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NHVLSIHHAQLSEQRQLGRYERPATMVGQTPVLRITVPFTDADRGFWAKLEGFNPGGMKDRPALHMVQRA RAAGALKPGARIVESTSGTLGLGLALAGTGYGHPVTLVTDPGLEPIVARMLTAFGAHIELVVEPHQHGGW QQARRERVQQILSSDPHAWHPDQYNNPDNVEAYRGLAHELIDQLGSVDVLVCSVGTGGHSAGVARVLRET DPQLRLIGVDTVGSTIFGQPAGARLMRGLGSSIYPGNVDYAAFDEVHWVAPAEAVWACRTLAATHYASGG WSVGAVALVAGWAARNSPPATTVAAIFPDGPQRYFDTVYNDDYCRAHHLLGGAPPSHPATIADPLAQVAT AWSRCTRIVDPTRVMPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5856 | - | - | 100% (368) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. vanbaalenii PYR-1 | Mvan_4674 | - | 4e-35 | 32.05% (312) | cystathionine beta-synthase |
| M. vanbaalenii PYR-1 | Mvan_4291 | - | 2e-20 | 29.37% (286) | cysteine synthases |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0871 | cysK2 | 1e-152 | 73.43% (350) | cysteine synthase A CysK2 |
| M. gilvum PYR-GCK | Mflv_0899 | - | 1e-180 | 81.67% (371) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. tuberculosis H37Rv | Rv0848 | cysK2 | 1e-153 | 73.43% (350) | cysteine synthase A CysK2 |
| M. leprae Br4923 | MLBr_02396 | cysM2 | 2e-33 | 32.05% (312) | cystathionine beta-synthase |
| M. abscessus ATCC 19977 | MAB_1273 | - | 1e-147 | 70.85% (343) | cysteine synthase A CysK2 |
| M. marinum M | MMAR_4768 | cysK2 | 1e-155 | 73.71% (350) | cysteine synthase a CysK2 |
| M. avium 104 | MAV_1201 | - | 4e-34 | 31.51% (311) | cystathionine beta-synthase |
| M. smegmatis MC2 155 | MSMEG_5270 | - | 6e-34 | 31.41% (312) | cystathionine beta-synthase |
| M. thermoresistible (build 8) | TH_1449 | cysK | 5e-36 | 33.88% (304) | PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE |
| M. ulcerans Agy99 | MUL_0203 | cbs | 2e-34 | 30.77% (312) | cystathionine beta-synthase CBS |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5856|M.vanbaalenii_PYR-1 ---------------------------------MNHVLS-----------
Mflv_0899|M.gilvum_PYR-GCK ---------------------------------MNHALS-----------
Mb0871|M.bovis_AF2122/97 ---------------------------------MRSRQT-----------
Rv0848|M.tuberculosis_H37Rv ---------------------------------MRSRQT-----------
MMAR_4768|M.marinum_M MNPNLPLVNAANSAGDNLNISPTTLPGRSHLTSMRPRQT-----------
MAB_1273|M.abscessus_ATCC_1997 MRPARAATSSPISALFGADRPSGTTGFSRHAHTRRHQLPGRFAAALTQGF
MAV_1201|M.avium_104 --------------------------------------------------
MUL_0203|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02396|M.leprae_Br4923 --------------------------------------------------
MSMEG_5270|M.smegmatis_MC2_155 --------------------------------------------------
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mvan_5856|M.vanbaalenii_PYR-1 --IHHAQLS---EQRQLG-RYERPATMVGQTPVLRIT---VPFTDADRGF
Mflv_0899|M.gilvum_PYR-GCK --IHHAQDTDRFEQLRLG-RYERPATMVGQTPVLRIG---APFTAAEHGF
Mb0871|M.bovis_AF2122/97 --RDRYRLLPEGYQVTPG-RNRHPGTMVGNTPVLWIP-ELSGTSDPDRGF
Rv0848|M.tuberculosis_H37Rv --RDRYRLLPEGYQVTPG-RNRHPGTMVGNTPVLWIP-ELSGTSDPDRGF
MMAR_4768|M.marinum_M --RDRYRVVPEGYHPIPG-RNRHPGTMVGNTPVLWVSGDASPVGSADRGF
MAB_1273|M.abscessus_ATCC_1997 SMNNSIALSSRRSCTHQGPKFHDPNTLVGNTPVLWVS---EPFSTPGTGF
MAV_1201|M.avium_104 ----------------MR-IAQHISDLIGGTPLVRLN---SVVPDGAGIV
MUL_0203|M.ulcerans_Agy99 ----------------MR-IAQHISDLIGGTPLVRLN---AVVPAGIGTV
MLBr_02396|M.leprae_Br4923 ----------------MR-IAQHISDLIGGTPLVRLN---SVVPAGTGVV
MSMEG_5270|M.smegmatis_MC2_155 ----------------MR-IARHISELIGNTPLVQLN---SVVPEGAGLV
TH_1449|M.thermoresistible__bu ----------------MGNIYNDVTEIVGRTPLVRLN---RLTEGLDAQV
. ::* **:: : .
Mvan_5856|M.vanbaalenii_PYR-1 WAKLEGFNPGG-MKDRPALHMVQRARAAGALKPGARIVESTSGTLGLGLA
Mflv_0899|M.gilvum_PYR-GCK WAKLEGFNPGG-MKDRPALHMVERARSRGKLVPGARIVESTSGTLGLGLA
Mb0871|M.bovis_AF2122/97 WAKLEGFNPGG-MKDRPALYMVECARARGDIAPGAAIVESTSGTLGLGLA
Rv0848|M.tuberculosis_H37Rv WAKLEGFNPGG-MKDRPALYMVECARARGDIAPGAAIVESTGGTLGLGLA
MMAR_4768|M.marinum_M WAKLEGFNPGG-MKDRPAMHMVERARARGELAPGAAIVESTSGTLGLGLA
MAB_1273|M.abscessus_ATCC_1997 WAKLEGHNPNG-MKDRPALHMIEQARARGDLKPGAMIVESTSGTLGLGLA
MAV_1201|M.avium_104 AAKVEYLNPGGSSKDRIAVRMIDAAEASGALKPGGTIVEPTSGNTGVGLA
MUL_0203|M.ulcerans_Agy99 AAKVEYLNPGGSSKDRIAIKMIDAAEASGALRPGGTIVEPTSGNTGVGLA
MLBr_02396|M.leprae_Br4923 AAKVEYFNSGGSSKDRIAAKMIDAAEASGQLKPGGTIVEPTSGNTGVGLA
MSMEG_5270|M.smegmatis_MC2_155 AAKIEYLNPGGSSKDRIALKMIEAAEVSGELKPGGTIVEPTSGNTGVGLA
TH_1449|M.thermoresistible__bu LAKLEFYNPANSVKDRIGVAIVDAAEASGALKPGGTIVEATSGNTGIALA
**:* *. . *** . ::: *. * : **. ***.*.*. *:.**
Mvan_5856|M.vanbaalenii_PYR-1 LAGTGYGHPVTLVTDPGLEPIVARMLTAFGAHIELVVEPHQHGGWQQARR
Mflv_0899|M.gilvum_PYR-GCK LAGTVYGHPVTLVTDPGMEPMIQHMLAAFGAHIELVTEPHPRGGWQQART
Mb0871|M.bovis_AF2122/97 LAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMGTQPHPVGGWQQARK
Rv0848|M.tuberculosis_H37Rv LAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMVTQPHPVGGWQQARK
MMAR_4768|M.marinum_M LAGSVYGHPVTLVTDPGLEPIIARMLTAYGARVDMVTEPHPVGGWQQARK
MAB_1273|M.abscessus_ATCC_1997 LAGIIYRHPVTLVTDPGLEPIVSSMLNAYGAQVDIVTEPHPIGGWQQARK
MAV_1201|M.avium_104 LVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYS
MUL_0203|M.ulcerans_Agy99 LVAQHRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPEDPDSYYS
MLBr_02396|M.leprae_Br4923 LVAQHRGYKCVFVCPDKVSEDKRNVLLAYGAEVVVCPTAVPPDDPDSYYS
MSMEG_5270|M.smegmatis_MC2_155 LVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYS
TH_1449|M.thermoresistible__bu MVGAARGYRVILTMPDTMSVERRVMLRAFGAEIVLTPGAEG---MAGAVA
:.. : :. : :* *:** : : .
Mvan_5856|M.vanbaalenii_PYR-1 ERVQQILSSDPHAWHPDQYNNPDNVEAYRGLA--HELIDQLGSVDVLVCS
Mflv_0899|M.gilvum_PYR-GCK ERVHEILGTDPQAWHPDQYNNPDNVEAYRGLA--MELIEQLGSVDVLVCS
Mb0871|M.bovis_AF2122/97 DRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCS
Rv0848|M.tuberculosis_H37Rv DRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCS
MMAR_4768|M.marinum_M DRVAQLLAADPSAWNPDQYSNPDNVDAYRPLA--LEMAAQLGRVDVLVCS
MAB_1273|M.abscessus_ATCC_1997 DRVAQLLAAEPDSWCPDQYQNPDNVDAYRGLA--EELIDQLGTVDTLVCS
MAV_1201|M.avium_104 -VSDRLVTEIEGAWKPDQYANPEGPASHYATTGPEIWADTDGKVTHFVAG
MUL_0203|M.ulcerans_Agy99 -VSDRLVREIDGAWKPDQYANPEGPASHYATTGPEIWADTDGKITHFVAG
MLBr_02396|M.leprae_Br4923 -VSDRLVAKIDGAWKPDQYANPAGPASHYETTGPEIWADTDGRVTHFVAG
MSMEG_5270|M.smegmatis_MC2_155 -VSNRLVTEIEGAWKPDQYSNQMGPESHYETTGPEIWADTEGKITHFVAG
TH_1449|M.thermoresistible__bu -RAEQILAETENAVAAKQFANPANPDIHERTTGEEVWADTDGTVDIFVAG
.:: : ..*: * . : : * : :*..
Mvan_5856|M.vanbaalenii_PYR-1 VGTGGHSAGVARVLRETDPQ-LRLIGVDTVGS-TIFGQPAGARLMRGLGS
Mflv_0899|M.gilvum_PYR-GCK VGTGGHSAGVARVLREYNPG-LRLIGVDTVGS-TIFGQPATTRLMRGLGS
Mb0871|M.bovis_AF2122/97 VGTGGHSAGVARVLREFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGS
Rv0848|M.tuberculosis_H37Rv VGTGGHSAGVARVLREFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGS
MMAR_4768|M.marinum_M VGTGGHSSGVARVLREFNPA-MRLIGVDTIGS-TIFGQPASSRLMRGLGS
MAB_1273|M.abscessus_ATCC_1997 VGTGGHSSGVGRVLREHNPN-LRLVGVDTIGS-TIFGQPAGSRLMRGLGS
MAV_1201|M.avium_104 IGTGGTITGAGRYLKEVSGGRVRVIGADPEGS-VYSGGTGRPYLVEGVGE
MUL_0203|M.ulcerans_Agy99 IGTGGTITGAGCYLKEVSGGKVRVIGADPEGS-VYSGGTGRPYLVEGVGE
MLBr_02396|M.leprae_Br4923 IGTGGTITGVGRYLKEVSGGLVRIIGADPEGS-VYSGGTGRPYLVEGVGE
MSMEG_5270|M.smegmatis_MC2_155 VGTGGTITGTGRYLKEVSGGKVKVIGADPEGS-VYSGGTGRPYLVEGVGE
TH_1449|M.thermoresistible__bu IGTGGTLTGVGRLLKSRKPG-VKIVGVEPLDSPILNGGQPGPHKIQGIGA
:**** :*.. *:. . ::::*.:. .* * :.*:*
Mvan_5856|M.vanbaalenii_PYR-1 SIYPGNVDYAAFDEVHWVAPAEAVWACRTLAATHYASGGWSVGAVALVAG
Mflv_0899|M.gilvum_PYR-GCK SIYPGNVDYAAFNEVHWVAPADAVWACRTLAATHYASGGWSVGAVAVVAG
Mb0871|M.bovis_AF2122/97 SIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAG
Rv0848|M.tuberculosis_H37Rv SIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAG
MMAR_4768|M.marinum_M SIFPRNVDYSAFNEVHWVAPAEAVWACRSMAATHYASGGWSVGAVALVAG
MAB_1273|M.abscessus_ATCC_1997 SIYPGNVDYPAFDEAHWVAPNEAVWAARTLAATYHASGGWSVGAVALVAG
MAV_1201|M.avium_104 DFWPQAYDRTVPDEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAAL
MUL_0203|M.ulcerans_Agy99 DFWPATYDHAVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAAL
MLBr_02396|M.leprae_Br4923 DFWPAAYDPMVPDQIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAAL
MSMEG_5270|M.smegmatis_MC2_155 DFWPTAYDPSVPDEIIAVSDADSFEMTRRLAREEALLVGGSCGMAVVAAI
TH_1449|M.thermoresistible__bu NFIPEVLDRDVYDEIIDAGFEDAISVSRALATQEGILGGISAGANVWAAL
.: * * . :: .. ::. * :* * * * . .*
Mvan_5856|M.vanbaalenii_PYR-1 WAARNSP-PATTVAAIFPDGPQRYFDTVYNDDYCRAHHLLGGA-------
Mflv_0899|M.gilvum_PYR-GCK WAARGSD-PGTTVAAIFPDGPQRYFDTIYNDEYCRTHGLLDKA-------
Mb0871|M.bovis_AF2122/97 WAARNLP-ADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQ-------
Rv0848|M.tuberculosis_H37Rv WAARNLP-ADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQ-------
MMAR_4768|M.marinum_M WAARTLP-SDITIAAVFPDGPQRYFDTVYNDDYCNEHGLLGQR-------
MAB_1273|M.abscessus_ATCC_1997 WVARTSD-PGARIAAIFPDGPMRYHGTIYDDDYCRSHDLLDRP-------
MAV_1201|M.avium_104 RVAEQAG-PDALVVVLLPDGGRGYMAKIFNDAWMSSYGFLRTRLDGSTDQ
MUL_0203|M.ulcerans_Agy99 RVAEQAG-PDALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGRTDT
MLBr_02396|M.leprae_Br4923 QVAEEAG-PAALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQ
MSMEG_5270|M.smegmatis_MC2_155 EVARKAG-PDAVVVVLLPDGGRGYLSKIFNDAWMSSYGFLRTRLDGSVEK
TH_1449|M.thermoresistible__bu EVAKRPENAGKVIVVVIPDFGERYVS------------------------
.*. . :..::** *
Mvan_5856|M.vanbaalenii_PYR-1 ------------------PPSHPATIADPLAQVATAWSRCTRIVDPTRVM
Mflv_0899|M.gilvum_PYR-GCK ------------------PPNEPATIDHPLRHAVKAWTRCPVVVDPTQVV
Mb0871|M.bovis_AF2122/97 ------------------PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVV
Rv0848|M.tuberculosis_H37Rv ------------------PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVV
MMAR_4768|M.marinum_M ------------------PATEPEVIASPSAAVVQRWTRSATVIDPTQVA
MAB_1273|M.abscessus_ATCC_1997 ------------------PAQDPDVIDDPSERVVDRWTRLTRVIDPIGRR
MAV_1201|M.avium_104 SRVGDVLRRKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
MUL_0203|M.ulcerans_Agy99 STVGDVLRRKSGALPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
MLBr_02396|M.leprae_Br4923 PIVGDVLRRKSGALPDLVHTHPSETVRDAIGILREYAVSQIPVVGAEPPV
MSMEG_5270|M.smegmatis_MC2_155 T-VGDVLRGKSGALPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
TH_1449|M.thermoresistible__bu -------------------TALFEHIRD----------------------
. :
Mvan_5856|M.vanbaalenii_PYR-1 PR------------------------------------------------
Mflv_0899|M.gilvum_PYR-GCK PR------------------------------------------------
Mb0871|M.bovis_AF2122/97 S-------------------------------------------------
Rv0848|M.tuberculosis_H37Rv S-------------------------------------------------
MMAR_4768|M.marinum_M A-------------------------------------------------
MAB_1273|M.abscessus_ATCC_1997 A-------------------------------------------------
MAV_1201|M.avium_104 MAGEVAGSVSERELLSAVFEGRAKLADAVSLHMSPPLPMIGAGESVSAAG
MUL_0203|M.ulcerans_Agy99 MAGEVAGSVSERELLSAVFSGKAKLADAVSQHMSPPLKLIGAGELVGVAG
MLBr_02396|M.leprae_Br4923 MAGEVVGSVSERELLSAVFEGRASLADAVSEHMGPPLRLIGDGELVSVAG
MSMEG_5270|M.smegmatis_MC2_155 MAGEVAGSVSERELLSAVFEGRAKLADAVAEHMSPPLPLIGAGELVSTAA
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mvan_5856|M.vanbaalenii_PYR-1 -----------------------------------------
Mflv_0899|M.gilvum_PYR-GCK -----------------------------------------
Mb0871|M.bovis_AF2122/97 -----------------------------------------
Rv0848|M.tuberculosis_H37Rv -----------------------------------------
MMAR_4768|M.marinum_M -----------------------------------------
MAB_1273|M.abscessus_ATCC_1997 -----------------------------------------
MAV_1201|M.avium_104 KALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR
MUL_0203|M.ulcerans_Agy99 KALRDWDALMVVEEGKPVGVITRYDLLGFLSEG----ALRR
MLBr_02396|M.leprae_Br4923 EALRDSDALMVVEKGKLVGVITRYDLLGFLSEG----APLR
MSMEG_5270|M.smegmatis_MC2_155 KTLRESDAVMVVEDGKPVGVLTRHDLLGFLSEG----GYRH
TH_1449|M.thermoresistible__bu -----------------------------------------