For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRDPRYGRGRAFYAGVMTPTSLPPGPRLPRSVQAALMLRCGPRFVAACRRRYGSAFTLRVASMGTLVYLT DPADIKTVFAGDPDIYHAGEANSMLKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEIAA DNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPRVLSVGPWETLAIANQDLLRRRP WRAVRDAIAEADRLLYAEIADRRADPDLDTRTDALAMLVRAGDMSDKELRDQLITLLVAGHDTTATALSW ALERLTRHPAVLAKAVRAARDGDDDYLDAVAKETLRDRPVVFDVGRVLKAPVELAGYRLPAGVMVIPGLV AVHADSQIYPHADRFDPDRMLGATLSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELETTTARG EHRRLKHVIFVPHRGARIRVRAKRVVAAEAPKCPMSGPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1038 | - | - | 100% (459) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5712 | - | 1e-70 | 37.04% (432) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3108 | - | 2e-67 | 34.77% (440) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0583 | cyp135B1 | 1e-178 | 73.97% (438) | cytochrome P450 135B1 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 8e-69 | 37.06% (429) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0568 | cyp135B1 | 1e-178 | 73.97% (438) | cytochrome P450 135B1 |
| M. leprae Br4923 | MLBr_02088 | - | 9e-17 | 27.55% (323) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 1e-154 | 63.68% (446) | cytochrome P450 |
| M. marinum M | MMAR_0938 | cyp135B4 | 1e-177 | 69.93% (459) | cytochrome P450 135B4 Cyp135B4 |
| M. avium 104 | MAV_5160 | - | 2e-72 | 38.08% (428) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1213 | - | 1e-168 | 70.30% (431) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2672 | - | 1e-173 | 70.43% (443) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 3e-27 | 27.73% (458) | cytochrome P450 185A4 Cyp185A4 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1104|M.gilvum_PYR-GCK -------------------MRLPPTPRIPR----FLQGLGFSLSRQWT--
MAV_5160|M.avium_104 --------MSEVATAPLAAVHLPPAVRGPK----LLQGIGFAVSRRTM--
Mb0583|M.bovis_AF2122/97 -------------MSGTSSMGLPPGPRLSG----SVQAVLMLRHGLRF--
Rv0568|M.tuberculosis_H37Rv -------------MSGTSSMGLPPGPRLSG----SVQAVLMLRHGLRF--
MMAR_0938|M.marinum_M ---------------MTKTATLPPGPRLPR----AVQAALMLRHAPRF--
Mvan_1038|M.vanbaalenii_PYR-1 MRDPRYGRGRAFYAGVMTPTSLPPGPRLPR----SVQAALMLRCGPRF--
MSMEG_1213|M.smegmatis_MC2_155 -----------------------------------MQTAMMLRHWSRF--
TH_2672|M.thermoresistible__bu -----------------------------------VQAWLMLRHGKWF--
MAB_4693|M.abscessus_ATCC_1997 -------------MSKTAKIALPPGPPLPL----AVQSILMASYGLRF--
MUL_0604|M.ulcerans_Agy99 ------------MVDPPDIRSLPLAPRNPLPYWQQLKALKTLHVGSEA--
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
Mflv_1104|M.gilvum_PYR-GCK --VAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTD--DVGNIQ
MAV_5160|M.avium_104 --MRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPD--ELGNIQ
Mb0583|M.bovis_AF2122/97 --LTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
Rv0568|M.tuberculosis_H37Rv --LTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
MMAR_0938|M.marinum_M --LTACKRRYGSVFTLRVAGLGTMVNVTDPVVIKKVFAGDPRVFHAGEAN
Mvan_1038|M.vanbaalenii_PYR-1 --VAACRRRYGSAFTLRVASMGTLVYLTDPADIKTVFAGDPDIYHAGEAN
MSMEG_1213|M.smegmatis_MC2_155 --VSACRRRYGDVFTLRIASMGTWVYLADPADIKTVFAGDPTVFHAGEAN
TH_2672|M.thermoresistible__bu --IAACQRRYGPVFTLRITSMGTLVYLTDPADIKAVFTGDPDTFHAGEAN
MAB_4693|M.abscessus_ATCC_1997 --LAGCQRRYGNMFTLRIPLSGKVVYLADPADIKTVYAGDPHVFHSGEAH
MUL_0604|M.ulcerans_Agy99 --LRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVLGRSGALSDRGTLP
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
: : .
Mflv_1104|M.gilvum_PYR-GCK PN----LSRVLGSGSVFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEE
MAV_5160|M.avium_104 PN----LSRLFGSGSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEE
Mb0583|M.bovis_AF2122/97 SM----LAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
Rv0568|M.tuberculosis_H37Rv SM----LAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
MMAR_0938|M.marinum_M TM----LAGLLGESSLLVVDDDVHRDRRRMMLPPFQREAVAHQAQLMSEI
Mvan_1038|M.vanbaalenii_PYR-1 SM----LKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEI
MSMEG_1213|M.smegmatis_MC2_155 SM----LSGLLGETSVLVIDEDVHRDRRRLMLAPFARDAVARQTGVMAEV
TH_2672|M.thermoresistible__bu SM----LSGILGETSVLVIDGDLHRRRRRLMLPSFHRDAVTRQADAMAEI
MAB_4693|M.abscessus_ATCC_1997 WF----FRGLLGDSSLFVLDEDEHHHQRRLLMPAFHRDAVARQATQMAQI
MUL_0604|M.ulcerans_Agy99 LLKD--LRRAIG-ESVLNLPHDTWLPRRRTLQPIFTKQRVAGFAGHMSEA
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
: *.: : *: : * . : :
Mflv_1104|M.gilvum_PYR-GCK TLREAASWPEGQPFETLEPMMRITLNAILRAVFGADG-AHLDELRRIIPP
MAV_5160|M.avium_104 TLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEG-AELDELRRLIPP
Mb0583|M.bovis_AF2122/97 AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
Rv0568|M.tuberculosis_H37Rv AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
MMAR_0938|M.marinum_M AAENIAGWPVGRTFAVAPKMAEITLEVILRTVIGATDPDRLAALRKVMPR
Mvan_1038|M.vanbaalenii_PYR-1 AADNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPR
MSMEG_1213|M.smegmatis_MC2_155 AATNIASWPVGTPFPVAPKMAEIALEVILRTVIGATEPARLAALRHVMPQ
TH_2672|M.thermoresistible__bu AAADIAGWPVGTTFAAAPRMSQITLEVILRVVIGAGDPGRLAALRTVLPR
MAB_4693|M.abscessus_ATCC_1997 AAANIAEWPVGESFPVAPRTTDITLEVILRTVIGASDPVRLAALRKVVPR
MUL_0604|M.ulcerans_Agy99 ANHILLGWPDGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVTL
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALL
. . . . .: ::*
Mflv_1104|M.gilvum_PYR-GCK WVTLGSRLAVLPTPHRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQADPN
MAV_5160|M.avium_104 WVTLGSRLAALPKPQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPN
Mb0583|M.bovis_AF2122/97 LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
Rv0568|M.tuberculosis_H37Rv LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
MMAR_0938|M.marinum_M LLNVGP-WETLALAKPDLLSRRAWRRLRRAIDEANELLYAEIAERRADPN
Mvan_1038|M.vanbaalenii_PYR-1 VLSVGP-WETLAIANQDLLRRRPWRAVRDAIAEADRLLYAEIADRRADPD
MSMEG_1213|M.smegmatis_MC2_155 LLGIGP-WQSLAIASPGLQRRRPWRTLQRNLAEADRLLYAEIAACRAGPD
TH_2672|M.thermoresistible__bu LIDIGP-WLSLAVASPHLQRHRPWQRLQRNLADADRLLYAEIAERRADPE
MAB_4693|M.abscessus_ATCC_1997 LLYMKP-WETPAITNPGLRRYWPWTAVGRRMAETDALLYAEIAERRADPN
MUL_0604|M.ulcerans_Agy99 AAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRADPS
MLBr_02088|M.leprae_Br4923 VQSVDP---FITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGE--
. . .
Mflv_1104|M.gilvum_PYR-GCK FESRDDVLALLLRSTYEDGS----SMSRQDIGDELLTLLAAGHETTAATL
MAV_5160|M.avium_104 FAERTDVLALLLRSTYDDGA----AMSHKEIGDELLTLLAAGHETTASTL
Mb0583|M.bovis_AF2122/97 LAARTDTLAMLVRAADEDGR----TMTERELRDQLITLLVAGHDTTATGL
Rv0568|M.tuberculosis_H37Rv LAARTDTLAMLVRAADEDGR----TMTERELRDQLITLLVAGHDTTATGL
MMAR_0938|M.marinum_M LAERTDVLATLVRAVDGDTAKPSGRMTDEELRDQLMTLLVAGHDTTATGL
Mvan_1038|M.vanbaalenii_PYR-1 LDTRTDALAMLVRAG---------DMSDKELRDQLITLLVAGHDTTATAL
MSMEG_1213|M.smegmatis_MC2_155 LASRPDALAMLVRAANDEGR----TMTDRELRDQLMTLLVAGHETTATGL
TH_2672|M.thermoresistible__bu LDTRTDTLAMLVRSADDDGQ----AMSDRELRDQLMTLLLAGHDTTATAL
MAB_4693|M.abscessus_ATCC_1997 LTERTDVLAMLVRATDDDGR----TMSDQELRDHLLTSIAAGHETTATAL
MUL_0604|M.ulcerans_Agy99 RE--APLITALIDATGPNTG---ESLSDQQICDEMVYFMILGEDTTSTVL
MLBr_02088|M.leprae_Br4923 -----DLISRLIELDESGDQ-----LTEEEIIATCGLLLVAGHETTVNLI
:: *: :: .:: : *.:** :
Mflv_1104|M.gilvum_PYR-GCK GWVFERISRHPDVLARLQAEAD-----------TDGNEYRQAVILETQRV
MAV_5160|M.avium_104 AWAFERISRHPELLARLVEEAD-----------NGGNELRQAAILEVQRA
Mb0583|M.bovis_AF2122/97 SWALERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRI
Rv0568|M.tuberculosis_H37Rv SWALERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRI
MMAR_0938|M.marinum_M AWALERLTRHPAILAKAVRAAEAS-----AAGDPSGDEYLDALAKETLRI
Mvan_1038|M.vanbaalenii_PYR-1 SWALERLTRHPAVLAKAVRAAR--------DGD---DDYLDAVAKETLRD
MSMEG_1213|M.smegmatis_MC2_155 SWTLERLIRHPAVLDKAVAAAR--------TTDGSGEAYLDAVVRESLRI
TH_2672|M.thermoresistible__bu SWALERLTRHPMLLAEAEQAAEAS-----AAGDPAGDEYLDAVCRETLRN
MAB_4693|M.abscessus_ATCC_1997 SWVLERLTRHPDALLKAAQAAEAS-----AAGDPAGDEYLDAVVKETLRI
MUL_0604|M.ulcerans_Agy99 TYALWALGQHCQLQDRLAAEAAELGDRPLTPADVPRLGYTIQVLQEAMRL
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSNPQ----------------RAPLVVEETLRY
.. : :: . * *
Mflv_1104|M.gilvum_PYR-GCK RTVIDFAGRHVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDFD
MAV_5160|M.avium_104 RTVIDFAGRHVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFD
Mb0583|M.bovis_AF2122/97 RPVVYDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFD
Rv0568|M.tuberculosis_H37Rv RPVVYDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFD
MMAR_0938|M.marinum_M RPVVFDVGR-ILTEPTELAGYQLPAGTMVVASIGLVHANAEVYPDPDRFD
Mvan_1038|M.vanbaalenii_PYR-1 RPVVFDVGR-VLKAPVELAGYRLPAGVMVIPGLVAVHADSQIYPHADRFD
MSMEG_1213|M.smegmatis_MC2_155 RPVVFEAGR-VLTEPVELGGYLLPAGTLVAPSIGLVHASADVYPDPDRFE
TH_2672|M.thermoresistible__bu RTVVFDVGR-VLKRPVELAGHRLPAGVMVVPGMVRVHADGELYPDPERFD
MAB_4693|M.abscessus_ATCC_1997 RPVIFSSGR-VLKESVEVGGYQLPVGIMVDPAIGLVHASGAVYPDPARFD
MUL_0604|M.ulcerans_Agy99 RPPGPTVAR-RAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFD
MLBr_02088|M.leprae_Br4923 DPAIHLIGR-VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFD
. .* : : * : : : . *:
Mflv_1104|M.gilvum_PYR-GCK PQRFVGQR-----PSTLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHF
MAV_5160|M.avium_104 PQRFIDNK-----PSALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHF
Mb0583|M.bovis_AF2122/97 PDRMVGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRV
Rv0568|M.tuberculosis_H37Rv PDRMVGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRV
MMAR_0938|M.marinum_M PDRMIDAT-----LTPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRV
Mvan_1038|M.vanbaalenii_PYR-1 PDRMLGAT-----LSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRV
MSMEG_1213|M.smegmatis_MC2_155 PDRMLAST-----QAPSTWLPFGGGNRRCLGATFALVEMRVVLREILHRV
TH_2672|M.thermoresistible__bu PHRMLGETPGQPALTPTTWFPFGGGNRRCLGATFAMVEMRVVLREILRRV
MAB_4693|M.abscessus_ATCC_1997 PDRMVGTT-----LSPTTWLPFGGGNRRCLGATFAMVEIRVVLREILRRV
MUL_0604|M.ulcerans_Agy99 PDRFAPKKS--KGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIREA
MLBr_02088|M.leprae_Br4923 PDRPSSRH-----------LAFAVGSHFCLGAALARLEATVTLSAIS--A
*.* :.*. * : *:* :* :* :.* :
Mflv_1104|M.gilvum_PYR-GCK TIETTTAPGEKMHSRGVAYTPDDGGRVVMRRR------------------
MAV_5160|M.avium_104 TIETTDAPDEPWHCRGVAFTPKHGGRIVVHRR------------------
Mb0583|M.bovis_AF2122/97 ELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATS--QATAQGAGC
Rv0568|M.tuberculosis_H37Rv ELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATS--QATAQGAGC
MMAR_0938|M.marinum_M DLATTTAPDERYKLKHVILVPHRDARIRVRA---ITAVS--PAVPEAPGC
Mvan_1038|M.vanbaalenii_PYR-1 ELETTTARGEHRRLKHVIFVPHRGARIRVRAKR--------VVAAEAPKC
MSMEG_1213|M.smegmatis_MC2_155 DLFATTARGEKQRLKHVTMIPHRGGRICVRALR--------DVAPAPMTC
TH_2672|M.thermoresistible__bu ELETTSARGERPRLKHVVFVPRRGARIRVRAHRKPVADNTVDDAAGPVPS
MAB_4693|M.abscessus_ATCC_1997 ELNTTTAPDEKQQAKHVTFVPHRGGSISVRAIR-------TCAPAVTPTC
MUL_0604|M.ulcerans_Agy99 EIHSLDG--DFPVAIPLPIVPAGPIRARVNQRR--------PSQEVCTTT
MLBr_02088|M.leprae_Br4923 RFPQVQLAGELVYKPNVAMRGMSALPVQV---------------------
: : : :
Mflv_1104|M.gilvum_PYR-GCK ---------------
MAV_5160|M.avium_104 ---------------
Mb0583|M.bovis_AF2122/97 PAARGGGPSRAVGSQ
Rv0568|M.tuberculosis_H37Rv PAARGGGPSRAVGSQ
MMAR_0938|M.marinum_M PVAHAKS--------
Mvan_1038|M.vanbaalenii_PYR-1 PMSGPA---------
MSMEG_1213|M.smegmatis_MC2_155 PAEARRA--------
TH_2672|M.thermoresistible__bu PVPPRR---------
MAB_4693|M.abscessus_ATCC_1997 PADVHGTGQARDPQR
MUL_0604|M.ulcerans_Agy99 LSDSSASS-------
MLBr_02088|M.leprae_Br4923 ---------------