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GRSHQISDWDPEDSVAWEAGNKFIARRNLIWSVAAEHVGFSVWSLWSVMVLFMPTSVYGFSAGDKFLLGA TATLVGACLRFPYTFATAKFGGRNWTIFSALVLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAA SMTNINAFFPQRLKGAALALNAGGGNLGVPMVQLVGLLVIATAGDREPYWVCAIYLVLLAVAGLGAALYM DNLTEYRIELNTMRAVVSEPHTWVISLLYIGTFGSFIGFSFAFGQVLQINFIASGQSTAQASLHAAQIAF LGPLLGSLSRIYGGKLADRIGGGRVTLAAFCAMLLATGILISASTFGDHLAGPMPTATMVGYVIGFTALF ILSGIGNGSVYKMIPSIFEARSHSLQISEAERRQWSRSMSGALIGLAGAVGALGGVGVNLALRESYLTSG TATSAFWAFGVFYLVASVLTWAIYVRRGLKSAGELVPATTAPAGLAYV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0261c | narK3 | - | 100% (469) | PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION PROTEIN NARK3 (NITRITE FACILITATOR) |
| M. tuberculosis H37Rv | Rv2329c | narK1 | e-172 | 62.63% (463) | nitrite extrusion protein 1 NarK1 |
| M. tuberculosis H37Rv | Rv0267 | narU | 6e-84 | 42.16% (453) | integral membrane nitrite extrusion protein NarU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0267c | narK3 | 0.0 | 100.00% (469) | integral membrane nitrite extrusion protein NarK3 |
| M. gilvum PYR-GCK | Mflv_3015 | - | 1e-157 | 60.00% (470) | nitrite extrusion protein |
| M. leprae Br4923 | MLBr_00844 | narK | 1e-167 | 62.83% (452) | putative nitrite extrusion protein |
| M. abscessus ATCC 19977 | MAB_3523c | - | 1e-159 | 60.88% (455) | integral membrane nitrite extrusion protein NarK3 |
| M. marinum M | MMAR_2079 | narK3 | 1e-179 | 67.78% (450) | integral membrane nitrite extrusion protein NarK3 |
| M. avium 104 | MAV_4899 | - | 1e-178 | 63.20% (462) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0433 | - | 0.0 | 76.98% (443) | nitrite extrusion protein |
| M. thermoresistible (build 8) | TH_0644 | narK2 | 2e-08 | 27.75% (191) | POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 |
| M. ulcerans Agy99 | MUL_3265 | narK3 | 1e-177 | 66.67% (450) | integral membrane nitrite extrusion protein NarK3 |
| M. vanbaalenii PYR-1 | Mvan_3492 | - | 8e-84 | 40.61% (458) | nitrite transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3015|M.gilvum_PYR-GCK ------------------------------MTWAFTGVMAKRTRDIDTWD
MAB_3523c|M.abscessus_ATCC_199 -----------------------------MANNTATAPIARRGRWIENWD
Rv0261c|M.tuberculosis_H37Rv ---------------------------------------MGRSHQISDWD
Mb0267c|M.bovis_AF2122/97 ---------------------------------------MGRSHQISDWD
MSMEG_0433|M.smegmatis_MC2_155 ------------------------------------MPTLLKPKRITNWD
MMAR_2079|M.marinum_M ---------------------------------------MGRSRHIAHWD
MUL_3265|M.ulcerans_Agy99 ---------------------------------------MGRSRHIAHWD
MAV_4899|M.avium_104 ---------------------------------------MGRDHRITDWN
MLBr_00844|M.leprae_Br4923 MDQLVLLQAEESLYGPGRRSKTVPIDHRHSLKSSFFRLRLRRACRISHWD
Mvan_3492|M.vanbaalenii_PYR-1 ------------------MTVTDSESTGALATAAPAPERHRGKHWIDDWR
TH_0644|M.thermoresistible__bu --------------------------------------------------
Mflv_3015|M.gilvum_PYR-GCK PEDVQAWEGTGGKAPGKEIAKRNLIWSIVAEHVGFSVWSIWSVMVLFMPQ
MAB_3523c|M.abscessus_ATCC_199 PEDVVAWD-NG----GAKIARRNLIWSVVAEHVGFSVWSIWSVMVLFMPQ
Rv0261c|M.tuberculosis_H37Rv PEDSVAWEAGN-----KFIARRNLIWSVAAEHVGFSVWSLWSVMVLFMPT
Mb0267c|M.bovis_AF2122/97 PEDSVAWEAGN-----KFIARRNLIWSVAAEHVGFSVWSLWSVMVLFMPT
MSMEG_0433|M.smegmatis_MC2_155 PEDVAAWEAGN-----KYVARRNLIWSVVAEHIGFSIWSIWSVMVLFMPE
MMAR_2079|M.marinum_M PEDVQAWEAGN-----KAIARRNLVFSIATMHVGFSIWTLWSVMVLFMPQ
MUL_3265|M.ulcerans_Agy99 PEDVQAWEAGN-----KAIARRNLVFSIATMHVGFSIWTLWSVMVLFMPQ
MAV_4899|M.avium_104 PEDAAAWEAGN-----KRIARRNLLCTIAGDHVAFSIWTLWPVMALFMPA
MLBr_00844|M.leprae_Br4923 PEDQAAWEAGN-----KTIARLNLLWSVLTVHLGYSVWTLWPVMELFMPK
Mvan_3492|M.vanbaalenii_PYR-1 PEDPEFWATTG-----KPVARRNLIFSIFAEHIGFSVWLLWSIVVVQMTA
TH_0644|M.thermoresistible__bu --------------------------------------MIGPLSTTYAVD
: .:
Mflv_3015|M.gilvum_PYR-GCK DVYGIDAAG--------KFYLVAVPTLVGAFMRIPYTIAPARFGGRNWTI
MAB_3523c|M.abscessus_ATCC_199 NVYHIDAAG--------KFFLVAMPTLVGAVLRLPYTFATAWFGGRNWTV
Rv0261c|M.tuberculosis_H37Rv SVYGFSAGD--------KFLLGATATLVGACLRFPYTFATAKFGGRNWTI
Mb0267c|M.bovis_AF2122/97 SVYGFSAGD--------KFLLGATATLVGACLRFPYTFATAKFGGRNWTI
MSMEG_0433|M.smegmatis_MC2_155 AVYGFSAGD--------KFLLGATATLVGSCLRIPYTLATATFGGRNWTV
MMAR_2079|M.marinum_M SVYGISAAD--------KLLLGATATLVGGCVRIPYVMATARFGGRNWAT
MUL_3265|M.ulcerans_Agy99 SVYGISAAN--------KLLLGATATLVGGCVRIPYVMATARFGGRNWAT
MAV_4899|M.avium_104 AVYGFSAGD--------KLLLGAVATLVGGCARIPYTLGIAAFGGRKWTT
MLBr_00844|M.leprae_Br4923 DVYGFSAGD--------KFLLATTATLVGACLRVPYSLATALFGGRNWAI
Mvan_3492|M.vanbaalenii_PYR-1 GADGSPAASGFALTTTQALWLVAVPSGVGAFLRLPYTFAVPVFGGRNWTV
TH_0644|M.thermoresistible__bu ISLSSAEAS----------MLVATPILVGAVGRIVVGSLTDRYGGRAMFI
.. * : . **. *. :***
Mflv_3015|M.gilvum_PYR-GCK VSALLLLIPTVLAYYYMKNPAS-YTTYMVIAAFAGLGGGNFASSMTNINA
MAB_3523c|M.abscessus_ATCC_199 FSALVLAVPTALTLYFMAHPETSYTTFMIVAAVAGFGGGNFASSMTNINA
Rv0261c|M.tuberculosis_H37Rv FSALVLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAASMTNINA
Mb0267c|M.bovis_AF2122/97 FSALVLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAASMTNINA
MSMEG_0433|M.smegmatis_MC2_155 FSALVLLIPTVMTVVLMANPGLPLWPYLVCAALAGFGGGNFASSMTNINA
MMAR_2079|M.marinum_M FSSLVLLVPTVGAIVLLANPGLPLWPYLVCAALSGLGGGNYSASLANVEA
MUL_3265|M.ulcerans_Agy99 FSSLVLLVPTVGAIVLLANPGLPLWPYLVCAALSGVGGGNYSASLANVEA
MAV_4899|M.avium_104 FSAVVLLIPTVGTIVLLANPGLPLWLFVLCAALTGLGGGNYAASLANVNA
MLBr_00844|M.leprae_Br4923 FSVMVLLIPTIATMVLLAHPGLPLWPYLACAALTGLGGGNFAASMTNANA
Mvan_3492|M.vanbaalenii_PYR-1 ISALLLLIPCLGLAWAVSNPDINFAVLLLIAATAGFGGGNFASSMANISF
TH_0644|M.thermoresistible__bu AITLASIVPVLAVG--AAGAAGSYPLLLVFGFFLGIAGTIFAVGIPFANN
: :* . : . *..* :: .:. .
Mflv_3015|M.gilvum_PYR-GCK FYPQRLKGWALGLNAGGGNIGVPVIQLIGLMVIAAVGNTRPEIVCAIYLV
MAB_3523c|M.abscessus_ATCC_199 FYPQRFKGWALGLNAGGGNIGVPVIQVIGLLVIATVGNRSPHWVAAIYLV
Rv0261c|M.tuberculosis_H37Rv FFPQRLKGAALALNAGGGNLGVPMVQLVGLLVIATAGDREPYWVCAIYLV
Mb0267c|M.bovis_AF2122/97 FFPQRLKGAALALNAGGGNLGVPMVQLVGLLVIATAGDREPYWVCAIYLV
MSMEG_0433|M.smegmatis_MC2_155 FYPQRLKGWALGLNAGGGNIGVPMIQLVGLFVIATAGNRAPYWVCAVYLV
MMAR_2079|M.marinum_M FYPQRLKGVALGLTGGIGNLGVAAIQAVGLLVLATAGHEAPYWVCAVYLV
MUL_3265|M.ulcerans_Agy99 FYPQRLKGVALGLTGGIGNLGVTAIQAVGLLVLATAGHEAPYWVCAVYLV
MAV_4899|M.avium_104 FYPQRLKGAAMAVNAGVANLGVAVIQLVGLLVLATAGHQAPYWVCAVYLV
MLBr_00844|M.leprae_Br4923 FYPHRLKGAAFGLAGGAGNLGVSVIQVVGMLVIASVGDRKPYIVCGLYVV
Mvan_3492|M.vanbaalenii_PYR-1 FYPESEKGWALGLNAAGGNIGVAVAQKIIPVVVTLGAGVALSLAGLFYIP
TH_0644|M.thermoresistible__bu WYAPSRRGFATGVFG-MGMVGTALSAFFTPRFVESFGLFTTHVIIAVALG
::. :* * .: . . :*.. . .: . . :
Mflv_3015|M.gilvum_PYR-GCK AISGAAVGAALFMDNLRNQKSNFGALV----EAMRFKHSWVMSFLYIGTF
MAB_3523c|M.abscessus_ATCC_199 LIAFAAVGAALFMDNLADQKTDGRSLI----DVMKYRDSWIIAFLYIGTF
Rv0261c|M.tuberculosis_H37Rv LLAVAGLGAALYMDNLTEYRIELNTMR----AVVSEPHTWVISLLYIGTF
Mb0267c|M.bovis_AF2122/97 LLAVAGLGAALYMDNLTEYRIELNTMR----AVVSEPHTWVISLLYIGTF
MSMEG_0433|M.smegmatis_MC2_155 ALAVAGLGAALYMDNLEHHKIDLGAMK----AILGERDTWIISLLYIGTF
MMAR_2079|M.marinum_M LIAIAGLGAALFMDNLT-HVIEVGHVR----SVLAVPDTWGVSFLYMCAS
MUL_3265|M.ulcerans_Agy99 LIAIAGLGAALFMENLT-HVIEVGHVR----SVLAVPDTWSVSFLYMCAS
MAV_4899|M.avium_104 FLAAVAIAAAMFMDDIN-HGTQLSTMR----SILFERDTHVISLLYIATF
MLBr_00844|M.leprae_Br4923 LLIIAGIGAMLFMNDIEHHRIGVNTIRPVLFVVVSTRDSWVLALLYLASF
Mvan_3492|M.vanbaalenii_PYR-1 FTVAAAVCAFLFMNNLTEAKADVKPVW----ESLRHADTWIMSLLYIGTF
TH_0644|M.thermoresistible__bu LTALLCLVAMHDSPDFTPNTERVLPKLK---AAARLPVTWEMSILYAIVF
: * :: : :::**
Mflv_3015|M.gilvum_PYR-GCK GSFIGFSFAFGQVLQINYLAG--------GDTPAQASLHAAQIAFLGPLL
MAB_3523c|M.abscessus_ATCC_199 GSFIGFSFAFGQVLQLNFLAGLAHSGVTPAQAAAQASLHAAQIAFIGPLL
Rv0261c|M.tuberculosis_H37Rv GSFIGFSFAFGQVLQINFIAS--------GQSTAQASLHAAQIAFLGPLL
Mb0267c|M.bovis_AF2122/97 GSFIGFSFAFGQVLQINFIAS--------GQSTAQASLHAAQIAFLGPLL
MSMEG_0433|M.smegmatis_MC2_155 GSFIGFAFAFGQVLQINFISG--------GQTPAQASLHAAQIAFIGPLL
MMAR_2079|M.marinum_M GSFIGFAFVFGQVLQFNLLAG--------GQSTAQASLHAAEIAFVGPLL
MUL_3265|M.ulcerans_Agy99 GSFIGFAFVFGQVLQFNLLAG--------GQSTAQASLHAAEIAFVGPLL
MAV_4899|M.avium_104 GSWIGFSFAFGQVMQVNFLEN--------GESAKHAALHAAQLAFIGPLL
MLBr_00844|M.leprae_Br4923 GSFIGFSFAFGQVLETNFVAG--------GQSTAQAALHAAELAFIGPTL
Mvan_3492|M.vanbaalenii_PYR-1 GSFIGYSAAFPTLLKAVFDRG----------------DIALMWAFLGAGI
TH_0644|M.thermoresistible__bu GGFVAFSNYLPTYXPSSPACT----------------------------I
*.::.:: : :
Mflv_3015|M.gilvum_PYR-GCK GSISRPFGGKLADRVGGGRITLYVFVAMIF-AAGVLVATGVMDDAAAGAP
MAB_3523c|M.abscessus_ATCC_199 GSLARPFGGWLSDRTGGGKISLYAFIAMIF-GAGILVAAGTISDRGAGAP
Rv0261c|M.tuberculosis_H37Rv GSLSRIYGGKLADRIGGGRVTLAAFCAMLL-ATGILISASTFGDHLAGP-
Mb0267c|M.bovis_AF2122/97 GSLSRIYGGKLADRIGGGRVTLAAFCAMLL-ATGILISASTFGDHLAGP-
MSMEG_0433|M.smegmatis_MC2_155 GSLSRVYGGKLADRIGGGRVTLAVFAGMIL-GAGLLVAVSTVSDGSSEA-
MMAR_2079|M.marinum_M GSLARIVGGKLGDRFGGGRVSLGVFVAMIL-SAALLVAVSTHADLNHGAG
MUL_3265|M.ulcerans_Agy99 GSLARIVGGKLGDRFGGGRVTLGVFVAMIL-SAALLVAVNTHADLNHGAG
MAV_4899|M.avium_104 GSVARIYGGRLADRVGGSRVTLGVLAAMTL-AAGLLVIVSTVDDQHAGA-
MLBr_00844|M.leprae_Br4923 AAVARFWGGRLADRLGGSRVTLVVFGAMVF-AAGLLGVLGIIEGSRVCP-
Mvan_3492|M.vanbaalenii_PYR-1 GSVARPLGGKLSDRVGGARITAVSFAMLAIGAAGALWSVQAKN-------
TH_0644|M.thermoresistible__bu TTCTSTPPPRHSTRFGSG--------------------------------
: : . * *..
Mflv_3015|M.gilvum_PYR-GCK ---TSAQMIGYVAGFILLFILSGLGNGSTYKMIPSIFEAKAQGRDDLDKE
MAB_3523c|M.abscessus_ATCC_199 ---SGSIMTAYVIGFIILFVVSGIGNGSVYKMIPSVFAAKARSAG-LDET
Rv0261c|M.tuberculosis_H37Rv --MPTATMVGYVIGFTALFILSGIGNGSVYKMIPSIFEARSHSLQ-ISEA
Mb0267c|M.bovis_AF2122/97 --MPTATMVGYVIGFTALFILSGIGNGSVYKMIPSIFEARSHSLQ-ISEA
MSMEG_0433|M.smegmatis_MC2_155 --ATGLMMSGYVVGFIALFLLSGIGNGSVYKMIPSIFEARSHSLD-VSED
MMAR_2079|M.marinum_M GRMTAATLIGYVSGFIALFIFCGMGKGTVFKLIPSIFAERSQHLD-ISDM
MUL_3265|M.ulcerans_Agy99 GRMTAATLIGYVSGFIALFIFCGMGKGTVFELIPSIFAERSQHLD-ISDM
MAV_4899|M.avium_104 ---HSVSMIGYVVGFMVLFILSGMGNGSVFKLIPSVYEARSRGRD-TSED
MLBr_00844|M.leprae_Br4923 --IRGVMMASYFAGFITLFILSGLGNGSVYKMIPTIFEACSHSLG-INDD
Mvan_3492|M.vanbaalenii_PYR-1 -------MPVFFIAFMFLFVATGIGNGSTYRMISKIFRVKGEDAG--GDP
TH_0644|M.thermoresistible__bu --------------------PGRSGPAGSWPMCSPPRNPVTTAGS-----
* . : : .
Mflv_3015|M.gilvum_PYR-GCK GKAAWSRAMSGALIGFAGAVGALGGVFINVVLRASYVGDAKSATAAFWVF
MAB_3523c|M.abscessus_ATCC_199 ----WSRTMSGALIGVAGAIGALGGVAINLVLRASYLSAAKSATMAFWVF
Rv0261c|M.tuberculosis_H37Rv ERRQWSRSMSGALIGLAGAVGALGGVGVNLALRESYLTSG-TATSAFWAF
Mb0267c|M.bovis_AF2122/97 ERRQWSRSMSGALIGLAGAVGALGGVGVNLALRESYLTSG-TATSAFWAF
MSMEG_0433|M.smegmatis_MC2_155 ERRHWSRSMSGALIGFAGAVGALGGVGINMALRQSYLSSG-SATTAFWTF
MMAR_2079|M.marinum_M QRRQWARIMSGALIGFAGSVGALGGVGINLALRQSYVHSG-TETPAFWAF
MUL_3265|M.ulcerans_Agy99 QRRQWARIVSGALIGFAGSVGALGGVGINLALRQSYVHSG-TETPAFWAF
MAV_4899|M.avium_104 ERRQWARAMAGSLIGICSAVGAFGGVAINLALRQSYLSTG-TETSAYWTF
MLBr_00844|M.leprae_Br4923 ECRDWSRVISGVVIGFVAEVGALGGVGIDLALRESYLNTG-GVTAAFWIF
Mvan_3492|M.vanbaalenii_PYR-1 LTMLHMRRQAAGALGIISSVGAFGGFIVPLAYAWSKSQFG-NIQPALQFY
TH_0644|M.thermoresistible__bu GRSAITRRSRGHWIGVRSTR------------SHPMCRCGCSTAAACCGR
* . :*. . . . *
Mflv_3015|M.gilvum_PYR-GCK LAFYVVCAFVTWFVFLRLQEHRAHSGEHIGRTSAPVPVG-----
MAB_3523c|M.abscessus_ATCC_199 LVFYVICAAVTWYAYVRRPMTVSVP--AISSSKNEVAV------
Rv0261c|M.tuberculosis_H37Rv GVFYLVASVLTWAIYVRRGLKSAGELVPATTAPAGLAYV-----
Mb0267c|M.bovis_AF2122/97 GVFYLVASVLTWAIYVRRGLKSAGELVPATTAPAGLAYV-----
MSMEG_0433|M.smegmatis_MC2_155 LAFYVLASVVTWFCYVRR---PAAMPVTGTERHAPAIAG-----
MMAR_2079|M.marinum_M LVCYLCAAALTWARYVRPRSPVASAPRKPNEDPQLSDAAA----
MUL_3265|M.ulcerans_Agy99 LVCYLCAAALTWARYVRPRSPVASAPRKPNEDPQLSGAAA----
MAV_4899|M.avium_104 MASYVVAAIMTWLVYVR--RPVT-APGVSLPETQAARL------
MLBr_00844|M.leprae_Br4923 MLCYAAAGVLTWKMYVCRPLPGNLHDEAANAFAASVGASRTHRG
Mvan_3492|M.vanbaalenii_PYR-1 VGFFIVLLGVTWFFYMRKGTRMAQAGV-----------------
TH_0644|M.thermoresistible__bu --------------------------------------------