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TVYTPTSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTSGIRRGDRVLDVAAGSGNVSIPAAMAG AHVTASDLTPELLRRAQARAAAAGLELGWREANAEALPFSAGEFDAVLSTIGVMFAPRHQRTADELARVC RRGGKISTLNWTPEGFYGKLLSTIRPYRPTLPAGAPHEVWWGSEDYVSGLFRDHVSDIRTRRGSLTVDRF GCPDECRDYFKNFYGPAINAYRSIADSPECVATLDAEITELCREYLCDGVMQWEYLIFTARKC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1403c | - | - | 100% (274) | PUTATIVE METHYLTRANSFERASE |
| M. tuberculosis H37Rv | Rv1405c | - | 7e-91 | 59.34% (273) | putative methyltransferase |
| M. tuberculosis H37Rv | Rv0558 | ubiE | 3e-07 | 32.65% (98) | ubiquinone/menaquinone biosynthesis methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1438c | - | 1e-162 | 100.00% (274) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_4060 | - | 3e-68 | 51.15% (262) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_00551 | - | 2e-89 | 56.78% (273) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_0867c | - | 3e-08 | 36.54% (104) | putative transferase |
| M. marinum M | MMAR_2212 | - | 1e-125 | 78.02% (273) | methyltransferase |
| M. avium 104 | MAV_3373 | - | 2e-85 | 55.68% (273) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_2285 | - | 2e-77 | 53.56% (267) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_2937 | - | 2e-14 | 30.89% (191) | PUTATIVE Methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_1798 | - | 1e-124 | 76.92% (273) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2287 | - | 2e-68 | 51.31% (267) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1403c|M.tuberculosis_H37Rv MTVYTP----TSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTSG
Mb1438c|M.bovis_AF2122/97 MTVYTP----TSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTSG
MMAR_2212|M.marinum_M MALDTP----ISDRRAPATTHRAMWALGDYAVLADEVLAPLGPILVSTSG
MUL_1798|M.ulcerans_Agy99 MALDTP----ISDRRAPATTHWAMWALGDYAVLADEVLAPLGPILFSTSG
MLBr_00551|M.leprae_Br4923 MNLYTP----IHEDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTATG
MAV_3373|M.avium_104 MTLDT-----TTADASVAARHRTVWALGDYALMAEEVMAPLGPTLVEAAG
Mflv_4060|M.gilvum_PYR-GCK MATVDN-----EDDRALKAKHRALWASGDYPAVAAELIPSLGPELVRACG
Mvan_2287|M.vanbaalenii_PYR-1 MSTTATSASAHDADRQLKAKHRALWASGDYPAVAAELIAELGPELVRACG
MSMEG_2285|M.smegmatis_MC2_155 MGVVTV-------DRELEAKHRALWALGNYGAIAAHIVAPLGPVLVEACG
TH_2937|M.thermoresistible__bu --VTTN------------------WAAGRYEAVGERIAPIADEVLDAAAR
MAB_0867c|M.abscessus_ATCC_199 MGAPTQ-------NIFEDLYRDSLHEGGPIVPWDSKDAKPRIKELALLGA
* . *
Rv1403c|M.tuberculosis_H37Rv IR--RGDRVLDVAAGSGNVSIPAAMAGAHVTASDLTPELLRRAQARAAAA
Mb1438c|M.bovis_AF2122/97 IR--RGDRVLDVAAGSGNVSIPAAMAGAHVTASDLTPELLRRAQARAAAA
MMAR_2212|M.marinum_M IR--PGDRVLDVAAGSGNASIAAAVAGAHVVACDLTPELLRSAQRRAAAA
MUL_1798|M.ulcerans_Agy99 IR--PGDRVLDVAAGSGNASITAAVAGAHVVACDLTPELLRSAQRRAAAA
MLBr_00551|M.leprae_Br4923 IR--PGMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRSQARATEL
MAV_3373|M.avium_104 IG--PGVRVLDVAAGSGNITLPAAAAGASVVSTDLTPELLQRSRDRAAGM
Mflv_4060|M.gilvum_PYR-GCK VR--SGDRVLDVAAGSGNASIPAAAAGAVVTASDLTPELFDAGRRIAAER
Mvan_2287|M.vanbaalenii_PYR-1 IQ--AGDRVLDVAAGSGNAAIPAAEVGAIVTASDLTPELFGAGRRIAAER
MSMEG_2285|M.smegmatis_MC2_155 IG--PGDRVLDIAAGTGNASIPAALAGAQVTASDLCPQLVDEGAHESAER
TH_2937|M.thermoresistible__bu RTPLRGATLVDLACGTGSAALSATARGAAVTGVDITSELIALAAGKPGGS
MAB_0867c|M.abscessus_ATCC_199 IR----GDVLDIGCGLGDNAIYLAQQGFNVTGLDFAPSAIEQAKGRAAAA
::*:..* *. :: : * :.. *: .. . . .
Rv1403c|M.tuberculosis_H37Rv GLELGWREANAEALPFSAGEFDAVLST--IGVMFAPRHQRTADELARVCR
Mb1438c|M.bovis_AF2122/97 GLELGWREANAEALPFSAGEFDAVLST--IGVMFAPRHQRTADELARVCR
MMAR_2212|M.marinum_M GVHLSWREANAETLPFGFNEFDAVLST--IGAMFAPRHQRTADELARVCR
MUL_1798|M.ulcerans_Agy99 GVHLSWREANAETLPFGFNEFDAVLST--IGAMFAPRHQRTADELAQVCR
MLBr_00551|M.leprae_Br4923 GLTLEYREADAQALPFGDGEFDVVMSA--IGVMFAPDHRRAASELVRVCR
MAV_3373|M.avium_104 GLTIDYREANAQALPFGDGEFDAVVSA--IGVQFAPDHQRAADELVRVCR
Mflv_4060|M.gilvum_PYR-GCK GVAVEWVEADAEALPFPDDSFDVVMSC--VGAMFAPHHQATADEIVRVTR
Mvan_2287|M.vanbaalenii_PYR-1 GVDLEWVEADAESLPFADGSFDVVMSC--VGAMFAPHHQATADELIRVCR
MSMEG_2285|M.smegmatis_MC2_155 GVDITWKEANAEALPFSDGEFDVVMSC--IGVMFAPHHDQSARELLRVTR
TH_2937|M.thermoresistible__bu --TVTWVTADAADTGLKTASFDVAVSN--MGIIFVP-PDRQVAELARLLK
MAB_0867c|M.abscessus_ATCC_199 GVAVDFQVADATTLDGWDARFDTVIDSGVYHCFDAEGHTEYASALHRATR
: : *:* **..:. . . : : :
Rv1403c|M.tuberculosis_H37Rv RGGKISTLNWTPEGFYGKLLSTIRPYRPTLPAGAPHEVWWGSEDYVSGLF
Mb1438c|M.bovis_AF2122/97 RGGKISTLNWTPEGFYGKLLSTIRPYRPTLPAGAPHEVWWGSEDYVSGLF
MMAR_2212|M.marinum_M RGGKISVLSWTPEGFYGQLLSTLRPYRPTLPMGAPHEVWWGREEYIGDLF
MUL_1798|M.ulcerans_Agy99 RGGKISVLSWTPEGFYGQLLSTLRPYRPTLPMGAPHEVWWGREEYIGDLF
MLBr_00551|M.leprae_Br4923 PNGTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREAYIRGLL
MAV_3373|M.avium_104 PGGRIGLISWTPEGFFGRMLATIRPYRPSLSHPVPPAALWGRPGYVRALL
Mflv_4060|M.gilvum_PYR-GCK PGGTLGLISWTPEGFIGHLFATMKPYAPPPPPGASPPPMWGSENHVEALF
Mvan_2287|M.vanbaalenii_PYR-1 PGGTIGMVNWTPGGFIGNLFATMKPYAPPPPPGANPPPLWGDTDHVTTLF
MSMEG_2285|M.smegmatis_MC2_155 SGGRIGLISWTPEGFIGQLFATMKPFVPAPPPGVSPPPLWGNADHVRTLL
TH_2937|M.thermoresistible__bu PGGVLSFSAWIRTDEN-PFSDPVAEVLGPPPAGFSPD-QWGDAETLTERL
MAB_0867c|M.abscessus_ATCC_199 PGARWYIWCFAQGAVHGVPTPFQNGQRAEEIEQVLTTSGWS---------
.. : *.
Rv1403c|M.tuberculosis_H37Rv RDHVSDIRTRRGSLTVDRFGCPDECRDYFKNFYGPAINAYRSIADSPECV
Mb1438c|M.bovis_AF2122/97 RDHVSDIRTRRGSLTVDRFGCPDECRDYFKNFYGPAINAYRSIADSPECV
MMAR_2212|M.marinum_M SDHVCDVRTQRGSLRVARFGQPEECVDYFKDYYGPTINAYRNISDDPQRV
MUL_1798|M.ulcerans_Agy99 SDHVCDVRTQRGSLRVKRFGQPEECVDYFKDYYGPTINAYRNISDDPQRV
MLBr_00551|M.leprae_Br4923 DDTVTNVKTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLA
MAV_3373|M.avium_104 GERIGEITTARGMLPVNRFGSAEDVHAYFKQHYGPTIEAYANIGHNRVLA
Mflv_4060|M.gilvum_PYR-GCK GDRVRDLTMRRQTVRFDHCASPLDFREYWKRNYGPTLAAYRFNEDRPERL
Mvan_2287|M.vanbaalenii_PYR-1 GDRVGDLTTRRQTVRMDHCADPAGFREYWKRNYGPTIAAYRFNAGHADRI
MSMEG_2285|M.smegmatis_MC2_155 GDGIEDFETQRRSLTVDMFADGAAFRDFFKANYGPTIAAYRAVGDDAERT
TH_2937|M.thermoresistible__bu TPHFDAIDLIRG-LHPWEFDSPATALHFLRTESPVHVEIFRRAG--PARR
MAB_0867c|M.abscessus_ATCC_199 ------------VLQINPTTMSAPKAEFLNAIRG-------SYRGDPAVL
: : .
Rv1403c|M.tuberculosis_H37Rv ATLDAEITELCREYLCD-----GVMQWEYLIFTARKC--
Mb1438c|M.bovis_AF2122/97 ATLDAEITELCREYLCD-----GVMQWEYLIFTARKC--
MMAR_2212|M.marinum_M AQLDAELIELSREYLTD-----GVMEWEYLIFTARKR--
MUL_1798|M.ulcerans_Agy99 AQLDAELIELSREYLTD-----GVMEWEYLIFTARKR--
MLBr_00551|M.leprae_Br4923 AELDAQLTELAQKYLTN-----STMGWEYLLLTAQKH--
MAV_3373|M.avium_104 AELDAQLVELAAQHLSD-----GTMGWEYLLVTAEKRSG
Mflv_4060|M.gilvum_PYR-GCK AELDAAFLDFLTTWNQADGTDGTAYDAEYLLVTATKR--
Mvan_2287|M.vanbaalenii_PYR-1 GALDRDFLALLTEWNRGDETN-AFWEAEYLLVTMTRL--
MSMEG_2285|M.smegmatis_MC2_155 AALDEAIALLGDRYLDS-----GAMQWEYLVVTAHKR--
TH_2937|M.thermoresistible__bu ERLAAAFRSALRPHAGPAG--TVGFTAPYVIVTARRRG-
MAB_0867c|M.abscessus_ATCC_199 DRLDQDVTDP-------------LLHVPVYTVIAERM--
* . . :