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M. vanbaalenii PYR-1 Mvan_5856 (-)

annotation: pyridoxal-5'-phosphate-dependent enzyme, beta subunit
coordinates: 6241930 - 6243036
length: 368

NHVLSIHHAQLSEQRQLGRYERPATMVGQTPVLRITVPFTDADRGFWAKLEGFNPGGMKDRPALHMVQRA
RAAGALKPGARIVESTSGTLGLGLALAGTGYGHPVTLVTDPGLEPIVARMLTAFGAHIELVVEPHQHGGW
QQARRERVQQILSSDPHAWHPDQYNNPDNVEAYRGLAHELIDQLGSVDVLVCSVGTGGHSAGVARVLRET
DPQLRLIGVDTVGSTIFGQPAGARLMRGLGSSIYPGNVDYAAFDEVHWVAPAEAVWACRTLAATHYASGG
WSVGAVALVAGWAARNSPPATTVAAIFPDGPQRYFDTVYNDDYCRAHHLLGGAPPSHPATIADPLAQVAT
AWSRCTRIVDPTRVMPR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_5856--100% (368)pyridoxal-5'-phosphate-dependent enzyme, beta subunit
M. vanbaalenii PYR-1Mvan_4674-4e-3532.05% (312) cystathionine beta-synthase
M. vanbaalenii PYR-1Mvan_4291-2e-2029.37% (286) cysteine synthases

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0871cysK21e-15273.43% (350) cysteine synthase A CysK2
M. gilvum PYR-GCKMflv_0899-1e-18081.67% (371) pyridoxal-5'-phosphate-dependent enzyme, beta subunit
M. tuberculosis H37RvRv0848cysK21e-15373.43% (350) cysteine synthase A CysK2
M. leprae Br4923MLBr_02396cysM22e-3332.05% (312) cystathionine beta-synthase
M. abscessus ATCC 19977MAB_1273-1e-14770.85% (343) cysteine synthase A CysK2
M. marinum MMMAR_4768cysK21e-15573.71% (350) cysteine synthase a CysK2
M. avium 104MAV_1201-4e-3431.51% (311) cystathionine beta-synthase
M. smegmatis MC2 155MSMEG_5270-6e-3431.41% (312) cystathionine beta-synthase
M. thermoresistible (build 8)TH_1449cysK5e-3633.88% (304) PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE
M. ulcerans Agy99MUL_0203cbs2e-3430.77% (312) cystathionine beta-synthase CBS

CLUSTAL 2.0.9 multiple sequence alignment


Mvan_5856|M.vanbaalenii_PYR-1       ---------------------------------MNHVLS-----------
Mflv_0899|M.gilvum_PYR-GCK          ---------------------------------MNHALS-----------
Mb0871|M.bovis_AF2122/97            ---------------------------------MRSRQT-----------
Rv0848|M.tuberculosis_H37Rv         ---------------------------------MRSRQT-----------
MMAR_4768|M.marinum_M               MNPNLPLVNAANSAGDNLNISPTTLPGRSHLTSMRPRQT-----------
MAB_1273|M.abscessus_ATCC_1997      MRPARAATSSPISALFGADRPSGTTGFSRHAHTRRHQLPGRFAAALTQGF
MAV_1201|M.avium_104                --------------------------------------------------
MUL_0203|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02396|M.leprae_Br4923          --------------------------------------------------
MSMEG_5270|M.smegmatis_MC2_155      --------------------------------------------------
TH_1449|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mvan_5856|M.vanbaalenii_PYR-1       --IHHAQLS---EQRQLG-RYERPATMVGQTPVLRIT---VPFTDADRGF
Mflv_0899|M.gilvum_PYR-GCK          --IHHAQDTDRFEQLRLG-RYERPATMVGQTPVLRIG---APFTAAEHGF
Mb0871|M.bovis_AF2122/97            --RDRYRLLPEGYQVTPG-RNRHPGTMVGNTPVLWIP-ELSGTSDPDRGF
Rv0848|M.tuberculosis_H37Rv         --RDRYRLLPEGYQVTPG-RNRHPGTMVGNTPVLWIP-ELSGTSDPDRGF
MMAR_4768|M.marinum_M               --RDRYRVVPEGYHPIPG-RNRHPGTMVGNTPVLWVSGDASPVGSADRGF
MAB_1273|M.abscessus_ATCC_1997      SMNNSIALSSRRSCTHQGPKFHDPNTLVGNTPVLWVS---EPFSTPGTGF
MAV_1201|M.avium_104                ----------------MR-IAQHISDLIGGTPLVRLN---SVVPDGAGIV
MUL_0203|M.ulcerans_Agy99           ----------------MR-IAQHISDLIGGTPLVRLN---AVVPAGIGTV
MLBr_02396|M.leprae_Br4923          ----------------MR-IAQHISDLIGGTPLVRLN---SVVPAGTGVV
MSMEG_5270|M.smegmatis_MC2_155      ----------------MR-IARHISELIGNTPLVQLN---SVVPEGAGLV
TH_1449|M.thermoresistible__bu      ----------------MGNIYNDVTEIVGRTPLVRLN---RLTEGLDAQV
                                                         .    ::* **:: :             .

Mvan_5856|M.vanbaalenii_PYR-1       WAKLEGFNPGG-MKDRPALHMVQRARAAGALKPGARIVESTSGTLGLGLA
Mflv_0899|M.gilvum_PYR-GCK          WAKLEGFNPGG-MKDRPALHMVERARSRGKLVPGARIVESTSGTLGLGLA
Mb0871|M.bovis_AF2122/97            WAKLEGFNPGG-MKDRPALYMVECARARGDIAPGAAIVESTSGTLGLGLA
Rv0848|M.tuberculosis_H37Rv         WAKLEGFNPGG-MKDRPALYMVECARARGDIAPGAAIVESTGGTLGLGLA
MMAR_4768|M.marinum_M               WAKLEGFNPGG-MKDRPAMHMVERARARGELAPGAAIVESTSGTLGLGLA
MAB_1273|M.abscessus_ATCC_1997      WAKLEGHNPNG-MKDRPALHMIEQARARGDLKPGAMIVESTSGTLGLGLA
MAV_1201|M.avium_104                AAKVEYLNPGGSSKDRIAVRMIDAAEASGALKPGGTIVEPTSGNTGVGLA
MUL_0203|M.ulcerans_Agy99           AAKVEYLNPGGSSKDRIAIKMIDAAEASGALRPGGTIVEPTSGNTGVGLA
MLBr_02396|M.leprae_Br4923          AAKVEYFNSGGSSKDRIAAKMIDAAEASGQLKPGGTIVEPTSGNTGVGLA
MSMEG_5270|M.smegmatis_MC2_155      AAKIEYLNPGGSSKDRIALKMIEAAEVSGELKPGGTIVEPTSGNTGVGLA
TH_1449|M.thermoresistible__bu      LAKLEFYNPANSVKDRIGVAIVDAAEASGALKPGGTIVEATSGNTGIALA
                                     **:*  *. .  *** .  ::: *.  * : **. ***.*.*. *:.**

Mvan_5856|M.vanbaalenii_PYR-1       LAGTGYGHPVTLVTDPGLEPIVARMLTAFGAHIELVVEPHQHGGWQQARR
Mflv_0899|M.gilvum_PYR-GCK          LAGTVYGHPVTLVTDPGMEPMIQHMLAAFGAHIELVTEPHPRGGWQQART
Mb0871|M.bovis_AF2122/97            LAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMGTQPHPVGGWQQARK
Rv0848|M.tuberculosis_H37Rv         LAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMVTQPHPVGGWQQARK
MMAR_4768|M.marinum_M               LAGSVYGHPVTLVTDPGLEPIIARMLTAYGARVDMVTEPHPVGGWQQARK
MAB_1273|M.abscessus_ATCC_1997      LAGIIYRHPVTLVTDPGLEPIVSSMLNAYGAQVDIVTEPHPIGGWQQARK
MAV_1201|M.avium_104                LVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYS
MUL_0203|M.ulcerans_Agy99           LVAQHRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPEDPDSYYS
MLBr_02396|M.leprae_Br4923          LVAQHRGYKCVFVCPDKVSEDKRNVLLAYGAEVVVCPTAVPPDDPDSYYS
MSMEG_5270|M.smegmatis_MC2_155      LVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYS
TH_1449|M.thermoresistible__bu      MVGAARGYRVILTMPDTMSVERRVMLRAFGAEIVLTPGAEG---MAGAVA
                                    :..    :   :.    :      :* *:** : :   .           

Mvan_5856|M.vanbaalenii_PYR-1       ERVQQILSSDPHAWHPDQYNNPDNVEAYRGLA--HELIDQLGSVDVLVCS
Mflv_0899|M.gilvum_PYR-GCK          ERVHEILGTDPQAWHPDQYNNPDNVEAYRGLA--MELIEQLGSVDVLVCS
Mb0871|M.bovis_AF2122/97            DRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCS
Rv0848|M.tuberculosis_H37Rv         DRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCS
MMAR_4768|M.marinum_M               DRVAQLLAADPSAWNPDQYSNPDNVDAYRPLA--LEMAAQLGRVDVLVCS
MAB_1273|M.abscessus_ATCC_1997      DRVAQLLAAEPDSWCPDQYQNPDNVDAYRGLA--EELIDQLGTVDTLVCS
MAV_1201|M.avium_104                -VSDRLVTEIEGAWKPDQYANPEGPASHYATTGPEIWADTDGKVTHFVAG
MUL_0203|M.ulcerans_Agy99           -VSDRLVREIDGAWKPDQYANPEGPASHYATTGPEIWADTDGKITHFVAG
MLBr_02396|M.leprae_Br4923          -VSDRLVAKIDGAWKPDQYANPAGPASHYETTGPEIWADTDGRVTHFVAG
MSMEG_5270|M.smegmatis_MC2_155      -VSNRLVTEIEGAWKPDQYSNQMGPESHYETTGPEIWADTEGKITHFVAG
TH_1449|M.thermoresistible__bu      -RAEQILAETENAVAAKQFANPANPDIHERTTGEEVWADTDGTVDIFVAG
                                        .::     :  ..*: *  .   :   :         * :  :*..

Mvan_5856|M.vanbaalenii_PYR-1       VGTGGHSAGVARVLRETDPQ-LRLIGVDTVGS-TIFGQPAGARLMRGLGS
Mflv_0899|M.gilvum_PYR-GCK          VGTGGHSAGVARVLREYNPG-LRLIGVDTVGS-TIFGQPATTRLMRGLGS
Mb0871|M.bovis_AF2122/97            VGTGGHSAGVARVLREFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGS
Rv0848|M.tuberculosis_H37Rv         VGTGGHSAGVARVLREFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGS
MMAR_4768|M.marinum_M               VGTGGHSSGVARVLREFNPA-MRLIGVDTIGS-TIFGQPASSRLMRGLGS
MAB_1273|M.abscessus_ATCC_1997      VGTGGHSSGVGRVLREHNPN-LRLVGVDTIGS-TIFGQPAGSRLMRGLGS
MAV_1201|M.avium_104                IGTGGTITGAGRYLKEVSGGRVRVIGADPEGS-VYSGGTGRPYLVEGVGE
MUL_0203|M.ulcerans_Agy99           IGTGGTITGAGCYLKEVSGGKVRVIGADPEGS-VYSGGTGRPYLVEGVGE
MLBr_02396|M.leprae_Br4923          IGTGGTITGVGRYLKEVSGGLVRIIGADPEGS-VYSGGTGRPYLVEGVGE
MSMEG_5270|M.smegmatis_MC2_155      VGTGGTITGTGRYLKEVSGGKVKVIGADPEGS-VYSGGTGRPYLVEGVGE
TH_1449|M.thermoresistible__bu      IGTGGTLTGVGRLLKSRKPG-VKIVGVEPLDSPILNGGQPGPHKIQGIGA
                                    :****  :*..  *:. .   ::::*.:. .*    *       :.*:* 

Mvan_5856|M.vanbaalenii_PYR-1       SIYPGNVDYAAFDEVHWVAPAEAVWACRTLAATHYASGGWSVGAVALVAG
Mflv_0899|M.gilvum_PYR-GCK          SIYPGNVDYAAFNEVHWVAPADAVWACRTLAATHYASGGWSVGAVAVVAG
Mb0871|M.bovis_AF2122/97            SIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAG
Rv0848|M.tuberculosis_H37Rv         SIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAG
MMAR_4768|M.marinum_M               SIFPRNVDYSAFNEVHWVAPAEAVWACRSMAATHYASGGWSVGAVALVAG
MAB_1273|M.abscessus_ATCC_1997      SIYPGNVDYPAFDEAHWVAPNEAVWAARTLAATYHASGGWSVGAVALVAG
MAV_1201|M.avium_104                DFWPQAYDRTVPDEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAAL
MUL_0203|M.ulcerans_Agy99           DFWPATYDHAVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAAL
MLBr_02396|M.leprae_Br4923          DFWPAAYDPMVPDQIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAAL
MSMEG_5270|M.smegmatis_MC2_155      DFWPTAYDPSVPDEIIAVSDADSFEMTRRLAREEALLVGGSCGMAVVAAI
TH_1449|M.thermoresistible__bu      NFIPEVLDRDVYDEIIDAGFEDAISVSRALATQEGILGGISAGANVWAAL
                                    .: *   *  . ::   ..  ::.   * :*       * * *  . .* 

Mvan_5856|M.vanbaalenii_PYR-1       WAARNSP-PATTVAAIFPDGPQRYFDTVYNDDYCRAHHLLGGA-------
Mflv_0899|M.gilvum_PYR-GCK          WAARGSD-PGTTVAAIFPDGPQRYFDTIYNDEYCRTHGLLDKA-------
Mb0871|M.bovis_AF2122/97            WAARNLP-ADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQ-------
Rv0848|M.tuberculosis_H37Rv         WAARNLP-ADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQ-------
MMAR_4768|M.marinum_M               WAARTLP-SDITIAAVFPDGPQRYFDTVYNDDYCNEHGLLGQR-------
MAB_1273|M.abscessus_ATCC_1997      WVARTSD-PGARIAAIFPDGPMRYHGTIYDDDYCRSHDLLDRP-------
MAV_1201|M.avium_104                RVAEQAG-PDALVVVLLPDGGRGYMAKIFNDAWMSSYGFLRTRLDGSTDQ
MUL_0203|M.ulcerans_Agy99           RVAEQAG-PDALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGRTDT
MLBr_02396|M.leprae_Br4923          QVAEEAG-PAALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQ
MSMEG_5270|M.smegmatis_MC2_155      EVARKAG-PDAVVVVLLPDGGRGYLSKIFNDAWMSSYGFLRTRLDGSVEK
TH_1449|M.thermoresistible__bu      EVAKRPENAGKVIVVVIPDFGERYVS------------------------
                                     .*.    .   :..::**    *                          

Mvan_5856|M.vanbaalenii_PYR-1       ------------------PPSHPATIADPLAQVATAWSRCTRIVDPTRVM
Mflv_0899|M.gilvum_PYR-GCK          ------------------PPNEPATIDHPLRHAVKAWTRCPVVVDPTQVV
Mb0871|M.bovis_AF2122/97            ------------------PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVV
Rv0848|M.tuberculosis_H37Rv         ------------------PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVV
MMAR_4768|M.marinum_M               ------------------PATEPEVIASPSAAVVQRWTRSATVIDPTQVA
MAB_1273|M.abscessus_ATCC_1997      ------------------PAQDPDVIDDPSERVVDRWTRLTRVIDPIGRR
MAV_1201|M.avium_104                SRVGDVLRRKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
MUL_0203|M.ulcerans_Agy99           STVGDVLRRKSGALPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
MLBr_02396|M.leprae_Br4923          PIVGDVLRRKSGALPDLVHTHPSETVRDAIGILREYAVSQIPVVGAEPPV
MSMEG_5270|M.smegmatis_MC2_155      T-VGDVLRGKSGALPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
TH_1449|M.thermoresistible__bu      -------------------TALFEHIRD----------------------
                                                       .     :                        

Mvan_5856|M.vanbaalenii_PYR-1       PR------------------------------------------------
Mflv_0899|M.gilvum_PYR-GCK          PR------------------------------------------------
Mb0871|M.bovis_AF2122/97            S-------------------------------------------------
Rv0848|M.tuberculosis_H37Rv         S-------------------------------------------------
MMAR_4768|M.marinum_M               A-------------------------------------------------
MAB_1273|M.abscessus_ATCC_1997      A-------------------------------------------------
MAV_1201|M.avium_104                MAGEVAGSVSERELLSAVFEGRAKLADAVSLHMSPPLPMIGAGESVSAAG
MUL_0203|M.ulcerans_Agy99           MAGEVAGSVSERELLSAVFSGKAKLADAVSQHMSPPLKLIGAGELVGVAG
MLBr_02396|M.leprae_Br4923          MAGEVVGSVSERELLSAVFEGRASLADAVSEHMGPPLRLIGDGELVSVAG
MSMEG_5270|M.smegmatis_MC2_155      MAGEVAGSVSERELLSAVFEGRAKLADAVAEHMSPPLPLIGAGELVSTAA
TH_1449|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mvan_5856|M.vanbaalenii_PYR-1       -----------------------------------------
Mflv_0899|M.gilvum_PYR-GCK          -----------------------------------------
Mb0871|M.bovis_AF2122/97            -----------------------------------------
Rv0848|M.tuberculosis_H37Rv         -----------------------------------------
MMAR_4768|M.marinum_M               -----------------------------------------
MAB_1273|M.abscessus_ATCC_1997      -----------------------------------------
MAV_1201|M.avium_104                KALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR
MUL_0203|M.ulcerans_Agy99           KALRDWDALMVVEEGKPVGVITRYDLLGFLSEG----ALRR
MLBr_02396|M.leprae_Br4923          EALRDSDALMVVEKGKLVGVITRYDLLGFLSEG----APLR
MSMEG_5270|M.smegmatis_MC2_155      KTLRESDAVMVVEDGKPVGVLTRHDLLGFLSEG----GYRH
TH_1449|M.thermoresistible__bu      -----------------------------------------