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AGVSWKVYRNKTLGPISSVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLANRLPRVSWVIPN VLESEHPAVPAAAGAFAIVNILRILLANPAVWEKTALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDI DQVPGSGGIRGPIGLGFRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVTGDMT STFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIPYRVPDPQIMPTQETTPTRGIPSGPC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1755c | plcD | - | 100% (280) | PROBABLE PHOSPHOLIPASE C 4 (FRAGMENT) PLCD |
| M. tuberculosis H37Rv | Rv2350c | plcB | e-124 | 74.47% (282) | membrane-associated phospholipase C |
| M. tuberculosis H37Rv | Rv2351c | plcA | e-120 | 71.13% (284) | membrane-associated phospholipase C |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1784c | plcD | 1e-166 | 100.00% (280) | phospholipase C 4 PLCD |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0555 | - | 3e-43 | 42.32% (267) | non-hemolytic phospholipase C |
| M. marinum M | MMAR_3823 | plcB_1 | 1e-120 | 69.86% (282) | membrane-associated phospholipase C 2 PlcB_1 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2799 | plcB | 1e-118 | 70.32% (283) | membrane-associated phospholipase C 2 PlcB |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1784c|M.bovis_AF2122/97 MSQSHIGGVSRREFLAKVAAG-GAGALMSFAGPVIEKAYGA-GPCSGHLT
MMAR_3823|M.marinum_M MSKSPVDAMSRREFLAKAAAASGAGAFMSLAGPVIEKAYAA-GPCSGHLS
MUL_2799|M.ulcerans_Agy99 --------MSRREFMAKLAAASSAGAMMSLAGPVIEKAYGA-GPCSGHLT
MAB_0555|M.abscessus_ATCC_1997 -----MSPLTRRRLLTSAAGTAAFSAAVSLMPANLQRVLAQPAPRSGSLR
Rv1755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1784c|M.bovis_AF2122/97 DIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSPLFQQKGWNPMTQA--LD
MMAR_3823|M.marinum_M DIEHIVLFMQENRSFDHYFGKLSGTNGFDSGSPLFAQKGWNPQTQS--ND
MUL_2799|M.ulcerans_Agy99 DIEHFVFMLQENRSFDHYFGSLSGINGFDTPSSAFQQKGWNPQTQS--ID
MAB_0555|M.abscessus_ATCC_1997 DVEHVVVLMMENRSFDHYFGTLSGVRGFDDPTAVTLSTGKSVFHQPDPQN
Rv1755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1784c|M.bovis_AF2122/97 ATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQA
MMAR_3823|M.marinum_M PAGTTIPYRFDTTRGPLVAGECVNDPGHDWIAMHNAWNNGGNDNWLPAQA
MUL_2799|M.ulcerans_Agy99 PAGVTIPYRFDTTRGPLLNGACANDPGHQWIDMHRAFNNGANDNWLGAQA
MAB_0555|M.abscessus_ATCC_1997 PDGYLLPFHLDTAVNSVQK---IPTTSHAWSVQHDSWNHGKMDNWMAAHR
Rv1755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1784c|M.bovis_AF2122/97 KTRSAA-HTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNRL
MMAR_3823|M.marinum_M AVSALQGNTPVTMGYYQREDIPIHYLLADTFTICDGYFCSLIGGTSPNRL
MUL_2799|M.ulcerans_Agy99 QAQTLQGNVPVTMGYYTRQDQPIHYLLADTFTICDGYHCSLIGGTSPNRL
MAB_0555|M.abscessus_ATCC_1997 --KADGEHYPYVMGYYERADIPFHFALAEAFTVCDNFHSSVMGPTWPNRM
Rv1755c|M.tuberculosis_H37Rv ---------------------------------------DAGVSWKVYRN
Mb1784c|M.bovis_AF2122/97 YWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYRN
MMAR_3823|M.marinum_M YWMSGTIDPDGANGGPLLVDPNIQPQGRFSWRTMPDNLEDAGVSWKIYQN
MUL_2799|M.ulcerans_Agy99 YWMSAWVDPNGEQGGPLLVDPNIQPQGRFSWRTMPDNLSDAGISWKVYQN
MAB_0555|M.abscessus_ATCC_1997 MWMTGTIDPDAAHGGPIIRNTPVS--GGYGWTTYAERLEAAGVSWRVYAE
**:**::* :
Rv1755c|M.tuberculosis_H37Rv -KTLGPIS-SVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLA
Mb1784c|M.bovis_AF2122/97 -KTLGPIS-SVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLA
MMAR_3823|M.marinum_M -KLLGALNNTVIGYDGMLNDFKQAQNPRTNLARYGIAPTYPRDFVSDVRN
MUL_2799|M.ulcerans_Agy99 -KLLGALNNTVIGYDGMLNDFVQARDPRSNMARYGIAPTYPLDFVADVAS
MAB_0555|M.abscessus_ATCC_1997 EDDYGGCN--VLK---LFSRFQRSR-PGEPLYDKGIAPVRATQFEDDARA
. * . *: :.. * :: * : *:** . .* *.
Rv1755c|M.tuberculosis_H37Rv NRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEKTA
Mb1784c|M.bovis_AF2122/97 NRLPRVSWVIPNVLESEHPAVPAA--AGAFAIVNILRILLANPAVWEKTA
MMAR_3823|M.marinum_M NRLPKVSWVLPGFLLSEHPAFPVN--VGAVAIVDVLRILLSNPAVWEKTA
MUL_2799|M.ulcerans_Agy99 NRLPQVSWVLPGFQVSEHPGVPVAPAVGGTAIVNILRILLSNPAVWEKTA
MAB_0555|M.abscessus_ATCC_1997 GRLPAVSWLIMTSTASEHPDYRPA--DGAAYIASKIDAIAANPEVWAKTV
.*** ***:: **** *. *.. : : :** ** **.
Rv1755c|M.tuberculosis_H37Rv LIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLG
Mb1784c|M.bovis_AF2122/97 LIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLG
MMAR_3823|M.marinum_M LIVSYDENGGFFDHVTPTTAPPGTPGEWITVPNIDAVTGSGGIRGPIGLG
MUL_2799|M.ulcerans_Agy99 LIVSFDENGGFFDHVTPTTAPEGTPGEWITVPDINAVTGSGGIRGPIGLG
MAB_0555|M.abscessus_ATCC_1997 FILNYDENDGLFDHVVPPTPPPGTPGEWVKG-------------VPIGGG
:*:.:***.*:****.*.*.* *****::. *** *
Rv1755c|M.tuberculosis_H37Rv FRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVT
Mb1784c|M.bovis_AF2122/97 FRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVT
MMAR_3823|M.marinum_M YRVPCFVISPYSRGPLMVHDTFDHTSQLKLIETRFGVPVPNISAWRNGLV
MUL_2799|M.ulcerans_Agy99 YRVPCFVISPYSRGPLMVHDIFDHTSQLRLLEQRFGVPVPNLTTWRRGVT
MAB_0555|M.abscessus_ATCC_1997 FRVPAIVISPWSVGGWVAGESFDHTSVLRFLEEFTGVREPNISGWRRKTF
:***.:****:* * :. : ***** *:::* ** **:: **.
Rv1755c|M.tuberculosis_H37Rv GDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINR-GIPY
Mb1784c|M.bovis_AF2122/97 GDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINR-GIPY
MMAR_3823|M.marinum_M GDMTSTFNFAVPPNSSRPNLSHPAINAVQKLPQCVPNYVLGTVTKTAVPY
MUL_2799|M.ulcerans_Agy99 GDMTSTFNFAVPPNASPPNLDHPALKAVPQQVQCVPDTVT-VFTKTVPPY
MAB_0555|M.abscessus_ATCC_1997 GNLLSAFGFDSPVRPAPELPDTAAVVAAADRTDTRP-----------PPV
*:: *:*.* * ..: . ..: * : * *
Rv1755c|M.tuberculosis_H37Rv RVPDPQIMPTQE-TTPTRGIPSGPC
Mb1784c|M.bovis_AF2122/97 RVPDPQIMPTQE-TTPTRGIPSGPC
MMAR_3823|M.marinum_M RVPFPQVMPTQE-TQPARGIPSGLC
MUL_2799|M.ulcerans_Agy99 RVPFPQVMPSQE-TSPTRGIPSGPC
MAB_0555|M.abscessus_ATCC_1997 IPPAPQTSPVQEPGSRPRRYPRR--
* ** * ** .* *