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MKVWITGAGGMMGSHLAEMLLAAGHDVYATYCRPTIDPSDLQFNGAEVDITDWCSVYDSIATFRPDAVFH LAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVRPHAKIIVAGSSAEYGFVDPSEVPINERRELRPLH PYGVSKAATDMLAYQYHKSYGMHTVVARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKR TIVDVRDLNRALMLMLDKGEAGADYNVGGSIAYEMGDVLKQVIAACKRDDIVPEVDPALLRPTDEKIIYG DCSKLAAITGWQQEICLTQTIADMFDYWRSKSESALMV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0112 | gca | - | 100% (318) | POSSIBLE GDP-MANNOSE 4,6-DEHYDRATASE GCA (GDP-D-MANNOSE DEHYDRATASE) |
| M. tuberculosis H37Rv | Rv1511 | gmdA | 3e-24 | 27.59% (319) | GDP-D-mannose dehydratase gmdA (GDP-mannose 4,6 dehydratase) |
| M. tuberculosis H37Rv | Rv3784 | - | 6e-18 | 36.02% (186) | dTDP-glucose 4,6-dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0116 | gca | 0.0 | 100.00% (318) | GDP-mannose 4,6-dehydratase |
| M. gilvum PYR-GCK | Mflv_4754 | - | 1e-20 | 27.57% (301) | GDP-mannose 4,6-dehydratase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 1e-14 | 25.38% (327) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 8e-16 | 25.16% (318) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5346 | rmlB_1 | 5e-18 | 34.41% (186) | dTDP-glucose-4,6-dehydratase, RmlB_1 |
| M. avium 104 | MAV_0524 | - | 2e-16 | 26.63% (323) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 2e-17 | 25.31% (320) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 1e-13 | 28.16% (309) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 2e-16 | 25.86% (321) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 6e-11 | 24.62% (325) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0112|M.tuberculosis_H37Rv ---------MKVWITG---AGGMMG-----SHLAEMLLAAGHDVYATYCR
Mb0116|M.bovis_AF2122/97 ---------MKVWITG---AGGMMG-----SHLAEMLLAAGHDVYATYCR
MLBr_00204|M.leprae_Br4923 ----MYGEPVRALVTG---AAGFIG-----STLVDRLLADGHTVVGLDNF
MAV_0524|M.avium_104 ---------MRALVTG---AAGFIG-----STLVDRLLADGHTVVGLDNF
MUL_4210|M.ulcerans_Agy99 ---------MRALVTG---AAGFIG-----STLVDRLLADGHTVVGLDNF
MAB_0503|M.abscessus_ATCC_1997 ---------MRAMVTG---AAGFIG-----STLVDRLLADGHEVTGLDNL
MSMEG_6142|M.smegmatis_MC2_155 -------MAVRTLVTG---AAGFIG-----STLVDRLLADGHGVVGLDDL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
Mvan_1365|M.vanbaalenii_PYR-1 ---------MRLLVTG---GAGFIGANFVRTTVQQRP---DVQVTVLDSL
MMAR_5346|M.marinum_M ---------MEILVIG---GAGFQG-----SHLTESLLADGHWVTVLNTP
Mflv_4754|M.gilvum_PYR-GCK -------MVKRALITG---ITGQDG-----SYLAELLLSKGYEVHGLIRR
: . * . .
Rv0112|M.tuberculosis_H37Rv P------TIDPSDLQFNG-------AEVDITDWCSVYDSIATFRPDAVFH
Mb0116|M.bovis_AF2122/97 P------TIDPSDLQFNG-------AEVDITDWCSVYDSIATFRPDAVFH
MLBr_00204|M.leprae_Br4923 A------TGHAANLEHLASTPALAFVEADIVT-ADLQTILDEHRPEVVFH
MAV_0524|M.avium_104 A------SGRASNLEHLVGNPAHVFVEADIVT-ADLEAILDEHRPEVVFH
MUL_4210|M.ulcerans_Agy99 A------TGRATNLEHLVDNLAHVFVEADIVD-ADLQAIFEQHRPEVIFH
MAB_0503|M.abscessus_ATCC_1997 A------TGKVANLEAAEANAKFTFVKDDIVE-ADLDAVVAEYSPEVIFH
MSMEG_6142|M.smegmatis_MC2_155 S------SGRAENLHSAENSDKFEFVKADIVD-ADLTGLLAEFKPEVIFH
TH_0330|M.thermoresistible__bu T------YAG-SRESLAPVADRIRVVEGDVTDSDLVDKLVAES--DAVVH
Mvan_1365|M.vanbaalenii_PYR-1 T------YAG-SRESLRGVDSQIRLVEGDITDAELVGKLVADS--DAVVH
MMAR_5346|M.marinum_M S------KNTTRNMQGFQSHERVSFISGSVTDGETVYRAVRDH--HVVFH
Mflv_4754|M.gilvum_PYR-GCK ASTFNTSRIDHLYVDPHSPEAKMFLHYGDLSDGARLVTLLADIDPDEVYN
. .: : . . : :
Rv0112|M.tuberculosis_H37Rv LAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVRPHAKIIVAGSSAEY
Mb0116|M.bovis_AF2122/97 LAAQSYPAVSWARPVETLTTNMVGTAIVFEALRRVRPHAKIIVAGSSAEY
MLBr_00204|M.leprae_Br4923 LAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTG--VRKIVHTSSGGS
MAV_0524|M.avium_104 LAAQIDVRHSVADPQFDASVNVIGTVRLAEAARRTG--VRKIVHTSSGGS
MUL_4210|M.ulcerans_Agy99 LAAQIDVRHSVADPQFDASVNVIGTLRLAEAARLTG--VRKVVHTSSGGS
MAB_0503|M.abscessus_ATCC_1997 LAAQIDVRHSVADPQFDSSVNVVGTVRLAEAARKAG--VRKIVHTSSGGS
MSMEG_6142|M.smegmatis_MC2_155 LAAQISVKRSVDDPPFDATVNVVGTVRLAEAARLAG--VRKVVHTSSGGS
TH_0330|M.thermoresistible__bu FAAESHVDNALAEPEPFLRTNVVGTFTVLEAVR----RHRVRLHHISTDE
Mvan_1365|M.vanbaalenii_PYR-1 FAAETHVDNALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDE
MMAR_5346|M.marinum_M LAARTNVDESLSDPKSFLETNVMGTYRALEAVRRYR----NRLIYVSTCE
Mflv_4754|M.gilvum_PYR-GCK LAAQSHVRVSFDEPEHTADTTGTGTIRLLEAVRLSG--VKTRFYQASSSE
:**. : * . ** ** * . *
Rv0112|M.tuberculosis_H37Rv GFVD-PSEVP---INERRELRPLHPYGVSKAATDMLAYQYHKSYGMHTVV
Mb0116|M.bovis_AF2122/97 GFVD-PSEVP---INERRELRPLHPYGVSKAATDMLAYQYHKSYGMHTVV
MLBr_00204|M.leprae_Br4923 IYGT-PSQYP---TPETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSH
MAV_0524|M.avium_104 IYGT-PPTYP---TPETVPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSH
MUL_4210|M.ulcerans_Agy99 IYGT-PPQYP---TSERVPTDPASPYAAGKVAGEIYLNTFRHLYGLECSH
MAB_0503|M.abscessus_ATCC_1997 IYGT-PKQIP---TSETVPTDPHSPYAAGKVAGEIYLNTFRHLYGLECSH
MSMEG_6142|M.smegmatis_MC2_155 VYGT-PPAYP---TSEDMPVNPASPYAAGKVAGEVYLNMYRNLYDLDCSH
TH_0330|M.thermoresistible__bu VYGD-LPLHDPRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYGVAATI
Mvan_1365|M.vanbaalenii_PYR-1 VYGD-LELDDPARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATI
MMAR_5346|M.marinum_M VYGDGHNLEEGQRLDEHAELKPNSPYAASKAAADRLCYSYFRSFGIDVTI
Mflv_4754|M.gilvum_PYR-GCK LYGATPPPQN-----EDTPFYPRSPYAVAKLYSYWITKNYREAYGMFAVN
: : * **. * : . :
Rv0112|M.tuberculosis_H37Rv ARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVR
Mb0116|M.bovis_AF2122/97 ARIFNCTGPRKVGDALSDFVRRCTWLEHHPEQSAIRVGNLKTKRTIVDVR
MLBr_00204|M.leprae_Br4923 IAPANVYGPRQDPYGEAGVVAIFVQALLS-DRPTKVFGDGTHTRDYVFVD
MAV_0524|M.avium_104 IAPANVYGPRQDPHGEAGVVAIFAQALLS-GKPTKVFGDGTNTRDYVFVD
MUL_4210|M.ulcerans_Agy99 IAPANVYGPRQDPHGEAGVVAIFAQALLS-GKPTKVFGDGTNTRDYVFVD
MAB_0503|M.abscessus_ATCC_1997 IAPANVYGPRQDPHGEAGVVAIFAQALLS-GRSTKVFGDGGNTRDYVFVD
MSMEG_6142|M.smegmatis_MC2_155 IAPANVYGPRQDPHGEAGVVAIFSEALLA-GRTTKIFGDGSDTRDYVFVD
TH_0330|M.thermoresistible__bu SNCSNNYGPYQH---VEKFIPRQITNVLT-GRRPKLYGTGANVRDWIHVE
Mvan_1365|M.vanbaalenii_PYR-1 SNCSNNYGPYQH---VEKFIPRQITNVLT-GRRPELYGTGANVRDWIHVD
MMAR_5346|M.marinum_M VRPFNIFGIRQKTGRFGALIPRLVRQAIN-GKNLTIFGAGTSSRDYLYIS
Mflv_4754|M.gilvum_PYR-GCK GILFNHESPRRGETFVTRKITRAVAAIKAGAQNYLYMGNLDAIRDWGYAP
* . : : : * *
Rv0112|M.tuberculosis_H37Rv DLNRALMLMLDKGEA-GADYNVGGSIAYEMGDVLKQVIAACKRDDIVPE-
Mb0116|M.bovis_AF2122/97 DLNRALMLMLDKGEA-GADYNVGGSIAYEMGDVLKQVIAACKRDDIVPE-
MLBr_00204|M.leprae_Br4923 DVVDAFIKASGDAGG-GQRFNIGTGIETSD-RQLHTAVSAAVGGPDDPE-
MAV_0524|M.avium_104 DVVDAFVKASGDAGG-GQRFNIGTGVETSD-RQLHSAVAAAVGGPDDPE-
MUL_4210|M.ulcerans_Agy99 DVVDAFVKAGSDVGG-GQRFNIGTGVETSD-RQLHSAVAAAVGGPDDPE-
MAB_0503|M.abscessus_ATCC_1997 DVVEAFVRASGPDGG-GQRFNVGTGVETSD-RQLHSLVAAAAGAPDDPE-
MSMEG_6142|M.smegmatis_MC2_155 DVVDAFVRAGGPAGG-GQRFNVGTGVETST-RELHTAIAGAVGAPDEPE-
TH_0330|M.thermoresistible__bu DHNDAVWRILTAGQI-GRTYLIGADGERDNRTVLRTILKLMDRDPDDFD-
Mvan_1365|M.vanbaalenii_PYR-1 DHNSAVWRILHDGTV-GRTYLIGADGERDNLSVMRTILRLMGRSPEDFD-
MMAR_5346|M.marinum_M DIVNAYNLILQTPSLRGQTINFASGKDTCVKDIVEYVAGKFDATIEHRD-
Mflv_4754|M.gilvum_PYR-GCK EYVEGMWRMLQVDEP--DDFVLATGVGITVREFLEVAFEHAGLDWEEHVR
: . .. . :.
Rv0112|M.tuberculosis_H37Rv VDPALLRPTDEKIIYGDCSKLAAITGWQQ-EICLTQT---IADMFDYWRS
Mb0116|M.bovis_AF2122/97 VDPALLRPTDEKIIYGDCSKLAAITGWQQ-EICLTQT---IADMFDYWRS
MLBr_00204|M.leprae_Br4923 FHPPRLG--DLKRSCLDIGLATTVLGWSP-QVQLDDG---VRRTVEYFRA
MAV_0524|M.avium_104 FHPPRLG--DLKRSCLDIGLAARVLGWQP-KVGLQQG---VARTVEYFRN
MUL_4210|M.ulcerans_Agy99 FHPPRLG--DLKRSCLDISRAEEVLGWRP-QVELADG---VRRTVDYFRR
MAB_0503|M.abscessus_ATCC_1997 FHPPRLG--DLRQSCLDVGLAKRVLGWEP-RVPLADG---IRRTVDFFRS
MSMEG_6142|M.smegmatis_MC2_155 FHPPRLG--DLRRSRLDNTRAREVLGWQP-QVALAEG---IAKTVEFFRN
TH_0330|M.thermoresistible__bu HVTDRAG--HDLRYAIDPSALIDELGWTPRHTDFEAG---LRDTIQWYRD
Mvan_1365|M.vanbaalenii_PYR-1 HVTDRVG--HDLRYAIDPTPLRDELGWRPEHTDFESG---LRDTIDWYRD
MMAR_5346|M.marinum_M ARPGEVQ-----RFPADIS-LARSIGFEP-QVDIWEG---IDRYIAWAKD
Mflv_4754|M.gilvum_PYR-GCK FDERYLRPTEVDALIGDPSRAAKKLDWIPTVKSRDLARLMVDADIEAFSH
* .: : .
Rv0112|M.tuberculosis_H37Rv KSESALMV----------------
Mb0116|M.bovis_AF2122/97 KSESALMV----------------
MLBr_00204|M.leprae_Br4923 AQRS--------------------
MAV_0524|M.avium_104 QHN---------------------
MUL_4210|M.ulcerans_Agy99 THGS--------------------
MAB_0503|M.abscessus_ATCC_1997 ------------------------
MSMEG_6142|M.smegmatis_MC2_155 KSQ---------------------
TH_0330|M.thermoresistible__bu NEDWWRPLKDATEDAYAERGQ---
Mvan_1365|M.vanbaalenii_PYR-1 NESWWGPLKDAVEATYQRRRR---
MMAR_5346|M.marinum_M QPQHAYELDGLGDRSTANG-----
Mflv_4754|M.gilvum_PYR-GCK AGTAWIDKVALESWKTPVAEQANP