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MQFLSVIPEQVESAAQDLAGIRSALSASYAAAAGPTTAVVSAAEDEVSTAIASIFGAYGRQCQVLSAQAS AFHDEFVNLLKTGATAYRNTEFANAQSNVLNAVNAPARSLLGHPSAAESVQNSAPTLGGGHSTVTAGLAA QAGRAVATVEQQAAAAVAPLPSAGAGLAQVVNGVVTAGQGSAAKLATALQSAAPWLAKSGGEFIVAGQSA LTGVALLQPAVVGVVQAGGTFLTAGTSAATGLGLLTLAGVEFSQGVGNLALASGTAATGLGLLGSAGVQL FSPAFLLAVPTALGGVGSLAIAVVQLVQGVQHLSLVVPNVVAGIAALQTAGAQFAQGVNHTMLAAQLGAP GIAVLQTAGGHFAQGIGHLTTAGNAAVTVLIS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2328 | PE23 | - | 100% (382) | PE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3595c | PE_PGRS59 | 1e-34 | 32.80% (311) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv0532 | PE_PGRS6 | 8e-33 | 36.09% (327) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2355 | PE23 | 0.0 | 100.00% (382) | PE family protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | MLBr_01183 | - | 5e-13 | 38.95% (95) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 2e-06 | 27.05% (292) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_2458 | - | 1e-36 | 34.75% (400) | PE-PGRS family protein |
| M. avium 104 | MAV_1346 | - | 4e-20 | 33.09% (278) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_0085 | - | 8e-05 | 26.19% (336) | PTS system, Fru family protein, IIABC components |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3247 | - | 6e-31 | 35.35% (297) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 6e-05 | 28.39% (155) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2328|M.tuberculosis_H37Rv -------------------------------------MQFLSVIPEQVES
Mb2355|M.bovis_AF2122/97 -------------------------------------MQFLSVIPEQVES
MMAR_2458|M.marinum_M -------------------------------------MSFVNVVPNTVAA
MLBr_01183|M.leprae_Br4923 ------------------------------------MPLFLNAEPQALTA
MAV_1346|M.avium_104 ------------------------------------MS-FVTTRPEALLA
MUL_3247|M.ulcerans_Agy99 --MSYMFA-----------------------------------VPDTVAA
Mvan_1264|M.vanbaalenii_PYR-1 --MMFLAPPGGPGPISAAIQLTSTGSEATEPWYVVSFGGSGAPTPNNLAA
MAB_4284c|M.abscessus_ATCC_199 MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAE
MSMEG_0085|M.smegmatis_MC2_155 -----------------------MTQPIITDDLVLLDVDAGSDKEAVIAR
:
Rv2328|M.tuberculosis_H37Rv AAQDLAGIRSALSASYAAAAGPTTAVVS-----------AAEDEVSTAIA
Mb2355|M.bovis_AF2122/97 AAQDLAGIRSALSASYAAAAGPTTAVVS-----------AAEDEVSTAIA
MMAR_2458|M.marinum_M AAGDLASIRSALSEATAAAAGPTTDVLA-----------AGGDEVSTAIS
MLBr_01183|M.leprae_Br4923 AANTLEGLSAATVASNAAAAQLTTEIAP-----------PAADDVSILLA
MAV_1346|M.avium_104 VASMLEGLGSSMDAQNAAAAAPTTSIAP-----------AAADEVSALQA
MUL_3247|M.ulcerans_Agy99 AAADLAGIGSTLNAATAAAAAPTTGVLA-----------AGADQVSAAVA
Mvan_1264|M.vanbaalenii_PYR-1 SLVDLSGTSCGLICNGQDGTGQNGGILFGNGGSGWNSEIAGVSGGNGGNA
MAB_4284c|M.abscessus_ATCC_199 SVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDN
MSMEG_0085|M.smegmatis_MC2_155 LAGALGGAGRASDTAGLVGAAMAREAQSATG-------LPGGIAIPHCRS
. .
Rv2328|M.tuberculosis_H37Rv SIFGAYG--------------------------------RQCQVLSAQAS
Mb2355|M.bovis_AF2122/97 SIFGAYG--------------------------------RQCQVLSAQAS
MMAR_2458|M.marinum_M QLFGAHG--------------------------------QEFQVVSAQLR
MLBr_01183|M.leprae_Br4923 HFFSGHG--------------------------------RQYQAHASQGA
MAV_1346|M.avium_104 AQFSAYG--------------------------------TWYQQVSAQAK
MUL_3247|M.ulcerans_Agy99 ALFPG----------------------------------HALDYQALSTQ
Mvan_1264|M.vanbaalenii_PYR-1 GLFGGNGGNGGNGLGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGA
MAB_4284c|M.abscessus_ATCC_199 DFLSHNDTDFASHNPIASGNQVMSP-------------SGNVDSFNRGPL
MSMEG_0085|M.smegmatis_MC2_155 PYVDTATIG-------------------------FARLDPKVDFGAPDGP
.
Rv2328|M.tuberculosis_H37Rv AFHDEFVNLLKTGATAYR------NTEFANAQSNVLNAVNAPARSLLGHP
Mb2355|M.bovis_AF2122/97 AFHDEFVNLLKTGATAYR------NTEFANAQSNVLNAVNAPARSLLGHP
MMAR_2458|M.marinum_M GFHDQLVRLMRAGAAAYASVEATAQQDLSMAEQGLVNAVNAPAQALLGHP
MLBr_01183|M.leprae_Br4923 TNHQDLIQSLLTSSSAYA-------------GTETAN-------------
MAV_1346|M.avium_104 AIHQTLVQNLDTNADSYG-------------ATEAANRVNTSAAALQGLA
MUL_3247|M.ulcerans_Agy99 VAAFHTQFVEAVTGAGN-----------AYAAAEAANASPLLGISQDMLN
Mvan_1264|M.vanbaalenii_PYR-1 VGAPGVAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAGA
MAB_4284c|M.abscessus_ATCC_199 LDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVRDSN
MSMEG_0085|M.smegmatis_MC2_155 ADLAFLIAAPESGGSEHMKLLS--SLARALVRKDFVESLRSASSTQEVVE
Rv2328|M.tuberculosis_H37Rv SAAESVQNS-APTLGGGHSTVTAGLAAQAGRAVATVEQQAAAAVAPLPSA
Mb2355|M.bovis_AF2122/97 SAAESVQNS-APTLGGGHSTVTAGLAAQAGRAVATVEQQAAAAVAPLPSA
MMAR_2458|M.marinum_M IIGTGGSGSQSATTGTSTSGVTSGSVASGSAAGSVSSGATAGTVSTGATT
MLBr_01183|M.leprae_Br4923 -----------------HDSL-----------------------------
MAV_1346|M.avium_104 PNVIPNAAPAADPPPAGTTSLGTSIGWAQNVGAAASDFITLGEGQFAPVP
MUL_3247|M.ulcerans_Agy99 AVNGPTEASLGRP-LIGNGADGTAPEQAGGDGSL-LYGNGGAGGPGGAGG
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWGNAGLPGAAGAAGGAGAIGTAGVAGAAGTAGATG
MAB_4284c|M.abscessus_ATCC_199 IINADHGSNVGVD--QSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRN
MSMEG_0085|M.smegmatis_MC2_155 LVNSAVKPAAAPPASAPKPAAEPKPAADKSVSIVAVTSCPTGIAHTYMAA
Rv2328|M.tuberculosis_H37Rv GAGLAQVVNGVVTAGQGSAAKLATALQSAAPWLAKSGGEFIVAGQSALTG
Mb2355|M.bovis_AF2122/97 GAGLAQVVNGVVTAGQGSAAKLATALQSAAPWLAKSGGEFIVAGQSALTG
MMAR_2458|M.marinum_M GSVSSGATAGTVSAGATDGAVTSGTTASSSDGTTVSAGGVAATDPGSDGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 GAAGIPNFNPGLTAATTAGPPAPAAPAAAAGAPVLAS-------------
MUL_3247|M.ulcerans_Agy99 NAGLIGNGGAGGSG-----------------AALGLFGGSG--AALGLFG
Mvan_1264|M.vanbaalenii_PYR-1 GTGVGGNGGAGQAGGIGGTGAAGAAGQAGTAGETGVTGGVGGIGGQGTEG
MAB_4284c|M.abscessus_ATCC_199 TTNINDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTSTSAGGSAAVGGNA
MSMEG_0085|M.smegmatis_MC2_155 DALKAAAEKAGVACTVETQGSAGSTPLSAETIAAADAVIFATDVGVKDRQ
Rv2328|M.tuberculosis_H37Rv VALLQPAVVG------------------------VVQAGGTFLTAGTSA-
Mb2355|M.bovis_AF2122/97 VALLQPAVVG------------------------VVQAGGTFLTAGTSA-
MMAR_2458|M.marinum_M VAVSDPGSDG------------------------GVAVSGSGSGSGVAVG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --MGRGPSIG------------------------GLSVPPSWAPGGVAP-
MUL_3247|M.ulcerans_Agy99 GTGGNGGL--------------------------LFGDGGTGGAAGDLAS
Mvan_1264|M.vanbaalenii_PYR-1 GTGGVGGVGGVGATGGAGGVGGKGIQGGQGLQGGQGGDGGTGGTGGDATS
MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAG------------------------NAGLAGNAGLAGNAGL
MSMEG_0085|M.smegmatis_MC2_155 RFAGKPVIASG--------------------VKRAINEPDKMVAEAISAA
Rv2328|M.tuberculosis_H37Rv --------------------------------------------------
Mb2355|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2458|M.marinum_M GTDTPGTSAPAPVTPNTFGDVVAAPYQTLISNTVTNLQSLDGAWAANPAP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MUL_3247|M.ulcerans_Agy99 G--VGLPG----------------------GAGGHAG------LFGIGGA
Mvan_1264|M.vanbaalenii_PYR-1 MGEAGATG----------------------GKGGNGGNGGRGSLFGRGGN
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNA--------------------GLAGNAGLAGNAGLAGNAGL
MSMEG_0085|M.smegmatis_MC2_155 SDPGAPWVAG-------------------------------QAAESASAP
Rv2328|M.tuberculosis_H37Rv ------ATGLGLLTLAGVEFSQGVGNLALASGTAATGLGLLGSAGVQLFS
Mb2355|M.bovis_AF2122/97 ------ATGLGLLTLAGVEFSQGVGNLALASGTAATGLGLLGSAGVQLFS
MMAR_2458|M.marinum_M FLHQLIANQMGYAQTAATALQSSVSNLPAALAHLPADIQLGTHSLMAADP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 ------AANATPAQLVGAGFTSAAPDTAPVTAVPGGVPSMATAGRGGYGL
MUL_3247|M.ulcerans_Agy99 GGEGGNSAT--------TAGVGGAGGAG-----GLLVGAGGHGGTGGTSA
Mvan_1264|M.vanbaalenii_PYR-1 AGNGGNGGTGGNGGNGGTGGTGGNGGTGGTGGTGGIGGAGSTGGTGGTGG
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG
MSMEG_0085|M.smegmatis_MC2_155 AGDVGWGTRIRQILLTGVSYMIPFVAAGGLLIALGFLLAGYEIGNTPDGE
Rv2328|M.tuberculosis_H37Rv PAFLLAVPTALGGVGSLAIAVVQLVQG---------------------VQ
Mb2355|M.bovis_AF2122/97 PAFLLAVPTALGGVGSLAIAVVQLVQG---------------------VQ
MMAR_2458|M.marinum_M GAFLHSLVTNQLGYAQTISTALQSAAHDFGTGAAALPAAYQAAFQDFMAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 GAPRYGVKPTVMPKPAI---------------------------------
MUL_3247|M.ulcerans_Agy99 SG-TGATGGSGGAGGLLFS-----------------PGGAGGDGGAGFSG
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGTGGTGGTGGTGGTGGKGGTGGTGGDGGTGGTGGTGGTGGTG
MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAGLAGNAGLAGNAAVAGNAAVAGNAAVAGNAAVGGVLNTGVSG
MSMEG_0085|M.smegmatis_MC2_155 TQSLGNIIATHNSLTNLPSGGVAQYLGAVLFTLGGLAFSFLVPALAGYIA
Rv2328|M.tuberculosis_H37Rv HLSLVVPNVVAGIAALQTAGAQFAQGVNHTMLAAQLGAPG-IAVLQTAGG
Mb2355|M.bovis_AF2122/97 HLSLVVPNVVAGIAALQTAGAQFAQGVNHTMLAAQLGAPG-IAVLQTAGG
MMAR_2458|M.marinum_M NVSGAADHVESGLANLFITGFDVTPGSDAVLSITPTGTVGDLLPILGIPG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MUL_3247|M.ulcerans_Agy99 ADGGAGGNGGAGGGGLWFG-NGGAGGIGGFDAHG-DGGDGGAGGNAGIY-
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTGGAGDGLGGTGGTGGTGGFGGQGGQGGTGGTGGQGGLGG
MAB_4284c|M.abscessus_ATCC_199 AIGGSSHVG--GAINESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGS
MSMEG_0085|M.smegmatis_MC2_155 FAIADRPGIAPGFTAGAVAVFVGGGFIGGIVGGLIAGFAALWISRIGVPQ
Rv2328|M.tuberculosis_H37Rv HFAQGIGHLTTAG------------------NAAVTVLIS----------
Mb2355|M.bovis_AF2122/97 HFAQGIGHLTTAG------------------NAAVTVLIS----------
MMAR_2458|M.marinum_M QMAQNFTNLLPAGSVPELVSQNFTNIVNAATNTAVTSTLTLVVDPSSPTG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MUL_3247|M.ulcerans_Agy99 -GGNGGAGGTGGVG-------VGGNLFTGGQGGAGGNAGL--LAGNGGAG
Mvan_1264|M.vanbaalenii_PYR-1 VGGTGGTGGTGGTGGQGGTGGTGGTGGTGGTGGAGGDGGLGGLGGFGGVG
MAB_4284c|M.abscessus_ATCC_199 HVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVGGGISE
MSMEG_0085|M.smegmatis_MC2_155 WARGLMPVVVIPLFASMVVGLLMFLLLGRPLAALTSGLTNWLGGLSGGSA
Rv2328|M.tuberculosis_H37Rv --------------------------------------------------
Mb2355|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2458|M.marinum_M VGVAIDATMGLPLALGVEALGGPVDAIDAFGTSATAFVTAAQSGNVLAAT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MUL_3247|M.ulcerans_Agy99 GTGGDAGMFG----NGGAGGAGGDR-VAGSQGNGGDGGDGGHGGTYFGSG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGQGGQGGPGGSTGGAGGAGGQAGVAGKGGLFGGSGSAGTAGVTGASG
MAB_4284c|M.abscessus_ATCC_199 SLGGSGSVGG-----STAVGGGAHTGVGGGVNTGVGVGSHVGGGISESLG
MSMEG_0085|M.smegmatis_MC2_155 IALGVILGLMMCFDLGGPVNKAAYAFATASLVNPTQANLQIMAAVMAAGM
Rv2328|M.tuberculosis_H37Rv --------------------------------------------------
Mb2355|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2458|M.marinum_M AAVLDAPAVVAN----------------------GLFNGQSTFPLTIDAL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MUL_3247|M.ulcerans_Agy99 GAGGHGGYDDS---------------------GSGGQGGHGGDGGAAGTI
Mvan_1264|M.vanbaalenii_PYR-1 ASGGKGAQGATGAQGATGAQGATGATGASGAQGSAGSAGSAGVAGSAGTT
MAB_4284c|M.abscessus_ATCC_199 GSGSVGGSTAVG--------------------GGAHTSAINDALGGSGSV
MSMEG_0085|M.smegmatis_MC2_155 VPPLAMALATVIRPRLFSEPERENGRAAWLLGASFITEGAIPFAAADPLR
Rv2328|M.tuberculosis_H37Rv --------------------------------------------------
Mb2355|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2458|M.marinum_M GIPTTLNLP-----------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MUL_3247|M.ulcerans_Agy99 GNGGDGGTG-----------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 GAQGSAGTNGANGANGSQGAAGKAGATGTTGATGAAGDAGDPGSEAVDIN
MAB_4284c|M.abscessus_ATCC_199 GGSTAVGGG-----------------------------------------
MSMEG_0085|M.smegmatis_MC2_155 VIPSMMVGG-----------------------------------------
Rv2328|M.tuberculosis_H37Rv --------------------------------------------------
Mb2355|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2458|M.marinum_M --MDGILVPAGPYTATIPDLGVTATVNGTPLGGVAPGLLTLLPEQLAEAI
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MUL_3247|M.ulcerans_Agy99 ---GDALVSGGTGGDGGDGGDGGDAREIGNGGNG--GNAGAGATAGNEGT
Mvan_1264|M.vanbaalenii_PYR-1 GGAGGAGGAGGEGGEGGAGGAGGDGSEGGAGGSGGAGGSGTGGAGGAGGS
MAB_4284c|M.abscessus_ATCC_199 -AHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGH
MSMEG_0085|M.smegmatis_MC2_155 -AVTGATVMAAAVTLRAPHGGIFVFFAIGNLLWFVIAVALGTVVSALTVI
Rv2328|M.tuberculosis_H37Rv ---------------------
Mb2355|M.bovis_AF2122/97 ---------------------
MMAR_2458|M.marinum_M GASPVTD--------------
MLBr_01183|M.leprae_Br4923 ---------------------
MAV_1346|M.avium_104 ---------------------
MUL_3247|M.ulcerans_Agy99 GGTGG--QLIGVSGTDGST--
Mvan_1264|M.vanbaalenii_PYR-1 GGSGGSGGAGGSGGAAGDSD-
MAB_4284c|M.abscessus_ATCC_199 ASETAHTTLPGAEHH------
MSMEG_0085|M.smegmatis_MC2_155 AAKQFTKRPVTAPEAPALATT