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MPRKPIDVTLPDLSGRRAVVTGASDGIGLGIAARLAAAGADVILPVRNEIKGKAAIAAVRQTNAAAKVSL RELDLSSLASVAALGKSLLEEAQPIHLLINNAGVMTPPERRTTTDGFESQFGTNHLGHFALVAHLLPLLR AGGARVTSQVSVAANQHAINWDDLNWERSYDGAKAYSQSKIAFGLFGLELDRRSHAHGWGITSNLSHPGL APTNLLAARPDTGRAQDDWKLRLIRTLSSRGILFGTVHTAQLPALYAAASPHAKRGGFYGPRGPGHLGGP PGEQRLYSRLRNNDEAQRIWEISEKLTDMSFPTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2212 | - | - | 100% (314) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0876 | - | 3e-54 | 44.48% (308) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0863 | - | 1e-52 | 42.53% (308) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2286 | - | 4e-87 | 54.49% (312) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0143 | - | 5e-53 | 43.55% (310) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2263 | - | 4e-87 | 54.49% (312) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 5e-48 | 42.02% (307) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3070 | - | 1e-116 | 65.27% (311) | short chain dehydrogenase |
| M. marinum M | MMAR_3355 | - | 3e-85 | 53.72% (309) | oxidoreductase |
| M. avium 104 | MAV_2969 | - | 2e-70 | 47.42% (310) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4179 | - | 4e-52 | 41.31% (305) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1288 | - | 4e-85 | 53.72% (309) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1061 | - | 1e-100 | 62.00% (300) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2212|M.smegmatis_MC2_155 ---MPRKPIDVTLPDLSGRRAVVTGASDGIGLGIAARLAAAGADVILPVR
MAB_3070|M.abscessus_ATCC_1997 ---MPRTPYDVDIPDLSGQRAVVTGASDGIGLEIAMKLAGAGADVFMPVR
Mvan_1061|M.vanbaalenii_PYR-1 MDHMTRK-ATVDARDLHGKLAVITGGSDGIGFGLAGRLAAAGAEVILPVR
Mb2286|M.bovis_AF2122/97 ----MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMAIR
Rv2263|M.tuberculosis_H37Rv ----MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMAIR
MMAR_3355|M.marinum_M ----MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMAIR
MUL_1288|M.ulcerans_Agy99 ----MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMAIR
MAV_2969|M.avium_104 ----MKPNLTLEIPDLRGKFAVVTGANSGLGFGLAKRLAAAGAEVVLAVR
Mflv_0143|M.gilvum_PYR-GCK MT-DWTNWNVADIPDQTGRTAVITGANTGLGFETAKALAEKGARVVIAVR
MLBr_00315|M.leprae_Br4923 MA-KWT---TADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLAVR
TH_4179|M.thermoresistible__bu MTGKWT---ARDVPDQTGRTAVITGANTGLGFETAKVLAEKGAHVVLAVR
* *: *::**.. *:* * *: ** *.:.:*
MSMEG_2212|M.smegmatis_MC2_155 NEIKGKAAIAAVRQTNAAAKVSLRELDLSSLASVAALGKSLLEEAQPIHL
MAB_3070|M.abscessus_ATCC_1997 NLRKGQAAVSRIRALHPRAHLTLAELDLSSLVSIADLGEKLCAEGTPIHL
Mvan_1061|M.vanbaalenii_PYR-1 NADKGRRAADAIRTTTPDARISTRPMDLSSLQSVADLADELLREGRPIHL
Mb2286|M.bovis_AF2122/97 NRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADGRPIDL
Rv2263|M.tuberculosis_H37Rv NRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADGRPIDL
MMAR_3355|M.marinum_M NRAKGEAAIEEIRSAVPDAKLSIKALDLSSLASVAALGDQLNSEGRPIDI
MUL_1288|M.ulcerans_Agy99 NRAKGEAAIEEIRSAVPDAKLSTKALDLSSLASVAALGDQLNSEGRPIDI
MAV_2969|M.avium_104 DPAKGDQAVAAIRRAVPQAKLTIRQLDLSSLRSVAALGEQLTAEGRPIDI
Mflv_0143|M.gilvum_PYR-GCK NTDKGAQAAARIRG-----DVDVQELDLTSLSSIRTAAEALKARFDKIDL
MLBr_00315|M.leprae_Br4923 NLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDYDHIDL
TH_4179|M.thermoresistible__bu DPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLRAGYPRIDL
: ** * : : :**:** .: .. * *.:
MSMEG_2212|M.smegmatis_MC2_155 LINNAGVMTPPERRTTTDGFESQFGTNHLGHFALVAHLLPLLRAGG-ARV
MAB_3070|M.abscessus_ATCC_1997 LINNAGVMTPPERQTTADGFELQFGTNHLGHFALTGHLLPLLRAGR-ARV
Mvan_1061|M.vanbaalenii_PYR-1 LINNAGVMNPPSRQTTVDGFELQWGTNHLGHFALTARLLPLLTAGA-ARV
Mb2286|M.bovis_AF2122/97 LINNAGVMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQRARV
Rv2263|M.tuberculosis_H37Rv LINNAGVMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQRARV
MMAR_3355|M.marinum_M LINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQGARV
MUL_1288|M.ulcerans_Agy99 LINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQGARV
MAV_2969|M.avium_104 LINNAGVMAPPRRQQTSDGFELQFGTNHLGHFALTGRLLALLRAADSARV
Mflv_0143|M.gilvum_PYR-GCK LINNAGVMTTP-KGTTADGFELQFGTNHLGHFALTGLLFDNILDIPGSRI
MLBr_00315|M.leprae_Br4923 LINNAGVMWTP-KSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRV
TH_4179|M.thermoresistible__bu LINNAGVMYPP-RQTTRDGFELQFGTNHLGHFALTGQLLDNILPVDGSRV
******** .* : * **** *:*:*******:.. :: : :*:
MSMEG_2212|M.smegmatis_MC2_155 TSQVSVAANQ-HAINWDDLNWERSYDGAKAYSQSKIAFGLFGLELDRRSH
MAB_3070|M.abscessus_ATCC_1997 TSHTSIAARS-GEINWDDLNWERGYDGMRAYRQSKIACGLFGLELSRLSN
Mvan_1061|M.vanbaalenii_PYR-1 TTQSSISAAR-HAINWDDLNFEKSYAVGKAYSQSKIANLMFGLELDRRSR
Mb2286|M.bovis_AF2122/97 VSLSSLAARR-GRIHFDDLQFERSYAPMTAYGQSKLAVLMFARELDRRSR
Rv2263|M.tuberculosis_H37Rv VSLSSLAARR-GRIHFDDLQFERSYAPMTAYGQSKLAVLMFARELDRRSR
MMAR_3355|M.marinum_M VSLSSLAARR-GRIHFDDLQFEKSYAAMTAYGQSKLAVLMFARELDRRSR
MUL_1288|M.ulcerans_Agy99 VSLSSLAARR-GRIHFDDLQFEKSYAAMTAYGQSKLAVLMFARELDRRSR
MAV_2969|M.avium_104 VTVSSIAATQ-RKLDFADVNAEHGYQPMYSYGVAKLAQLMFAVELDWRSR
Mflv_0143|M.gilvum_PYR-GCK VTVSSNGHKMGGAIHWDDLQWERSYNRMGAYTQSKLANLLFTYELQRRLA
MLBr_00315|M.leprae_Br4923 ITVSSLSHRLFADIHFNDLQWECNYNRVAAYGQSKLANLLFTYELQRRLA
TH_4179|M.thermoresistible__bu VTVASIAHRNMADIHFDDLQWERGYHRVAAYGQSKLANLMFAYELQRRLS
: * . :.: *:: * .* :* :*:* :* **.
MSMEG_2212|M.smegmatis_MC2_155 AHGWGITSNLSHPGLAPTNLLAARPDTGRAQDDWKLRLIRTLSSRG-ILF
MAB_3070|M.abscessus_ATCC_1997 TAGWGITSNIAHPGVAPTSLLAARPEVGRTKDTTEVRMIRWLSARG-LIV
Mvan_1061|M.vanbaalenii_PYR-1 HAGWGITSNVAHPGVTATNLLAAQPHMGRDGDTLSVRLIRRLAGLG-ILT
Mb2286|M.bovis_AF2122/97 AAGWGIISNAAHPGLTKTNLQIAGPSHGRDKPALMERLYKTSWRFAPFLW
Rv2263|M.tuberculosis_H37Rv AAGWGIISNAAHPGLTKTNLQIAGPSHGRDKPALMERLYKTSWRFAPFLW
MMAR_3355|M.marinum_M AAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFAPFLW
MUL_1288|M.ulcerans_Agy99 AAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFAPFLW
MAV_2969|M.avium_104 LGGWGLMSNAAHPGLAKTNL-LSGASYGSSAPTLQARLTRLTWRLLPFMW
Mflv_0143|M.gilvum_PYR-GCK PR-GKTIAVAAHPGTSTTELARNLPRPVERA---------FLAAAPVLFA
MLBr_00315|M.leprae_Br4923 TR-QTTIAVAAHPGGSRTELTRTLP-ALIAP---------IFSVAELFLT
TH_4179|M.thermoresistible__bu AKNAPTISVAAHPGVSNTELTRYIP-GARLP---------GVSLLAGLLT
: :*** : *.* . ::
MSMEG_2212|M.smegmatis_MC2_155 GTVHTAQLPALYAAASPHAKRGGFYGPRG-PGHLGGPPGEQRLYSRLRNN
MAB_3070|M.abscessus_ATCC_1997 GTVASATLPALMAAVAPEATDGGFYGPRW-PGSAGGPPGPQKLWKPLHSI
Mvan_1061|M.vanbaalenii_PYR-1 QTVDQGLLPALYAATHPDAEGGKFYGPSG-FQHLSGAPAEQQVYGPARDA
Mb2286|M.bovis_AF2122/97 QEIEEGILPALYAAATPQADGGAFYGPRGRYEVAGGGVREAKVPAAARND
Rv2263|M.tuberculosis_H37Rv QEIEEGILPALYAAATPQADGGAFYGPRGRYEVAGGGVREAKVPAAARND
MMAR_3355|M.marinum_M QEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPARAGND
MUL_1288|M.ulcerans_Agy99 QEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPARAGND
MAV_2969|M.avium_104 LDIDEAVKPTLYAAVSPDAQGARYYGPRGFYETARGGVTFARVPPLARSE
Mflv_0143|M.gilvum_PYR-GCK QTADRGALPTLRAAADPGVLGGQYYGPDG-LGQQRGAPVVVASSAQSYDV
MLBr_00315|M.leprae_Br4923 QDAATGALPTLRAATDAAVLGGQYFGPDG-FAEIRGHPKVVASNGKSHDV
TH_4179|M.thermoresistible__bu NSPAVGALATLRAATDPEVKGGQYYGPDG-FQEIRGHPVLVGSSAKSRDE
. .:* **. . . . ::** * .
MSMEG_2212|M.smegmatis_MC2_155 DEAQRIWEISEKLTDMSFPTA----
MAB_3070|M.abscessus_ATCC_1997 RNASRLWQASQELTGVTFT------
Mvan_1061|M.vanbaalenii_PYR-1 ADAARLWRVSEQLAGAQFALPRAGA
Mb2286|M.bovis_AF2122/97 ADSKRLWEVSEQLTGVSYPKSR---
Rv2263|M.tuberculosis_H37Rv ADSKRLWEVSEQLTGVSYPKSR---
MMAR_3355|M.marinum_M ADCQRLWEVSERLTGVGYPTSS---
MUL_1288|M.ulcerans_Agy99 ADCQRLWEVSERLTGVGYPTSS---
MAV_2969|M.avium_104 PEMARLWRLSEQLSGVDYPG-----
Mflv_0143|M.gilvum_PYR-GCK DQQRRLWEISEELTKVTFPDL----
MLBr_00315|M.leprae_Br4923 DRQLRLWAVSEELTGVVYPVG----
TH_4179|M.thermoresistible__bu DIQRRLWTVSEELTGVTFPV-----
*:* *:.*: :.