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M. thermoresistible (build 8) TH_4083 (-)

annotation: cytochrome P450
coordinates: 2419096 - 2420319
length: 408

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4083--100% (408)cytochrome P450
M. thermoresistible (build 8)TH_1956-1e-6637.05% (413) PROBABLE CYTOCHROME P450 125 CYP125
M. thermoresistible (build 8)TH_4132-3e-6336.45% (406) PUTATIVE putative cytochrome P450

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0801cyp1260.075.50% (404) cytochrome P450 126
M. gilvum PYR-GCKMflv_1908-1e-10447.65% (405) cytochrome P450
M. tuberculosis H37RvRv0778cyp1260.075.50% (404) cytochrome P450 126
M. leprae Br4923MLBr_02088-3e-3831.92% (307) putative cytochrome p450
M. abscessus ATCC 19977MAB_0611-1e-5735.38% (407) putative cytochrome P450
M. marinum MMMAR_4915cyp126A31e-17875.79% (409) cytochrome P450 126A3 Cyp126A3
M. avium 104MAV_0723-0.075.80% (405) P450 monooxygenase
M. smegmatis MC2 155MSMEG_5846-0.078.84% (397) NikQ protein
M. ulcerans Agy99MUL_0491cyp126A31e-17875.55% (409) cytochrome P450 126A3 Cyp126A3
M. vanbaalenii PYR-1Mvan_5144-0.078.86% (402) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


Mb0801|M.bovis_AF2122/97            -----MTTAAGLSGIDLTDLDNFADGFP----HHLFAIHRREAP------
Rv0778|M.tuberculosis_H37Rv         -----MTTAAGLSGIDLTDLDNFADGFP----HHLFAIHRREAP------
MMAR_4915|M.marinum_M               -----MTSAGVLSKIDFTDLDNFADGFP----HALFAIHRREAP------
MUL_0491|M.ulcerans_Agy99           -----MTSAGVLSKIDFTDLDNFADGFP----HALFAIHRREAP------
MAV_0723|M.avium_104                -----MTLAGTLSQIDFTDLDNFANGFP----HHLFAVHRREAP------
MSMEG_5846|M.smegmatis_MC2_155      ------------MRADLTDLDNFADGFP----HALFEAHRREAP------
TH_4083|M.thermoresistible__bu      ---------VSLAGVDLTDLDNFAAGFP----HELFAEHRAAAP------
Mvan_5144|M.vanbaalenii_PYR-1       -----MRVAGALAAVDFTDLDNFAAGFP----HGLFALHREQAP------
Mflv_1908|M.gilvum_PYR-GCK          --------MPNLADVDLADLDRFTAGFP----FEVFDVLRREAP------
MAB_0611|M.abscessus_ATCC_1997      --MVQAQHPHLPDGIDFTDPELFVHGIP----ERELAELRHTEP------
MLBr_02088|M.leprae_Br4923          MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
                                                   :  . :      *       :   *   *      

Mb0801|M.bovis_AF2122/97            --VYWHRPTEHTP--DGEGFWSVATYAETLEVLRDPVTYSS--VTGGQRR
Rv0778|M.tuberculosis_H37Rv         --VYWHRPTEHTP--DGEGFWSVATYAETLEVLRDPVTYSS--VTGGQRR
MMAR_4915|M.marinum_M               --VYWHEPTDNTP--DGEGFWSVATYPETLEVLRDPVTYSS--VTGGQRP
MUL_0491|M.ulcerans_Agy99           --VYWHEPTDNTP--DGEGFWSVATYPETLEVLRDPVTYSS--VTGGQRP
MAV_0723|M.avium_104                --VYWHEPTDNTP--DGEGFWSVASYAETLEVLKDPATYSS--VTGGERP
MSMEG_5846|M.smegmatis_MC2_155      --VYWHEPTEHTP--DGEGFWSVATYAETLAVLRDPVTFSS--VTGGSRP
TH_4083|M.thermoresistible__bu      --VYWHEPTEHTP--DGEGFWSVATYLETLAVLRDPVTYSS--VTGGDRQ
Mvan_5144|M.vanbaalenii_PYR-1       --VYWHEPTENTP--DGEGFWSVATHAETLAVFRDPETYSS--VTGGERA
Mflv_1908|M.gilvum_PYR-GCK          --VWWHPPTAHTP--GGEGFWVLSRHADIVAAAADSETFSS--ETGGGRD
MAB_0611|M.abscessus_ATCC_1997      --IWWNHTERGVAGFDDDGFWVVSKHKDVKEVSLRCEVFSSEQNTAIPRY
MLBr_02088|M.leprae_Br4923          FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
                                      ::            .  :  .: . :   .       *.   :   : 

Mb0801|M.bovis_AF2122/97            FGGTVLQDLP---VAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDL
Rv0778|M.tuberculosis_H37Rv         FGGTVLQDLP---VAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDL
MMAR_4915|M.marinum_M               FGGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIRRVEDDL
MUL_0491|M.ulcerans_Agy99           FGGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIRRVEDDL
MAV_0723|M.avium_104                YGGTLLQDLA---IAGQVLNMMDDPRHSQIRRLVSSGLTPRMIRLVEDDL
MSMEG_5846|M.smegmatis_MC2_155      YGGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIARVEEDL
TH_4083|M.thermoresistible__bu      YGGTLLQDLP---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMITRVEDDL
Mvan_5144|M.vanbaalenii_PYR-1       FGGTLLQDLP---IAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDL
Mflv_1908|M.gilvum_PYR-GCK          GGGTTLEDMPRGFAVGALLNMMDDPRHAQFRRLLAPTTSPRALRAIETDL
MAB_0611|M.abscessus_ATCC_1997      LPTTPRERID---ATRLIMLNMDPPRHSRLRHIISRGFTPRAISRLRDDL
MLBr_02088|M.leprae_Br4923          AIAAGAEPRP---FYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
                                       :  :           :  :* * *: .*::::   :*: :  :. *:

Mb0801|M.bovis_AF2122/97            RRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDR-------
Rv0778|M.tuberculosis_H37Rv         RRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDR-------
MMAR_4915|M.marinum_M               RARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESER-------
MUL_0491|M.ulcerans_Agy99           RARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESER-------
MAV_0723|M.avium_104                RARARRLLDAVVPGEPFDFLVDIAAELPMQMICILLGVPESER-------
MSMEG_5846|M.smegmatis_MC2_155      RVRARRLLDAVEPGVPLDFLVEVAAELPMQMICILLGVPESER-------
TH_4083|M.thermoresistible__bu      RSRAARLFEAIEPGRPVDFVVEVAVELPMQMICILLGIPESER-------
Mvan_5144|M.vanbaalenii_PYR-1       RERARRLLDEVEPGTPVDFLTDIAAEVPMQMICILLGVPESER-------
Mflv_1908|M.gilvum_PYR-GCK          RRRAIDIVDAALAKGECDFLVDVAAELPLQAVAELAGVPQEDR-------
MAB_0611|M.abscessus_ATCC_1997      NARAQGIARAAAQLRHGDFVEQVACELPLQAIAGLMGTPLDER-------
MLBr_02088|M.leprae_Br4923          AALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
                                       .  :          *.: ::*  :.:  :. * * *  :        

Mb0801|M.bovis_AF2122/97            HWLFEAVEPGFDFRGSRRATMPRLNVE----DAGSRLYTYALELIAGKRA
Rv0778|M.tuberculosis_H37Rv         HWLFEAVEPGFDFRGSRRATMPRLNVE----DAGSRLYTYALELIAGKRA
MMAR_4915|M.marinum_M               HWLFEAIEPQFDFGGSRKAAVSQLSVAQTAEEAASRMYSYGQELIASKRA
MUL_0491|M.ulcerans_Agy99           HWLFEAIEPQFDFGGSRKAAVSQLSVAQTAEEAASRMYSYGQDLIASKRA
MAV_0723|M.avium_104                HWLFQAIEPQFDFGGSRKAALSQLSEA----EAGSRMYEYGQQLIAAKRA
MSMEG_5846|M.smegmatis_MC2_155      HWLFHAIEPQFDFSGSRTASVGQLTPE----EAGNRMYRYGMELIAAKRA
TH_4083|M.thermoresistible__bu      HWLFAAIEPSFDFGAARSASITRLSVE----EAGSRIYAFGQELIAAKRR
Mvan_5144|M.vanbaalenii_PYR-1       HWLFEAIEPSFDFGGARKASITRLSVE----EAGSRMFEYGQELIAAKRA
Mflv_1908|M.gilvum_PYR-GCK          HELMNWANVTLDYEEREIGQTSDRVAA-----AQAQMFVYGTTLLERKRR
MAB_0611|M.abscessus_ATCC_1997      EQLFDWSN---RLVGSSDGEDDSAVAS-------AELLMYAMGVAARKTA
MLBr_02088|M.leprae_Br4923          ALLVQSVDPFITITGEPPEATEERLRA------GVWLRDYLEQLVKCRRG
                                      *.   :                            :  :   :   :  

Mb0801|M.bovis_AF2122/97            EP-ADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAG
Rv0778|M.tuberculosis_H37Rv         EP-ADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAG
MMAR_4915|M.marinum_M               AP-TDDMLSVVANAMVDGGDEPALSDLELYLFFSLLFSAGAETTRNAVAG
MUL_0491|M.ulcerans_Agy99           AP-TDDMLSVVANAMVDGGDEPALSDLELYLFFSLLFSAGAETTRNAVAG
MAV_0723|M.avium_104                EP-TDDMLSVVANATLDDAAAPALSDLELYLFFSLLFSAGAETTRNAVAG
MSMEG_5846|M.smegmatis_MC2_155      AP-TDDMLSVVAN-----AHDAELSDLELYLFFSLLFSAGAETTRNAVAG
TH_4083|M.thermoresistible__bu      TP-TDDMLSVVANA----DLPDPVTDLEVYLFFNLLFSAGAETTRNAIAG
Mvan_5144|M.vanbaalenii_PYR-1       QP-GDDMLSVVVNS----GDPQ-LSDLESYLFFNLLFSAGAETTRNAIAG
Mflv_1908|M.gilvum_PYR-GCK          EPPTEDLLSIVTHALID---GEPLSENEQRMFLSLIIAAGSETTRNSIAL
MAB_0611|M.abscessus_ATCC_1997      EP-GADICTDLVNADID---GQKLSDDEFGFFVMLLAVAGNETTRNSITH
MLBr_02088|M.leprae_Br4923          TP-GEDLISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNLIAN
                                     *   *: : : .          ::: *      *:  ** *** * :: 

Mb0801|M.bovis_AF2122/97            GLLALAENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLG
Rv0778|M.tuberculosis_H37Rv         GLLALAENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLG
MMAR_4915|M.marinum_M               GLLALAEHPEQLRALRGDLDLLPTAVEEMVRWTSPSPSKRRTATRDVTLA
MUL_0491|M.ulcerans_Agy99           GLLALAEHPEQLRALRGDLDLLPTAVEEMVRWTSPSPSKRRTATRDVTLA
MAV_0723|M.avium_104                GLLALAEHPEQLRWLRDDLGALPRAVEEMVRWTSPSPSKRRTATRDATLG
MSMEG_5846|M.smegmatis_MC2_155      GLLALIEHPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVELG
TH_4083|M.thermoresistible__bu      GLLALAERPDQFAALRADPGLLPTAVEEMVRWTSPSPSKRRTATRPATLG
Mvan_5144|M.vanbaalenii_PYR-1       GLLALIENPDAYRALRADPGLLPTAIEEMIRWTSPSPSKRRTATRRATLG
Mflv_1908|M.gilvum_PYR-GCK          GMSALSREPEVWERIRRDRTLLPSAVEEMLRWASSTPYNRRTATRDVDLH
MAB_0611|M.abscessus_ATCC_1997      GMHAFTQFPEQWELYKKTR--PETAADEIVRWATPVTSFQRTALEDTELG
MLBr_02088|M.leprae_Br4923          AVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIG
                                    .: *: . *.              . :* :*: ..     *.* .   : 

Mb0801|M.bovis_AF2122/97            GQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFG-QGVHYC
Rv0778|M.tuberculosis_H37Rv         GQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFG-QGVHYC
MMAR_4915|M.marinum_M               GCSIEAGQKVQIWEGSANRDARIFDHADEFDITRKPNPHLGFG-QGVHYC
MUL_0491|M.ulcerans_Agy99           GCSIEAGQKVQIWEGSANRDARIFDHADEFDITRKPNPHLGFG-QGVHYC
MAV_0723|M.avium_104                GQSIKAGQKVQIWEGSANRDASVFDRADEFDVTRKPNPHLGFG-QGVHYC
MSMEG_5846|M.smegmatis_MC2_155      GCRIAAGDKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFG-QGVHYC
TH_4083|M.thermoresistible__bu      GQHIEPGDKVLVWEASANRDGTVFDAPDVFDVTRKPNPHLGFG-QGVHYC
Mvan_5144|M.vanbaalenii_PYR-1       GHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLGFG-QGVHYC
Mflv_1908|M.gilvum_PYR-GCK          GHRIRAGDKVTLWWASANRDDAVFADPYAFDVSRNPNPHVAFG-RGTHFC
MAB_0611|M.abscessus_ATCC_1997      GVRIKKGQRVVMMYRSANFDEEVFENPFTFDIMRDPNPHVGFGGNGEHHC
MLBr_02088|M.leprae_Br4923          QTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-VGSHFC
                                       :  *: : :   :** *  ::  .  **  * .. *:.*.  * *.*

Mb0801|M.bovis_AF2122/97            LGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRG
Rv0778|M.tuberculosis_H37Rv         LGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRG
MMAR_4915|M.marinum_M               LGANLARLELRVLFEELLGRFGAVLVGQPVEWTRSNRHTGIRHLVVELFG
MUL_0491|M.ulcerans_Agy99           LGANLARLELRVLFEELLGRFGVVLVGQPVEWTRSNRHTGIRHLVVELFG
MAV_0723|M.avium_104                LGANLARLELRVLFEELLSRFGAVRVVRPVEWARSNRHTGIRHLVVELRE
MSMEG_5846|M.smegmatis_MC2_155      LGANLARLELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA
TH_4083|M.thermoresistible__bu      LGANLARLEIRVLFGELLRRFGSVRLAAPPEWTRSNRHTGLRHLMVEFGP
Mvan_5144|M.vanbaalenii_PYR-1       LGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFAS
Mflv_1908|M.gilvum_PYR-GCK          LGAALARMEMRVIFDVLLDRVAGVTVTGPVEYVRSNKHSGVRHMPVTLVG
MAB_0611|M.abscessus_ATCC_1997      VGANLARMTINLMFNAIADHMPDLASAGEPDRLRSGWLNGVKHWEVDFCP
MLBr_02088|M.leprae_Br4923          LGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV--
                                    :** ***:   : :  :  :              .    *:    * .  

Mb0801|M.bovis_AF2122/97            G------
Rv0778|M.tuberculosis_H37Rv         G------
MMAR_4915|M.marinum_M               G------
MUL_0491|M.ulcerans_Agy99           G------
MAV_0723|M.avium_104                EQ-----
MSMEG_5846|M.smegmatis_MC2_155      -------
TH_4083|M.thermoresistible__bu      ND-----
Mvan_5144|M.vanbaalenii_PYR-1       R------
Mflv_1908|M.gilvum_PYR-GCK          RS-----
MAB_0611|M.abscessus_ATCC_1997      AGYGRAS
MLBr_02088|M.leprae_Br4923          -------