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MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALSTQAA AFHQQIVQTLTSTAGAYASAEAANVEQQLLGAINAPTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNG GNGGSGATGQAGGAGGAAGLIGHGGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAG GAGGAAGLWGSGGSGGTGGQGGVGGGKSGDGGTGGIGGAGGGGGWLHGDGGAGGHGGQGGTGVSSGGNGG AGGTGGDGRGLSGSGGAGGHGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAGGTGGKGGDGFGVFGKG GAGGTGGRGGAAGLIGDAGTGGTGGKGGTAGEDGTGGNGGTGGNGGAAVLIGNGGGGGAGGNGGAGNDGT PGNGGGGGVGGTGGTLFGQPGQPGPPGQPGPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1431c | PE_PGRS25 | - | 100% (452) | PE-PGRS family protein |
| M. bovis AF2122 / 97 | Mb0129 | PE_PGRS2 | e-159 | 64.62% (489) | PE-PGRS family protein |
| M. bovis AF2122 / 97 | Mb0545 | PE_PGRS6a | e-154 | 58.67% (513) | hypothetical protein Mb0545 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5091 | - | 3e-97 | 49.33% (450) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1396c | PE_PGRS25 | 0.0 | 74.65% (576) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 7e-17 | 44.57% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-38 | 36.07% (341) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_4224 | - | 1e-148 | 58.85% (503) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 3e-23 | 41.38% (174) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 5e-65 | 41.57% (433) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 5e-45 | 42.70% (281) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0572 | - | 1e-137 | 53.97% (517) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 9e-98 | 47.81% (456) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1431c|M.bovis_AF2122/97 --------------------------------------------------
Rv1396c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4224|M.marinum_M --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1431c|M.bovis_AF2122/97 --------MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAA
Rv1396c|M.tuberculosis_H37Rv --------MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAA
MMAR_4224|M.marinum_M --------MSFLVTAPEILAAAATDLDGIGAAIGAANAAAAAPTTAVLAA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MUL_0572|M.ulcerans_Agy99 --------MSYVVAIPDMLASAAADVAGIGSSVGAANTAAVGATTGVMAA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVG
MAV_4827|M.avium_104 ----MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATAS
Mb1431c|M.bovis_AF2122/97 GADEVSAAVAALFSGHAQTYQALSTQAAAFHQQIVQTLTSTAGAYASAEA
Rv1396c|M.tuberculosis_H37Rv GADEVSAAVAALFSGHAQTYQALRTQAAAFHQQIVQTLTSTAGAYASAEA
MMAR_4224|M.marinum_M GADEISAAMASLFTAHAQAYQGLSVQVGAFHNQFVQALTGAGGAYAAAEA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MUL_0572|M.ulcerans_Agy99 ADDEVSVAIAALFSGHGQAYQAISAQAAAFHDQFLRALTGAGGAYAAAEA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSP
MAV_4827|M.avium_104 APDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDN
Mb1431c|M.bovis_AF2122/97 ANV-------------------------------------------EQQL
Rv1396c|M.tuberculosis_H37Rv ANV-------------------------------------------EQQL
MMAR_4224|M.marinum_M ANVS-------------------------------------PLQAAAQDM
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MUL_0572|M.ulcerans_Agy99 AN-------------------------------------ASPLQAAEQEV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SLLSPR--------------------------------DNDFLSHNDTDF
MAV_4827|M.avium_104 ----------------------------------------VMLVSAFLAA
Mb1431c|M.bovis_AF2122/97 LGAIN-----------------APTMALLG--------RPLIGHGADGAP
Rv1396c|M.tuberculosis_H37Rv LGAIN-----------------APTMALLG--------RPLIGHGADGAP
MMAR_4224|M.marinum_M LTAIR-----------------APAQALLG--------RPLIGNGADGAP
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MUL_0572|M.ulcerans_Agy99 LAVIN-----------------APTNALLG--------RPLIGNGTDGLA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ASHNP----------------IASGNQVMS----------PSGNVDSFNR
MAV_4827|M.avium_104 AALAQN------------------VGGAMG------------YERTAVLL
Mb1431c|M.bovis_AF2122/97 GTGQAGGAGGILYGNGGNGGSGATG-QAGGAGGAAGLIG---HGGAGGLG
Rv1396c|M.tuberculosis_H37Rv GTGQAGGAGGILYGNGGNGGSGATG-QAGGAGGAAGLIG---HGGAGGLG
MMAR_4224|M.marinum_M --GQAGGDGGLLYGNGGNGGTSTTAGVAGGAGGSAGLIG---NGGAGGGG
TH_3810|M.thermoresistible__bu ------------------------VDGDGGSGGRTGLFSKLSRGGDGGDG
Mflv_5091|M.gilvum_PYR-GCK QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGG--NGGNGGNG
Mvan_1264|M.vanbaalenii_PYR-1 QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGG--NGGNGGNG
MSMEG_0868|M.smegmatis_MC2_155 DNPNGG-TGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG---NGGNGGVG
MUL_0572|M.ulcerans_Agy99 GTGAAGGAGGLLWGNGGNGG-SGAAGQAGGAGGAAGLIGTGGAGGMGGAG
MLBr_01183|M.leprae_Br4923 ---------MPLFLN------AEPQALTAAANTLEGLSAAT-VASNAAAA
MAB_4284c|M.abscessus_ATCC_199 GPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVR
MAV_4827|M.avium_104 VEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLES
. . . .
Mb1431c|M.bovis_AF2122/97 GTGASGGAGGAGG--WLWGNGGAGGNGG--------------------VG
Rv1396c|M.tuberculosis_H37Rv GTGASGGAGGAGG--WLWGNGGAGGNGG--------------------VG
MMAR_4224|M.marinum_M GAGAVGGNGGAGG--WLFGNGGAGGAGG--------------------AT
TH_3810|M.thermoresistible__bu GLGGNGGHGGGTGIISLLSLAGNGGNGGNGYR----------------TT
Mflv_5091|M.gilvum_PYR-GCK LGGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATG
Mvan_1264|M.vanbaalenii_PYR-1 LGSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATG
MSMEG_0868|M.smegmatis_MC2_155 WAGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGG
MUL_0572|M.ulcerans_Agy99 --GGAGGMGGSGG--WLLGNGGAGGAGGVGCAGVSGGVG--------GTG
MLBr_01183|M.leprae_Br4923 QLTTEIAPPAADDVSILLAHFFSG-HGR--------------------QY
MAB_4284c|M.abscessus_ATCC_199 DSNIINADHGSNVGVDQSQTRVGGDYTNVSGHG----------SADIDKS
MAV_4827|M.avium_104 LPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAE---------------EP
.
Mb1431c|M.bovis_AF2122/97 -VAGDPGGVGGAGGAGGAAGLWGSGGSGGTGGQGGVGG------------
Rv1396c|M.tuberculosis_H37Rv -VAGDPGGVGGAGGAGGAAGLWGSGGSGGTGGQGGVGG------------
MMAR_4224|M.marinum_M PGIGGGGGAGGAGGIGGAAGLFGNGGAGGVGGDGGLN-------------
TH_3810|M.thermoresistible__bu DNNALDGGHGGNGGNVGFFSLFNLGGAGGWGGSGVDG-------------
Mflv_5091|M.gilvum_PYR-GCK ATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------------
Mvan_1264|M.vanbaalenii_PYR-1 ATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------------
MSMEG_0868|M.smegmatis_MC2_155 GTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGP
MUL_0572|M.ulcerans_Agy99 GNAMLFGNGGAGG--MGGAGADGAVGAAGTAGTSTSAG------------
MLBr_01183|M.leprae_Br4923 QAHASQGATNHQDLIQSLLTSSSAYAGTETANHDSL--------------
MAB_4284c|M.abscessus_ATCC_199 VTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTNTEIG------------
MAV_4827|M.avium_104 ETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQYS------LPDY
Mb1431c|M.bovis_AF2122/97 ----GKSGDGGTGGIGGAGGG-GGWLHGDGGAG-----------------
Rv1396c|M.tuberculosis_H37Rv ----GKSGDGGTGGIGGAGGG-GGWLHGDGGAG-----------------
MMAR_4224|M.marinum_M -----YYGDGGVAGAGGDGGR-GGWLHGDGGDG-----------------
TH_3810|M.thermoresistible__bu ---VDVVGGNPDGGTPGAHG--ESHTPGVYTDR-----------------
Mflv_5091|M.gilvum_PYR-GCK --AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG-------------
Mvan_1264|M.vanbaalenii_PYR-1 --AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG-------------
MSMEG_0868|M.smegmatis_MC2_155 NVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTV
MUL_0572|M.ulcerans_Agy99 --GVGGAGWDATAAGVLAATGGDGGDSGGGGAGGNGG-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SHNQANIGTSTSAGGSAAVGG-NAGLAGNAGLAGNAG-------------
MAV_4827|M.avium_104 LYVPVDPEPGDDELAYSAVGEEDAESPTVVIEKLFLP-------------
Mb1431c|M.bovis_AF2122/97 ----------------------------------------------GHGG
Rv1396c|M.tuberculosis_H37Rv ----------------------------------------------GHGG
MMAR_4224|M.marinum_M ----------------------------------------------GAGG
TH_3810|M.thermoresistible__bu ---------------------------------------------QGEDG
Mflv_5091|M.gilvum_PYR-GCK ---AVGAAGAAG------TVGTAGATGGTG---------------TGANG
Mvan_1264|M.vanbaalenii_PYR-1 ---AIGTAGVAG------AAGTAGATGGTG---------------VGGNG
MSMEG_0868|M.smegmatis_MC2_155 DGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDG
MUL_0572|M.ulcerans_Agy99 ----AGGAGGHG----SALFGADGANGNGG---------------AGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------LAGNAG
MAV_4827|M.avium_104 --------------------------------------------EDSEPR
Mb1431c|M.bovis_AF2122/97 QGGTGVSSGGNGGAG-----------------------------------
Rv1396c|M.tuberculosis_H37Rv QGGTGVSSGGNGGAG-----------------------------------
MMAR_4224|M.marinum_M DGGRGLP-GGDGGSG-----------------------------------
TH_3810|M.thermoresistible__bu EDGTGTGIGGRGGNG-----------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVG
Mvan_1264|M.vanbaalenii_PYR-1 GAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIG
MSMEG_0868|M.smegmatis_MC2_155 GHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMG
MUL_0572|M.ulcerans_Agy99 GNPGAPGNGGTGGVG----------------------PDAATSGGMGGTG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAG-----------------------------------
MAV_4827|M.avium_104 RRPVLLVGSGLAVVG-----------------------------------
Mb1431c|M.bovis_AF2122/97 -------------------GTGGDGRGLSGSGG-----------------
Rv1396c|M.tuberculosis_H37Rv -------------------GTGGDGRGLSGSGG-----------------
MMAR_4224|M.marinum_M -------------------GAGG-GTGLWGSGG-----------------
TH_3810|M.thermoresistible__bu -------------------GSSSGTHPMAEDG------------------
Mflv_5091|M.gilvum_PYR-GCK GQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG--------
Mvan_1264|M.vanbaalenii_PYR-1 GQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG--------
MSMEG_0868|M.smegmatis_MC2_155 EIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKAS
MUL_0572|M.ulcerans_Agy99 GD-------PGAVGGRGNSGAAGGAGAVAGASG-----------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------NAGLAGNAGLAGNAG-----------------
MAV_4827|M.avium_104 -------------------ISAVLALEIALAIG-----------------
Mb1431c|M.bovis_AF2122/97 ------AGGHGGQ--TGVGGKVGENN--------------------FGGA
Rv1396c|M.tuberculosis_H37Rv ------AGGRGGQ--TGVGGKVGENN--------------------FGGA
MMAR_4224|M.marinum_M ------AGGQGGTGGTGLNGNAPFADGQHPVI-------------LDGGH
TH_3810|M.thermoresistible__bu ------EHVKALDGRPGLDGG----------------------------N
Mflv_5091|M.gilvum_PYR-GCK -----LQGGKGGDGGAGGKGGDADSMGS------------------AGAT
Mvan_1264|M.vanbaalenii_PYR-1 -----LQGGQGGDGGTGGTGGDATSMGE------------------AGAT
MSMEG_0868|M.smegmatis_MC2_155 GTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASAN
MUL_0572|M.ulcerans_Agy99 ----AAGTIIAGNGGNGGAGGAGYAADG-----------------PAGPA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----LAGNAGLAGNAGLAGNAGLAGNAG-----------------LAGN
MAV_4827|M.avium_104 ---IRTTGTVALQPTPNQHLIVPTEQAPAPPP-----------VQASAPQ
Mb1431c|M.bovis_AF2122/97 GGAGGTGGLIGNG-------------------------------------
Rv1396c|M.tuberculosis_H37Rv GGAGGTGGLIGNG-------------------------------------
MMAR_4224|M.marinum_M GGTGGNGGAAGNGGLLF---------------------------------
TH_3810|M.thermoresistible__bu GSHGGNGGHGGRGGFLG---------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGKGGNGGNGGRGGLFG---------------KGGNAGNGAD--------
Mvan_1264|M.vanbaalenii_PYR-1 GGKGGNGGNGGRGSLFG---------------RGGNAGNGGN--------
MSMEG_0868|M.smegmatis_MC2_155 GAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDP
MUL_0572|M.ulcerans_Agy99 IGNGGDGGHGGAGGFYG---------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAGLAG---------------------------------
MAV_4827|M.avium_104 PKISVPEPVAAPKPLSPP--------------------------------
Mb1431c|M.bovis_AF2122/97 ---------------GAGG-------------------------------
Rv1396c|M.tuberculosis_H37Rv ---------------GAGGNGGQGAISG----AGGAGGNAW---------
MMAR_4224|M.marinum_M ---------------GNGGNGGLGGMGG----GGGNG-------------
TH_3810|M.thermoresistible__bu -------------IGGSGGWGGHGGNGGDTDADGGNGG------------
Mflv_5091|M.gilvum_PYR-GCK --------------GGTGGAGGAGGTGG-TGGAGGTGG------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------GGTGGNGGNGGTGG-TGGNGGTGG------------
MSMEG_0868|M.smegmatis_MC2_155 NGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHS
MUL_0572|M.ulcerans_Agy99 -------------NGGAGGAGGNSAPGGGTGGNGGTGGDSG---------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------NAGLAGNAGLAGNAGLAGNAGLAGN------------
MAV_4827|M.avium_104 -------------VAAPLPAAPPPAAPPLPEAPPIPAAPPVVP-------
Mb1431c|M.bovis_AF2122/97 --------------------------------------------------
Rv1396c|M.tuberculosis_H37Rv ------------------------------------LIGDGGAGGNGGDI
MMAR_4224|M.marinum_M -------------------------------------LPSTGVGGDGGD-
TH_3810|M.thermoresistible__bu ------------------------------------------DGGNGGSA
Mflv_5091|M.gilvum_PYR-GCK -----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 -----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155 TGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDG
MUL_0572|M.ulcerans_Agy99 ----AMGSSGGRGGDGGVGTNGGAGGGGGNATSYGTANATGGAGGDGGTG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------------------AGLAGNAAVAGNAAVAG
MAV_4827|M.avium_104 ---------------------------------VPVVVPPVPVPVPVRIP
Mb1431c|M.bovis_AF2122/97 --------------------------------------------------
Rv1396c|M.tuberculosis_H37Rv RGQGGGAGGAGGAGGQL------------------------------IGN
MMAR_4224|M.marinum_M ----GGNGGTAGNGGWL------------------------------IGN
TH_3810|M.thermoresistible__bu --GRGGTGGLRGVFGIN---------------------------------
Mflv_5091|M.gilvum_PYR-GCK --GKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGT
Mvan_1264|M.vanbaalenii_PYR-1 --GKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGT
MSMEG_0868|M.smegmatis_MC2_155 --GRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGN
MUL_0572|M.ulcerans_Agy99 STGNGGSGGDGGNGGTG--HGGGGGPGGTAINYGAG--------DAFGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NAAVAGNAAVGGVLNTG----------------------------VSGAI
MAV_4827|M.avium_104 VPDPVSPPQLLAPPRLS----------------------------VPQPV
Mb1431c|M.bovis_AF2122/97 --------------------------------------------------
Rv1396c|M.tuberculosis_H37Rv GGTGGAGGT-------VTSPNGLGGAGGAGGSAGLIGHGGTGGAGGH---
MMAR_4224|M.marinum_M GGTGGQGG---------------------------AGFAGGTGADNV---
TH_3810|M.thermoresistible__bu GGNGRAG-------------------------------LGGRGXXXX---
Mflv_5091|M.gilvum_PYR-GCK GGTGGAG-----------DGTGGTGGTGG------TGGQGGQGGQGG---
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGAG-----------DGLGGTGGTGG------TGGFGGQGGQGG---
MSMEG_0868|M.smegmatis_MC2_155 GGNGGAGRIRVNNGTATGTATGGNGGNGGNGD--ADGHRGGKGGDGGEAL
MUL_0572|M.ulcerans_Agy99 AGKGGTG------------VVGGNGGSGGAAYNYGTGNATGAGGSSG---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GGSSHVGG-------------------------AINESLGGSGSVGG---
MAV_4827|M.avium_104 QPPVRVPQP------------------------PSPPQVGGTVPQSP---
Mb1431c|M.bovis_AF2122/97 --------------------------------------------------
Rv1396c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4224|M.marinum_M --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------GGGVG-------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------TGGTGGQGG-LGGGGGTG------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------TGGTGGQGG-LGGVGGTG------------------
MSMEG_0868|M.smegmatis_MC2_155 IRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQAS
MUL_0572|M.ulcerans_Agy99 --------------SGGAASVPNSASTATATSGSG---------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mb1431c|M.bovis_AF2122/97 --------------------------------------------------
Rv1396c|M.tuberculosis_H37Rv --------SAQGPDGNGGIGGAGGAGGNG--------GQL--YGTGGTGG
MMAR_4224|M.marinum_M --------SAGRPGGAGGTGGIGAGGGNA--------GLIGTGGSGGNGG
TH_3810|M.thermoresistible__bu --------------------------------------AAVRSGNGVFSG
Mflv_5091|M.gilvum_PYR-GCK -----GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGG
Mvan_1264|M.vanbaalenii_PYR-1 -----GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGG
MSMEG_0868|M.smegmatis_MC2_155 GTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGG
MUL_0572|M.ulcerans_Agy99 -----GAGGDGTDGGNGGSGGFAFTFGTG--NIIAGVGGGGGTGSTGVGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------STAVGGGAHTGVGGGVSTG-------VGVGSHVGGGISES
MAV_4827|M.avium_104 -------PQHQTPPGEGTPPKPDGPGNYG-------------GGHVPTPG
Mb1431c|M.bovis_AF2122/97 TGGKGGD-GFG-----------VFGKGGAGG-TGGRGGAAG---------
Rv1396c|M.tuberculosis_H37Rv TGGKGGD-GFG-----------VFGKGGAGG-TGGRGGAAG---------
MMAR_4224|M.marinum_M MGGHGGDSGYGD---------QTGGQGGNGG-MGGAGGAAGN--------
TH_3810|M.thermoresistible__bu GGGTPSAGFGV----------PTTIQFPAGSCTSRAVSREGIMPSSRAAS
Mflv_5091|M.gilvum_PYR-GCK LGGFGGSGGTG----------GQGGLGGPGGSTGGAGGAGG--QAGTAGK
Mvan_1264|M.vanbaalenii_PYR-1 LGGFGGVGGTG----------GQGGQGGPGGSTGGAGGAGG--QAGVAGK
MSMEG_0868|M.smegmatis_MC2_155 LGGNGGDGVVN----------TTANAANPGSATGTATGGDGGKATGTASQ
MUL_0572|M.ulcerans_Agy99 IGGSGGGADINNGAFTVVPQGGAGGHGGDGATDGGAGGAGGFTEIDSSAS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 LGGSGSVGGST-----------AVGGGAHTGVGGGVSTGVG---------
MAV_4827|M.avium_104 AGGSGGSGGGHVP---------TPGAGGSGGSGGGHVPTPG---------
Mb1431c|M.bovis_AF2122/97 -------------------LIGDAGTGGTGGKGGTAGE------------
Rv1396c|M.tuberculosis_H37Rv -------------------LIGDAGTGGTGGKGGTAGE------------
MMAR_4224|M.marinum_M ----------------GGLLLGSGSRGGDGGDGGNGGEGRGG--------
TH_3810|M.thermoresistible__bu --------------ARAGAACASSTSRSRRSFCCSRA-------------
Mflv_5091|M.gilvum_PYR-GCK GGLFG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQ
Mvan_1264|M.vanbaalenii_PYR-1 GGLFG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQ
MSMEG_0868|M.smegmatis_MC2_155 GGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAA
MUL_0572|M.ulcerans_Agy99 VIAATG---GAGGDGGSGGTGRGGTGGGGTGGGGTGGGGGVG------IN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------VGSHVGGGISESLGGSGSVGGSTAVG--------
MAV_4827|M.avium_104 ------------------TGGPGGTGGSGGGHVPTPGAGTPG--------
Mb1431c|M.bovis_AF2122/97 -----------------------------------------------DGT
Rv1396c|M.tuberculosis_H37Rv -----------------------------------------------DGT
MMAR_4224|M.marinum_M ------------------------------------------FSVPQHGV
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GATG-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGT
Mvan_1264|M.vanbaalenii_PYR-1 GATG-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGT
MSMEG_0868|M.smegmatis_MC2_155 GTTGVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGH
MUL_0572|M.ulcerans_Agy99 NGSGEAIGGAPGAGGTGAVGGDGGQGGAAYSYG----TGDATGSAGAAGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------GGAHTGV
MAV_4827|M.avium_104 ------------------------------------------------GS
Mb1431c|M.bovis_AF2122/97 GGN-----------------------------------GGTGGNGG-AAV
Rv1396c|M.tuberculosis_H37Rv GGN-----------------------------------GGTGGNGG-AAV
MMAR_4224|M.marinum_M GGQ-----------------------------------GGTGGNGSDGGW
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK NGA---NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGS
Mvan_1264|M.vanbaalenii_PYR-1 NGA---NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAV
MSMEG_0868|M.smegmatis_MC2_155 GGAG--NGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGT
MUL_0572|M.ulcerans_Agy99 AGTTGVGGTGGAGGAAYTLNGASTATATG-------GIGGNGGDGGTANG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GGGVNTGVGVGSHVGGGISESLGGSGSVG-------GSTAVGGGAHTSAI
MAV_4827|M.avium_104 GGG------------------------------HLPFPGAGSTPGGSGGG
Mb1431c|M.bovis_AF2122/97 LIGNGGGGGAGG--------------------NGGAGNDGTP--------
Rv1396c|M.tuberculosis_H37Rv LIGNGGGGGAGG--------------------NGGAGNDGTP--------
MMAR_4224|M.marinum_M LYGDGGAGGAGG--------------------NGGFGGSGVQN-------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK G-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE--------
Mvan_1264|M.vanbaalenii_PYR-1 D-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE--------
MSMEG_0868|M.smegmatis_MC2_155 GGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGA
MUL_0572|M.ulcerans_Agy99 S--NGGNGGAGG-------YASTTGTGTASVGNGGRGGDGTAT-------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NDALGGSGSVGG---------------STAVGGGAHTSAINESMNSSINA
MAV_4827|M.avium_104 HLPTPGAGTPGG-------------------GLGGFGGGHAP--------
Mb1431c|M.bovis_AF2122/97 -GNGGGGGVGGTG-----GTLFGQPGQPGPPGQPGPA------------
Rv1396c|M.tuberculosis_H37Rv -GNGGGGGVGGTG-----GTLFGQPGQPGPPGQPGPA------------
MMAR_4224|M.marinum_M -GAGGDAGSGGDSRLIGDGGAAGAGGTGAPPGADGHSGADGLLSAALGA
TH_3810|M.thermoresistible__bu -------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGAGGGGGAGG--SGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD-
Mvan_1264|M.vanbaalenii_PYR-1 GGAGGSGGAGG--SGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD--
MSMEG_0868|M.smegmatis_MC2_155 GGAGGNGGTGG--TTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP-
MUL_0572|M.ulcerans_Agy99 VATGGTGGVGGNAHAPAGSPVPGVGGKGGNPGPGGKPGPNGADGIVV--
MLBr_01183|M.leprae_Br4923 -------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH-
MAV_4827|M.avium_104 -APGGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK--------