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RVAGALAAVDFTDLDNFAAGFPHGLFALHREQAPVYWHEPTENTPDGEGFWSVATHAETLAVFRDPETYS SVTGGERAFGGTLLQDLPIAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDLRERARRLLDEVEPGT PVDFLTDIAAEVPMQMICILLGVPESERHWLFEAIEPSFDFGGARKASITRLSVEEAGSRMFEYGQELIA AKRAQPGDDMLSVVVNSGDPQLSDLESYLFFNLLFSAGAETTRNAIAGGLLALIENPDAYRALRADPGLL PTAIEEMIRWTSPSPSKRRTATRRATLGGHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLGF GQGVHYCLGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5144 | - | - | 100% (409) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0246 | - | 6e-77 | 41.91% (408) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 3e-64 | 37.20% (414) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 0.0 | 74.69% (407) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_1908 | - | 1e-106 | 48.29% (410) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 0.0 | 74.69% (407) | cytochrome P450 126 |
| M. leprae Br4923 | MLBr_02088 | - | 7e-42 | 32.32% (328) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1211c | - | 4e-56 | 36.94% (379) | cytochrome P450 |
| M. marinum M | MMAR_4915 | cyp126A3 | 0.0 | 77.05% (414) | cytochrome P450 126A3 Cyp126A3 |
| M. avium 104 | MAV_0723 | - | 0.0 | 77.56% (410) | P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_5846 | - | 0.0 | 78.28% (396) | NikQ protein |
| M. thermoresistible (build 8) | TH_4083 | - | 0.0 | 78.86% (402) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0491 | cyp126A3 | 0.0 | 76.57% (414) | cytochrome P450 126A3 Cyp126A3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0801|M.bovis_AF2122/97 ------MTTAAGLSGIDLTDLDNFADGFPHHLFAIHR------------R
Rv0778|M.tuberculosis_H37Rv ------MTTAAGLSGIDLTDLDNFADGFPHHLFAIHR------------R
MMAR_4915|M.marinum_M ------MTSAGVLSKIDFTDLDNFADGFPHALFAIHR------------R
MUL_0491|M.ulcerans_Agy99 ------MTSAGVLSKIDFTDLDNFADGFPHALFAIHR------------R
MAV_0723|M.avium_104 ------MTLAGTLSQIDFTDLDNFANGFPHHLFAVHR------------R
MSMEG_5846|M.smegmatis_MC2_155 -------------MRADLTDLDNFADGFPHALFEAHR------------R
Mvan_5144|M.vanbaalenii_PYR-1 ------MRVAGALAAVDFTDLDNFAAGFPHGLFALHR------------E
TH_4083|M.thermoresistible__bu ----------VSLAGVDLTDLDNFAAGFPHELFAEHR------------A
Mflv_1908|M.gilvum_PYR-GCK ---------MPNLADVDLADLDRFTAGFPFEVFDVLR------------R
MAB_1211c|M.abscessus_ATCC_199 MTAMKTAAELGLPEGFDFTDPELYGNRMPHEEFATLR------------R
MLBr_02088|M.leprae_Br4923 -MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRAD
: . : * .
Mb0801|M.bovis_AF2122/97 EAPVYWHRPTEHTP--DGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRF
Rv0778|M.tuberculosis_H37Rv EAPVYWHRPTEHTP--DGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRF
MMAR_4915|M.marinum_M EAPVYWHEPTDNTP--DGEGFWSVATYPETLEVLRDPVTYSSVTGGQRPF
MUL_0491|M.ulcerans_Agy99 EAPVYWHEPTDNTP--DGEGFWSVATYPETLEVLRDPVTYSSVTGGQRPF
MAV_0723|M.avium_104 EAPVYWHEPTDNTP--DGEGFWSVASYAETLEVLKDPATYSSVTGGERPY
MSMEG_5846|M.smegmatis_MC2_155 EAPVYWHEPTEHTP--DGEGFWSVATYAETLAVLRDPVTFSSVTGGSRPY
Mvan_5144|M.vanbaalenii_PYR-1 QAPVYWHEPTENTP--DGEGFWSVATHAETLAVFRDPETYSSVTGGERAF
TH_4083|M.thermoresistible__bu AAPVYWHEPTEHTP--DGEGFWSVATYLETLAVLRDPVTYSSVTGGDRQY
Mflv_1908|M.gilvum_PYR-GCK EAPVWWHPPTAHTP--GGEGFWVLSRHADIVAAAADSETFSSETGGGRDG
MAB_1211c|M.abscessus_ATCC_199 EAPVWWNPQPRTVGGFADEGYWVISKHRDVREVSLHTDTFSSGRKGAIPR
MLBr_02088|M.leprae_Br4923 PFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
**: . .: . : . .. : *. .
Mb0801|M.bovis_AF2122/97 GGTVLQDLP---VAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLR
Rv0778|M.tuberculosis_H37Rv GGTVLQDLP---VAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLR
MMAR_4915|M.marinum_M GGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIRRVEDDLR
MUL_0491|M.ulcerans_Agy99 GGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIRRVEDDLR
MAV_0723|M.avium_104 GGTLLQDLA---IAGQVLNMMDDPRHSQIRRLVSSGLTPRMIRLVEDDLR
MSMEG_5846|M.smegmatis_MC2_155 GGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIARVEEDLR
Mvan_5144|M.vanbaalenii_PYR-1 GGTLLQDLP---IAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDLR
TH_4083|M.thermoresistible__bu GGTLLQDLP---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMITRVEDDLR
Mflv_1908|M.gilvum_PYR-GCK GGTTLEDMPRGFAVGALLNMMDDPRHAQFRRLLAPTTSPRALRAIETDLR
MAB_1211c|M.abscessus_ATCC_199 LEDHISPEE-FQATLSVLINKDAPEHTQLRGLVSRMFTPRSIAALRITLE
MLBr_02088|M.leprae_Br4923 QAIAAGAEP-RPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIA
: * * *: .* *:: :*: : :. :
Mb0801|M.bovis_AF2122/97 RRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVE
Rv0778|M.tuberculosis_H37Rv RRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVE
MMAR_4915|M.marinum_M ARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESERHWLFEAIE
MUL_0491|M.ulcerans_Agy99 ARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESERHWLFEAIE
MAV_0723|M.avium_104 ARARRLLDAVVPGEPFDFLVDIAAELPMQMICILLGVPESERHWLFQAIE
MSMEG_5846|M.smegmatis_MC2_155 VRARRLLDAVEPGVPLDFLVEVAAELPMQMICILLGVPESERHWLFHAIE
Mvan_5144|M.vanbaalenii_PYR-1 ERARRLLDEVEPGTPVDFLTDIAAEVPMQMICILLGVPESERHWLFEAIE
TH_4083|M.thermoresistible__bu SRAARLFEAIEPGRPVDFVVEVAVELPMQMICILLGIPESERHWLFAAIE
Mflv_1908|M.gilvum_PYR-GCK RRAIDIVDAALAKGECDFLVDVAAELPLQAVAELAGVPQEDRHELMNWAN
MAB_1211c|M.abscessus_ATCC_199 ERAERIVRAALEGGHGEFVREVASELPMQAIAELIGVPEEDRVKLFEWSN
MLBr_02088|M.leprae_Br4923 ALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSA
. :. :.: ::* :.: :. * *:* : :
Mb0801|M.bovis_AF2122/97 PGFDFRGSRRATMPRLNVE-----DAGSRLYTYALELIAGKRAEP-ADDM
Rv0778|M.tuberculosis_H37Rv PGFDFRGSRRATMPRLNVE-----DAGSRLYTYALELIAGKRAEP-ADDM
MMAR_4915|M.marinum_M PQFDFGGSRKAAVSQLSVAQTA-EEAASRMYSYGQELIASKRAAP-TDDM
MUL_0491|M.ulcerans_Agy99 PQFDFGGSRKAAVSQLSVAQTA-EEAASRMYSYGQDLIASKRAAP-TDDM
MAV_0723|M.avium_104 PQFDFGGSRKAALSQLSEA-----EAGSRMYEYGQQLIAAKRAEP-TDDM
MSMEG_5846|M.smegmatis_MC2_155 PQFDFSGSRTASVGQLTPE-----EAGNRMYRYGMELIAAKRAAP-TDDM
Mvan_5144|M.vanbaalenii_PYR-1 PSFDFGGARKASITRLSVE-----EAGSRMFEYGQELIAAKRAQP-GDDM
TH_4083|M.thermoresistible__bu PSFDFGAARSASITRLSVE-----EAGSRIYAFGQELIAAKRRTP-TDDM
Mflv_1908|M.gilvum_PYR-GCK VTLDYEEREIGQTSDRVAA------AQAQMFVYGTTLLERKRREPPTEDL
MAB_1211c|M.abscessus_ATCC_199 QMTGYDEADVEIDPRVGAA---------QILGYSYQLAEQRRDCP-GNDV
MLBr_02088|M.leprae_Br4923 LLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTP-GEDL
: : * :* * :*:
Mb0801|M.bovis_AF2122/97 LSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAE
Rv0778|M.tuberculosis_H37Rv LSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAE
MMAR_4915|M.marinum_M LSVVANAMVDGGDEPALSDLELYLFFSLLFSAGAETTRNAVAGGLLALAE
MUL_0491|M.ulcerans_Agy99 LSVVANAMVDGGDEPALSDLELYLFFSLLFSAGAETTRNAVAGGLLALAE
MAV_0723|M.avium_104 LSVVANATLDDAAAPALSDLELYLFFSLLFSAGAETTRNAVAGGLLALAE
MSMEG_5846|M.smegmatis_MC2_155 LSVVAN-----AHDAELSDLELYLFFSLLFSAGAETTRNAVAGGLLALIE
Mvan_5144|M.vanbaalenii_PYR-1 LSVVVNS----GDPQ-LSDLESYLFFNLLFSAGAETTRNAIAGGLLALIE
TH_4083|M.thermoresistible__bu LSVVANA----DLPDPVTDLEVYLFFNLLFSAGAETTRNAIAGGLLALAE
Mflv_1908|M.gilvum_PYR-GCK LSIVTHALID---GEPLSENEQRMFLSLIIAAGSETTRNSIALGMSALSR
MAB_1211c|M.abscessus_ATCC_199 VSRLLTGTVD---GEQLTPEQFGFFVVMLSVAGNETTRNATTMGMMAFLE
MLBr_02088|M.leprae_Br4923 ISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLR
:* : :: : :: ** *** * : .: *: .
Mb0801|M.bovis_AF2122/97 NPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAG
Rv0778|M.tuberculosis_H37Rv NPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAG
MMAR_4915|M.marinum_M HPEQLRALRGDLDLLPTAVEEMVRWTSPSPSKRRTATRDVTLAGCSIEAG
MUL_0491|M.ulcerans_Agy99 HPEQLRALRGDLDLLPTAVEEMVRWTSPSPSKRRTATRDVTLAGCSIEAG
MAV_0723|M.avium_104 HPEQLRWLRDDLGALPRAVEEMVRWTSPSPSKRRTATRDATLGGQSIKAG
MSMEG_5846|M.smegmatis_MC2_155 HPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVELGGCRIAAG
Mvan_5144|M.vanbaalenii_PYR-1 NPDAYRALRADPGLLPTAIEEMIRWTSPSPSKRRTATRRATLGGHTIEAG
TH_4083|M.thermoresistible__bu RPDQFAALRADPGLLPTAVEEMVRWTSPSPSKRRTATRPATLGGQHIEPG
Mflv_1908|M.gilvum_PYR-GCK EPEVWERIRRDRTLLPSAVEEMLRWASSTPYNRRTATRDVDLHGHRIRAG
MAB_1211c|M.abscessus_ATCC_199 HPGQWELFKS--ARPSTTVDEIVRYTSPLISQQRTALQDTVISDVRIRAG
MLBr_02088|M.leprae_Br4923 NPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEG
.* : . .::* :*: .. *.* : : : *
Mb0801|M.bovis_AF2122/97 QKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFG-QGVHYCLGANLAR
Rv0778|M.tuberculosis_H37Rv QKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFG-QGVHYCLGANLAR
MMAR_4915|M.marinum_M QKVQIWEGSANRDARIFDHADEFDITRKPNPHLGFG-QGVHYCLGANLAR
MUL_0491|M.ulcerans_Agy99 QKVQIWEGSANRDARIFDHADEFDITRKPNPHLGFG-QGVHYCLGANLAR
MAV_0723|M.avium_104 QKVQIWEGSANRDASVFDRADEFDVTRKPNPHLGFG-QGVHYCLGANLAR
MSMEG_5846|M.smegmatis_MC2_155 DKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFG-QGVHYCLGANLAR
Mvan_5144|M.vanbaalenii_PYR-1 QKVLVWEGSANRDAAVFASPDHFDITRKPNPHLGFG-QGVHYCLGANLAR
TH_4083|M.thermoresistible__bu DKVLVWEASANRDGTVFDAPDVFDVTRKPNPHLGFG-QGVHYCLGANLAR
Mflv_1908|M.gilvum_PYR-GCK DKVTLWWASANRDDAVFADPYAFDVSRNPNPHVAFG-RGTHFCLGAALAR
MAB_1211c|M.abscessus_ATCC_199 ERVVMLYPSANFDEEVFENPHTFDITRDPNPHLGFGGTGAHYCLGANLAK
MLBr_02088|M.leprae_Br4923 DTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-VGSHFCLGAALAR
: : : :** * :: . ** * .. *:.*. * *:**** **:
Mb0801|M.bovis_AF2122/97 LELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG--
Rv0778|M.tuberculosis_H37Rv LELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG--
MMAR_4915|M.marinum_M LELRVLFEELLGRFGAVLVGQPVEWTRSNRHTGIRHLVVELFGG--
MUL_0491|M.ulcerans_Agy99 LELRVLFEELLGRFGVVLVGQPVEWTRSNRHTGIRHLVVELFGG--
MAV_0723|M.avium_104 LELRVLFEELLSRFGAVRVVRPVEWARSNRHTGIRHLVVELREEQ-
MSMEG_5846|M.smegmatis_MC2_155 LELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA---
Mvan_5144|M.vanbaalenii_PYR-1 LELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFASR--
TH_4083|M.thermoresistible__bu LEIRVLFGELLRRFGSVRLAAPPEWTRSNRHTGLRHLMVEFGPND-
Mflv_1908|M.gilvum_PYR-GCK MEMRVIFDVLLDRVAGVTVTGPVEYVRSNKHSGVRHMPVTLVGRS-
MAB_1211c|M.abscessus_ATCC_199 AELEIIFNKIADRMPDISRIGDAPRFHSGWINGIKKFDTAYCPVTH
MLBr_02088|M.leprae_Br4923 LEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-----
* : : : * . *: : .