For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
NLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARGGTSRDRFIQRAHHRLSFQLSGAQLGIS ITTLATGYLTEPLVAELPHPGLVAVGMSDRVADGLITFFALVIVTSLSMVFGELVPKYLAVARPLRTARS VVAGQVLFSLLLTPAIRLTNGAANWIVRRLGIEPAEELRSARTPQELVSLVRSSARSGALDDATAWLMRR SLQFGALTAEELMTPRSKIVALQTDDTIADLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEVPPGDR AHTLLTTVAEPVAVVPSTLDGDAVMAQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIVGDVRDEHDDAT PDVVAAGNGWRVSGLLRIDEVASATGYRAPDGPYETIGGLVLRELGHIPVAGETVELTALDQDGLPDDSM RWLATVIQMDGRRIDLLELIKMGGHADPGSGRGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1842c | - | - | 100% (455) | hypothetical protein Rv1842c |
| M. tuberculosis H37Rv | Rv1841c | - | 9e-42 | 32.28% (347) | hypothetical protein Rv1841c |
| M. tuberculosis H37Rv | Rv2366c | - | 8e-29 | 32.17% (286) | transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1873c | - | 0.0 | 99.78% (455) | hypothetical protein Mb1873c |
| M. gilvum PYR-GCK | Mflv_3364 | - | 1e-170 | 67.70% (452) | hypothetical protein Mflv_3364 |
| M. leprae Br4923 | MLBr_00387 | guaB2 | 2e-06 | 24.85% (165) | inosine 5'-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2411c | - | 1e-160 | 66.67% (438) | hypothetical protein MAB_2411c |
| M. marinum M | MMAR_2716 | - | 0.0 | 82.02% (445) | hypothetical protein MMAR_2716 |
| M. avium 104 | MAV_2878 | - | 0.0 | 78.81% (453) | CBS domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3637 | - | 1e-173 | 69.33% (450) | CBS domain-containing protein |
| M. thermoresistible (build 8) | TH_2608 | - | 1e-174 | 71.01% (445) | PUTATIVE protein of unknown function DUF21 |
| M. ulcerans Agy99 | MUL_0900 | guaB2 | 6e-05 | 26.61% (124) | inosine 5'-monophosphate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3094 | - | 1e-168 | 69.07% (443) | hypothetical protein Mvan_3094 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1842c|M.tuberculosis_H37Rv -----MNLT---DTVAT-----------ILAILALTAG----TGVFVAAE
Mb1873c|M.bovis_AF2122/97 -----MNLT---DTVAT-----------ILAILALTAG----TGVFVAAE
MMAR_2716|M.marinum_M -----MMFT---ATTVS-----------IVAILVLTLG----TAVFVGAE
MAV_2878|M.avium_104 -----MNVT---VTVVS-----------IVAIAVLIFG----NAVFVAAE
Mflv_3364|M.gilvum_PYR-GCK -----MNTA---MSLLA-----------LLAFMLLTAG----TAVFVAAE
Mvan_3094|M.vanbaalenii_PYR-1 -----MSSN---LSLLA-----------LLAFMLLTAG----TAVFVAAE
TH_2608|M.thermoresistible__bu -----MSSV---SVALS-----------ILAILLLTAG----TAAFVAAE
MSMEG_3637|M.smegmatis_MC2_155 MGEVAMSDTNVWLSLLA-----------ILAVVLLTFG----TAVFVAAE
MAB_2411c|M.abscessus_ATCC_199 -----MTVL---LTGLS-----------LLAFVALTAG----TALFVAAE
MLBr_00387|M.leprae_Br4923 -MIRGMSNLKESSDFVASSYVR---LGGLMDDPAATGGDNPHKVAMLGLT
MUL_0900|M.ulcerans_Agy99 -MSRGMSHLEDSSDLVDTPYMRDARVGDLSGDSVPTGGDDPHKVAMLGLT
* : * . ::.
Rv1842c|M.tuberculosis_H37Rv FSLTALDRSTVEANARGGTSRDRFIQRAHHRLSFQLSGAQLG----ISIT
Mb1873c|M.bovis_AF2122/97 FSLTALDRSTVEANARGGTSRDRFIQRAHHRLSFQLSGAQLG----ISIT
MMAR_2716|M.marinum_M FSLTALDRSTVEANARGGDSRDRFIRRAQHRLSFHLSGAQLG----ISIT
MAV_2878|M.avium_104 FSLTTLDRSTVEANARTGGRRDRWIRRAHHRLSFQLSGAQLG----ISAT
Mflv_3364|M.gilvum_PYR-GCK FSLTALERSTVEANVRSGDRRDAMVQRAHRSLSTQLSGAQVG----ISIT
Mvan_3094|M.vanbaalenii_PYR-1 FSLTALERSTVEANVRSGDRRDVMVQRAHRTLSTQLSGAQVG----ISIT
TH_2608|M.thermoresistible__bu FSLTALERSTVEANARSGDRRDQMVRRAHRTLSFQLSGAQVG----ISIT
MSMEG_3637|M.smegmatis_MC2_155 FSLTALERSTVEANARAGDRRDHMVRHAHRTLSFQLSGAQVG----ISIT
MAB_2411c|M.abscessus_ATCC_199 FSLTALERSGIEARAKTGDSRDRLVKRAHSTLSFQLSGAQLG----ITIT
MLBr_00387|M.leprae_Br4923 FDDVLLLPAASDVVPATADISSQLTKKIRLKVPLVSSAMDTVTEARMAIA
MUL_0900|M.ulcerans_Agy99 FDDVLLLPAASDVVPSTADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIA
*. . * : :. . . :: : :. *. : :: :
Rv1842c|M.tuberculosis_H37Rv TLATGYLTEPLVAELPHPGLVAVGMSDRVADGLITFFALVIVTSLSMVFG
Mb1873c|M.bovis_AF2122/97 TLATGYLTEPLVAELPHPGLVAVGMSDRVADGLITFFALVIVTSLSMVFG
MMAR_2716|M.marinum_M TLATGYLTEPLVDALPHPALTAIGISDQMSDAITVFLALVVVTSVSMVFG
MAV_2878|M.avium_104 TLAAGYLTDPMVEDLPHPWLDAVGIPDRVGDAIMAFLALLIVTSVSMVFG
Mflv_3364|M.gilvum_PYR-GCK TLATGFLAEPVVARLIHPGLTALNVPGQFVSGLSLFLAILIATSISMIFG
Mvan_3094|M.vanbaalenii_PYR-1 TLATGFLAEPVVARLIHPGLTAIGIPDRFVGGLALTLAILIATSISMVFG
TH_2608|M.thermoresistible__bu TLATGYLAEPVVARLLQPAIDAVGVPDRLAGGLSLFLAVSIATSLSMVFG
MSMEG_3637|M.smegmatis_MC2_155 TLATGYLAEPVIGKLIHPGLDAIGIPANFAGGLSLFFAVVIATSLSMVFG
MAB_2411c|M.abscessus_ATCC_199 TLVTGYLAEPVIARLLSQLFGYTGIA--VSSAISLALALIIATSISMIFG
MLBr_00387|M.leprae_Br4923 MARAGGMGVLHRNLPVGEQAGQVETVKRSEAGMVTDPVTCRPDNTLAQVG
MUL_0900|M.ulcerans_Agy99 MARAGGMGVLHRNLPVAEQASQVETVKRSEAGMVTDPVTCRPDNTLAQVD
:* : .: . . ..
Rv1842c|M.tuberculosis_H37Rv ELVPKYLAVARPLRTARSVVA-----GQVLFSLLLTPAIRLTNGAANWIV
Mb1873c|M.bovis_AF2122/97 ELVPKYLAVARPLRTARSVVA-----GQVLFSLLLTPAIRLTNGAANWIV
MMAR_2716|M.marinum_M ELVPKYLAVARPLPTARAVVL-----PQWLFSVLLTPAIRLTNGAANWIV
MAV_2878|M.avium_104 ELVPKYLAVARPMSTARAVVA-----AQLLFSALLTPAIRLTNGAANWIV
Mflv_3364|M.gilvum_PYR-GCK ELVPKNLAVAKPVPTARWSAP-----LQLMFSFLALPLIRLTNGTANWIL
Mvan_3094|M.vanbaalenii_PYR-1 ELVPKNLAVARPVPTARWSAP-----LQLMFSFLFTPLIRLTNGTANWIL
TH_2608|M.thermoresistible__bu ELVPKNLAVARPVETARWSAP-----LQVVFSALVTPLIRVTNGTANWIL
MSMEG_3637|M.smegmatis_MC2_155 ELVPKNLAVARPVPTARAAAP-----FQLLFSLIFTPVIRLTNGTANWIL
MAB_2411c|M.abscessus_ATCC_199 ELVPKNFALARPVWTSRATSG-----PMVLFSAVFAFAIRALNGTANWVL
MLBr_00387|M.leprae_Br4923 ALCARFRISGLPVVDDSGALAGIITNRDMRFEVDQSKQVAEVMTKTPLIT
MUL_0900|M.ulcerans_Agy99 ALCARFRISGLPVVDDAGALVGIITNRDMRFEVDQSKQVAEVMTKAPLIT
* .: . *: *. : : :
Rv1842c|M.tuberculosis_H37Rv RRLGIEPAEELRSAR-TPQELVSLVRSSARSGALDDATAWLMRRSLQFGA
Mb1873c|M.bovis_AF2122/97 RRLGIEPAEELRSAR-TPQELVSLVRSSARSGALDDATAWLMRRSLQFGA
MMAR_2716|M.marinum_M RQLGIEPAEELRSAR-TPQELVSLVRSSARSGSLDDVTASLMRRSLQFGT
MAV_2878|M.avium_104 RRLGVEPAEELRSAR-SPQELLSLVRSSARSGALDAATAALVRRSLQFGT
Mflv_3364|M.gilvum_PYR-GCK RRLGIEPAEELRSAR-SPQELVSLVRSSAERGSLDPVTAQLVDRSLQFGD
Mvan_3094|M.vanbaalenii_PYR-1 RRLGIEPAEELRSAR-SPQELVSLVRSSAERGSLDPVTALLVDRSLQFGD
TH_2608|M.thermoresistible__bu RRLGIEPAEELRSAR-SAQELVSLVRNSAQSGSLDPVTARLVDRSLQFGD
MSMEG_3637|M.smegmatis_MC2_155 RRLGIEPAEELRSAR-TGQELAALVRNSARSGSLDPVTALLVDRSLQFGE
MAB_2411c|M.abscessus_ATCC_199 RRMGIEPAEELRSAR-SPQELGSLVRTSARSGALDETTAVLVDRSLRFGS
MLBr_00387|M.leprae_Br4923 AAEGVSADAALGLLRRNKIEKLPVVDGHGRLTGLITVKDFVKTEQHPLAT
MUL_0900|M.ulcerans_Agy99 AQEGVSASAALGLLRRHKIEKLPVVDGSGRLTGLITVKDFVKTEQHPLAT
*:.. * * * .:* .. .* .. : .. :.
Rv1842c|M.tuberculosis_H37Rv LTAEELMTP--------RSKIVALQTDDTIADLVAAAAASGFSRFPVVEG
Mb1873c|M.bovis_AF2122/97 LTAEELMTP--------RSKIVALQTDDTIADLVAAAAASGFSRFPVVEG
MMAR_2716|M.marinum_M LTAEELMTP--------RSKVVALQTDDTIADLVAAVAASGYSRFPVVQG
MAV_2878|M.avium_104 LSAEELMTP--------RSKIVALQTDDTVADLVTAAAESGFSRFPIVDG
Mflv_3364|M.gilvum_PYR-GCK RTAEELMTP--------RSKIDTLDADDTVLDLSEAAVSTGHSRFPVIHG
Mvan_3094|M.vanbaalenii_PYR-1 RSAEELMTP--------RSKIDTLEADDTVADLSDAATRTGHSRFPVIRG
TH_2608|M.thermoresistible__bu RTAEELMTP--------RSKIEALDADDTVADLIRVADETGFSRFPITRG
MSMEG_3637|M.smegmatis_MC2_155 RTAEELMTP--------RPKIETLDADDTVVDLMDAAIRTGFSRFPIIKG
MAB_2411c|M.abscessus_ATCC_199 RTAEELMTP--------RTEIESLEATDTVADLVTIAVETGFSRFPITEG
MLBr_00387|M.leprae_Br4923 KDNDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMV
MUL_0900|M.ulcerans_Agy99 KDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLIVDTAHAHNRLVLDMV
: : . : :: *: *: ...*: :
Rv1842c|M.tuberculosis_H37Rv ---DLDATVGIVHVKQVFEVPPGDRAHTLLTTVAEPVAVVPSTLDGDAVM
Mb1873c|M.bovis_AF2122/97 ---DLDATVGIVHVKQVFEVPPGDRAHTLLTTVAEPVAVVPSTLDGDAVM
MMAR_2716|M.marinum_M ---DLDETFGIVHVKQVFQVPAAKRAHTLLSSIAKPVPVVPSTLDGDALM
MAV_2878|M.avium_104 ---DLDETVGIVHVKQVFAIPRAARAHTLLTTVAQPVPVVPSTLDGDAVM
Mflv_3364|M.gilvum_PYR-GCK ---DLDETIGMVHVKQVFEVPAVSRSTTRLADLVQPLTKVPSTLDGDAVM
Mvan_3094|M.vanbaalenii_PYR-1 ---DLDETVGMVHVKQVFAVPADARATTRLATLVQPVTKVPSTLDGDAVM
TH_2608|M.thermoresistible__bu ---DLDETVGMVHVKQVFEVPHDQRATTRLARLAVPVIKVPSTLDGDALM
MSMEG_3637|M.smegmatis_MC2_155 ---DLDETIGVVHVKQVFAVPRDKRDRVRLASLALPVAKVPSTLDGDAVM
MAB_2411c|M.abscessus_ATCC_199 ---DLDATIGIVHVKQVFEVPRDRRATTTLASLARPVAVVPSTLDGDAVM
MLBr_00387|M.leprae_Br4923 GKLKVEIGDRVQVIGGNVATRSAAAALVEAGADAVKVGVGPGSTCTTRVV
MUL_0900|M.ulcerans_Agy99 SKLKLEVGERVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVV
.:: : : . . . : *.: ::
Rv1842c|M.tuberculosis_H37Rv AQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIVGDVRDEHDDATPDVVA
Mb1873c|M.bovis_AF2122/97 AQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIVGDVRDEHDDATPDVVA
MMAR_2716|M.marinum_M AQIRANSLQTAMVVDEYGGTAGMVTVEDLVEEIVGDVRDEHDDATPDVVA
MAV_2878|M.avium_104 AEIRANSLQTALVVDEYGGTAGMVTVEDLIEEIVGDVRDEHDDATPDVVP
Mflv_3364|M.gilvum_PYR-GCK AEVRANGLQTALVVDEYGGTAGMVTVEDLIEEIVGDVRDEHDDEPPDVVA
Mvan_3094|M.vanbaalenii_PYR-1 SEVRANGLQTALVVDEYGGTAGMVTVEDLIEEIVGDVRDEHDVEPPDVVQ
TH_2608|M.thermoresistible__bu TQLRGNGLQTALVVDEYGGTAGMVTVEDMIEELVGDVRDEHDDATPAVVR
MSMEG_3637|M.smegmatis_MC2_155 TQIRANGLQTALVVDEYGGTAGMVTVEDLIEEIVGDVRDEHDDATPDVMP
MAB_2411c|M.abscessus_ATCC_199 EQVRANGMQTALVVDEYGGTAGLVTVEDMIEEIVGDVRDEHDDATPDVVS
MLBr_00387|M.leprae_Br4923 AGVGAPQITAILEAVAACGPAGVPVIADGGLQYSGDIAKALAAGASTTML
MUL_0900|M.ulcerans_Agy99 AGVGAPQITAILEAVAVCRRAGIPVIADGGLQYSGDIAKALAAGASTAML
: . : : : . **: .: * : **: . .. .:
Rv1842c|M.tuberculosis_H37Rv A---GNGWRVSGLLRIDEVASATGYR--APDGPYETIGG-----------
Mb1873c|M.bovis_AF2122/97 A---GNGWRVSGLLRIDEVASATGYR--APDGPYETIGG-----------
MMAR_2716|M.marinum_M A---GNGWRVSGLLRIDEVAIAIGYQ--APEGPYETIGG-----------
MAV_2878|M.avium_104 A---GTGWRVSGLLRIDEVAAATGFR--APEGPYETIGG-----------
Mflv_3364|M.gilvum_PYR-GCK A---GQGWQVSGLLRIDEVAEGTAFR--APEGDYETIGG-----------
Mvan_3094|M.vanbaalenii_PYR-1 A---GRGWQVSGLLRIDEVAQGTEFR--APEGDYETIGG-----------
TH_2608|M.thermoresistible__bu A---PHGWQVSGLLRIDEVADQTGFR--PPEGDYETIGG-----------
MSMEG_3637|M.smegmatis_MC2_155 A---GKGWQVSGLLRIDEVAAQTGFR--APEGEYETIGG-----------
MAB_2411c|M.abscessus_ATCC_199 S---GGGWVVSGLLRIDEVAAATGYR--APEGEYETIGG-----------
MLBr_00387|M.leprae_Br4923 GSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGGDKSYSKDRYFA
MUL_0900|M.ulcerans_Agy99 GSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMQGRGGAKSYSKDRYFA
. ..* * : : :: . * : **
Rv1842c|M.tuberculosis_H37Rv -LVLRELGHIPVAGETVELTALDQDGLPDDSMRWLATVIQMDGR-RIDLL
Mb1873c|M.bovis_AF2122/97 -LVLRELGHIPVAGETVELTALDQDGLPDDSMRWLATVIQMDGR-RIDSL
MMAR_2716|M.marinum_M -LVLRQLGHIPVAGETVELPALDEDRVPDQSVRWRATVVQMDGR-RIDLL
MAV_2878|M.avium_104 -LVLREIGHIPAAGETVKLPALDPDGLLDPVLRWQARVIRMDGR-RIDVL
Mflv_3364|M.gilvum_PYR-GCK -LILEKLGHIPDEGETVELTAFDPDGAIEDPVRWLATVIKMDGR-RIDQL
Mvan_3094|M.vanbaalenii_PYR-1 -LVLEKLGHIPEEGESVELIAFDPDGPIQDPVHWLATVVKMDGR-RIDQL
TH_2608|M.thermoresistible__bu -LVLQELGHIPEAGEAVELTAFEPDGPMEDPVRWLATVVQMEGR-RIDLL
MSMEG_3637|M.smegmatis_MC2_155 -LVLQELGHIPETGEAVDLTAFDPDTDADEPTHWLATVVRMDGR-RIDLL
MAB_2411c|M.abscessus_ATCC_199 -LVLQELGHIPTVGETVELTAVVPDHPLAELPRWRARVAGMDGR-RIDQI
MLBr_00387|M.leprae_Br4923 DDALSEDKLVPEGIEGRVPFRGPLSSVIHQLVGGLRAAMGYTGSPTIEVL
MUL_0900|M.ulcerans_Agy99 DDALSEDKLVPEGIEGRVPFRGPLASVIHQLTGGLRAAMGYTGSPTIEVL
* : :* * . * *: :
Rv1842c|M.tuberculosis_H37Rv ELIKMG----GHADPGSGRGR------------
Mb1873c|M.bovis_AF2122/97 ELIKMG----GHADPGSGRGR------------
MMAR_2716|M.marinum_M ELTELAGAEDGQDDSDPERGGR-----------
MAV_2878|M.avium_104 ELTEID----AHAEAPGGRR-------------
Mflv_3364|M.gilvum_PYR-GCK RLTRLG---RLSDAPEGEDHRG-----------
Mvan_3094|M.vanbaalenii_PYR-1 RLTELG---RKGDS------RG-----------
TH_2608|M.thermoresistible__bu ELVELG---RGNGGPKAGVQR------------
MSMEG_3637|M.smegmatis_MC2_155 ELTKLE---PAGEGEPNG---------------
MAB_2411c|M.abscessus_ATCC_199 ELTELT---DADSRGNNDDG-------------
MLBr_00387|M.leprae_Br4923 QQAQFVRITPAGLKESHPHDVAMTVEAPNYYPR
MUL_0900|M.ulcerans_Agy99 QQAQFVRITSAGLKESHPHDVAMTVEAPNYYAR
. .: