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MFTQIAAEQPDLQVPTEEQIGSAYSRWRRKARSLSMATDVGFRMPSVWLAEGHSGVAPVYLYRFDYSTPL LKLLLVRAAHATELPYVWGNLGGSQDPALKLGDAKAAIAVSRRVRTRWINFATRGKPTGPDGEPDWPCYE EAHRACLIIGRRDAVVHDVDAHIRATWGSKW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1105 | - | - | 100% (171) | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) |
| M. tuberculosis H37Rv | Rv2045c | lipT | 5e-16 | 33.55% (152) | carboxylesterase LipT |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1135 | - | 1e-100 | 100.00% (171) | hypothetical protein Mb1135 |
| M. gilvum PYR-GCK | Mflv_3419 | - | 2e-50 | 54.44% (169) | carboxylesterase, type B |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3453c | - | 2e-16 | 33.55% (152) | carboxylesterase LipT |
| M. marinum M | MMAR_4363 | - | 2e-76 | 78.57% (168) | carboxylesterase |
| M. avium 104 | MAV_1226 | - | 3e-73 | 74.12% (170) | carboxylesterase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3667 | - | 3e-53 | 55.56% (171) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_3679 | - | 6e-59 | 61.18% (170) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 2e-16 | 33.96% (159) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_3172 | - | 3e-52 | 55.62% (169) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1105|M.tuberculosis_H37Rv --------------------------------------------------
Mb1135|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4363|M.marinum_M ----------------MTSDIRRMASDGYVVETAYGPVRGAEDGIAAAGS
MAV_1226|M.avium_104 -----------------------MAVDDLVVETGYGPVR----GVPVDG-
Mflv_3419|M.gilvum_PYR-GCK --------------MTAEATPRSSA---PVVDTSTGPVRGLDDGI-----
Mvan_3172|M.vanbaalenii_PYR-1 --------------MTADATTRSSAGGRPVVETTNGPVRGVDDGS-----
MSMEG_3667|M.smegmatis_MC2_155 ---------------MANAARIADG---PVAETGYGPVRGTDDGT-----
TH_3679|M.thermoresistible__bu MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRGRDDGV-----
MAB_3453c|M.abscessus_ATCC_199 -------------------MASGSKTPTVRVTTPNGIVEGFVRGG-----
MUL_2261|M.ulcerans_Agy99 -----------------------MHERTVRARTATGVVEGFTRDG-----
Rv1105|M.tuberculosis_H37Rv --------------------------------------------------
Mb1135|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4363|M.marinum_M GVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFGPVCPQPVLA
MAV_1226|M.avium_104 ---VKAWKGIRYAAPPIGDLRFRAPQPPERWTEVADATVFGPACPQPVFP
Mflv_3419|M.gilvum_PYR-GCK ---IKSWKGVPYAAAPVGELRWRAPEPPPAWTEPRDATRVGPVCPQPTDP
Mvan_3172|M.vanbaalenii_PYR-1 ---VKSWKAVRYAAAPVGELRWRAPEPPQAWSEPVDAGRVGPVCPQPTDP
MSMEG_3667|M.smegmatis_MC2_155 ---AKAWLGIRYARAPIGELRWRAPEPPASWHDVFDATRVGAVCPQATDA
TH_3679|M.thermoresistible__bu ---VKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRVGPACPQPADP
MAB_3453c|M.abscessus_ATCC_199 ---VRRFRSIPYARPPIGLLRLRAPQPALPWEGVRDCTEFGAAAPQRRRY
MUL_2261|M.ulcerans_Agy99 ---VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFTHCSPQQRRY
Rv1105|M.tuberculosis_H37Rv --------------------------------------------------
Mb1135|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4363|M.marinum_M NMP-IDLGAPQDEDCLRLNIWAPANTAPGAAKPVMVWLHGGAYMLGSASQ
MAV_1226|M.avium_104 NMP-LDLGAPQGEDCLRLNVWASADTQPGDAKPVMVWLHGGAYVLGSSSQ
Mflv_3419|M.gilvum_PYR-GCK KIP-LDLGAPQGEDFLSLNVWAPSGTQPGDRKPVMVWVHGGAYVLGSASQ
Mvan_3172|M.vanbaalenii_PYR-1 RIP-IDLGAPQGEDFLTLNIWAPSGTQPGDAKPVMVWIHGGAYILGSASQ
MSMEG_3667|M.smegmatis_MC2_155 RIP-IDLGGKQDEDSLVLNVWAPSGCRPGDRRPVMVWVHGGAYVLGSASQ
TH_3679|M.thermoresistible__bu RIP-LDLGAAIGEDCLNLNVWASSDTEPGDRKPVLVWVHGGAYVIGAASQ
MAB_3453c|M.abscessus_ATCC_199 RVLGPGRVQRASEDCLTVNVVTPD-RPSNEPLPVMFFIYGGGYLLGSSAT
MUL_2261|M.ulcerans_Agy99 TMLGLGKYQPMSEDCLTLNVVAPE-APTHRPLPVMVFIHGGGYILGSSAT
Rv1105|M.tuberculosis_H37Rv --------------------------------------------------
Mb1135|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4363|M.marinum_M ALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRSFDSNVGLRDV
MAV_1226|M.avium_104 TLYDGRRLVSHGDVVVVTVNYRLGALGFLDLSSLNSAGRSFDSNVGLRDV
Mflv_3419|M.gilvum_PYR-GCK PLYHGRAMAGAGDVIVVTVNYRLGALGFLELSTLD-DSGRFASNLGLRDV
Mvan_3172|M.vanbaalenii_PYR-1 PLYHGGTLASGGDAVVVTVNYRLGALGFLELSTLGADPERFATNLGLRDV
MSMEG_3667|M.smegmatis_MC2_155 PLCRGRVLASEGDVVVVTVNYRLGPFGFLDLSEYSSRAMRFDTNLGLRDV
TH_3679|M.thermoresistible__bu PLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALSSGRRRFDTNVGLRDV
MAB_3453c|M.abscessus_ATCC_199 PLYDGAALARRG-CVYVSVNYRVGALGALDLSSLSDRDHTIDGNLFLRDV
MUL_2261|M.ulcerans_Agy99 PIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIAIDGNLYLRDL
Rv1105|M.tuberculosis_H37Rv --------------------------------------------------
Mb1135|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4363|M.marinum_M LAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTPAARGLFSRAI
MAV_1226|M.avium_104 LAALEWVRDNITAFGGDPRRVTLFGESAGAGIVTTLLASPAAAGLFAAAI
Mflv_3419|M.gilvum_PYR-GCK LAALGWVRDNIAAFGGDPGRVTVFGESAGGGIVTSLLGSPAAAGLFHAAI
Mvan_3172|M.vanbaalenii_PYR-1 LAALEWVRDNIAAFGGDPGRVTVFGESAGGGIVASLLASPAAAGLFSAAI
MSMEG_3667|M.smegmatis_MC2_155 IFALQWVRDNIAAFGGDPSRVTLFGESAGGGMITTLLASPAAEGLFSAAI
TH_3679|M.thermoresistible__bu LFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSPAAAGLFHRAI
MAB_3453c|M.abscessus_ATCC_199 VLALQWVHDNIGTFGGDPGNVTIFGESAGAHCVETLMATPAAAGLFHRAI
MUL_2261|M.ulcerans_Agy99 VMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVPAAKGLFARAI
Rv1105|M.tuberculosis_H37Rv --------------------------------------------------
Mb1135|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4363|M.marinum_M AQSSPATSVYDRERAQRVAVHLLDKLGVAASDVDK-LTQLPTAAIVAAST
MAV_1226|M.avium_104 AQSSPATSVYDRDRAARVAEAFLGKLGITASESRR-LIDMPMAAILAASQ
Mflv_3419|M.gilvum_PYR-GCK AQSSPATSMYDVGRARRVATRFLEVIGVDRADMSA-LTTAPISALVEASR
Mvan_3172|M.vanbaalenii_PYR-1 AQSAPVTSTYELGRAQRVAERFLDVLGARPDDLHR-LSEAPIDVLVEASR
MSMEG_3667|M.smegmatis_MC2_155 AQSSPATSVYDAERSRRVARALLERLLIEPDDAAR-LAHVPIPAILGASQ
TH_3679|M.thermoresistible__bu AQSSPATSCYGTERAIDVAEQFLGHLGLSPRDVDR-LPDVPVAAIVEVSK
MAB_3453c|M.abscessus_ATCC_199 CQSTASGMAVPADSAAMYAQKFAQILGATTQSAAETVLRSSPAELGAALN
MUL_2261|M.ulcerans_Agy99 SESPAAGMVRPREIAAEFATRFARLLGARKHDAASALMRATAAQLVQTQH
Rv1105|M.tuberculosis_H37Rv --------------------------------------------------
Mb1135|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4363|M.marinum_M EVFNEVPVRNPG-TLAFVPIVDGDVLTDYPVKVAQEGRSHPVPLLIGTNK
MAV_1226|M.avium_104 QVFDEVPVRNPG-TLAFVPIVDGDVLADYPVKVAQQGCSHPVPLIIGTNQ
Mflv_3419|M.gilvum_PYR-GCK TVFNEVPVRTPG-TLAFAPTIDGDLLPDYPVNLARNGKTHPVPLLIGTNK
Mvan_3172|M.vanbaalenii_PYR-1 TVFDEVPVRTPG-TLAFAPTVDGDLLPDYPVNLARQGRTHPVPLIIGTNK
MSMEG_3667|M.smegmatis_MC2_155 QIFNEVPAQSPG-TLAFAPIVDGDVVPDYPVQAARAGRTHRVPLIIGTNK
TH_3679|M.thermoresistible__bu HVFDDVPARRPG-TLAFAPIVDGDIVPDYPVALARAGRTLPVPLVIGTNK
MAB_3453c|M.abscessus_ATCC_199 MLIADIVTNMPGGSFAIGPCIDGHYLPRHPIEAMEHGEAHRVPLIVGHNA
MUL_2261|M.ulcerans_Agy99 RLIDQGMQKRLG-AFPIGPTFGDDCLPLDPVEAMRAGQSHKVPLIVGTNA
Rv1105|M.tuberculosis_H37Rv -----------------------MFTQIAAEQPDLQVPTEEQIGSAYSRW
Mb1135|M.bovis_AF2122/97 -----------------------MFTQIAAEQPDLQVPTEEQIGSAYSRW
MMAR_4363|M.marinum_M HEAALFRLMRSPLMPITPRAITSMFTQIAAEQPDLQLPTEEEIGLAYSRL
MAV_1226|M.avium_104 HEAALFRLMRSALMPITPHAITSMFNQIAAEQPDLQLPTEKQIGSAYSRF
Mflv_3419|M.gilvum_PYR-GCK NEAALFRYMKSPLMPVAPESVRAMFAEISAEQPTLQLPSEDHLRGIYRG-
Mvan_3172|M.vanbaalenii_PYR-1 NEAALFRYMKSPLMPIAPASIKAMFAEIAAEQPGLQLPSEDILKGTYRG-
MSMEG_3667|M.smegmatis_MC2_155 HEASLFRWMKSPLMPITPEAIRAMFEGIASEQPGLALPTEEEIRAAYSGM
TH_3679|M.thermoresistible__bu DEASLFRWMKSPLLPITPDAIKKMFADIAAEQPGLRLPTETQISAAYRRQ
MAB_3453c|M.abscessus_ATCC_199 DEAKLFTRVLK-MMPLSESALEGMLARGGPG-------HRDRIVAAYPGY
MUL_2261|M.ulcerans_Agy99 DEGRLFTRFLK-MLPTNKAMIDELLADTEPA-------TRERITAAYPNY
:: . . : *
Rv1105|M.tuberculosis_H37Rv RRKARSLSMATDVGFRMPSVWLAEGHSGVAPVYLYRFDYSTPLLKLLLVR
Mb1135|M.bovis_AF2122/97 RRKARSLSMATDVGFRMPSVWLAEGHSGVAPVYLYRFDYSTPLLKLLLVR
MMAR_4363|M.marinum_M RRRARPLSIATDVGFRMPSVWLAEGHSRVAPVYLYRFDYSTPLLKLLLVR
MAV_1226|M.avium_104 RRRARYLSIATDVGFRMPSVWLAEGHARVAPVYLYRFDYSTPLLRLLMVK
Mflv_3419|M.gilvum_PYR-GCK RGKNHALGLTSDLGFRMPSIWFADGHRAVAPVYLYRFDFATPLLRVARLH
Mvan_3172|M.vanbaalenii_PYR-1 RGKTKGLGLTSDLGFRMPSLWFADGHRAVAPVYLYRFDFHTPLLRLVRLH
MSMEG_3667|M.smegmatis_MC2_155 RTKAIGMGVARDIGFRMPTLWFADGHSTSAPVYLYRFDFATPMLRLLRLG
TH_3679|M.thermoresistible__bu RGKRLGVGVASDIGFRMPSVWFAEGHTAVAPTYLYRFDWSTPTLRLLRLG
MAB_3453c|M.abscessus_ATCC_199 PERSARVKLAGDMNFSTAAWQMAEAHHRYAPVYFYRYDYAPGALRIAGMG
MUL_2261|M.ulcerans_Agy99 PESAACIQLGGDFAFNAAAWQIAEAQGVHAPTYLYRYDYAPRTLRWSGFG
: : *. * .: :*:.: **.*:**:*: . *: .
Rv1105|M.tuberculosis_H37Rv AAHATELPYVWGNLGG-SQDPALKLGDAKAAIAVSRRVRTRWINFATRGK
Mb1135|M.bovis_AF2122/97 AAHATELPYVWGNLGG-SQDPALKLGDAKAAIAVSRRVRTRWINFATRGK
MMAR_4363|M.marinum_M AAHATELPYVWGNLGG-PQDPTLRLGGAKTAKAVSKRMRTRWINFATQDN
MAV_1226|M.avium_104 AAHATELPYVWGTLGA-PKDPTLKLGGSKTAKAVSKRVRTRWTNFAAHAK
Mflv_3419|M.gilvum_PYR-GCK AAHATELPFVWGNLGSGRKDPTFALGGRKSGTAVSQRMQSRWTNFAANGD
Mvan_3172|M.vanbaalenii_PYR-1 AAHATELPFVWGNLVAGRRDPTFALGGRKSGAAVSERMRARWVSFAAHGA
MSMEG_3667|M.smegmatis_MC2_155 AAHATELPYVWGNLAAGPKDPTFKMGGLKQGRKVSQRIRRRWVNFATTGE
TH_3679|M.thermoresistible__bu AAHATELPYVFGNLDT-PKDPTFTLGGRRTGRQVSQRIRTRWINFAVHGR
MAB_3453c|M.abscessus_ATCC_199 ATHATELLAVFDSYRGAMGTVMAGALGRRDAVRVSNDVQRRWLAFARSGV
MUL_2261|M.ulcerans_Agy99 ATHATELFAVFDIYRTRFGALLTAAADRRHALRVSDEVIRRWRSFSQTGT
*:***** *:. . : . ** : ** *:
Rv1105|M.tuberculosis_H37Rv PTGPDGEPDWPCYEEAHRACLIIGRRDAVVHDVDAHIRATWGSKW----
Mb1135|M.bovis_AF2122/97 PTGPDGEPDWPCYEEAHRACLIIGRRDAVVHDVDAHIRATWGSKW----
MMAR_4363|M.marinum_M PAGPAGEPDWPAYQDGDRACLVIDKSDRVARDIDAPIRAAWGREVVGFR
MAV_1226|M.avium_104 PAGPAGSPEWAPYQEQDRACLIIGKNDVLAHDVDAKARAAWGSEMVSFR
Mflv_3419|M.gilvum_PYR-GCK PSAPG-APTWRPYDAS-RATLVIDKHDSVVDDLDAHVRRAWGDDVLSFL
Mvan_3172|M.vanbaalenii_PYR-1 PTGPAGEPVWRPYGADDRATLVIDKQDTVVDDLDADVRRAWGDDVLSFL
MSMEG_3667|M.smegmatis_MC2_155 PTGALGEPVWRRYRREDRAALVIDKQDKTVTDLDQQLQAAWGDQVLNFR
TH_3679|M.thermoresistible__bu PDGPPGEPRWHAYDRAERPCLLIDRRDRVVRDVDEPIRLTWGSEVLSFR
MAB_3453c|M.abscessus_ATCC_199 P-----GDGWPTYGPPDRAVMVFDHATRVELDPEAARRAAWEGFSLTL-
MUL_2261|M.ulcerans_Agy99 P-----GEDWPAYTHTRRAVMVIDRKSRVEIDPHRHRRLAWDGFSLAR-
* * * *. :::.: * . : :*