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ASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFSLRVPPYADNLVVYTRPEHIKEIFAADP RSLHAGEGNHILGFVMGEHSVLMTDEAEHARMRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATIN SLDHMNALTLDIILRVVFGVTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDE ILYREIASRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLWELAHA PEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPAGTVVNTSILLAHASEVS HPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIFRRFTITAAGPSKGETPLVRN ITTVPKHGAHLRLIPQRRLGGLGDSDPP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0327c | cyp135A1 | - | 100% (449) | POSSIBLE CYTOCHROME P450 135A1 CYP135A1 |
| M. tuberculosis H37Rv | Rv0568 | cyp135B1 | 1e-86 | 40.68% (440) | cytochrome P450 135B1 |
| M. tuberculosis H37Rv | Rv3685c | cyp137 | 2e-60 | 34.47% (441) | cytochrome P450 137 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0334c | cyp135A1 | 0.0 | 99.78% (449) | cytochrome P450 135A1 |
| M. gilvum PYR-GCK | Mflv_3376 | - | 4e-60 | 31.47% (448) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-09 | 23.20% (319) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 3e-81 | 38.04% (439) | cytochrome P450 |
| M. marinum M | MMAR_0938 | cyp135B4 | 6e-87 | 41.04% (441) | cytochrome P450 135B4 Cyp135B4 |
| M. avium 104 | MAV_5160 | - | 3e-55 | 31.87% (433) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1213 | - | 2e-81 | 40.05% (417) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2672 | - | 5e-86 | 40.51% (432) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 8e-19 | 24.50% (453) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_1038 | - | 9e-85 | 40.05% (432) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3376|M.gilvum_PYR-GCK -----------MATATTDPVRLPPGPRFPKLIQGGAVLA--FRYGSVAAL
MAV_5160|M.avium_104 --------MSEVATAPLAAVHLPPAVRGPKLLQGIGFAV--SRRTMMRRL
Rv0327c|M.tuberculosis_H37Rv -------------MASTLTTGLPPGPRLPRYLQSVLYLR--FREWFLPAM
Mb0334c|M.bovis_AF2122/97 -------------MASTLTTGLPPGPRLPRYLQSVLYLR--FREWFLPAM
TH_2672|M.thermoresistible__bu -------------------------------VQAWLMLR--HGKWFIAAC
Mvan_1038|M.vanbaalenii_PYR-1 MRDPRYGRGRAFYAGVMTPTSLPPGPRLPRSVQAALMLR--CGPRFVAAC
MSMEG_1213|M.smegmatis_MC2_155 -------------------------------MQTAMMLR--HWSRFVSAC
MMAR_0938|M.marinum_M ---------------MTKTATLPPGPRLPRAVQAALMLR--HAPRFLTAC
MAB_4693|M.abscessus_ATCC_1997 -------------MSKTAKIALPPGPPLPLAVQSILMAS--YGLRFLAGC
MUL_0604|M.ulcerans_Agy99 ------------MVDPPDIRSLPLAPRNPLPYWQQLKAL--KTLHVGSEA
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
Mflv_3376|M.gilvum_PYR-GCK GRRYGSTFT---LQLPVFG-ETVVISDPVLVKDLFSTSRELVGRPQ-NNL
MAV_5160|M.avium_104 SRRYGNVFT---LRLPMWG-PVVMVSDPQLAKQIFTTSPDELGNIQ-PNL
Rv0327c|M.tuberculosis_H37Rv HRKYGDVFS---LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHI
Mb0334c|M.bovis_AF2122/97 HRKYGDVFS---LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHI
TH_2672|M.thermoresistible__bu QRRYGPVFT---LRITSMG-TLVYLTDPADIKAVFTGDPDTFHAGEANSM
Mvan_1038|M.vanbaalenii_PYR-1 RRRYGSAFT---LRVASMG-TLVYLTDPADIKTVFAGDPDIYHAGEANSM
MSMEG_1213|M.smegmatis_MC2_155 RRRYGDVFT---LRIASMG-TWVYLADPADIKTVFAGDPTVFHAGEANSM
MMAR_0938|M.marinum_M KRRYGSVFT---LRVAGLG-TMVNVTDPVVIKKVFAGDPRVFHAGEANTM
MAB_4693|M.abscessus_ATCC_1997 QRRYGNMFT---LRIPLSG-KVVYLADPADIKTVYAGDPHVFHSGEAHWF
MUL_0604|M.ulcerans_Agy99 LRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVLGRSGALSDRGTLPLL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMP--LTVFSSFSDCDEALRHPLSASDRLKATLA
. : . :
Mflv_3376|M.gilvum_PYR-GCK GGDVLGP--------GSIFNLEGDELLARRKLLLPPFNGKNMRAYEDITE
MAV_5160|M.avium_104 S-RLFGS--------GSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIE
Rv0327c|M.tuberculosis_H37Rv LGFVMGE--------HSVLMTDEAEHARMRSLLMPAFTRAALRGYRDMIA
Mb0334c|M.bovis_AF2122/97 LGFVMGE--------HSVLMTDEAEYARMRSLLMPAFTRAALRGYRDMIA
TH_2672|M.thermoresistible__bu LSGILGE--------TSVLVIDGDLHRRRRRLMLPSFHRDAVTRQADAMA
Mvan_1038|M.vanbaalenii_PYR-1 LKGLLGD--------TSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIA
MSMEG_1213|M.smegmatis_MC2_155 LSGLLGE--------TSVLVIDEDVHRDRRRLMLAPFARDAVARQTGVMA
MMAR_0938|M.marinum_M LAGLLGE--------SSLLVVDDDVHRDRRRMMLPPFQREAVAHQAQLMS
MAB_4693|M.abscessus_ATCC_1997 FRGLLGD--------SSLFVLDEDEHHHQRRLLMPAFHRDAVARQATQMA
MUL_0604|M.ulcerans_Agy99 KDLRRAIG-------ESVLNLPHDTWLPRRRTLQPIFTKQRVAGFAGHMS
MLBr_02088|M.leprae_Br4923 QQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIA
. *.: * : * :
Mflv_3376|M.gilvum_PYR-GCK QEVIREMQSWPEGVEFETLEPMMRITLNTILRAVFGAKG-DELDELRVVI
MAV_5160|M.avium_104 EETLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEG-AELDELRRLI
Rv0327c|M.tuberculosis_H37Rv SVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTDPKVKAELTSRL
Mb0334c|M.bovis_AF2122/97 SVAREHITRWRPHATINSLDHMNALTLDIILRVVFGVTDPKVKAELTSRL
TH_2672|M.thermoresistible__bu EIAAADIAGWPVGTTFAAAPRMSQITLEVILRVVIGAGDPGRLAALRTVL
Mvan_1038|M.vanbaalenii_PYR-1 EIAADNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVM
MSMEG_1213|M.smegmatis_MC2_155 EVAATNIASWPVGTPFPVAPKMAEIALEVILRTVIGATEPARLAALRHVM
MMAR_0938|M.marinum_M EIAAENIAGWPVGRTFAVAPKMAEITLEVILRTVIGATDPDRLAALRKVM
MAB_4693|M.abscessus_ATCC_1997 QIAAANIAEWPVGESFPVAPRTTDITLEVILRTVIGASDPVRLAALRKVV
MUL_0604|M.ulcerans_Agy99 EAANHILLGWPDGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGV
MLBr_02088|M.leprae_Br4923 ALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSA
. . : ::*
Mflv_3376|M.gilvum_PYR-GCK PAAVEFGSKIALLPSVVRKDLGAWSPGGKFARYRRRMDEICTQLIADARS
MAV_5160|M.avium_104 PPWVTLGSRLAALPKPQRYPR--FGPWGQLDRWRRQYDGVIERLIAAEQA
Rv0327c|M.tuberculosis_H37Rv QQIINIHPAILAGVPYPSLKR--MNPWKRFFHNQTKIDEILYREIASRRI
Mb0334c|M.bovis_AF2122/97 QQIINIHPAILAGVPYPSLKR--MNPWKRFFHNQTKIDEILYREIASRRI
TH_2672|M.thermoresistible__bu PRLIDIGPWLSLAVASPHLQR--HRPWQRLQRNLADADRLLYAEIAERRA
Mvan_1038|M.vanbaalenii_PYR-1 PRVLSVGPWETLAIANQDLLR--RRPWRAVRDAIAEADRLLYAEIADRRA
MSMEG_1213|M.smegmatis_MC2_155 PQLLGIGPWQSLAIASPGLQR--RRPWRTLQRNLAEADRLLYAEIAACRA
MMAR_0938|M.marinum_M PRLLNVGPWETLALAKPDLLS--RRAWRRLRRAIDEANELLYAEIAERRA
MAB_4693|M.abscessus_ATCC_1997 PRLLYMKPWETPAITNPGLRR--YWPWTAVGRRMAETDALLYAEIAERRA
MUL_0604|M.ulcerans_Agy99 TLAAKWAADRSARPVRAPHWLP-TPARPRARGAYDAMYKIAADMLAACRA
MLBr_02088|M.leprae_Br4923 LLVQSVDPFITITGEPP-------EATEERLRAGVWLRDYLEQLVKCRRG
. . : :
Mflv_3376|M.gilvum_PYR-GCK DPDFTDRGDVLSLLLQARYDNGDP----IPDAFVVDELLTMLVAGHETTS
MAV_5160|M.avium_104 DPNFAERTDVLALLLRSTYDDGAA----MSHKEIGDELLTLLAAGHETTA
Rv0327c|M.tuberculosis_H37Rv DSDLTARTDVLSRLLQTKDTPTKP----LTDAELRDQLITLLLAGHETTA
Mb0334c|M.bovis_AF2122/97 DSDLTARTDVLSRLLQTKDTPTKP----LTDAELRDQLITLLLAGHETTA
TH_2672|M.thermoresistible__bu DPELDTRTDTLAMLVRSADDDGQA----MSDRELRDQLMTLLLAGHDTTA
Mvan_1038|M.vanbaalenii_PYR-1 DPDLDTRTDALAMLVRAGD---------MSDKELRDQLITLLVAGHDTTA
MSMEG_1213|M.smegmatis_MC2_155 GPDLASRPDALAMLVRAANDEGRT----MTDRELRDQLMTLLVAGHETTA
MMAR_0938|M.marinum_M DPNLAERTDVLATLVRAVDGDTAKPSGRMTDEELRDQLMTLLVAGHDTTA
MAB_4693|M.abscessus_ATCC_1997 DPNLTERTDVLAMLVRATDDDGRT----MSDQELRDHLLTSIAAGHETTA
MUL_0604|M.ulcerans_Agy99 DP--SREAPLITALIDATGPNTGES---LSDQQICDEMVYFMILGEDTTS
MLBr_02088|M.leprae_Br4923 TP----GEDLISRLIELDESGDQ-----LTEEEIIATCGLLLVAGHETTV
. :: *: :.. : : *.:**
Mflv_3376|M.gilvum_PYR-GCK TQLAWTIERIRRHPDLLARLSDEVDA-----------GGNELMAATIAES
MAV_5160|M.avium_104 STLAWAFERISRHPELLARLVEEADN-----------GGNELRQAAILEV
Rv0327c|M.tuberculosis_H37Rv AALSWTLWELAHAPEIQSQVVWAAVG--------GD---DGFLEAVLKEG
Mb0334c|M.bovis_AF2122/97 AALSWTLWELAHAPEIQSQVVWAAVG--------GD---DGFLEAVLKEG
TH_2672|M.thermoresistible__bu TALSWALERLTRHPMLLAEAEQAAEAS-----AAGDPAGDEYLDAVCRET
Mvan_1038|M.vanbaalenii_PYR-1 TALSWALERLTRHPAVLAKAVRAARD--------GD---DDYLDAVAKET
MSMEG_1213|M.smegmatis_MC2_155 TGLSWTLERLIRHPAVLDKAVAAART--------TDGSGEAYLDAVVRES
MMAR_0938|M.marinum_M TGLAWALERLTRHPAILAKAVRAAEAS-----AAGDPSGDEYLDALAKET
MAB_4693|M.abscessus_ATCC_1997 TALSWVLERLTRHPDALLKAAQAAEAS-----AAGDPAGDEYLDAVVKET
MUL_0604|M.ulcerans_Agy99 TVLTYALWALGQHCQLQDRLAAEAAELGDRPLTPADVPRLGYTIQVLQEA
MLBr_02088|M.leprae_Br4923 NLIANAVLAMLRNPSQWKALSSNPQR----------------APLVVEET
:: .. : : *
Mflv_3376|M.gilvum_PYR-GCK QRTRPVLTAALRRAR-TRIRLGEWVIPEGDTIMASTQLAMAAEQSFPDAE
MAV_5160|M.avium_104 QRARTVIDFAGRHVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPR
Rv0327c|M.tuberculosis_H37Rv MRRHTVIASTARKVT-APAEIGGWRLPAGTVVNTSILLAHASEVSHPKPT
Mb0334c|M.bovis_AF2122/97 MRRHTVIASTARKVT-APAEIGGWRLPAGTVVNTSILLAHASEVSHPKPT
TH_2672|M.thermoresistible__bu LRNRTVVFDVGRVLK-RPVELAGHRLPAGVMVVPGMVRVHADGELYPDPE
Mvan_1038|M.vanbaalenii_PYR-1 LRDRPVVFDVGRVLK-APVELAGYRLPAGVMVIPGLVAVHADSQIYPHAD
MSMEG_1213|M.smegmatis_MC2_155 LRIRPVVFEAGRVLT-EPVELGGYLLPAGTLVAPSIGLVHASADVYPDPD
MMAR_0938|M.marinum_M LRIRPVVFDVGRILT-EPTELAGYQLPAGTMVVASIGLVHANAEVYPDPD
MAB_4693|M.abscessus_ATCC_1997 LRIRPVIFSSGRVLK-ESVEVGGYQLPVGIMVDPAIGLVHASGAVYPDPA
MUL_0604|M.ulcerans_Agy99 MRLRPPGPTVARRAM-QDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPL
MLBr_02088|M.leprae_Br4923 LRYDPAIHLIGRVAA-KDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPD
* . * : : * .
Mflv_3376|M.gilvum_PYR-GCK KFNPDRFVGNP-----PNPFAWIPFGGGMMRCIGASFATMEMDVTLRTML
MAV_5160|M.avium_104 RFDPQRFIDNK-----PSALSWIPFGGGTRRCVGAAFANMEMDVVLRTVL
Rv0327c|M.tuberculosis_H37Rv EFRPSRFLDGS-----VAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIF
Mb0334c|M.bovis_AF2122/97 EFRPSRFLDGS-----VAPNTWLPFGGGVRRCLGFGFALTEGAVILQEIF
TH_2672|M.thermoresistible__bu RFDPHRMLGETPGQPALTPTTWFPFGGGNRRCLGATFAMVEMRVVLREIL
Mvan_1038|M.vanbaalenii_PYR-1 RFDPDRMLGAT-----LSPSSYLPFGGGNRRCLGATFAMVEFKVVLREIL
MSMEG_1213|M.smegmatis_MC2_155 RFEPDRMLAST-----QAPSTWLPFGGGNRRCLGATFALVEMRVVLREIL
MMAR_0938|M.marinum_M RFDPDRMIDAT-----LTPTTWLPFGGGNRRCLGATFAMVEMRVVLREIL
MAB_4693|M.abscessus_ATCC_1997 RFDPDRMVGTT-----LSPTTWLPFGGGNRRCLGATFAMVEIRVVLREIL
MUL_0604|M.ulcerans_Agy99 AFDPDRFAPKKS--KGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATII
MLBr_02088|M.leprae_Br4923 EFDPDRPSSRH-----------LAFAVGSHFCLGAALARLEATVTLSAIS
* * * :.*. * *:* :* * : * :
Mflv_3376|M.gilvum_PYR-GCK REFRLEPT-DEPDEKPHSRGVTVTPGRGGRAVVRRRRTPASGDANSVSVA
MAV_5160|M.avium_104 RHFTIETT-DAPDEPWHCRGVAFTPKHGGRIVVHRR--------------
Rv0327c|M.tuberculosis_H37Rv RRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGD-SDPP-
Mb0334c|M.bovis_AF2122/97 RRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGD-SDPP-
TH_2672|M.thermoresistible__bu RRVELETT-SARGERPRLKHVVFVPRRGARIRVRAHRKPVADNT-VDDAA
Mvan_1038|M.vanbaalenii_PYR-1 RRVELETT-TARGEHRRLKHVIFVPHRGARIRVRAKRVVAAEAP-KCPMS
MSMEG_1213|M.smegmatis_MC2_155 HRVDLFAT-TARGEKQRLKHVTMIPHRGGRICVRALRDVAPAPM-TCPAE
MMAR_0938|M.marinum_M RRVDLATT-TAPDERYKLKHVILVPHRDARIRVRAITAVSPAVP-EAPGC
MAB_4693|M.abscessus_ATCC_1997 RRVELNTT-TAPDEKQQAKHVTFVPHRGGSISVRAIRTCAPAVTPTCPAD
MUL_0604|M.ulcerans_Agy99 REAEIHSL---DGDFPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDS
MLBr_02088|M.leprae_Br4923 ARFPQVQL---AGELVYKPNVAMRGMSALPVQV-----------------
. .: : :
Mflv_3376|M.gilvum_PYR-GCK ETSR--------
MAV_5160|M.avium_104 ------------
Rv0327c|M.tuberculosis_H37Rv ------------
Mb0334c|M.bovis_AF2122/97 ------------
TH_2672|M.thermoresistible__bu GPVPSPVPPRR-
Mvan_1038|M.vanbaalenii_PYR-1 GPA---------
MSMEG_1213|M.smegmatis_MC2_155 ARRA--------
MMAR_0938|M.marinum_M PVAHAKS-----
MAB_4693|M.abscessus_ATCC_1997 VHGTGQARDPQR
MUL_0604|M.ulcerans_Agy99 SASS--------
MLBr_02088|M.leprae_Br4923 ------------