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MGAPRLIHVIRQIGALVVAAVTAAATINAYRPLARNGFASLWSWFIGLVVTEFPLPTLASQLGGLVLTAQ RLTRPVRAVSWLVAAFSALGLLNLSRAGRQADAQLTAALDSGLGPDRRTASAGLWRRPAGGGTAKTPGPL RMLRIYRDYAHDGDISYGEYGRANHLDIWRRPDLDLTGTAPVLFQIPGGAWTTGNKRGQAHPLMSHLAEL GWICVAINYRHSPRNTWPDHIIDVKRALAWVKAHISEYGGDPDFIAITGGSAGGHLSSLAALTPNDPRFQ PGFEEADTRVQAAVPFYGVYDFTRLQDAMHPMMLPLLERMVVKQPRTANMQSYLDASPVTHISADAPPFF VLHGRNDSLVPVQQARGFVDQLRQVSKQPVVYAELPFTQHAFDLLGSARAAHTAIAVEQFLAEVYATQHA GSEPGPAVAIP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2284 | lipM | - | 100% (431) | Probable esterase LipM |
| M. tuberculosis H37Rv | Rv1426c | lipO | e-104 | 50.12% (411) | esterase LipO |
| M. tuberculosis H37Rv | Rv2485c | lipQ | 2e-91 | 47.21% (394) | carboxylesterase LipQ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2305 | lipM | 0.0 | 100.00% (431) | esterase LipM |
| M. gilvum PYR-GCK | Mflv_0436 | - | 1e-98 | 46.68% (422) | alpha/beta hydrolase domain-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2814 | - | 3e-12 | 32.71% (107) | lipase LipH |
| M. marinum M | MMAR_3429 | lipM | 0.0 | 81.82% (418) | membrane-bound esterase LipM |
| M. avium 104 | MAV_2146 | - | 0.0 | 76.79% (418) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0302 | - | 3e-96 | 48.27% (404) | peptidase, S9A/B/C families |
| M. thermoresistible (build 8) | TH_3835 | - | 0.0 | 76.90% (420) | PUTATIVE alpha/beta hydrolase fold domain protein |
| M. ulcerans Agy99 | MUL_2704 | lipM | 0.0 | 81.34% (418) | membrane-bound esterase LipM |
| M. vanbaalenii PYR-1 | Mvan_0231 | - | 3e-96 | 47.65% (426) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0436|M.gilvum_PYR-GCK ---------MPKPRPLLRAAAELLNAANGVQPLARDGYPTIPVFAFGWPT
Mvan_0231|M.vanbaalenii_PYR-1 ---------MPKRRPLLRAVAELLNAANGLRPLARDGYLTIPVFAFGWPT
MSMEG_0302|M.smegmatis_MC2_155 ---------MAK--PLLTASAEVLNAVNAVKPFGRKGYSTVVAFAFGWPT
Rv2284|M.tuberculosis_H37Rv MGAPRLIHVIRQIGALVVAAVTAAATINAYRPLARNGFASLWSWFIGLVV
Mb2305|M.bovis_AF2122/97 MGAPRLIHVIRQIGALVVAAVTAAATINAYRPLARNGFASLWSWFIGLVV
MMAR_3429|M.marinum_M MGRAQIIHIIRQFGALGVAAVTAVSTLNAYKPLARKGFLSIWSWMFGLVV
MUL_2704|M.ulcerans_Agy99 MGRAQIIHIIRQFGALGVAAVTAVSTLNAYKPLARKGFLSIWSWTFGLVV
MAV_2146|M.avium_104 MRKARIVHLIRQIGSLTASAVTAASTLNAYRPLARKGYPSLYAWMFGLVV
TH_3835|M.thermoresistible__bu -MRDRIVHLARQIAAILAALLSLASTVNGYRPLFSKGYPSIFAWGFGLVV
MAB_2814|M.abscessus_ATCC_1997 -----------------------MTATAGIDPIIVK-------------I
: . *: .
Mflv_0436|M.gilvum_PYR-GCK SELSPLYMAGSMADAVRRGIRGDFRGPRGRIALGLTAVAWALLYLIHRRN
Mvan_0231|M.vanbaalenii_PYR-1 SEVSPLYMAGSMLDAIRRGVRGDFRGARGRIALLLTAAAWALLYLIHRRN
MSMEG_0302|M.smegmatis_MC2_155 SENGPLITTVSALDALRRAVRGDYRTTPGRISLLLKAVAWALLYIVHRRN
Rv2284|M.tuberculosis_H37Rv TEF-PLPTLASQLGGLVLTAQRLTRPVR-AVSWLVAAFSALGLLNLSRAG
Mb2305|M.bovis_AF2122/97 TEF-PLPTLASQLGGLVLTAQRLTRPVR-AVSWLVAAFSALGLLNLSRAG
MMAR_3429|M.marinum_M TEF-PLQTMASQVGGLLLTAQRLTRPVR-AISWLVAGISALGLLNFNRAG
MUL_2704|M.ulcerans_Agy99 TEF-PLQTMASQVGGLLLTAQRLTRPVR-AISWLVAGISALGLLNFNRAG
MAV_2146|M.avium_104 TEL-PLQTMLSQLGGLALTARRLTRPVR-IIAWLVAGLSALGLLNLSRAG
TH_3835|M.thermoresistible__bu SEF-PLQTLASQVGGLALTSRGLTRRVR-IFAWSAAAVSALGLLNFNRAG
MAB_2814|M.abscessus_ATCC_1997 LEAVPIQLVSPDGPQASRDAYRAIATAR----------------------
* *: .
Mflv_0436|M.gilvum_PYR-GCK VASQPHFEEPLRDVLG-----DDYQEIAEKAKSSRRRYFGVFPNEVIRRR
Mvan_0231|M.vanbaalenii_PYR-1 VAAQPYFEDPLREALG-----ENYQRIAEAAKSSRRRRVGVFPPDLVRRR
MSMEG_0302|M.smegmatis_MC2_155 RTSRRFFEEPLRSALG-----ADY-AVARRAR----RPGGVIRTSWARHR
Rv2284|M.tuberculosis_H37Rv RQADAQLTAALDSGLGPDRRTASAGLWRRPAGGGTAKTPGPLRMLRIYRD
Mb2305|M.bovis_AF2122/97 RQADAQLTAALDSGLGPDRRTASAGLWRRPAGGGTAKTPGPLRMLRIYRD
MMAR_3429|M.marinum_M HRADITLKDALDSGLGTDRRAGSAGLWHRPAGPGTAKAPGPLRMLRIYRD
MUL_2704|M.ulcerans_Agy99 HRADITLKDALDSGLGTDRRAGSAGLWHRPAGPGTAKAPGPLRMLRIYRD
MAV_2146|M.avium_104 HRANVPLTDALDSELGADRLTESADLWRRPTGAGTAKTPGLLRMLRIYRD
TH_3835|M.thermoresistible__bu HRADRTLTAALDNGLGLHRRTDSEGLWRRPAGGGTAKTPGAVRMLRIYRD
MAB_2814|M.abscessus_ATCC_1997 ------------------------PPWIEVANIEDRTIPGPAGEIPVRIY
. : *
Mflv_0436|M.gilvum_PYR-GCK YVEKAGTVQYGPLR-VNRADIWRRPDLPRDGKAPVLLQVPGGAWAIGMRK
Mvan_0231|M.vanbaalenii_PYR-1 YVESV--VQYGPLR-VNRADIWRRADLPRDGKAPVLLQVPGGAWAIGMRR
MSMEG_0302|M.smegmatis_MC2_155 YATTT--VRYGPHR-ANLADIWMRPDLPRDGKAPVLLQVPGGAWMIGMRR
Rv2284|M.tuberculosis_H37Rv YAHDG-DISYGEYGRANHLDIWRRPDLDLTGTAPVLFQIPGGAWTTGNKR
Mb2305|M.bovis_AF2122/97 YAHDG-DISYGEYGRANHLDIWRRPDLDLTGTAPVLFQIPGGAWTTGNKR
MMAR_3429|M.marinum_M YAHDS-NISYGEYGSANHLDIWRRPDLDLSAKAPVLFQIPGGAWTTGNKR
MUL_2704|M.ulcerans_Agy99 YAHDS-NISYGEYGSANHLDIWRRPDLDLSAKAPVLFQIPGGAWTTGNKR
MAV_2146|M.avium_104 YAHDS-NISYGEFGSANHLDIWRRPDLDLTGRAPVLFQIPGGAWTTGNKR
TH_3835|M.thermoresistible__bu YAHDG-DISYGPYGSANHLDIWRRPDLDRNGKAPVLFQIPGGAWTTGNKR
MAB_2814|M.abscessus_ATCC_1997 SPAEG-------------------------GVRPVFVLIHGGGWVIGDLD
. **:. : **.* *
Mflv_0436|M.gilvum_PYR-GCK PQSYPLMSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEHIAE
Mvan_0231|M.vanbaalenii_PYR-1 PQAYPLLSHLADHGWICVSIDYRVSPRNTWPDHIVDVKRALAWIKEHIAE
MSMEG_0302|M.smegmatis_MC2_155 PQSYPLMSHLAEQGWICVSIGYRISPKHSWPDHIVDVKQALAWVKANIAD
Rv2284|M.tuberculosis_H37Rv GQAHPLMSHLAELGWICVAINYRHSPRNTWPDHIIDVKRALAWVKAHISE
Mb2305|M.bovis_AF2122/97 GQAHPLMSHLAELGWICVAINYRHSPRNTWPDHIIDVKRALAWVKAHISE
MMAR_3429|M.marinum_M GQAHPLMSHLAELGWVCVAINYRHSPRNTWPDHIIDVKRALAWVKAHIAE
MUL_2704|M.ulcerans_Agy99 GQAHPLMSHLAELGWVCVAINYRHSPRNTWPDHIIDVKRALASVKAHIAE
MAV_2146|M.avium_104 GQAHPLMSHLAELGWICVAINYRHSPRNTWPDHIVDVKRALAWVKQHIAG
TH_3835|M.thermoresistible__bu GQAHPLMSHLAELGWICVAINYRHSPRNTWPDHIIDVKRALAWVKEHIAD
MAB_2814|M.abscessus_ATCC_1997 THDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAALQWVHEHAAE
: : .: . : *::.** :*.:.:* : * ** :: : :
Mflv_0436|M.gilvum_PYR-GCK YGGDPDFVAITGGSAGGHLSSLAALTADDPQFQPGFEDADTSVVAAVPVY
Mvan_0231|M.vanbaalenii_PYR-1 YGGDPDFVAITGGSAGGHLSALAALTADDPQFQPGFEDADTSVAAAVPIY
MSMEG_0302|M.smegmatis_MC2_155 FGGDPESVCITGGSAGGHLTALAALTPNDPKWQPGFEDADTSVVAAVPVY
Rv2284|M.tuberculosis_H37Rv YGGDPDFIAITGGSAGGHLSSLAALTPNDPRFQPGFEEADTRVQAAVPFY
Mb2305|M.bovis_AF2122/97 YGGDPDFIAITGGSAGGHLSSLAALTPNDPRFQPGFEEADTRVQAAVPFY
MMAR_3429|M.marinum_M YGGDPDFIAITGGSAGGHLSSLAALTPNDPQFQPGFEEADTRVQAAVPFY
MUL_2704|M.ulcerans_Agy99 YGGDPDFIAITGGSAGGHLSSLAALTPNDPQFQPGFEEADTRVQAAVPFY
MAV_2146|M.avium_104 YGGDPDFIAITGGSAGGHLSSLAALTPNDPKYQPGFEDADTRVQAAVPFY
TH_3835|M.thermoresistible__bu YGGDPDFLAITGGSAGGHLSSLAALTPNDPRFQPGFEDADTRVQAAVPFY
MAB_2814|M.abscessus_ATCC_1997 IGGDPGRLAVGGDSAGGNLSAVMAQLARDNGIDLAFQVLWYPATTFDTTL
**** :.: *.****:*::: * . * : .*: . : .
Mflv_0436|M.gilvum_PYR-GCK GRYDWVSAQGSGRREFLAFLQKFVVKKPVTRNRQVYVDASPTHRLRADAP
Mvan_0231|M.vanbaalenii_PYR-1 GRYDWVSGRGSGRREFIAFLQEFVVKKPISGNRQLYVDASPRYRLRADAP
MSMEG_0302|M.smegmatis_MC2_155 GRYDWYSTTGPGRTEFMEILERLIVKRPLDGNAELYRDASPIMLVRPDAP
Rv2284|M.tuberculosis_H37Rv GVYDFTRLQDAMHPMMLPLLERMVVKQPRTANMQSYLDASPVTHISADAP
Mb2305|M.bovis_AF2122/97 GVYDFTRLQDAMHPMMLPLLERMVVKQPRTANMQSYLDASPVTHISADAP
MMAR_3429|M.marinum_M GVYDFTRFDDAMHPMMPGLLVRSVVKQRPSANLQPFITASPVNHVSADAP
MUL_2704|M.ulcerans_Agy99 GVYDFTRFDDAMHPMMPGLLVRSVVKQRPSANLQPFITASPVNHVSADAP
MAV_2146|M.avium_104 GIYDFTRFDDSLHPMMPGLLIKSIIKQRPSTHLETFAAASPITHVNPDAP
TH_3835|M.thermoresistible__bu GVYDFTRFDDAMHPSMPELLERWVIKQPHSSNRETYASASPVNHISADAP
MAB_2814|M.abscessus_ATCC_1997 PSMVENAEAPVLDFKTVGALSKWYLGDTNPATAGPTLVPARAENFEGLAP
* . : .: . **
Mflv_0436|M.gilvum_PYR-GCK PFFILHGQDDSIIPVPEGREFAEALKEVSTSPVVYAEIPYAQHAFDFYYG
Mvan_0231|M.vanbaalenii_PYR-1 PFFILHGRDDSIIPVPEGRAFAEALRNVSTSPVVYAEIPHAQHAFDFYYG
MSMEG_0302|M.smegmatis_MC2_155 PFFVLHGTNDSLIPVVEGRDFVAALREVSNSPVVYAEIPHAQHAFDFF-G
Rv2284|M.tuberculosis_H37Rv PFFVLHGRNDSLVPVQQARGFVDQLRQVSKQPVVYAELPFTQHAFDLL-G
Mb2305|M.bovis_AF2122/97 PFFVLHGRNDSLVPVQQARGFVDQLRQVSKQPVVYAELPFTQHAFDLL-G
MMAR_3429|M.marinum_M PFFVLHGRNDSLVPVEQARAFVTALQGVSTQPVAYAELPFTQHAFDIF-G
MUL_2704|M.ulcerans_Agy99 PFFVLHGRNDSLVPVEQARAFVTALQGVSTQPVAYAELPSTQHAFDIF-G
MAV_2146|M.avium_104 PFFVLHGRNDSLAYVEQARAFVERLRQVSTQPVVYAELPFTQHAFDIF-G
TH_3835|M.thermoresistible__bu PFFVLHGRNDSLVPVEQGRDFVRRLREVSTQPVVYAELPLAQHAFDIF-G
MAB_2814|M.abscessus_ATCC_1997 -AFIGTAQFDPLR--DDGAKYAELLRDAG-VPVQLHNAPTLIHGYLGY--
*: . *.: :. :. *: .. ** : * *.:
Mflv_0436|M.gilvum_PYR-GCK SPRAHYTAQAIETFLSWVMATRRSESADRPTSPVRAS
Mvan_0231|M.vanbaalenii_PYR-1 SPRAHYTAQAVEEFLSWVQGER---MLARKAG-----
MSMEG_0302|M.smegmatis_MC2_155 SPHGHFTADAVEKFLNWVLAKR---GVAQNR------
Rv2284|M.tuberculosis_H37Rv SARAAHTAIAVEQFLAEVYATQHAGSEPGPAVAIP--
Mb2305|M.bovis_AF2122/97 SARAAHTAIAVEQFLAEVYATQHAGSEPGPAVAIP--
MMAR_3429|M.marinum_M SARAAHAAIAVEQFLAETYVRQQR-------------
MUL_2704|M.ulcerans_Agy99 SARAAHAAIAVEQFLAETYVRQQR-------------
MAV_2146|M.avium_104 SVRAAHTAVAVEQFLAEVYSARDRLPDQLIARSR---
TH_3835|M.thermoresistible__bu SARAAHTAVAVEQFLAEIYANTVLGEGPRAQPAPR--
MAB_2814|M.abscessus_ATCC_1997 --ADIVPSATEERDLSLAALKQALHG-----------
.: : * *