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TEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRR ALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGA ATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQN PSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVA NDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0533c | fabH | - | 100% (335) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. tuberculosis H37Rv | Rv1660 | pks10 | 4e-07 | 25.09% (283) | chalcone synthase |
| M. tuberculosis H37Rv | Rv1372 | - | 1e-06 | 27.33% (172) | hypothetical protein Rv1372 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0547c | fabH | 0.0 | 100.00% (335) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. gilvum PYR-GCK | Mflv_2540 | - | 4e-16 | 27.33% (300) | Beta-ketoacyl-acyl-carrier-protein synthase I |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1141c | - | 1e-144 | 74.03% (335) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. marinum M | MMAR_0879 | fabH | 1e-157 | 80.78% (333) | 3-oxoacyl- |
| M. avium 104 | MAV_4612 | - | 1e-150 | 76.72% (335) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. smegmatis MC2 155 | MSMEG_3953 | - | 2e-16 | 26.32% (342) | hypothetical protein MSMEG_3953 |
| M. thermoresistible (build 8) | TH_1179 | - | 7e-16 | 25.21% (349) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0632 | fabH | 1e-156 | 80.48% (333) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. vanbaalenii PYR-1 | Mvan_1354 | - | 1e-10 | 25.15% (330) | 3-oxoacyl-(ACP) synthase III |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2540|M.gilvum_PYR-GCK MAVDSHWLVMEGAGPR-ARYRSRLAGAGRHLPPTHLSTRDLMASTRHNTH
TH_1179|M.thermoresistible__bu --MRTQWLLTEDAEADGAPFRTRLAGAGRHLPVTRLSTDDLTARTRHRTT
MSMEG_3953|M.smegmatis_MC2_155 --MGPHWLVMDAADEASSPFRTRIAAAGRCLPKTRLTTSELMSETRHNTH
Rv0533c|M.tuberculosis_H37Rv ---------MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDE
Mb0547c|M.bovis_AF2122/97 ---------MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDE
MMAR_0879|M.marinum_M ---------MTEIATTSGISSVGLLSVGAYRPTRVVTNDEICENIDSSDE
MUL_0632|M.ulcerans_Agy99 ---------MTEIATTSGISSVGLLSVGAYRPTRVVTNDEICENIDSSDE
MAV_4612|M.avium_104 ---------MKQISATSGPTNIGLLSVGSYRPQRAVTNDELCQNIDSSDE
MAB_1141c|M.abscessus_ATCC_199 ---------MTDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDE
Mvan_1354|M.vanbaalenii_PYR-1 -----------------MTTTVSLVDVSVHLPGEPIGADHYAQFAESDDL
: . * : .
Mflv_2540|M.gilvum_PYR-GCK IDLERLTGIRDRRVSTGDEDSYSLATAAAVDCLDRAGQDAAG-LDVVINC
TH_1179|M.thermoresistible__bu IDLERLTGIRERRISVGDEDSYSLATAAALDCLHRADRAAES-VEVVINC
MSMEG_3953|M.smegmatis_MC2_155 IDLERLTGIRERRVSLGEDDSYSLATKAALDCLEKADRSADS-VEVVINC
Rv0533c|M.tuberculosis_H37Rv WIYTR-TGIKTRRFAADDESAASMATEACRRALSNAGLSAAD-IDGVIVT
Mb0547c|M.bovis_AF2122/97 WIYTR-TGIKTRRFAADDESAASMATEACRRALSNAGLSAAD-IDGVIVT
MMAR_0879|M.marinum_M WIYSR-TGIKTRRFAAPEESAASMAIEASREAIAKAALTGSD-IDGVIVA
MUL_0632|M.ulcerans_Agy99 WIYSR-TGIKTRRFAAPEESAASMAIEASREAIAKAALTGSD-IDGVIVA
MAV_4612|M.avium_104 WIYSR-TGIKTRRFAARDESTASMATEAGREAIAKAGLEASD-IDCVVVA
MAB_1141c|M.abscessus_ATCC_199 WIYTR-TGIKTRRFAADEETAQTLAIEAGRKAIANALLTGAE-IDAVIVA
Mvan_1354|M.vanbaalenii_PYR-1 RDNVMFRAPHLRHHVDPETSAIDMAEQAAQGLIARHGQDAVTGADVLITH
. : *: : : :* * : . . : ::
Mflv_2540|M.gilvum_PYR-GCK SITKFRDGLTQWMEPTMSAAVARAIGAEHAMTFDLSNA-CAGMLTGATVL
TH_1179|M.thermoresistible__bu SITKFRDGLTQWLEPPMSTAVARAIGADTAMTFDLSNA-CAGMLTGVSIL
MSMEG_3953|M.smegmatis_MC2_155 SITKFHGGLTQYLEPTMSSDVAHAIGARDAMTFDISNA-CAGMLTGVMVL
Rv0533c|M.tuberculosis_H37Rv TNTHFLQ------TPPAAPMVAASLGAKGILGFDLSAG-CAGFGYALGAA
Mb0547c|M.bovis_AF2122/97 TNTHFLQ------TPPAAPMVAASLGAKGILGFDLSAG-CAGFGYALGAA
MMAR_0879|M.marinum_M TSTHFLQ------TPACAPIVAAALGCQNVPAFDISAG-CSGFGHALGIA
MUL_0632|M.ulcerans_Agy99 TSTHFLQ------TPACAPIVAAALGCQNVPAFDISAG-CSGFGHALGIA
MAV_4612|M.avium_104 TSTHFLQ------TPACGPAVAAALGATGVPAFDISAG-CAGFGYALGVA
MAB_1141c|M.abscessus_ATCC_199 TSTHYLQ------TPASAPAVATALGAQGVPAFDLSAG-CAGFGYAVGVA
Mvan_1354|M.vanbaalenii_PYR-1 TQLPDMP------FYGAGGGMAHRLGMKPNWVIDLHNGGCAAFLLGLKLA
: . :* :* :*: . *:.: .
Mflv_2540|M.gilvum_PYR-GCK NNWIRQGTVQRGLVVSGE----YISQLGQNAARHIRSIMSKELACLTLGD
TH_1179|M.thermoresistible__bu NNWIRQGVVERGMVVSGE----YISQLTANAAQHIRTIMSKELASLTLGD
MSMEG_3953|M.smegmatis_MC2_155 NTWIRQGLVARGMVVSGE----YISQLGQNAAKHIRTVLSKELASLTLGD
Rv0533c|M.tuberculosis_H37Rv ADMIRGGGAATMLVVGTE----KLSPTIDMYDRGNCFIFADGAAAVVVGE
Mb0547c|M.bovis_AF2122/97 ADMIRGGGAATMLVVGTE----KLSPTIDMYDRGNCFIFADGAAAVVVGE
MMAR_0879|M.marinum_M ADMIRGGSAATILVIGTE----KLSPTVDMTDRSNCFIFADGAASVLVGH
MUL_0632|M.ulcerans_Agy99 ADMIRGGSAATILVIGTE----KLSPTVDMTDRSNCFIFVDGAASVLVGH
MAV_4612|M.avium_104 ADMVRGGTAGKVLVLGSE----KLSPTVDMTDRSNCFIFADGAAGVVVGE
MAB_1141c|M.abscessus_ATCC_199 GDMIRGGSASKVLVIGSE----KLSPALDMTDRGNCFIFGDGAGAVVVGE
Mvan_1354|M.vanbaalenii_PYR-1 RNLLASGEGRTALIAVVQNAAGQIFEQPTIRRRAQAAVPGDGAAIGLVTV
: * :: : : : : . . :
Mflv_2540|M.gilvum_PYR-GCK AGAALLFERAPADSAAGISLAGFTTVADHSRLCLAYPKG-DDPGARMFTD
TH_1179|M.thermoresistible__bu AGAALLLERAYPGSGS-IRLSGFTTIADHSRLCLAYPKG-PEPGARMFTD
MSMEG_3953|M.smegmatis_MC2_155 AGAALLLERVPAGGSG-ITLAGFTTIADYSRLCLAYPKG-RDPGARMFTD
Rv0533c|M.tuberculosis_H37Rv TPFQGIGPTVAGSDGE----QADAIRQDIDWITFAQNP--SGPRPFVRLE
Mb0547c|M.bovis_AF2122/97 TPFQGIGPTVAGSDGE----QADAIRQDIDWITFAQNP--SGPRPFVRLE
MMAR_0879|M.marinum_M SPIQGIGPTVWGSDGE----QAAAIRQDIDWISHAENP--AGPRPFLRME
MUL_0632|M.ulcerans_Agy99 SPIQGIGPTVWGSDGE----QAAAIRQDIDWISHAENP--AGPRPFLRME
MAV_4612|M.avium_104 TPTQGIGPTVWGSDGT----QATAIRQDIDWMDYLDRP--TGPRPFLRLE
MAB_1141c|M.abscessus_ATCC_199 TAEQGIGPTVWGSDGS----QSNAIRQDIDWMDFAAAPDPEGPRPYLRIE
Mvan_1354|M.vanbaalenii_PYR-1 SDESPILDVECRTYGEYAG--DMTIAVDPPRKWWQAGPG-EGCIGFTESK
: : . : * .
Mflv_2540|M.gilvum_PYR-GCK SRGIQRAAIAATPYLLHEVLDAAGISIGDIDHVITHQTSARAIRKGMAAL
TH_1179|M.thermoresistible__bu SRGIQRAAIAATPVLLQEVLDQTGLSIHDIDHVITHQTSARAIRKGMRRI
MSMEG_3953|M.smegmatis_MC2_155 SRAIHRAAITNTPVLLREVLDTAGISIDDIDHVITHQTSARAIKKGMAVM
Rv0533c|M.tuberculosis_H37Rv GPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRIN----ELL
Mb0547c|M.bovis_AF2122/97 GPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRIN----ELL
MMAR_0879|M.marinum_M GTAVFRWAAFEMGKVGQQAMDAAGVKPDEIDVFIPHQANSRIN----ELL
MUL_0632|M.ulcerans_Agy99 GTAVFRWAAFEMGKVGQQAMDAAGVKPDEIDVFIPHQANSRIN----ELL
MAV_4612|M.avium_104 GSAVFRWAAFEMGKVGQQAMDAAGVRPDEIDVFLPHQANSRIN----EIL
MAB_1141c|M.abscessus_ATCC_199 GTSVFRWAAFEMGKVGQRAMEAAKVGPEQIDVFVPHQANTRIN----ELL
Mvan_1354|M.vanbaalenii_PYR-1 ITKVLARGNRQVPEVSYAVCDRIGLPPKDVDLFVTNQPNRVFLR----NW
: . : . : : ::* .:.:*..
Mflv_2540|M.gilvum_PYR-GCK TESFGGGPRHDAVITVDRYGNTASTTHTVALVEELEAGRIRAGETIALIA
TH_1179|M.thermoresistible__bu ADEFGGTPAHDAVITVDKYGNTASTTHTVALVDELEAGGIAPGETIALIA
MSMEG_3953|M.smegmatis_MC2_155 AAEFGDHPRHDAVITVDRYGNTASTTHTVALIEELEARRIEPGETVALIA
Rv0533c|M.tuberculosis_H37Rv VKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIG
Mb0547c|M.bovis_AF2122/97 VKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIG
MMAR_0879|M.marinum_M TKNLQLRPDAVIANDIEHTGNTSAASIPLAMAELLATGAAKPGDLALLIG
MUL_0632|M.ulcerans_Agy99 TKNLQLRPDAVIANDIEHTGNTSAASIPLAMAELLATGAAKPGDLALLIG
MAV_4612|M.avium_104 AKSLELRPDAVIANDIEHTGNTSAASIPLAMAEVLATGAAKAGDLALLIG
MAB_1141c|M.abscessus_ATCC_199 AKNLHLRADAVIANDIEHTGNTSAASVPLAMETLLSTGAAKPGDLALLIG
Mvan_1354|M.vanbaalenii_PYR-1 REALELPP-ERHVDTFDECGNLFAAGIPVNLDRAVREGRVKRGDTVLMAA
: . . .:. ** :: .: : : *: : .
Mflv_2540|M.gilvum_PYR-GCK LASGLEIGVVLLTLDEELVNRYGHRD
TH_1179|M.thermoresistible__bu LASGLEIGIVLLTLDEEMVGRHGNRG
MSMEG_3953|M.smegmatis_MC2_155 LASGLEIGIHLADR------------
Rv0533c|M.tuberculosis_H37Rv YGAGLSYAAQVVRMPKG---------
Mb0547c|M.bovis_AF2122/97 YGAGLSYAAQVVRMPKG---------
MMAR_0879|M.marinum_M YGAGLSYAAQVVRMPNS---------
MUL_0632|M.ulcerans_Agy99 YGAGLSYAAQVVRMPNS---------
MAV_4612|M.avium_104 YGAGLSYAAQVVRLPPG---------
MAB_1141c|M.abscessus_ATCC_199 YGAGLSYAAQVVRMPPVPFE------
Mvan_1354|M.vanbaalenii_PYR-1 FAHAGDFAAAAALRWGGRD-------
. . . .