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VKRALITGITGQDGSYLAELLLAKGYEVHGLIRRASTFNTSRIDHLYVDPHQPGARLFLHYGDLIDGTRL VTLLSTIEPDEVYNLAAQSHVRVSFDEPVHTGDTTGMGSMRLLEAVRLSRVHCRFYQASSSEMFGASPPP QNELTPFYPRSPYGAAKVYSYWATRNYREAYGLFAVNGILFNHESPRRGETFVTRKITRAVARIKAGIQS EVYMGNLDAVRDWGYAPEYVEGMWRMLQTDEPDDFVLATGRGFTVREFARAAFEHAGLDWQQYVKFDQRY LRPTEVDSLIGDATKAAELLGWRASVHTDELARIMVDADMAALECEGKPWIDKPMIAGRT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1511 | gmdA | - | 100% (340) | GDP-D-mannose dehydratase gmdA (GDP-mannose 4,6 dehydratase) (GMD) |
| M. tuberculosis H37Rv | Rv0112 | gca | 3e-24 | 27.59% (319) | GDP-mannose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 4e-16 | 27.86% (323) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0116 | gca | 3e-24 | 27.59% (319) | GDP-mannose 4,6-dehydratase |
| M. gilvum PYR-GCK | Mflv_4754 | - | 1e-158 | 79.58% (333) | GDP-mannose 4,6-dehydratase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 5e-15 | 27.38% (325) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 2e-16 | 27.24% (323) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5133 | galE1 | 8e-19 | 28.79% (323) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_0524 | - | 5e-17 | 31.76% (233) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 3e-18 | 28.21% (312) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 1e-14 | 32.04% (181) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 1e-18 | 28.48% (323) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 5e-13 | 26.45% (242) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1511|M.tuberculosis_H37Rv --------MKRALITG---ITGQDGSYLAELLLAKGY-----EVHGLIRR
Mflv_4754|M.gilvum_PYR-GCK -------MVKRALITG---ITGQDGSYLAELLLSKGY-----EVHGLIRR
MLBr_00204|M.leprae_Br4923 ----MYGEPVRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
MAV_0524|M.avium_104 ---------MRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
MMAR_5133|M.marinum_M ---------MRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
MUL_4210|M.ulcerans_Agy99 ---------MRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
MAB_0503|M.abscessus_ATCC_1997 ---------MRAMVTG---AAGFIGSTLVDRLLADGH-----EVTGLDNL
MSMEG_6142|M.smegmatis_MC2_155 -------MAVRTLVTG---AAGFIGSTLVDRLLADGH-----GVVGLDDL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
Mvan_1365|M.vanbaalenii_PYR-1 ---------MRLLVTG---GAGFIGANFVRTTVQQRP---DVQVTVLDSL
Mb0116|M.bovis_AF2122/97 ---------MKVWITG---AGGMMGSHLAEMLLAAGH-----DVYATYCR
::. * .
Rv1511|M.tuberculosis_H37Rv ASTFNTSRIDHLYVDPHQPGARLFLHYGDLIDGTRLVTLLSTIEPDEVYN
Mflv_4754|M.gilvum_PYR-GCK ASTFNTSRIDHLYVDPHSPEAKMFLHYGDLSDGARLVTLLADIDPDEVYN
MLBr_00204|M.leprae_Br4923 ATGHAAN------LEHLASTPALAFVEADIVT-ADLQTILDEHRPEVVFH
MAV_0524|M.avium_104 ASGRASN------LEHLVGNPAHVFVEADIVT-ADLEAILDEHRPEVVFH
MMAR_5133|M.marinum_M ATGRATN------LEHLVDNLAHVFVEADIVD-ADLQAIFEQHRPEVIFH
MUL_4210|M.ulcerans_Agy99 ATGRATN------LEHLVDNLAHVFVEADIVD-ADLQAIFEQHRPEVIFH
MAB_0503|M.abscessus_ATCC_1997 ATGKVAN------LEAAEANAKFTFVKDDIVE-ADLDAVVAEYSPEVIFH
MSMEG_6142|M.smegmatis_MC2_155 SSGRAEN------LHSAENSDKFEFVKADIVD-ADLTGLLAEFKPEVIFH
TH_0330|M.thermoresistible__bu TYAGSRE-------SLAPVADRIRVVEGDVTDSDLVDKLVAES--DAVVH
Mvan_1365|M.vanbaalenii_PYR-1 TYAGSRE-------SLRGVDSQIRLVEGDITDAELVGKLVADS--DAVVH
Mb0116|M.bovis_AF2122/97 PTIDPSD-------------LQFNGAEVDITDWCSVYDSIATFRPDAVFH
. . *: : . : : :
Rv1511|M.tuberculosis_H37Rv LAAQSHVRVSFDEPVHTGDTTGMGSMRLLEAVRLSR--VHCRFYQASSSE
Mflv_4754|M.gilvum_PYR-GCK LAAQSHVRVSFDEPEHTADTTGTGTIRLLEAVRLSG--VKTRFYQASSSE
MLBr_00204|M.leprae_Br4923 LAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTG--VRKIVHTSSGGS
MAV_0524|M.avium_104 LAAQIDVRHSVADPQFDASVNVIGTVRLAEAARRTG--VRKIVHTSSGGS
MMAR_5133|M.marinum_M LAAQIDVRHSVADPQFDASVNVIGTLRLAEAARLTG--VRKVVHTSSGGS
MUL_4210|M.ulcerans_Agy99 LAAQIDVRHSVADPQFDASVNVIGTLRLAEAARLTG--VRKVVHTSSGGS
MAB_0503|M.abscessus_ATCC_1997 LAAQIDVRHSVADPQFDSSVNVVGTVRLAEAARKAG--VRKIVHTSSGGS
MSMEG_6142|M.smegmatis_MC2_155 LAAQISVKRSVDDPPFDATVNVVGTVRLAEAARLAG--VRKVVHTSSGGS
TH_0330|M.thermoresistible__bu FAAESHVDNALAEPEPFLRTNVVGTFTVLEAVR----RHRVRLHHISTDE
Mvan_1365|M.vanbaalenii_PYR-1 FAAETHVDNALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDE
Mb0116|M.bovis_AF2122/97 LAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVR--PHAKIIVAGSSA
:**: : * . *: : ** * . . .
Rv1511|M.tuberculosis_H37Rv MFG---ASPP-PQNELTPFYPRSPYGAAKVYSYWATRNYREAYGLFAVNG
Mflv_4754|M.gilvum_PYR-GCK LYG---ATPP-PQNEDTPFYPRSPYAVAKLYSYWITKNYREAYGMFAVNG
MLBr_00204|M.leprae_Br4923 IYG---TPSQYPTPETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHI
MAV_0524|M.avium_104 IYG---TPPTYPTPETVPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHI
MMAR_5133|M.marinum_M IYG---TPPQYPTSERVPTDPASPYAAGKVAGEIYLNTFRHLYGLECSHI
MUL_4210|M.ulcerans_Agy99 IYG---TPPQYPTSERVPTDPASPYAAGKVAGEIYLNTFRHLYGLECSHI
MAB_0503|M.abscessus_ATCC_1997 IYG---TPKQIPTSETVPTDPHSPYAAGKVAGEIYLNTFRHLYGLECSHI
MSMEG_6142|M.smegmatis_MC2_155 VYG---TPPAYPTSEDMPVNPASPYAAGKVAGEVYLNMYRNLYDLDCSHI
TH_0330|M.thermoresistible__bu VYGDLPLHDPRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYGVAATIS
Mvan_1365|M.vanbaalenii_PYR-1 VYGDLELDDPARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATIS
Mb0116|M.bovis_AF2122/97 EYG-FVDPSEVPINERRELRPLHPYGVSKAATDMLAYQYHKSYGMHTVVA
:* : * **. * : . :
Rv1511|M.tuberculosis_H37Rv ILFNHESPRRGETFVTRKITRAVARIKAGIQSEVYMGNLDAVRDWGYAPE
Mflv_4754|M.gilvum_PYR-GCK ILFNHESPRRGETFVTRKITRAVAAIKAGAQNYLYMGNLDAIRDWGYAPE
MLBr_00204|M.leprae_Br4923 APANVYGPRQ-DPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDD
MAV_0524|M.avium_104 APANVYGPRQ-DPHGEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDD
MMAR_5133|M.marinum_M APANVYGPRQ-DPHGEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDD
MUL_4210|M.ulcerans_Agy99 APANVYGPRQ-DPHGEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDD
MAB_0503|M.abscessus_ATCC_1997 APANVYGPRQ-DPHGEAGVVAIFAQALLSGRSTKVFGDGGNTRDYVFVDD
MSMEG_6142|M.smegmatis_MC2_155 APANVYGPRQ-DPHGEAGVVAIFSEALLAGRTTKIFGDGSDTRDYVFVDD
TH_0330|M.thermoresistible__bu NCSNNYGPYQ---HVEKFIPRQITNVLTG-RRPKLYGTGANVRDWIHVED
Mvan_1365|M.vanbaalenii_PYR-1 NCSNNYGPYQ---HVEKFIPRQITNVLTG-RRPELYGTGANVRDWIHVDD
Mb0116|M.bovis_AF2122/97 RIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVRD
* .* : : : * * . :
Rv1511|M.tuberculosis_H37Rv YVEGMWRMLQTDEPDD-FVLATGRGFTVREFARAAFEHAGLDWQQYVKFD
Mflv_4754|M.gilvum_PYR-GCK YVEGMWRMLQVDEPDD-FVLATGVGITVREFLEVAFEHAGLDWEEHVRFD
MLBr_00204|M.leprae_Br4923 VVDAFIKASGDAGGGQRFNIGTGIETSDRQLHTAVSAAVGG--PDDPEFH
MAV_0524|M.avium_104 VVDAFVKASGDAGGGQRFNIGTGVETSDRQLHSAVAAAVGG--PDDPEFH
MMAR_5133|M.marinum_M VVDAFVRAGSDVGGGQRFNIGTGVETSDRQLHSAVAAAVGG--PDDPEFH
MUL_4210|M.ulcerans_Agy99 VVDAFVKAGSDVGGGQRFNIGTGVETSDRQLHSAVAAAVGG--PDDPEFH
MAB_0503|M.abscessus_ATCC_1997 VVEAFVRASGPDGGGQRFNVGTGVETSDRQLHSLVAAAAGA--PDDPEFH
MSMEG_6142|M.smegmatis_MC2_155 VVDAFVRAGGPAGGGQRFNVGTGVETSTRELHTAIAGAVGA--PDEPEFH
TH_0330|M.thermoresistible__bu HNDAVWRILTAGQIGRTYLIGADGERDNRTVLRTILKLMDRD-PDDFDHV
Mvan_1365|M.vanbaalenii_PYR-1 HNSAVWRILHDGTVGRTYLIGADGERDNLSVMRTILRLMGRS-PEDFDHV
Mb0116|M.bovis_AF2122/97 LNRALMLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRD-DIVPEVD
.. . : :. . .
Rv1511|M.tuberculosis_H37Rv QRYLRPTEVDSLIGDATKAAELLGWRA-SVHTDELARIMVDADMAALECE
Mflv_4754|M.gilvum_PYR-GCK ERYLRPTEVDALIGDPSRAAKKLDWIP-TVKSRDLARLMVDADIEAFSHA
MLBr_00204|M.leprae_Br4923 PPRLG--DLKRSCLDIGLATTVLGWSP-QVQLDDGVRRTVEYFRAAQRS-
MAV_0524|M.avium_104 PPRLG--DLKRSCLDIGLAARVLGWQP-KVGLQQGVARTVEYFRNQHN--
MMAR_5133|M.marinum_M PPRLG--DLKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS-
MUL_4210|M.ulcerans_Agy99 PPRLG--DLKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS-
MAB_0503|M.abscessus_ATCC_1997 PPRLG--DLRQSCLDVGLAKRVLGWEP-RVPLADGIRRTVDFFRS-----
MSMEG_6142|M.smegmatis_MC2_155 PPRLG--DLRRSRLDNTRAREVLGWQP-QVALAEGIAKTVEFFRNKSQ--
TH_0330|M.thermoresistible__bu TDRAG--HDLRYAIDPSALIDELGWTPRHTDFEAGLRDTIQWYRDNEDWW
Mvan_1365|M.vanbaalenii_PYR-1 TDRVG--HDLRYAIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWW
Mb0116|M.bovis_AF2122/97 PALLRPTDEKIIYGDCSKLAAITGWQQ-EICLTQTIADMFDYWRSKSESA
. * .* .:
Rv1511|M.tuberculosis_H37Rv GKPWIDKPMIAGRT---------
Mflv_4754|M.gilvum_PYR-GCK GTAWIDKVALESWKTPVAEQANP
MLBr_00204|M.leprae_Br4923 -----------------------
MAV_0524|M.avium_104 -----------------------
MMAR_5133|M.marinum_M -----------------------
MUL_4210|M.ulcerans_Agy99 -----------------------
MAB_0503|M.abscessus_ATCC_1997 -----------------------
MSMEG_6142|M.smegmatis_MC2_155 -----------------------
TH_0330|M.thermoresistible__bu RPLKDATEDAYAERGQ-------
Mvan_1365|M.vanbaalenii_PYR-1 GPLKDAVEATYQRRRR-------
Mb0116|M.bovis_AF2122/97 LMV--------------------