Mb2510c|M.bovis_AF2122/97 IADYGGDPDFITITGGSAGAHLAALAALSANDPALQPGFESADTAVQAAA
Rv2485c|M.tuberculosis_H37Rv IADYGGDPDFITITGGSAGAHLAALAALSANDPALQPGFESADTAVQAAA
MLBr_01243|M.leprae_Br4923 ---------------------------------GFALCLAGSHLRLKRLS
Mflv_0436|M.gilvum_PYR-GCK IAEYGGDPDFVAITGGSAGGHLSSLAALTADDPQFQPGFEDADTSVVAAV
Mvan_0231|M.vanbaalenii_PYR-1 IAEYGGDPDFVAITGGSAGGHLSALAALTADDPQFQPGFEDADTSVAAAV
MSMEG_0302|M.smegmatis_MC2_155 IADFGGDPESVCITGGSAGGHLTALAALTPNDPKWQPGFEDADTSVVAAV
TH_3835|M.thermoresistible__bu IADYGGDPDFLAITGGSAGGHLSSLAALTPNDPRFQPGFEDADTRVQAAV
MAB_2814|M.abscessus_ATCC_1997 AAEIGGDPGRLAVGGDSAGGNLSAVMAQLARDNGIDLAFQVLWYPATTFD
:
MMAR_3836|M.marinum_M PYYGVYDFTDFDN-MHELMLPFLEHFVMKSRYADDPEPFTAASPISYVHR
MUL_3766|M.ulcerans_Agy99 PYYGVYDFTDFDN-MHELMLPFLEHFVMKSRYADDPEPFTAASPISYVHR
MAV_1685|M.avium_104 PYYGVYDFTDFEN-MHPLMVPFLEQFVLKARYADAPQRFAAASPISYVHA
Mb2510c|M.bovis_AF2122/97 PYYGVYDLTNAEN-MHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYVHS
Rv2485c|M.tuberculosis_H37Rv PYYGVYDLTNAEN-MHEMMMPFLEHFVMRSRYVDNPGLFKAASPISYVHS
MLBr_01243|M.leprae_Br4923 RGYAITLLT----------------------AAADSERFNAAAPISYTQS
Mflv_0436|M.gilvum_PYR-GCK PVYGRYDWVSAQGSGRREFLAFLQKFVVKKPVTRNRQVYVDASPTHRLRA
Mvan_0231|M.vanbaalenii_PYR-1 PIYGRYDWVSGRGSGRREFIAFLQEFVVKKPISGNRQLYVDASPRYRLRA
MSMEG_0302|M.smegmatis_MC2_155 PVYGRYDWYSTTGPGRTEFMEILERLIVKRPLDGNAELYRDASPIMLVRP
TH_3835|M.thermoresistible__bu PFYGVYDFTRFDDAMHPSMPELLERWVIKQPHSSNRETYASASPVNHISA
MAB_2814|M.abscessus_ATCC_1997 TTLPSMVENAEAPVLDFKTVGALSKWYLGDTNPATAGPTLVPARAENFEG
.:
MMAR_3836|M.marinum_M EAPPFFVLHGE-RDELVPSGQARAFCAALRGAGADTVAYAELANAHHAFD
MUL_3766|M.ulcerans_Agy99 EAPPFFVLHGE-RDELVPSGQARAFCAALRGAGADTVAYAELANAHHAFD
MAV_1685|M.avium_104 DAPPFFVLHGQ-KDELVPSGQARAFCAALRAAGARTVGHAELSNAHHAFD
Mb2510c|M.bovis_AF2122/97 EAPPFFVLHGE-KDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHAFD
Rv2485c|M.tuberculosis_H37Rv EAPPFFVLHGE-KDPMVPSAQSRAFSAALRDAGAATVSYAELPNAHHAFD
MLBr_01243|M.leprae_Br4923 EASSCLMLHGEEKNPLAPSAKAHAFCAALLTVGVRTGPCRHPRRD-----
Mflv_0436|M.gilvum_PYR-GCK DAPPFFILHGQ-DDSIIPVPEGREFAEALKEVSTSPVVYAEIPYAQHAFD
Mvan_0231|M.vanbaalenii_PYR-1 DAPPFFILHGR-DDSIIPVPEGRAFAEALRNVSTSPVVYAEIPHAQHAFD
MSMEG_0302|M.smegmatis_MC2_155 DAPPFFVLHGT-NDSLIPVVEGRDFVAALREVSNSPVVYAEIPHAQHAFD
TH_3835|M.thermoresistible__bu DAPPFFVLHGR-NDSLVPVEQGRDFVRRLREVSTQPVVYAELPLAQHAFD
MAB_2814|M.abscessus_ATCC_1997 LAPAFIGTAQF--DPLR--DDGAKYAELLRDAGVPVQLHNAPTLIHGYLG
*.. : : : .. : * ..
MMAR_3836|M.marinum_M IT-PTVRSRLAASAVSDFLGVVYGRWTSSVLGSLAFSANSAS
MUL_3766|M.ulcerans_Agy99 IT-PTVRSRLAASAVSDFLGVVYGRWTSSVLGSLAFSANSAS
MAV_1685|M.avium_104 IT-PTVRSRLAADAVADFLGVVYGRRVSSLVDSLPLSATSAS
Mb2510c|M.bovis_AF2122/97 LA-ATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPAS
Rv2485c|M.tuberculosis_H37Rv LA-ATVRSRMVAEAVSDFLGVIYGRRMGARKGSLALSSPPAS
MLBr_01243|M.leprae_Br4923 ------------------------------------------
Mflv_0436|M.gilvum_PYR-GCK FYYGSPRAHYTAQAIETFLSWVMATRRSESADRPTSPVRAS-
Mvan_0231|M.vanbaalenii_PYR-1 FYYGSPRAHYTAQAVEEFLSWVQGER---MLARKAG------
MSMEG_0302|M.smegmatis_MC2_155 FF-GSPHGHFTADAVEKFLNWVLAKR---GVAQNR-------
TH_3835|M.thermoresistible__bu IF-GSARAAHTAVAVEQFLAEIYANTVLGEGPRAQPAPR---
MAB_2814|M.abscessus_ATCC_1997 YADIVPSATEERDLSLAALKQALHG-----------------