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PDLTSRGGERLRIVLAEDAPLLRAGIVTVLESDGHHVCAAVESADELRDAARAHDPDVVVTDVRMPPTHT DEGIRVAVDLRRTTPGLPVVILSQYTTVGSLDQLLDRTAATGRGGLGYLLKDRVAHVRHFLDAVRDIAAG ATIIDPEIVVALVGASRRRGVLAALTPREEEVLGLMAQGLTNPQIAQRLVVSEAAVRKHVGGIFAKLPLS DDGDRRVLAVLTYLNES*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5906 | - | - | 100% (228) | two component LuxR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4386 | - | 7e-49 | 50.47% (212) | two component LuxR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0263 | - | 2e-46 | 48.61% (216) | two component LuxR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3157c | devR | 1e-21 | 34.16% (202) | two component transcriptional regulatory protein DevR |
| M. gilvum PYR-GCK | Mflv_0968 | - | 1e-107 | 90.74% (216) | two component LuxR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3133c | devR | 1e-21 | 34.16% (202) | two component transcriptional regulatory protein DevR |
| M. leprae Br4923 | MLBr_01286 | - | 5e-08 | 29.09% (110) | putative two-component response regulatory protein |
| M. abscessus ATCC 19977 | MAB_4498c | - | 1e-42 | 43.52% (216) | two-component LuxR family response regulator |
| M. marinum M | MMAR_1516 | devR | 3e-21 | 34.16% (202) | two-component transcriptional regulatory protein DevR |
| M. avium 104 | MAV_5280 | - | 8e-22 | 34.13% (208) | two-component system response regulator |
| M. smegmatis MC2 155 | MSMEG_0459 | - | 2e-54 | 51.39% (216) | two-component system response regulator |
| M. thermoresistible (build 8) | TH_1532 | - | 5e-46 | 48.61% (216) | two-component system response regulator |
| M. ulcerans Agy99 | MUL_2423 | devR | 2e-21 | 34.16% (202) | two component transcriptional regulatory protein DevR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3157c|M.bovis_AF2122/97 ------------MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAE
Rv3133c|M.tuberculosis_H37Rv ------------MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAE
MMAR_1516|M.marinum_M ------------MVTVFLVDDHEVVRRGLIDLLDADPQLDVVGEAGSVSE
MUL_2423|M.ulcerans_Agy99 ------------MVTVFLVDDHEVVRRGLIDLLDADPQLDVVGEAGSVSE
MAV_5280|M.avium_104 ------MTDPAPEITVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDE
Mvan_5906|M.vanbaalenii_PYR-1 --MPDLTSRGGERLRIVLAEDAPLLRAGIVTVLE-SDGHHVCAAVESADE
Mflv_0968|M.gilvum_PYR-GCK -----MTG-----LRVVLAEDAPLLRAGIVTVLE-SDGHQVCAAVESADE
MSMEG_0459|M.smegmatis_MC2_155 -------------MKVVVADDSVLLREGLIRLLT-EGGHEVAAAVGDGPA
TH_1532|M.thermoresistible__bu -------------MRIVIAEDSALLRAGIERILT-DAGHEVVAGVPDATD
MAB_4498c|M.abscessus_ATCC_199 ----------MSAIRVLVADDDTLLREGVASVLE-KAGFEVVGRAGDATA
MLBr_01286|M.leprae_Br4923 MTGPTTDADAATPHRVLIAEDEALIRLDLAEMLR-DEGYDIVGEAADGQE
:.:.:* ::* .: :* . : . .
Mb3157c|M.bovis_AF2122/97 AMARVPAARPDVAVLDVRLP---DGNGIELCRDLLSRMPDLRCLILTSYT
Rv3133c|M.tuberculosis_H37Rv AMARVPAARPDVAVLDVRLP---DGNGIELCRDLLSRMPDLRCLILTSYT
MMAR_1516|M.marinum_M AMARIPAANPDVAVLDVRLP---DGDGIELCRDLLSRMPNLRCLILTSYT
MUL_2423|M.ulcerans_Agy99 AMARIPAANPDVAVLDVRLP---DGDGIELCRDLLSRMPNLRCLILTSYT
MAV_5280|M.avium_104 VPAAVAAHRPDVVVMDLRMR---RVDGIEATRRLGGRPP---VLALTTFN
Mvan_5906|M.vanbaalenii_PYR-1 LRDAARAHDPDVVVTDVRMPPTHTDEGIRVAVDLRRTTPGLPVVILSQYT
Mflv_0968|M.gilvum_PYR-GCK LRAAVRAHNPDLVVTDVRMPPTHTDEGIRVAIELRRATPGLPVVILSQYT
MSMEG_0459|M.smegmatis_MC2_155 LVQAVDTHRPDVSVVDVRMPPSHTDEGLRAAVEARRRVPRSPILVLSQYV
TH_1532|M.thermoresistible__bu LLRLVNELRPDLAIVDVRMPPTFTDEGIRAAALLRSQNPESPVLVLSHYV
MAB_4498c|M.abscessus_ATCC_199 LLELVRTESPNLVVVDIRMPPTHTTEGLEAAQKIRGEHPGIGVLVLSAHV
MLBr_01286|M.leprae_Br4923 AVELAERHKPDLVIMDVKMP---RRDGIDAASEIASKRIAP-IVVLTAFS
*:: : *::: :*: : *: .
Mb3157c|M.bovis_AF2122/97 SDEAMLDAIL------AGASGYVVKD--IKGMELARAVKDVGAGRSLLDN
Rv3133c|M.tuberculosis_H37Rv SDEAMLDAIL------AGASGYVVKD--IKGMELARAVKDVGAGRSLLDN
MMAR_1516|M.marinum_M SDEAMLDAIL------AGASGYVVKD--IKGMELARAIKEVGAGRSLLDN
MUL_2423|M.ulcerans_Agy99 SDEAMLDAIL------AGASGYVVKD--IKGMELARAIKEVGAGRSLLDN
MAV_5280|M.avium_104 EDELLSGALR------AGAAGFVLKD--SSAEELIRAVRAVARGEGYLDP
Mvan_5906|M.vanbaalenii_PYR-1 TVGSLDQLLDRTAATGRGGLGYLLKDRVAHVRHFLDAVRDIAAGATIIDP
Mflv_0968|M.gilvum_PYR-GCK SVGSLDQLLDRTEDAGRAGLGYLLKDRVAHVRHFLDAVRDIASGATIIDP
MSMEG_0459|M.smegmatis_MC2_155 EVSYADDLLA----DGAGAIGYLLKDRVMALTQFLDAVQRVASGGTVLDP
TH_1532|M.thermoresistible__bu EERYAADLIA----SDTKGFGYLLKDRVADVPAFLDAVEVVGGGGTVLDP
MAB_4498c|M.abscessus_ATCC_199 EVEYAAELIT-----SGDGVGYLLKSRIGDVGEFADACTRVAGGGSIVDP
MLBr_01286|M.leprae_Br4923 QRDLVERARD------AGAMAYLVKP--FTISDLIPAIALAMSRFSELTA
. .:::* : * :
Mb3157c|M.bovis_AF2122/97 RAAAALMAKLRGAAEKQD--PLSGLTDQERTLLGLLSEGLTNKQIADRMF
Rv3133c|M.tuberculosis_H37Rv RAAAALMAKLRGAAEKQD--PLSGLTDQERTLLGLLSEGLTNKQIADRMF
MMAR_1516|M.marinum_M RAAAALMSRLRGVVERPD--PLSGLTDQERTLLGLLSEGLTNKQIADRMF
MUL_2423|M.ulcerans_Agy99 RAAAALMSRLRGVVERPD--PLSGLTDQERTLLGLLSEGLTNKQIADRMF
MAV_5280|M.avium_104 AVTSRVLTTYRKAAPGPHGAAIAELTTRERDVLTLIGKGLSNSEIADELC
Mvan_5906|M.vanbaalenii_PYR-1 EIVVALVGASRRRG------VLAALTPREEEVLGLMAQGLTNPQIAQRLV
Mflv_0968|M.gilvum_PYR-GCK DIVVALVGASRRRG------VLATLTPREQEVLGLMAQGLTNPQIAQRLV
MSMEG_0459|M.smegmatis_MC2_155 DVVAQLLVRRRRDD------PLRQLSDRELQVLGLMAEGRSNTNIARTLV
TH_1532|M.thermoresistible__bu EVVSQILVRSHRRS------ALDELTAREHDVLRLMAEGKTNSAIAGALH
MAB_4498c|M.abscessus_ATCC_199 ELVRELLSARRKDD------PLSALSQRELEVLELMAQGLSNSGIAGRLW
MLBr_01286|M.leprae_Br4923 LEREVATLADRLETR-----KLVERAKGLLQVKQGMTEPEAFKWIQRAAM
: : : : : : : *
Mb3157c|M.bovis_AF2122/97 LAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Rv3133c|M.tuberculosis_H37Rv LAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
MMAR_1516|M.marinum_M LAEKTVKNYVSRLLAKLGMERRTQAAVFAAELKRARSAGHR-
MUL_2423|M.ulcerans_Agy99 LAEKTVKNYVSRLLAKLGMERRTQAAVFAAELKRARSAGHR-
MAV_5280|M.avium_104 ISGVTVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR----
Mvan_5906|M.vanbaalenii_PYR-1 VSEAAVRKHVGGIFAKLPLSDDGD--RRVLAVLTYLNES---
Mflv_0968|M.gilvum_PYR-GCK VSEAAVRKHVGNIFAKLPLSADGD--RRVLAVLTYLNEH---
MSMEG_0459|M.smegmatis_MC2_155 VSDGAVEKHIGNIFAKLALPPDSEQHRRVLAVLAYLRG----
TH_1532|M.thermoresistible__bu ISIGSAEKHIASIFTKLGLEPDESENRRVLAVLRYLES----
MAB_4498c|M.abscessus_ATCC_199 ITESTVEKHVHSVMRRLDLGHADEYHRRVLAVLAFLTHR---
MLBr_01286|M.leprae_Br4923 DRRTTMKRVAEVVLETLDTPKDT-------------------
: . :: *