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MLSPGVVTATHLDAQLKSATSPQILDVRTPAEFETNHIAGSYNVPLDLLREHRDEIVEHLDTDVVVVCRS GQRATQAGETLRNAGLTNVHILEGGITAWEAAGFAVDRGAQRWDLERQVRLVAGSIVLTGVLASVAVPAA KWVAAAVGSGLAIAALTNTCAMGMALAKLPYNRGTACDAASILAQLAGPKNRKAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5386 | - | - | 100% (195) | rhodanese-like domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4589 | - | 5e-08 | 30.69% (101) | fused rhodanese domain-containing protein/cystathionine |
| M. smegmatis MC2 155 | MSMEG_6425 | - | 1e-07 | 32.50% (80) | rhodanese-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3143 | moeB2 | 7e-12 | 38.30% (94) | molybdenum cofactor biosynthesis protein MoeB |
| M. gilvum PYR-GCK | Mflv_0984 | - | 1e-76 | 73.66% (186) | rhodanese domain-containing protein |
| M. tuberculosis H37Rv | Rv3116 | moeB2 | 7e-12 | 38.30% (94) | molybdenum cofactor biosynthesis protein MoeB |
| M. leprae Br4923 | MLBr_00817 | moeZ | 7e-09 | 30.85% (94) | molybdopterin biosynthesis-like protein MoeZ |
| M. abscessus ATCC 19977 | MAB_3525c | - | 3e-07 | 28.57% (98) | molybdenum cofactor biosynthesis protein MoeB1 |
| M. marinum M | MMAR_1352 | moeB1 | 3e-08 | 29.90% (97) | molybdenum cofactor biosynthesis protein MoeB1 |
| M. avium 104 | MAV_4153 | - | 2e-08 | 31.18% (93) | molybdopterin biosynthesis-like protein MoeZ |
| M. thermoresistible (build 8) | TH_1233 | - | 4e-74 | 72.11% (190) | rhodanese-like domain protein |
| M. ulcerans Agy99 | MUL_2527 | moeB1 | 1e-08 | 29.90% (97) | molybdopterin biosynthesis-like protein MoeZ |
| M. vanbaalenii PYR-1 | Mvan_1829 | - | 2e-74 | 68.00% (200) | rhodanese domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1352|M.marinum_M --MSTTALPPLVAPAATLSREEVARYSRHLIIPDLGVDGQKRLKNARVLV
MUL_2527|M.ulcerans_Agy99 --MSTTALPPLVAPAATLSREEVARYSRHLIIPDLGVDGQKRLKNARVLV
MAB_3525c|M.abscessus_ATCC_199 --MPT--LPPLVRPAAELTREEVARYSRHLIIPDLGVDGQKRLKNAKVLV
MLBr_00817|M.leprae_Br4923 MSTSSTSLPPLVEPAGQLSRDEVIRYSRHLIIPDIGVDGQMRLKSARVLV
MAV_4153|M.avium_104 --MSTP-LPPLVAPADQLTADEMARYSRQLIIPGLGVDGQKRLKNARVLV
Mb3143|M.bovis_AF2122/97 --MTEALIPAPSQIS--LTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLC
Rv3116|M.tuberculosis_H37Rv --MTEALIPAPSQIS--LTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLC
Mflv_0984|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1829|M.vanbaalenii_PYR-1 ------------------------------------------------ME
TH_1233|M.thermoresistible__bu --------------------------------------------------
MSMEG_5386|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1352|M.marinum_M IGAGGLGSPTLLYLAAAGVGTIGIVDFDVVDESNLQRQIIHGVADVGRSK
MUL_2527|M.ulcerans_Agy99 IGAGGLGSPTLLYLAAAGVGTIGIVDFDVVDESNLQRQIIHGVADVGRSK
MAB_3525c|M.abscessus_ATCC_199 IGAGGLGSPTLLYLAAAGVGTIGIVEFDVVDESNLQRQIIHGQSDIGRSK
MLBr_00817|M.leprae_Br4923 IGAGGLGAPVLLYLAAAGVGTIGIIDFDVVDESNLQRQIIHGVADVGRSK
MAV_4153|M.avium_104 IGAGGLGAPTLLYLAAAGVGTIGIVEFDAVEESNLQRQIIHGVADVGRSK
Mb3143|M.bovis_AF2122/97 IGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPK
Rv3116|M.tuberculosis_H37Rv IGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPK
Mflv_0984|M.gilvum_PYR-GCK -----------------------MTAPVTIDSHDLSQMLGSPTPPRVLDV
Mvan_1829|M.vanbaalenii_PYR-1 RYPPRYHASRGFRHQQLRKGLTSMTAPATIDSHDLHQMLGSATPPRVLDV
TH_1233|M.thermoresistible__bu -----------------------MTA--TIDCRHLRDCLDSDSPPRVLDV
MSMEG_5386|M.smegmatis_MC2_155 -----------------------MLSPGVVTATHLDAQLKSATSPQILDV
: : .* : .
MMAR_1352|M.marinum_M AQSARDSIVAINPLIEVRLHEFRLESDNAVDLFGHYDLIIDGTDNFATRY
MUL_2527|M.ulcerans_Agy99 AQSARDSIVAINPLIEVRLHEFRLESDNAVDLFGHYDLIIDGTDNFATRY
MAB_3525c|M.abscessus_ATCC_199 AQSARDSVLEINPLVEVRLHELRLDPENAVELFAQYDLILDGTDNFATRY
MLBr_00817|M.leprae_Br4923 AQSARDSIVAINPLVQVRLHEFRLESSNVVNLFKQYDLIVDGTDNFATRY
MAV_4153|M.avium_104 AASARDSIAAINPLVDVRLHEFRLDASNAVELFGHYDLIVDGTDNFATRY
Mb3143|M.bovis_AF2122/97 VESAAEAVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRY
Rv3116|M.tuberculosis_H37Rv VESAAEAVAEINPHVRVTQYREMLTHDNALEIFGDHDLIVDGTDNFTTRY
Mflv_0984|M.gilvum_PYR-GCK RTPGEFETAHIAGAYNVPLDLLREHRDEIVKHLDEDVVLVCRSG------
Mvan_1829|M.vanbaalenii_PYR-1 RTPGEFETAHINGAYNVPLDLLREHRDEIIGHLDQDVVLVCRSG------
TH_1233|M.thermoresistible__bu RTPGEFETAHIAGAYNVPLDLLREHRDEIARHLDQDVILVCRSG------
MSMEG_5386|M.smegmatis_MC2_155 RTPAEFETNHIAGSYNVPLDLLREHRDEIVEHLDTDVVVVCRSG------
.. * * .: : ::: :.
MMAR_1352|M.marinum_M LVNDAAVLAGKPYVWGSIYRFEGQVSVFWEDAPGGLGLNYRDLYPEPPPP
MUL_2527|M.ulcerans_Agy99 LVNDAAVLAGKPYVWGSIYRFEGQVSVFWEDAPGGLGLNYRDLYPEPPPP
MAB_3525c|M.abscessus_ATCC_199 LVNDAAVLAHKPYVWGSIYRFEGQVSVFWEDAPDGLGLNYRDLYPEPPPP
MLBr_00817|M.leprae_Br4923 LINDAAVLAKKPYVWGSLYRFEGQVSVFWEDAPDGLGLNYRDLYLEPPPP
MAV_4153|M.avium_104 LINDAAVLAGKPYVWGSIYRFEGQASVCWEDAPDGRGLNYRDLYPEPPPP
Mb3143|M.bovis_AF2122/97 LINDAAVLAGKPYVWGSIYRFNGQTSVFWP----GRGPCYRCLHPAPPPP
Rv3116|M.tuberculosis_H37Rv LINDAAVLAGKPYVWGSIYRFNGQTSVFWP----GRGPCYRCLHPAPPPP
Mflv_0984|M.gilvum_PYR-GCK ---QRAAQAEETLRNAGLSNVH----------------------------
Mvan_1829|M.vanbaalenii_PYR-1 ---QRAAQAEETLRNTGLTNVH----------------------------
TH_1233|M.thermoresistible__bu ---QRAAQAEETLRAAGLTNVH----------------------------
MSMEG_5386|M.smegmatis_MC2_155 ---QRATQAGETLRNAGLTNVH----------------------------
: *. * :. .: ...
MMAR_1352|M.marinum_M GMVPSCAEGGVLGIICASIASVMGTEAVKLITGIGETLLGRLMIYDALEM
MUL_2527|M.ulcerans_Agy99 GMVPSCAEGGVLGIICASIASVMGTEAVKLITGIGETLLGRLMIYDALEM
MAB_3525c|M.abscessus_ATCC_199 GMVPSCAEGGVLGILCASIASVMGTEAIKLITGIGDSLLGRLMVYDALDM
MLBr_00817|M.leprae_Br4923 GMVPSCAEGGVLGIVCASIASVMGTEAIKLITGIGAPLLGRLMIYNALEM
MAV_4153|M.avium_104 GAVPSCAEGGVLGVVCAAIASVMSTEVIKLITGIGESLLGRLMIYDALEM
Mb3143|M.bovis_AF2122/97 GLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEALDA
Rv3116|M.tuberculosis_H37Rv GLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEALDA
Mflv_0984|M.gilvum_PYR-GCK -----ILDGGITAWEAKGFAVNRGAQRWDLER------------------
Mvan_1829|M.vanbaalenii_PYR-1 -----ILDGGITAWEAQGFAVNRGATRWDLER------------------
TH_1233|M.thermoresistible__bu -----ILEGGITAWEAQGFDVVRGRQRWDLER------------------
MSMEG_5386|M.smegmatis_MC2_155 -----ILEGGITAWEAAGFAVDRGAQRWDLER------------------
:**: . . : .*
MMAR_1352|M.marinum_M TYRTIRIRKDP------ATPKITALIDYEQFCG---VVSDDVARAASDST
MUL_2527|M.ulcerans_Agy99 TYRTIRIRKDP------ATPKITALIDYEQFCG---VVSDDVARAASDST
MAB_3525c|M.abscessus_ATCC_199 TYRTIKIRKDP------ATPKITELIDYEAFCG---VISDEASAAVADST
MLBr_00817|M.leprae_Br4923 SYRRIRIHKDP------SRPKITELTDYQQFCG---VVSDDAAQVATGSI
MAV_4153|M.avium_104 SYRTIAIRRDPCD---ASRPAITTLVDYEQLCGAAPAASTDAATGGAEAA
Mb3143|M.bovis_AF2122/97 TYHQIRIAKNPDCAICGDAPTITELVDDSVSCA-------STQSVDPELV
Rv3116|M.tuberculosis_H37Rv TYHQIRIAKNPDCAICGDAPTITELVDDSVSCA-------STQSVDPELV
Mflv_0984|M.gilvum_PYR-GCK -----------------------------------------QVRLVAGSI
Mvan_1829|M.vanbaalenii_PYR-1 -----------------------------------------QVRLVAGSL
TH_1233|M.thermoresistible__bu -----------------------------------------QVRLVAGAI
MSMEG_5386|M.smegmatis_MC2_155 -----------------------------------------QVRLVAGSI
.
MMAR_1352|M.marinum_M ITPQELRAMIDSGKKLALIDVREQVEWDIVHIDGAQLIPKSLISTGEGLA
MUL_2527|M.ulcerans_Agy99 ITPQELRAMINSGKKLALIDVREQVEWDIVHIDGAQLIPKSLISTGEGLA
MAB_3525c|M.abscessus_ATCC_199 ITPRELRELLDTDKKVALIDVREPVEWDIVHIDGAELVPKSTLESGDGLA
MLBr_00817|M.leprae_Br4923 VTPRELRELLDSGKKLALIDVREPVEWDIVHIDGAQLIPRSLINSGEGLA
MAV_4153|M.avium_104 ITPRQLRELLDSGAKLALIDVREPVEFDIVHLDGAQLIPQSSINSGEGLA
Mb3143|M.bovis_AF2122/97 ISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLA
Rv3116|M.tuberculosis_H37Rv ISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLA
Mflv_0984|M.gilvum_PYR-GCK VLSSILGSIAAPKLKWVAGAVGGGLTFAALSNTCAMGMLLSKLPYNRG-A
Mvan_1829|M.vanbaalenii_PYR-1 VLSAILGSIAAPKLKWLAAGVGGGLTFAAVSNTCAMGMLLSKLPYNRGTA
TH_1233|M.thermoresistible__bu VLFSVLASVVVPGLQWVAAAIGGGLMFAALTNTCAMGMLLAKLPYNRG-A
MSMEG_5386|M.smegmatis_MC2_155 VLTGVLASVAVPAAKWVAAAVGSGLAIAALTNTCAMGMALAKLPYNRG-T
: * . : : : : . : * :
MMAR_1352|M.marinum_M KLPQDRTTVLYCKTGVRSAEALAALKKAGFADAVHLQGGIVAWANQMQPD
MUL_2527|M.ulcerans_Agy99 KLPQDRTTVLYCKTGVRSAEALAALKKAGFADAAHLQGGIVAWANQMQPD
MAB_3525c|M.abscessus_ATCC_199 KLPQDRQAVLYCKTGIRSAEALVAVKKAGFSDAVHLQGGIAAWAKQVDPD
MLBr_00817|M.leprae_Br4923 KLPQDRMSVLYCKTGVRSAETLATVKKAGFSDAVHLQGGIVAWAKQVQPD
MAV_4153|M.avium_104 KLPADRMPVLYCKTGVRSAQALAVVRQAGFSDAVHLQGGIVAWAQQMQPD
Mb3143|M.bovis_AF2122/97 QLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSS
Rv3116|M.tuberculosis_H37Rv QLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSS
Mflv_0984|M.gilvum_PYR-GCK SCDAEGIVAQLVEGSAS---------------------------------
Mvan_1829|M.vanbaalenii_PYR-1 TCDAQTVVAQLVDANTTDKNKKVS--------------------------
TH_1233|M.thermoresistible__bu TCDARTIVAQLIDSGPETGRS-----------------------------
MSMEG_5386|M.smegmatis_MC2_155 ACDAASILAQLAGPKNRKAA------------------------------
.
MMAR_1352|M.marinum_M MVMY
MUL_2527|M.ulcerans_Agy99 MVMY
MAB_3525c|M.abscessus_ATCC_199 MVMY
MLBr_00817|M.leprae_Br4923 MVIY
MAV_4153|M.avium_104 MILY
Mb3143|M.bovis_AF2122/97 LLVY
Rv3116|M.tuberculosis_H37Rv LLVY
Mflv_0984|M.gilvum_PYR-GCK ----
Mvan_1829|M.vanbaalenii_PYR-1 ----
TH_1233|M.thermoresistible__bu ----
MSMEG_5386|M.smegmatis_MC2_155 ----