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SRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRFAVRAGLASLAAASYLTTGRSL PRLHPDERARVLHRIAALSPEVAAAVEGLKAIVLLANGADTYAHELLARAQEHDAARPDAELTVILSADS PSVTRADAVVVGSGAGGAMVARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRP AVVLPMGRAVGGTTVVNSGTCFRPSLAVQRRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRN GRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISWARVERILHR AGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRLGHNLALHPATMLAGLFDDDVFA WRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMVADRGVGTVRSV RGETVVRYDIAPGEIAKLRVALQAIGRLLFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAAF HPTGTAAAGADEQLCPVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0492c | - | - | 100% (629) | PROBABLE OXIDOREDUCTASE GMC-TYPE |
| M. tuberculosis H37Rv | Rv1279 | - | 1e-16 | 26.76% (527) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0502c | - | 0.0 | 99.84% (629) | oxidoreductase GMC-type |
| M. gilvum PYR-GCK | Mflv_3085 | - | 1e-11 | 25.96% (443) | glucose-methanol-choline oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1232c | - | 7e-14 | 24.11% (531) | cholesterol oxidase ChoD |
| M. marinum M | MMAR_0817 | - | 0.0 | 80.85% (611) | oxidoreductase GMC-type |
| M. avium 104 | MAV_3093 | - | 2e-23 | 27.95% (551) | glucose-methanol-choline oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5967 | - | 4e-22 | 27.82% (532) | glucose-methanol-choline oxidoreductase |
| M. thermoresistible (build 8) | TH_4588 | - | 1e-08 | 27.40% (281) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4561 | - | 0.0 | 80.20% (611) | oxidoreductase GMC-type |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 2e-08 | 24.58% (533) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0492c|M.tuberculosis_H37Rv MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRF
Mb0502c|M.bovis_AF2122/97 MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRF
MMAR_0817|M.marinum_M MSRTQA-----ALASFGAALLPEERGGPTSTEFAERVDRYLSQLPTTSRL
MUL_4561|M.ulcerans_Agy99 MSRTQA-----ALASFGAALLPEERGGPTSTEFAERVDRYLSQLPTTSRL
Mflv_3085|M.gilvum_PYR-GCK ------------------------MADAG---------------------
Mvan_1606|M.vanbaalenii_PYR-1 ------------------------MGDHGHTDLAERIRLNQNRLRQNLRP
MAV_3093|M.avium_104 -------------------------------MHSRDLPGERTMRRYADDD
MSMEG_5967|M.smegmatis_MC2_155 ----------------------------MCPKWVFSTGMVQSMSTDQMTD
MAB_1232c|M.abscessus_ATCC_199 -----------------------------------------------MDY
TH_4588|M.thermoresistible__bu ----------------------------------------VTGRPGAERC
Rv0492c|M.tuberculosis_H37Rv AVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGL
Mb0502c|M.bovis_AF2122/97 AVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGL
MMAR_0817|M.marinum_M AVRAGLVSLAAASYLTTGRSLARLEPAQREQVLRRVAAINPDTSAALEGL
MUL_4561|M.ulcerans_Agy99 AVRAGLVSLAAASYLTTGRSLARLEPAQREQVLRRVAAINPDTSAALEGL
Mflv_3085|M.gilvum_PYR-GCK VFDYVIAGGGTAGCVLAAR----LSEDPDVTVCLLEAGPSDVGDDAILVL
Mvan_1606|M.vanbaalenii_PYR-1 QYDFIVCGAGSAGSVIARR----LAENPDVSVLLLEAG-GDDDDESVVRA
MAV_3093|M.avium_104 EVDLVVVGAGAGGSVLAQR----LARAGWRVVILEAGPFWHPDED-----
MSMEG_5967|M.smegmatis_MC2_155 ELDVIVVGAGLAGSVAALT----VARAGYSVGVIECGPPRSQNRDPAPGK
MAB_1232c|M.abscessus_ATCC_199 DYDVVVIGSGFGGSVAALR----LTEKGYRVGVLDMGKRWKREDFPPNNW
TH_4588|M.thermoresistible__bu HSDVLIVGAGSAGSVLAER----LSADSGCRVTVVEAGPGPSDPRVAHQI
: . . .. : : : .
Rv0492c|M.tuberculosis_H37Rv KAIVLLANGADTYAHE---LLARAQEHDAARPDAELTVILSADSPSVTRA
Mb0502c|M.bovis_AF2122/97 KAIVLLANGADTYAHE---LLARAQEHDAARPDAELTVILSADSPSVTRA
MMAR_0817|M.marinum_M KAVALLANGADTYAPD---LLARAQAHDAARSDAALDITASPDSPSVVTA
MUL_4561|M.ulcerans_Agy99 KAVALLANGADTYAPD---LLARAQAHDAARSDAALDITASPDSPSVVTA
Mflv_3085|M.gilvum_PYR-GCK SDWMRLLDSGYDWDYP---IEPQERGNS-FMRHARAKVLGGCSSHNSCIA
Mvan_1606|M.vanbaalenii_PYR-1 DQWPLNLGTSRDWNFV---AEASPHVNGRSLPMNMGKVLGGGSSINVMMW
MAV_3093|M.avium_104 -----WVSDEAGSHPL---YWTQKRIIGGADPIELGKNNSGRGVGGSMIH
MSMEG_5967|M.smegmatis_MC2_155 MRRAIARLAGRTLPRPGRWPVPLMRDRGGGRPAKAMAAVLGFGPGGSSTV
MAB_1232c|M.abscessus_ATCC_199 HVRKAMWAPALGCYGP-------QRLTVLGKTFIASAVGVGGGSLIYGNT
TH_4588|M.thermoresistible__bu TDGLRLPIGDASSVVR-RYPTTLTDHPRRPAQLMRGAVVGGSGAVNGGYF
. .
Rv0492c|M.tuberculosis_H37Rv DAVVVGSGAGGAMVARTLARAG--LDVVVLEEGRRWTVEEFRSTHP----
Mb0502c|M.bovis_AF2122/97 DAVVVGSGAGGAMVARTLARAG--LDVVVLEEGRRWTVEEFRSTHP----
MMAR_0817|M.marinum_M DVVIVGSGAGGAMTARTLARAG--LRTVVLEEGRRWTVREFRTTHP----
MUL_4561|M.ulcerans_Agy99 DVVIVGSGAGGAMTARTLARAG--LRTVVLEEGRRWTVREFRTTHP----
Mflv_3085|M.gilvum_PYR-GCK FHPPAEALDEWAAMG-ATGWSA--AEVLPLVQRLTETVR-----------
Mvan_1606|M.vanbaalenii_PYR-1 SRGHRSDWDFFAAEASDPGWGY--DAVLDIYRRIEDWHGSPDPDYRGSGG
MAV_3093|M.avium_104 YAGYTPRFHPSDFATYTLDGVG--ADWPIRYEDLRRHYEQVELELP----
MSMEG_5967|M.smegmatis_MC2_155 YGAALSRYRRSDFTAMRPPGALP-REWPIDYDDFRPFYARTEKLLR----
MAB_1232c|M.abscessus_ATCC_199 LYEPLEQFYVDKQWAHISDWKS---ELAPYYDQASRMLGVAQTPHT----
TH_4588|M.thermoresistible__bu CRGLPADFDRWGLGDWTWDRVLPHFRAIETDLDFDGPLHGADGPIP----
Rv0492c|M.tuberculosis_H37Rv --VDRYAGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRP-SLA
Mb0502c|M.bovis_AF2122/97 --VDRYAGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRP-SLA
MMAR_0817|M.marinum_M --IDRYAGLYRGGGATIALGRPAVILPMGRAVGGTTVVNSGTCFRP-PLA
MUL_4561|M.ulcerans_Agy99 --IDRYAGLYRGGGATIALGR----LPMGRAVGGTTVVNSGTCFRP-PLA
Mflv_3085|M.gilvum_PYR-GCK ---LRDVPPDDPCGAAVLEAAARIGIPTVSFNRGQTVR-NGAGWFQ-INA
Mvan_1606|M.vanbaalenii_PYR-1 EVFVQPAPDPNPVAPAAVDAAAAVGIPTFDHPNGKMMEGCGGAAIS-DMR
MAV_3093|M.avium_104 -----VAGQNWPWGDPHRYSFAPHPISGAAAKLWEGALKLGIEMRVGPVG
MSMEG_5967|M.smegmatis_MC2_155 --VAGAPDPLDPDDDAVLRSPPPLGPRDAALVKAMQAAGLHPYRLHVGID
MAB_1232c|M.abscessus_ATCC_199 ----------TPPDEVLLAVAKDLGVEDTYHPTNVGVFFGDEPGKTVPDP
TH_4588|M.thermoresistible__bu ---VRRSTEFDGCTAKFIEAVEDAGYPWIPDLNGATPDQPLPPGVGQVPL
Rv0492c|M.tuberculosis_H37Rv VQRRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRNGRLLLQA
Mb0502c|M.bovis_AF2122/97 VQRRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRNGRLLLQA
MMAR_0817|M.marinum_M VQQRWRDEFGLDLADPDRLAGRLDDVEHTLQVAPAPRDIMGRNGNLLLDA
MUL_4561|M.ulcerans_Agy99 VQQRWRDEFGLDLADPDRLAGRLDDVEHTLQVAPAPRDIMGRNGNLLLDA
Mflv_3085|M.gilvum_PYR-GCK TPEGARLSTSHAFLHPILGTRRNLEVRTDSWVSEILFDDASRATGVRYQR
Mvan_1606|M.vanbaalenii_PYR-1 VRDGLRESVFRSYTYPYLD-RPNLTVLTGAVVTRVPVH-MQRATGVEFEM
MAV_3093|M.avium_104 IVNGTFGNRPHCIYRGYCLQGCKVNAKASPYVTHLPDALAHDVEIRANCM
MSMEG_5967|M.smegmatis_MC2_155 YLPGCSECLGDACPRACKADGNNRALQQAVASGASVFCDETVVRLEPLSG
MAB_1232c|M.abscessus_ATCC_199 FFGGAGPERTGCIGCAACMTGCKHNAKNTTETNYLYLAEHAGAQIHPLTQ
TH_4588|M.thermoresistible__bu NINGGTRVGPGAAYLQPALARPNLTVLTETRVRRVRIADGRADGVECLGP
Rv0492c|M.tuberculosis_H37Rv AKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGAR
Mb0502c|M.bovis_AF2122/97 AKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGAR
MMAR_0817|M.marinum_M AASLGWQAAPIPRNAPGCAGCCQCAIGCPSNAKFGVHLNALPQACAAGAR
MUL_4561|M.ulcerans_Agy99 AASLGWQAAPIPRNAPGCAGCCQCAIGCPSNAKFGVHLNALPQACAAGAR
Mflv_3085|M.gilvum_PYR-GCK ADLTGYDTVAARREVILTAGAIDTP-------------KLLMLSGIGPTA
Mvan_1606|M.vanbaalenii_PYR-1 AGTT--HRIDAGVETVLCLGAIHTP-------------KVLMHSGIGDAA
MAV_3093|M.avium_104 AARVELDGSGAARGVVYYDEAGGTER----------LQRAKVVAIAGYSI
MSMEG_5967|M.smegmatis_MC2_155 QLQVISREGGPAATSGVLRKRLARN-------------VILAAGALNTPL
MAB_1232c|M.abscessus_ATCC_199 VLDVRPLEDGEGYAVSTKQTGRLLRK---KKRTFTAQHVVFSAASLGTQR
TH_4588|M.thermoresistible__bu DGATVLTADR----IVLSAGAIGSAH-------------LLMLSGIGPQR
.
Rv0492c|M.tuberculosis_H37Rv IISWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLL
Mb0502c|M.bovis_AF2122/97 IISWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLL
MMAR_0817|M.marinum_M IISDARVQRVLHQGGRARGVRARRPDGTAIDVLADIVIIAAGATETPTLL
MUL_4561|M.ulcerans_Agy99 IISDARVQRVLHQGGRARGVRARRPDGTAIDVRADIVIIAAGATETPTLL
Mflv_3085|M.gilvum_PYR-GCK HLREVGIDVRVDSPGVGANLDDHVEGLVFWEASRPMVTASTQWWEIGLFT
Mvan_1606|M.vanbaalenii_PYR-1 ELHRLGIAPVQHLPGVGANLQDHPGFGCVWEYRDPLPPRNTASEATYFWK
MAV_3093|M.avium_104 ETPRLLLNSVSDRFPNGLGNNDDQVGRYVMVQGATQSAGRWSEEVRMYKA
MSMEG_5967|M.smegmatis_MC2_155 LLARSSGLWRDGTAPPLLGRGLMFHITDILGLRAPSDVPNYGPQKTLAIR
MAB_1232c|M.abscessus_ATCC_199 LLHKFKDSGSLPNLSERLGEQTRTNSESVPIVYSPTRDDFSQGVAITSSI
TH_4588|M.thermoresistible__bu LLGALGIPVVAAXXXXGVGEPDPAHLAGQVDGGQGVDR-DARRVTLHREH
.
Rv0492c|M.tuberculosis_H37Rv RRSGLGGHPRLGHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESD
Mb0502c|M.bovis_AF2122/97 RRSGLGGHPRLGHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESD
MMAR_0817|M.marinum_M RRSGLGSHPRLGRNLALHPATMLAGRFDDDVYAWRGVLQSAAVHEFHESD
MUL_4561|M.ulcerans_Agy99 RRSGLGSHPRLGRNLALHPATMLAGRFDDDVYAWRGVLQSAAVHEFHESD
Mflv_3085|M.gilvum_PYR-GCK TVDEIPEGVRAQPDLMMHYGSVPF-----------DMNTLRHGYPTTDNG
Mvan_1606|M.vanbaalenii_PYR-1 SDPQLPT-----PDLQTCQVEVPL-----------TSAENAARFGVPQAG
MAV_3093|M.avium_104 PPPEVTSEQFYETDSSRGFARGFS-------------IQTVSPMPIGWAE
MSMEG_5967|M.smegmatis_MC2_155 DLYEVGEVQSMAMRVGTAPIASYLR-------------AEAERLGLGWLG
MAB_1232c|M.abscessus_ATCC_199 HPEPNTHVEVVRYGEGSTFLSMLG-------------TNMVDGGPWRFAR
TH_4588|M.thermoresistible__bu RGPRIGGGQHVEHRRGR--------------------RVEHERLLAGEPP
Rv0492c|M.tuberculosis_H37Rv GVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMVADRGVGTV
Mb0502c|M.bovis_AF2122/97 GVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMVADRGVGTV
MMAR_0817|M.marinum_M GVLIEATATPPGMGSMVFPGYGTELLDWLDRAPQVATFGAMVADRGAGSV
MUL_4561|M.ulcerans_Agy99 GVLIEATATPPGMGSMVFPGYGTELLDWLDRAPQVATFGAMVADRGAGSV
Mflv_3085|M.gilvum_PYR-GCK FCLTPNVTQGRSRGTVRLR------------------------------S
Mvan_1606|M.vanbaalenii_PYR-1 WTMFAGVVRPASRGRVWLS------------------------------S
MAV_3093|M.avium_104 HVLADGHWGRALREYMRDY-------------------------------
MSMEG_5967|M.smegmatis_MC2_155 GGLEALRIPAAVAARFLGK-------------------------------
MAB_1232c|M.abscessus_ATCC_199 TWLANLRHPAMMLRSMFPYR------------------------------
TH_4588|M.thermoresistible__bu LVARAAGGGRRHVGDQRRG-------------------------------
Rv0492c|M.tuberculosis_H37Rv RSVRGETVVRYDIAPGEIAKLRVALQAIGRLLFAAGAVEVLTGIPGAPPM
Mb0502c|M.bovis_AF2122/97 RSVRGETVVRYDIAPGEIAKLRVALQAIGRLFFAAGAVEVLTGIPGAPPM
MMAR_0817|M.marinum_M RSVRGETVVHYQVAPDDIAKLRVAVQAIGRLLFAAGAVEVLTGLPGAPTV
MUL_4561|M.ulcerans_Agy99 RSVRGETVVHYQVAPDDIAKLRVAVQAIGRLLFAAGAVEVLTGLPGAPTV
Mflv_3085|M.gilvum_PYR-GCK RDFRDRARVDPRYFTDPDSYDERIMLAGIKLARAIAAQAPLTPWVARELA
Mvan_1606|M.vanbaalenii_PYR-1 AQPSDPVHIDTGMLSDP--ADVAAAVAAVELCREIGNAAPLRPFTKREVM
MAV_3093|M.avium_104 -NHWATIGVLNELLPQPDNRVTLADEKDAYGIPVARFDYTLCDNDKANMA
MSMEG_5967|M.smegmatis_MC2_155 ---AATFATVQEDYAYEANRVWEDPSHPERICFRYEVPDELRERSARGRR
MAB_1232c|M.abscessus_ATCC_199 AAQHSIIVLVMQSLDNSLTTYLKRGMFGKKMTAKQGSGEPNPDWIPVAHD
TH_4588|M.thermoresistible__bu -RALGIGHGGDELPGGDPRQHRRPFVTGAELVEQVRHHDRAGQIRPAQQR
Rv0492c|M.tuberculosis_H37Rv RSLPELQDVLRRANPRSLHLAA----FHPTGTAAAGAD-EQLCPVDATGR
Mb0502c|M.bovis_AF2122/97 RSLPELQDVLRRANPRSLHLAA----FHPTGTAAAGAD-EQLCPVDATGR
MMAR_0817|M.marinum_M TSPAALQDALQRSDPRNLHLAA----FHPTGTAAAGAD-SQICPVDATGR
MUL_4561|M.ulcerans_Agy99 TSPAALQDALQRSDPRNLHLAA----FHPTGTAAAGAD-SQICPVDATGR
Mflv_3085|M.gilvum_PYR-GCK PGPDATTDDELLDYIHRCHNTV----YHPAATARMGSPSDPMAVLDPQLR
Mvan_1606|M.vanbaalenii_PYR-1 PG--NLRGPALEEFVRNAASTY----WHPTGTAKMGR--DDMSVVDGALR
MAV_3093|M.avium_104 YSTNVIGDILRAADAQDVLTIER--FAHLIGGARMGTR-PDNSVVDSDHR
MSMEG_5967|M.smegmatis_MC2_155 IIRDRLRHLRPFFLSPLATPNLG----HPMGTCRMGND-PAVSVTDAQGR
MAB_1232c|M.abscessus_ATCC_199 VARRMADKVDGYAGSTHLDSMNIPLTAHFIGGCPIGDS-PETGVIDPYQR
TH_4588|M.thermoresistible__bu AAHLLGDDAQLDRSRARSAEVLG---NHQAEQTHPGQLLPQRRIVAGVGR
* * *
Rv0492c|M.tuberculosis_H37Rv LRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR----
Mb0502c|M.bovis_AF2122/97 LRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR----
MMAR_0817|M.marinum_M LRGVDGVWVADASILPSCPEVNPQISIMALALAVADEVVADRSGSIYISP
MUL_4561|M.ulcerans_Agy99 LRGVDGVWVADASILPSCPEVNPQISIMALALAVADEVVADRSGSIYISP
Mflv_3085|M.gilvum_PYR-GCK VKGVRGLRVVDASAMPKLPAVNPNITVMTMAEKCAELIRTG---------
Mvan_1606|M.vanbaalenii_PYR-1 VYGVAGLRVADGSIMPRVSTGNTMAPCVVIGERAAALLGATHGLRAA---
MAV_3093|M.avium_104 VWGVPNLFVADGSVCPTQGSANPALTIMALASRLAERLAAGKVDTAAGRR
MSMEG_5967|M.smegmatis_MC2_155 VWGLPNVVVADAATLPTSGSTNPALTVSANALRIAESLVNRMNEAALEPS
MAB_1232c|M.abscessus_ATCC_199 IYGHPGLHICDGSAISANLGVNPSFTITAQAERAMAFWPNKGEADPRPAL
TH_4588|M.thermoresistible__bu HQRPH--LLLRRALLHEVGDSFA---------------------------
: : .
Rv0492c|M.tuberculosis_H37Rv --------------------------------
Mb0502c|M.bovis_AF2122/97 --------------------------------
MMAR_0817|M.marinum_M PACSPGPAP-----------------------
MUL_4561|M.ulcerans_Agy99 PACSPGPAP-----------------------
Mflv_3085|M.gilvum_PYR-GCK --------------------------------
Mvan_1606|M.vanbaalenii_PYR-1 --------------------------------
MAV_3093|M.avium_104 SKAAARG-------------------------
MSMEG_5967|M.smegmatis_MC2_155 PHHAE---------------------------
MAB_1232c|M.abscessus_ATCC_199 GSAYRRVAPVQPNHPTVPESAPGALRLPLTPV
TH_4588|M.thermoresistible__bu --------------------------------