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AKPLLTASAEVLNAVNAVKPFGRKGYSTVVAFAFGWPTSENGPLITTVSALDALRRAVRGDYRTTPGRIS LLLKAVAWALLYIVHRRNRTSRRFFEEPLRSALGADYAVARRARRPGGVIRTSWARHRYATTTVRYGPHR ANLADIWMRPDLPRDGKAPVLLQVPGGAWMIGMRRPQSYPLMSHLAEQGWICVSIGYRISPKHSWPDHIV DVKQALAWVKANIADFGGDPESVCITGGSAGGHLTALAALTPNDPKWQPGFEDADTSVVAAVPVYGRYDW YSTTGPGRTEFMEILERLIVKRPLDGNAELYRDASPIMLVRPDAPPFFVLHGTNDSLIPVVEGRDFVAAL REVSNSPVVYAEIPHAQHAFDFFGSPHGHFTADAVEKFLNWVLAKRGVAQNR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0302 | - | - | 100% (403) | peptidase, S9A/B/C families |
| M. smegmatis MC2 155 | MSMEG_0289 | - | 1e-71 | 50.75% (266) | alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_3059 | - | 3e-15 | 32.03% (153) | esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1461c | lipO | 1e-136 | 59.51% (405) | esterase LipO |
| M. gilvum PYR-GCK | Mflv_0436 | - | 1e-153 | 65.01% (403) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1426c | lipO | 1e-136 | 59.51% (405) | esterase LipO |
| M. leprae Br4923 | MLBr_00314 | - | 8e-06 | 29.36% (109) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2814 | - | 3e-13 | 30.25% (238) | lipase LipH |
| M. marinum M | MMAR_2232 | lipO | 1e-137 | 59.41% (409) | esterase LipO |
| M. avium 104 | MAV_3350 | - | 1e-140 | 60.73% (410) | alpha/beta hydrolase domain-containing protein |
| M. thermoresistible (build 8) | TH_1904 | - | 1e-158 | 66.67% (405) | peptidase, S9A/B/C families |
| M. ulcerans Agy99 | MUL_1819 | lipO | 1e-137 | 59.17% (409) | esterase LipO |
| M. vanbaalenii PYR-1 | Mvan_0231 | - | 1e-154 | 64.20% (405) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1461c|M.bovis_AF2122/97 MR---FRRMA-RPR--PLTRAAVELLNAANGLRPLSGSGYSTVLAFWLGW
Rv1426c|M.tuberculosis_H37Rv MR---FRRMA-RPR--PLTRAAVELLNAANGLRPLSGSGYSTVLAFWLGW
MMAR_2232|M.marinum_M MRGDRLRKLARRPRPRPLTRATAELVNAANGLRPISRNPYAAFFVFWLGW
MUL_1819|M.ulcerans_Agy99 MRGDRLRKLARRPR--PLTRATAELVNAANGLRPISRNPYAAFFVFSLGW
MAV_3350|M.avium_104 MR---LMRTLRKPR--PLARATLELANAANGFRPLARKGYSTVLVFWFGW
Mflv_0436|M.gilvum_PYR-GCK ---------MPKPR--PLLRAAAELLNAANGVQPLARDGYPTIPVFAFGW
Mvan_0231|M.vanbaalenii_PYR-1 ---------MPKRR--PLLRAVAELLNAANGLRPLARDGYLTIPVFAFGW
TH_1904|M.thermoresistible__bu -------VAVRKRR--PLLRAAAELANAANGVRPLGREGYITIPAFAFGW
MSMEG_0302|M.smegmatis_MC2_155 -----------MAK--PLLTASAEVLNAVNAVKPFGRKGYSTVVAFAFGW
MAB_2814|M.abscessus_ATCC_1997 -------------------------MTATAGIDPIIVKILEAVPIQLVSP
MLBr_00314|M.leprae_Br4923 --------------MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILA
: .. . . . .
Mb1461c|M.bovis_AF2122/97 PTSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRY
Rv1426c|M.tuberculosis_H37Rv PTSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRY
MMAR_2232|M.marinum_M PTSEVPGLYLTASVVDALRRGRRGDFAGPKGKVALALTAAAWATLGVIRY
MUL_1819|M.ulcerans_Agy99 PTSEVPGLYLTASVVDALRRGRRGDFAGPKGKVALALTAAAWATLGVIRY
MAV_3350|M.avium_104 PASEVPGIYFSASLLDALRRGRRGDFAGRRGKAALALTAASWAILGVIKY
Mflv_0436|M.gilvum_PYR-GCK PTSELSPLYMAGSMADAVRRGIRGDFRGPRGRIALGLTAVAWALLYLIHR
Mvan_0231|M.vanbaalenii_PYR-1 PTSEVSPLYMAGSMLDAIRRGVRGDFRGARGRIALLLTAAAWALLYLIHR
TH_1904|M.thermoresistible__bu PTSEAAPLYLLASVLDALRRGLRGDFSGARGRIALLLTGVTWALLGLLMY
MSMEG_0302|M.smegmatis_MC2_155 PTSENGPLITTVSALDALRRAVRGDYRTTPGRISLLLKAVAWALLYIVHR
MAB_2814|M.abscessus_ATCC_1997 DGPQAS--------RDAYR--------------AIATARPPWIEVANIED
MLBr_00314|M.leprae_Br4923 VGSYVPQLPWPFGLIDHAAR------------VLLPVTNAARAEVNLSNT
. * : . :
Mb1461c|M.bovis_AF2122/97 RGATTPGPVLEAGLTEQLGPDYAKELATLP-TEPMRSRGRNLPLRTAMAR
Rv1426c|M.tuberculosis_H37Rv RGATTPGPVLEAGLTEQLGPDYAKELATLP-TEPMRSRGRNLPLRTAMAR
MMAR_2232|M.marinum_M RGITTPGPVLEEGLTEGLGADYAQELATLP-TEPTRRGRRNLPLRTTVAR
MUL_1819|M.ulcerans_Agy99 RGITTPGPVLEEGLTEGLGADYAQELATLP-AEPTRRGRRNLPLRTTVAR
MAV_3350|M.avium_104 RGITTPGPVLEVGLRDQLGDDYTEALNKLPQSRPTRSGRRTLPLGNIVAR
Mflv_0436|M.gilvum_PYR-GCK RNVASQ-PHFEEPLRDVLGDDYQEIAEKAKSSRR-RYFG---VFPNEVIR
Mvan_0231|M.vanbaalenii_PYR-1 RNVAAQ-PYFEDPLREALGENYQRIAEAAKSSRR-RRVG---VFPPDLVR
TH_1904|M.thermoresistible__bu RNVRSE-RYFEAGLRETLGDDYETVADRSQPARQLRRRG---IVGTSLSR
MSMEG_0302|M.smegmatis_MC2_155 RNRTSR-RFFEEPLRSALGADYA-VARRAR-----RPGG---VIRTSWAR
MAB_2814|M.abscessus_ATCC_1997 RTIPGP--------------------------------------AGEIPV
MLBr_00314|M.leprae_Br4923 SAQLVR----------------------------------------AAGV
Mb1461c|M.bovis_AF2122/97 RRYVETTNVVCYGPYGRANLADIWRRRDLPRDAKAPVLVQVPGGAWVLGW
Rv1426c|M.tuberculosis_H37Rv RRYVETTNVVCYGPYGRANLADIWRRRDLPRDAKAPVLVQVPGGAWVLGW
MMAR_2232|M.marinum_M RLYVEKTNIVAYGPHRRANLADIWRRRDLPRDGKAPVLVQVPGGAWVLGW
MUL_1819|M.ulcerans_Agy99 RLYVEKTNIVAYGPHRRANLADIWRRRDLPRDGKAPVLVQVPGGAWVLGS
MAV_3350|M.avium_104 RRYVEKTNVVSYGPHGRANLADIWRRRDLPRDGKAPVLLQVPGGAWAIGM
Mflv_0436|M.gilvum_PYR-GCK RRYVEKAGTVQYGPLR-VNRADIWRRPDLPRDGKAPVLLQVPGGAWAIGM
Mvan_0231|M.vanbaalenii_PYR-1 RRYVESV--VQYGPLR-VNRADIWRRADLPRDGKAPVLLQVPGGAWAIGM
TH_1904|M.thermoresistible__bu RRYVQRHSVVRYGPHGNANLADIWRRSDLPPDAKAPVLLQVPGGAWSIGM
MSMEG_0302|M.smegmatis_MC2_155 HRYATTT--VRYGPHR-ANLADIWMRPDLPRDGKAPVLLQVPGGAWMIGM
MAB_2814|M.abscessus_ATCC_1997 RIYSPAEG------------------------GVRPVFVLIHGGGWVIGD
MLBr_00314|M.leprae_Br4923 R----------------------------PADGSGRIVLYLHGGAFLGCG
: . :.: : **.:
Mb1461c|M.bovis_AF2122/97 RRPQAYPLMSHLAARGWVCVSLNYRVSPRHTWPDHIVDVKRALAWVKENI
Rv1426c|M.tuberculosis_H37Rv RRPQAYPLMSHLAARGWVCVSLNYRVSPRHTWPDHIVDVKRALAWVKENI
MMAR_2232|M.marinum_M RRPQAYPLMSNLVSRGWVCVSLNYRVSPLHTWPAHIVDVKRALAWVKENI
MUL_1819|M.ulcerans_Agy99 RRPQAYPLMSNLVSRGWVCVSLNYRVSPLHTWPAHIVDVKRALAWVKENI
MAV_3350|M.avium_104 RRPQAYPLMSHLAARGWVCVSIGYRVSPRHTWPDHIVDVKRALAWVKENI
Mflv_0436|M.gilvum_PYR-GCK RKPQSYPLMSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEHI
Mvan_0231|M.vanbaalenii_PYR-1 RRPQAYPLLSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEHI
TH_1904|M.thermoresistible__bu RRPQAYPLLSRLAERGWVCVSIAYRVSPRHTWPDHIVDVKRALAWIKENI
MSMEG_0302|M.smegmatis_MC2_155 RRPQSYPLMSHLAEQGWICVSIGYRISPKHSWPDHIVDVKQALAWVKANI
MAB_2814|M.abscessus_ATCC_1997 LDTHDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQWVHEHA
MLBr_00314|M.leprae_Br4923 ANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRR--
.: : . : : **: * :. : * . *::
Mb1461c|M.bovis_AF2122/97 AAYGGDPNFVAISGGSAGGHLCALAALTPNDPRFQPGFEQVDTSVAAAVP
Rv1426c|M.tuberculosis_H37Rv AAYGGDPNFVAISGGSAGGHLCALAALTPNDPRFQPGFEQVDTSVAAAVP
MMAR_2232|M.marinum_M ADYGGDPDFVAISGGSAGGHLSALAALTPNEPRFQPGFEEADTSVAAAVP
MUL_1819|M.ulcerans_Agy99 ADYGGDPDFVAISGGSAGGHLSALAALTPNEPRFQPGFEEADTSVAAAVP
MAV_3350|M.avium_104 ARYGGDPNFVAITGGSAGGHLCSLAALTPNDPKYQPGFEDADTSVVAAVP
Mflv_0436|M.gilvum_PYR-GCK AEYGGDPDFVAITGGSAGGHLSSLAALTADDPQFQPGFEDADTSVVAAVP
Mvan_0231|M.vanbaalenii_PYR-1 AEYGGDPDFVAITGGSAGGHLSALAALTADDPQFQPGFEDADTSVAAAVP
TH_1904|M.thermoresistible__bu ADYGGDPDQVSITGGSAGGHLTALAALTQNDPVWQPGFEDADTSVVAAVP
MSMEG_0302|M.smegmatis_MC2_155 ADFGGDPESVCITGGSAGGHLTALAALTPNDPKWQPGFEDADTSVVAAVP
MAB_2814|M.abscessus_ATCC_1997 AEIGGDPGRLAVGGDSAGGNLSAVMAQLARDNGIDLAFQVLWYPATTFDT
MLBr_00314|M.leprae_Br4923 --LGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISPLLQLAK
* ** : : *.**** * * : : . .
Mb1461c|M.bovis_AF2122/97 VYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDASPIHHVRAD
Rv1426c|M.tuberculosis_H37Rv VYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDASPIHHVRAD
MMAR_2232|M.marinum_M IYGRYDWYSTEAEGRPEFVELLARFVVKRKFRDHREVFVDASPIHHVRAD
MUL_1819|M.ulcerans_Agy99 IYGRYDWYSTEAEGRPEFVELLARFVVKRKFRDHREVFVDASPIHHVQAD
MAV_3350|M.avium_104 VYGRYDWFTTEGEGRREFVQLLEKFVVKKKFATHRDIYVDASPIRRLRAD
Mflv_0436|M.gilvum_PYR-GCK VYGRYDWVSAQGSGRREFLAFLQKFVVKKPVTRNRQVYVDASPTHRLRAD
Mvan_0231|M.vanbaalenii_PYR-1 IYGRYDWVSGRGSGRREFIAFLQEFVVKKPISGNRQLYVDASPRYRLRAD
TH_1904|M.thermoresistible__bu IYGRYDWYSSTGPGRREFIYFLQRLVVKKRITENRQIYLDASPIRHVRAD
MSMEG_0302|M.smegmatis_MC2_155 VYGRYDWYSTTGPGRTEFMEILERLIVKRPLDGNAELYRDASPIMLVRPD
MAB_2814|M.abscessus_ATCC_1997 TLPSMVENAEAPVLDFKTVGALSKWYLGDTNPATAGPTLVPARAENFEGL
MLBr_00314|M.leprae_Br4923 KGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHI
: : .
Mb1461c|M.bovis_AF2122/97 APPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDVF
Rv1426c|M.tuberculosis_H37Rv APPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDVF
MMAR_2232|M.marinum_M APPFFVLHGQDDSLIPVVEAREFVEELRAVSKSPVAYAELPNAQHAFDIF
MUL_1819|M.ulcerans_Agy99 APPFFVLHGQDDSLIPVVEAREFVEELRAVSKSPVAYAELPNAQHAFDIF
MAV_3350|M.avium_104 APPFFVLHGRDDSLIPVGEAQEFVEELRAVSKSPVAYAELPHAQHAFDIF
Mflv_0436|M.gilvum_PYR-GCK APPFFILHGQDDSIIPVPEGREFAEALKEVSTSPVVYAEIPYAQHAFDFY
Mvan_0231|M.vanbaalenii_PYR-1 APPFFILHGRDDSIIPVPEGRAFAEALRNVSTSPVVYAEIPHAQHAFDFY
TH_1904|M.thermoresistible__bu APPFFVLHGVDDSIIPVGEAREFVEALRAVSTAPVAYVEVPHAQHAFDFF
MSMEG_0302|M.smegmatis_MC2_155 APPFFVLHGTNDSLIPVVEGRDFVAALREVSNSPVVYAEIPHAQHAFDFF
MAB_2814|M.abscessus_ATCC_1997 APAFIGTAQFDP---LRDDGAKYAELLRDAG-VPVQLHNAPTLIHGYLGY
MLBr_00314|M.leprae_Br4923 APGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAA
** : . . . *. * * :
Mb1461c|M.bovis_AF2122/97 --GSPRAHHTAEAVARFLSWVYATNPPAT-----------
Rv1426c|M.tuberculosis_H37Rv --GSPRAHHTAEAVARFLSWVYATNPPAT-----------
MMAR_2232|M.marinum_M --GSPRAHKASEAVARFLSWVYVTNGPGPR----------
MUL_1819|M.ulcerans_Agy99 --GSPRAHKASEAVARFLSWVYVTNGPGPR----------
MAV_3350|M.avium_104 --SSPRAHRSAEAVARFLSWVYATNPPERD----------
Mflv_0436|M.gilvum_PYR-GCK Y-GSPRAHYTAQAIETFLSWVMATRRSESADRPTSPVRAS
Mvan_0231|M.vanbaalenii_PYR-1 Y-GSPRAHYTAQAVEEFLSWVQGER---MLARKAG-----
TH_1904|M.thermoresistible__bu --GSPRGHYTAEAVETFLSWVQATRR--------------
MSMEG_0302|M.smegmatis_MC2_155 --GSPHGHFTADAVEKFLNWVLAKRGVAQNR---------
MAB_2814|M.abscessus_ATCC_1997 --ADIVPSATEERDLSLAALKQALHG--------------
MLBr_00314|M.leprae_Br4923 APMVPEATLSLRQISQYIREATASKASRDRQSL-------
: .