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SGAKKLIFEQFALVGQALSSGHRLELLDLLVQGERSVDALARASGLTFANASQHLLQLRRAGLVTSRRDG KRVIYALSDPQVWDVVRAVRAVAERNLASVGSLVRQYYTDRDSLEPISRDELQARVAAGSVLVLDVRPAM EYAAGHLPGAVSIPLDELAERLDELPSGIDIVACCRGPYCVYAYDALELLRPNGFSARRLDGGFSEWLAA DLPVVRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1674c | - | - | 100% (218) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. tuberculosis H37Rv | Rv0324 | - | 3e-45 | 45.33% (214) | ArsR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0081 | - | 3e-10 | 39.29% (84) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1701c | - | 1e-120 | 100.00% (218) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3178 | - | 6e-09 | 39.77% (88) | regulatory protein, ArsR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2562c | - | 3e-10 | 41.89% (74) | transcriptional regulatory protein ArsR |
| M. marinum M | MMAR_2139 | - | 7e-09 | 36.52% (115) | transcriptional regulatory protein |
| M. avium 104 | MAV_5108 | - | 2e-09 | 35.48% (93) | transcriptional regulator, ArsR family protein |
| M. smegmatis MC2 155 | MSMEG_5386 | - | 4e-07 | 36.56% (93) | rhodanese-like domain-containing protein |
| M. thermoresistible (build 8) | TH_1233 | - | 2e-07 | 37.93% (87) | rhodanese-like domain protein |
| M. ulcerans Agy99 | MUL_3611 | - | 1e-05 | 37.18% (78) | ArsR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5835 | - | 3e-08 | 54.17% (48) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1674c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1701c|M.bovis_AF2122/97 --------------------------------------------------
MAB_2562c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_5108|M.avium_104 --------------------------------------------------
Mflv_3178|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2139|M.marinum_M --------------------------------------------------
MSMEG_5386|M.smegmatis_MC2_155 --------------------------------------------------
TH_1233|M.thermoresistible__bu --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5835|M.vanbaalenii_PYR-1 MDISIIETSGLGDRSYLISHGGSAVVIDPQRDIDRVLALADERATRITHV
Rv1674c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1701c|M.bovis_AF2122/97 --------------------------------------------------
MAB_2562c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_5108|M.avium_104 --------------------------------------------------
Mflv_3178|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2139|M.marinum_M --------------------------------------------------
MSMEG_5386|M.smegmatis_MC2_155 --------------------------------------------------
TH_1233|M.thermoresistible__bu --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5835|M.vanbaalenii_PYR-1 LETHLHNDYVTGGLELSRTVGAEYVVPAVDGIGYPHRAVTDGDVIDAGPM
Rv1674c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1701c|M.bovis_AF2122/97 --------------------------------------------------
MAB_2562c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_5108|M.avium_104 --------------------------------------------------
Mflv_3178|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2139|M.marinum_M --------------------------------------------------
MSMEG_5386|M.smegmatis_MC2_155 --------------------------------------------------
TH_1233|M.thermoresistible__bu --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5835|M.vanbaalenii_PYR-1 RFEVLHTPGHTHHHVSYVLRDDTGAVHGVFTGGSMLFGTTGRTDLVAAED
Rv1674c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1701c|M.bovis_AF2122/97 --------------------------------------------------
MAB_2562c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_5108|M.avium_104 --------------------------------------------------
Mflv_3178|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2139|M.marinum_M --------------------------------------------------
MSMEG_5386|M.smegmatis_MC2_155 --------------------------------------------------
TH_1233|M.thermoresistible__bu --------------------------------------------------
MUL_3611|M.ulcerans_Agy99 ----------------------------------------------MATS
Mvan_5835|M.vanbaalenii_PYR-1 TEELTHAQFHSVRRLADTLPTDTPVYPTHGFGSFCSATPASGDESTIGEQ
Rv1674c|M.tuberculosis_H37Rv ----------------------------MSGAKKLIFEQFALVGQALSSG
Mb1701c|M.bovis_AF2122/97 ----------------------------MSGAKKLIFEQFALVGQALSSG
MAB_2562c|M.abscessus_ATCC_199 -----------------------------MDARQPLYRMKADFFKTLGHP
MAV_5108|M.avium_104 ----------------------------MADSRQPLYRMKAEFFKTLGHP
Mflv_3178|M.gilvum_PYR-GCK --------------------MNKRDTC--LAGNTSDLDAAVALFHSLSDA
MMAR_2139|M.marinum_M ------------------MPMKIADDAPPTASPREDLAGAVALFHSLSDP
MSMEG_5386|M.smegmatis_MC2_155 --------------------MLSPGVVTATHLDAQLKSATSPQILDVRTP
TH_1233|M.thermoresistible__bu ----------------------MTATIDCRHLRDCLDSDSPPRVLDVRTP
MUL_3611|M.ulcerans_Agy99 PSPSTAAHDDFVSRHEHDVGDFAEHPAFPAPPPREILEGAGELLRALAAP
Mvan_5835|M.vanbaalenii_PYR-1 RQSNPALTQDEQSYVDELLAGLSAYPTYYAHMGVINREGPAPVDLTPPAP
Rv1674c|M.tuberculosis_H37Rv HRLELLDLLVQGERSVDALARASGLTFANAS------------QHLLQLR
Mb1701c|M.bovis_AF2122/97 HRLELLDLLVQGERSVDALARASGLTFANAS------------QHLLQLR
MAB_2562c|M.abscessus_ATCC_199 VRIRVLELLSERDQAVSEMLPEVGIEAANLS------------QQLAVLR
MAV_5108|M.avium_104 ARIRVLELLSSREYAVSEMLPEVGVEPANLS------------QQLSILR
Mflv_3178|M.gilvum_PYR-GCK TRLTIVRRLADGEARVVDLIGELGLAQSTVS------------AHVACLR
MMAR_2139|M.marinum_M TRLAIARRLADGERRVVDLTRELGLPQSTVS------------SHLACLR
MSMEG_5386|M.smegmatis_MC2_155 AEFETNHIAGSYNVPLDLLREHRDEIVEHLD------------TDVVVVC
TH_1233|M.thermoresistible__bu GEFETAHIAGAYNVPLDLLREHRDEIARHLD------------QDVILVC
MUL_3611|M.ulcerans_Agy99 VRIAIVLQLREAQRCVHELVDALGVPQPLVS------------QHLKILK
Mvan_5835|M.vanbaalenii_PYR-1 IDPAELRRRIEAGEWVVDLRNRTAFAAGHLQGTLGFELSGSFVSYFGWLY
: : . . :
Rv1674c|M.tuberculosis_H37Rv RAGLVTSRRDGKRVIYALSDPQVWDVVRAVRAVAERNLASVGSLVRQYYT
Mb1701c|M.bovis_AF2122/97 RAGLVTSRRDGKRVIYALSDPQVWDVVRAVRAVAERNLASVGSLVRQYYT
MAB_2562c|M.abscessus_ATCC_199 RAGLVTARREGLSVLYTLTSPQVAQLLATARTILTG--------------
MAV_5108|M.avium_104 RAGLVTARREGLSVRYALTSPQVAELLVVARTILTG--------------
Mflv_3178|M.gilvum_PYR-GCK DCGLVTGRPEGRQVFYSLSRPELLDVLAAAETLLAA--------------
MMAR_2139|M.marinum_M DCGLIAGRPEGRQVFYALAVPDLLDLFAAAETVLAA--------------
MSMEG_5386|M.smegmatis_MC2_155 RSGQRATQAGETLRNAGLTNVHILEGGITAWEAAGFAVDRG---------
TH_1233|M.thermoresistible__bu RSGQRAAQAEETLRAAGLTNVHILEGGITAWEAQGFDVVRG---------
MUL_3611|M.ulcerans_Agy99 AAGVVTGERSGREVLYRLVDQHLAHIVVDAVAHAGE--------------
Mvan_5835|M.vanbaalenii_PYR-1 EWGAPVTLIGESPDQIAEAKRELVRIGVDRLTGSATGDVDTLRAEAPLG-
* . .:
Rv1674c|M.tuberculosis_H37Rv DRDSLEPISRDELQARVAAGSVLVLDVRPAMEYAAGHLPGAVSIPLDELA
Mb1701c|M.bovis_AF2122/97 DRDSLEPISRDELQARVAAGSVLVLDVRPAMEYAAGHLPGAVSIPLDELA
MAB_2562c|M.abscessus_ATCC_199 ----------------VVADQAEWLDGAGPVPVGPAEATRARR-------
MAV_5108|M.avium_104 ----------------VVAGQAETLEEIPESLL--AEPTG----------
Mflv_3178|M.gilvum_PYR-GCK ------------------TGNAVALCPTYGTG-ARGAAIDTEETRQ----
MMAR_2139|M.marinum_M ------------------TGNAVTLCPNYGTRPTRASASRRRGVKRAAPG
MSMEG_5386|M.smegmatis_MC2_155 -------------AQRWDLERQVRLVAGSIVLTGVLASVAVPAAKWVAAA
TH_1233|M.thermoresistible__bu -------------RQRWDLERQVRLVAGAIVLFSVLASVVVPGLQWVAAA
MUL_3611|M.ulcerans_Agy99 -------------------DSA----------------------------
Mvan_5835|M.vanbaalenii_PYR-1 ---SYEVGDFARLARERKTTAVAVLDVRQTNEFDQEHIPGAVSIPLHELP
Rv1674c|M.tuberculosis_H37Rv ERLDELPSGIDIVACCRGPYCVYAYDALELLRPNGFSARRLDGGFSEWLA
Mb1701c|M.bovis_AF2122/97 ERLDELPSGIDIVACCRGPYCVYAYDALELLRPNGFSARRLDGGFSEWLA
MAB_2562c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_5108|M.avium_104 --------------------------------------------------
Mflv_3178|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_2139|M.marinum_M VADWSPGR------------------------------------------
MSMEG_5386|M.smegmatis_MC2_155 VGSGLAIAALTNTCAMGMALAKLPYNRGTACDAASILAQLA--GPKNRKA
TH_1233|M.thermoresistible__bu IGGGLMFAALTNTCAMGMLLAKLPYNRGATCDARTIVAQLIDSGPETGRS
MUL_3611|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5835|M.vanbaalenii_PYR-1 QRLDDVPAGPVWVHCASGYRSSIAAS---YLDRAGISVVLIDDDFDNAVK
Rv1674c|M.tuberculosis_H37Rv ADLPVVRT
Mb1701c|M.bovis_AF2122/97 ADLPVVRT
MAB_2562c|M.abscessus_ATCC_199 --------
MAV_5108|M.avium_104 --------
Mflv_3178|M.gilvum_PYR-GCK --------
MMAR_2139|M.marinum_M --------
MSMEG_5386|M.smegmatis_MC2_155 A-------
TH_1233|M.thermoresistible__bu --------
MUL_3611|M.ulcerans_Agy99 --------
Mvan_5835|M.vanbaalenii_PYR-1 LGLTVSG-