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MRPARAATSSPISALFGADRPSGTTGFSRHAHTRRHQLPGRFAAALTQGFSMNNSIALSSRRSCTHQGPK FHDPNTLVGNTPVLWVSEPFSTPGTGFWAKLEGHNPNGMKDRPALHMIEQARARGDLKPGAMIVESTSGT LGLGLALAGIIYRHPVTLVTDPGLEPIVSSMLNAYGAQVDIVTEPHPIGGWQQARKDRVAQLLAAEPDSW CPDQYQNPDNVDAYRGLAEELIDQLGTVDTLVCSVGTGGHSSGVGRVLREHNPNLRLVGVDTIGSTIFGQ PAGSRLMRGLGSSIYPGNVDYPAFDEAHWVAPNEAVWAARTLAATYHASGGWSVGAVALVAGWVARTSDP GARIAAIFPDGPMRYHGTIYDDDYCRSHDLLDRPPAQDPDVIDDPSERVVDRWTRLTRVIDPIGRRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1273 | - | - | 100% (417) | cysteine synthase A CysK2 |
| M. abscessus ATCC 19977 | MAB_0451c | - | 0.0 | 92.62% (366) | cysteine synthase |
| M. abscessus ATCC 19977 | MAB_1195 | - | 6e-30 | 31.23% (317) | cystathionine beta-synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0871 | cysK2 | 1e-145 | 72.43% (341) | cysteine synthase A CysK2 |
| M. gilvum PYR-GCK | Mflv_0899 | - | 1e-147 | 69.97% (343) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. tuberculosis H37Rv | Rv0848 | cysK2 | 1e-146 | 72.43% (341) | cysteine synthase A CysK2 |
| M. leprae Br4923 | MLBr_02396 | cysM2 | 3e-31 | 32.66% (349) | cystathionine beta-synthase |
| M. marinum M | MMAR_4768 | cysK2 | 1e-150 | 73.98% (342) | cysteine synthase a CysK2 |
| M. avium 104 | MAV_1201 | - | 2e-31 | 31.05% (351) | cystathionine beta-synthase |
| M. smegmatis MC2 155 | MSMEG_5270 | - | 1e-31 | 32.27% (313) | cystathionine beta-synthase |
| M. thermoresistible (build 8) | TH_1449 | cysK | 3e-35 | 33.88% (307) | PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE |
| M. ulcerans Agy99 | MUL_0203 | cbs | 1e-30 | 31.61% (310) | cystathionine beta-synthase CBS |
| M. vanbaalenii PYR-1 | Mvan_5856 | - | 1e-147 | 70.85% (343) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0871|M.bovis_AF2122/97 ---------------------------------MRSRQT-----------
Rv0848|M.tuberculosis_H37Rv ---------------------------------MRSRQT-----------
MMAR_4768|M.marinum_M MNPNLPLVNAANSAGDNLNISPTTLPGRSHLTSMRPRQT-----------
Mflv_0899|M.gilvum_PYR-GCK ---------------------------------MNHALS-----------
Mvan_5856|M.vanbaalenii_PYR-1 ---------------------------------MNHVLS-----------
MAB_1273|M.abscessus_ATCC_1997 MRPARAATSSPISALFGADRPSGTTGFSRHAHTRRHQLPGRFAAALTQGF
MAV_1201|M.avium_104 --------------------------------------------------
MUL_0203|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02396|M.leprae_Br4923 --------------------------------------------------
MSMEG_5270|M.smegmatis_MC2_155 --------------------------------------------------
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mb0871|M.bovis_AF2122/97 --RDRYRLLPEGYQVTPG-RNRHPGTMVGNTPVLWIP-ELSGTSDPDRGF
Rv0848|M.tuberculosis_H37Rv --RDRYRLLPEGYQVTPG-RNRHPGTMVGNTPVLWIP-ELSGTSDPDRGF
MMAR_4768|M.marinum_M --RDRYRVVPEGYHPIPG-RNRHPGTMVGNTPVLWVSGDASPVGSADRGF
Mflv_0899|M.gilvum_PYR-GCK --IHHAQDTDRFEQLRLG-RYERPATMVGQTPVLRIG---APFTAAEHGF
Mvan_5856|M.vanbaalenii_PYR-1 --IHHAQLS---EQRQLG-RYERPATMVGQTPVLRIT---VPFTDADRGF
MAB_1273|M.abscessus_ATCC_1997 SMNNSIALSSRRSCTHQGPKFHDPNTLVGNTPVLWVS---EPFSTPGTGF
MAV_1201|M.avium_104 ----------------MR-IAQHISDLIGGTPLVRLN---SVVPDGAGIV
MUL_0203|M.ulcerans_Agy99 ----------------MR-IAQHISDLIGGTPLVRLN---AVVPAGIGTV
MLBr_02396|M.leprae_Br4923 ----------------MR-IAQHISDLIGGTPLVRLN---SVVPAGTGVV
MSMEG_5270|M.smegmatis_MC2_155 ----------------MR-IARHISELIGNTPLVQLN---SVVPEGAGLV
TH_1449|M.thermoresistible__bu ----------------MGNIYNDVTEIVGRTPLVRLN---RLTEGLDAQV
. ::* **:: : .
Mb0871|M.bovis_AF2122/97 WAKLEGFNPGG-MKDRPALYMVECARARGDIAPGAAIVESTSGTLGLGLA
Rv0848|M.tuberculosis_H37Rv WAKLEGFNPGG-MKDRPALYMVECARARGDIAPGAAIVESTGGTLGLGLA
MMAR_4768|M.marinum_M WAKLEGFNPGG-MKDRPAMHMVERARARGELAPGAAIVESTSGTLGLGLA
Mflv_0899|M.gilvum_PYR-GCK WAKLEGFNPGG-MKDRPALHMVERARSRGKLVPGARIVESTSGTLGLGLA
Mvan_5856|M.vanbaalenii_PYR-1 WAKLEGFNPGG-MKDRPALHMVQRARAAGALKPGARIVESTSGTLGLGLA
MAB_1273|M.abscessus_ATCC_1997 WAKLEGHNPNG-MKDRPALHMIEQARARGDLKPGAMIVESTSGTLGLGLA
MAV_1201|M.avium_104 AAKVEYLNPGGSSKDRIAVRMIDAAEASGALKPGGTIVEPTSGNTGVGLA
MUL_0203|M.ulcerans_Agy99 AAKVEYLNPGGSSKDRIAIKMIDAAEASGALRPGGTIVEPTSGNTGVGLA
MLBr_02396|M.leprae_Br4923 AAKVEYFNSGGSSKDRIAAKMIDAAEASGQLKPGGTIVEPTSGNTGVGLA
MSMEG_5270|M.smegmatis_MC2_155 AAKIEYLNPGGSSKDRIALKMIEAAEVSGELKPGGTIVEPTSGNTGVGLA
TH_1449|M.thermoresistible__bu LAKLEFYNPANSVKDRIGVAIVDAAEASGALKPGGTIVEATSGNTGIALA
**:* *. . *** . ::: *. * : **. ***.*.*. *:.**
Mb0871|M.bovis_AF2122/97 LAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMGTQPHPVGGWQQARK
Rv0848|M.tuberculosis_H37Rv LAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMVTQPHPVGGWQQARK
MMAR_4768|M.marinum_M LAGSVYGHPVTLVTDPGLEPIIARMLTAYGARVDMVTEPHPVGGWQQARK
Mflv_0899|M.gilvum_PYR-GCK LAGTVYGHPVTLVTDPGMEPMIQHMLAAFGAHIELVTEPHPRGGWQQART
Mvan_5856|M.vanbaalenii_PYR-1 LAGTGYGHPVTLVTDPGLEPIVARMLTAFGAHIELVVEPHQHGGWQQARR
MAB_1273|M.abscessus_ATCC_1997 LAGIIYRHPVTLVTDPGLEPIVSSMLNAYGAQVDIVTEPHPIGGWQQARK
MAV_1201|M.avium_104 LVAQQRGYKCVFVCPDKVGEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYS
MUL_0203|M.ulcerans_Agy99 LVAQHRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPEDPDSYYS
MLBr_02396|M.leprae_Br4923 LVAQHRGYKCVFVCPDKVSEDKRNVLLAYGAEVVVCPTAVPPDDPDSYYS
MSMEG_5270|M.smegmatis_MC2_155 LVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYS
TH_1449|M.thermoresistible__bu MVGAARGYRVILTMPDTMSVERRVMLRAFGAEIVLTPGAEG---MAGAVA
:.. : :. : :* *:** : : .
Mb0871|M.bovis_AF2122/97 DRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCS
Rv0848|M.tuberculosis_H37Rv DRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCS
MMAR_4768|M.marinum_M DRVAQLLAADPSAWNPDQYSNPDNVDAYRPLA--LEMAAQLGRVDVLVCS
Mflv_0899|M.gilvum_PYR-GCK ERVHEILGTDPQAWHPDQYNNPDNVEAYRGLA--MELIEQLGSVDVLVCS
Mvan_5856|M.vanbaalenii_PYR-1 ERVQQILSSDPHAWHPDQYNNPDNVEAYRGLA--HELIDQLGSVDVLVCS
MAB_1273|M.abscessus_ATCC_1997 DRVAQLLAAEPDSWCPDQYQNPDNVDAYRGLA--EELIDQLGTVDTLVCS
MAV_1201|M.avium_104 -VSDRLVTEIEGAWKPDQYANPEGPASHYATTGPEIWADTDGKVTHFVAG
MUL_0203|M.ulcerans_Agy99 -VSDRLVREIDGAWKPDQYANPEGPASHYATTGPEIWADTDGKITHFVAG
MLBr_02396|M.leprae_Br4923 -VSDRLVAKIDGAWKPDQYANPAGPASHYETTGPEIWADTDGRVTHFVAG
MSMEG_5270|M.smegmatis_MC2_155 -VSNRLVTEIEGAWKPDQYSNQMGPESHYETTGPEIWADTEGKITHFVAG
TH_1449|M.thermoresistible__bu -RAEQILAETENAVAAKQFANPANPDIHERTTGEEVWADTDGTVDIFVAG
.:: : ..*: * . : : * : :*..
Mb0871|M.bovis_AF2122/97 VGTGGHSAGVARVLREFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGS
Rv0848|M.tuberculosis_H37Rv VGTGGHSAGVARVLREFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGS
MMAR_4768|M.marinum_M VGTGGHSSGVARVLREFNPA-MRLIGVDTIGS-TIFGQPASSRLMRGLGS
Mflv_0899|M.gilvum_PYR-GCK VGTGGHSAGVARVLREYNPG-LRLIGVDTVGS-TIFGQPATTRLMRGLGS
Mvan_5856|M.vanbaalenii_PYR-1 VGTGGHSAGVARVLRETDPQ-LRLIGVDTVGS-TIFGQPAGARLMRGLGS
MAB_1273|M.abscessus_ATCC_1997 VGTGGHSSGVGRVLREHNPN-LRLVGVDTIGS-TIFGQPAGSRLMRGLGS
MAV_1201|M.avium_104 IGTGGTITGAGRYLKEVSGGRVRVIGADPEGS-VYSGGTGRPYLVEGVGE
MUL_0203|M.ulcerans_Agy99 IGTGGTITGAGCYLKEVSGGKVRVIGADPEGS-VYSGGTGRPYLVEGVGE
MLBr_02396|M.leprae_Br4923 IGTGGTITGVGRYLKEVSGGLVRIIGADPEGS-VYSGGTGRPYLVEGVGE
MSMEG_5270|M.smegmatis_MC2_155 VGTGGTITGTGRYLKEVSGGKVKVIGADPEGS-VYSGGTGRPYLVEGVGE
TH_1449|M.thermoresistible__bu IGTGGTLTGVGRLLKSRKPG-VKIVGVEPLDSPILNGGQPGPHKIQGIGA
:**** :*.. *:. . ::::*.:. .* * :.*:*
Mb0871|M.bovis_AF2122/97 SIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAG
Rv0848|M.tuberculosis_H37Rv SIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAG
MMAR_4768|M.marinum_M SIFPRNVDYSAFNEVHWVAPAEAVWACRSMAATHYASGGWSVGAVALVAG
Mflv_0899|M.gilvum_PYR-GCK SIYPGNVDYAAFNEVHWVAPADAVWACRTLAATHYASGGWSVGAVAVVAG
Mvan_5856|M.vanbaalenii_PYR-1 SIYPGNVDYAAFDEVHWVAPAEAVWACRTLAATHYASGGWSVGAVALVAG
MAB_1273|M.abscessus_ATCC_1997 SIYPGNVDYPAFDEAHWVAPNEAVWAARTLAATYHASGGWSVGAVALVAG
MAV_1201|M.avium_104 DFWPQAYDRTVPDEIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAAL
MUL_0203|M.ulcerans_Agy99 DFWPATYDHAVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAAL
MLBr_02396|M.leprae_Br4923 DFWPAAYDPMVPDQIIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAAL
MSMEG_5270|M.smegmatis_MC2_155 DFWPTAYDPSVPDEIIAVSDADSFEMTRRLAREEALLVGGSCGMAVVAAI
TH_1449|M.thermoresistible__bu NFIPEVLDRDVYDEIIDAGFEDAISVSRALATQEGILGGISAGANVWAAL
.: * * . :: .. ::. * :* * * * . .*
Mb0871|M.bovis_AF2122/97 WAARNLP-ADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQ-------
Rv0848|M.tuberculosis_H37Rv WAARNLP-ADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQ-------
MMAR_4768|M.marinum_M WAARTLP-SDITIAAVFPDGPQRYFDTVYNDDYCNEHGLLGQR-------
Mflv_0899|M.gilvum_PYR-GCK WAARGSD-PGTTVAAIFPDGPQRYFDTIYNDEYCRTHGLLDKA-------
Mvan_5856|M.vanbaalenii_PYR-1 WAARNSP-PATTVAAIFPDGPQRYFDTVYNDDYCRAHHLLGGA-------
MAB_1273|M.abscessus_ATCC_1997 WVARTSD-PGARIAAIFPDGPMRYHGTIYDDDYCRSHDLLDRP-------
MAV_1201|M.avium_104 RVAEQAG-PDALVVVLLPDGGRGYMAKIFNDAWMSSYGFLRTRLDGSTDQ
MUL_0203|M.ulcerans_Agy99 RVAEQAG-PDALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGRTDT
MLBr_02396|M.leprae_Br4923 QVAEEAG-PAALVVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQ
MSMEG_5270|M.smegmatis_MC2_155 EVARKAG-PDAVVVVLLPDGGRGYLSKIFNDAWMSSYGFLRTRLDGSVEK
TH_1449|M.thermoresistible__bu EVAKRPENAGKVIVVVIPDFGERYVS------------------------
.*. . :..::** *
Mb0871|M.bovis_AF2122/97 ------------------PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVV
Rv0848|M.tuberculosis_H37Rv ------------------PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVV
MMAR_4768|M.marinum_M ------------------PATEPEVIASPSAAVVQRWTRSATVIDPTQVA
Mflv_0899|M.gilvum_PYR-GCK ------------------PPNEPATIDHPLRHAVKAWTRCPVVVDPTQVV
Mvan_5856|M.vanbaalenii_PYR-1 ------------------PPSHPATIADPLAQVATAWSRCTRIVDPTRVM
MAB_1273|M.abscessus_ATCC_1997 ------------------PAQDPDVIDDPSERVVDRWTRLTRVIDPIGRR
MAV_1201|M.avium_104 SRVGDVLRRKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
MUL_0203|M.ulcerans_Agy99 STVGDVLRRKSGALPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
MLBr_02396|M.leprae_Br4923 PIVGDVLRRKSGALPDLVHTHPSETVRDAIGILREYAVSQIPVVGAEPPV
MSMEG_5270|M.smegmatis_MC2_155 T-VGDVLRGKSGALPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPV
TH_1449|M.thermoresistible__bu -------------------TALFEHIRD----------------------
. :
Mb0871|M.bovis_AF2122/97 S-------------------------------------------------
Rv0848|M.tuberculosis_H37Rv S-------------------------------------------------
MMAR_4768|M.marinum_M A-------------------------------------------------
Mflv_0899|M.gilvum_PYR-GCK PR------------------------------------------------
Mvan_5856|M.vanbaalenii_PYR-1 PR------------------------------------------------
MAB_1273|M.abscessus_ATCC_1997 A-------------------------------------------------
MAV_1201|M.avium_104 MAGEVAGSVSERELLSAVFEGRAKLADAVSLHMSPPLPMIGAGESVSAAG
MUL_0203|M.ulcerans_Agy99 MAGEVAGSVSERELLSAVFSGKAKLADAVSQHMSPPLKLIGAGELVGVAG
MLBr_02396|M.leprae_Br4923 MAGEVVGSVSERELLSAVFEGRASLADAVSEHMGPPLRLIGDGELVSVAG
MSMEG_5270|M.smegmatis_MC2_155 MAGEVAGSVSERELLSAVFEGRAKLADAVAEHMSPPLPLIGAGELVSTAA
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mb0871|M.bovis_AF2122/97 -----------------------------------------
Rv0848|M.tuberculosis_H37Rv -----------------------------------------
MMAR_4768|M.marinum_M -----------------------------------------
Mflv_0899|M.gilvum_PYR-GCK -----------------------------------------
Mvan_5856|M.vanbaalenii_PYR-1 -----------------------------------------
MAB_1273|M.abscessus_ATCC_1997 -----------------------------------------
MAV_1201|M.avium_104 KALRDWDALMVVEEGKPVGVITRYDLLGFLSEGPRGSGGRR
MUL_0203|M.ulcerans_Agy99 KALRDWDALMVVEEGKPVGVITRYDLLGFLSEG----ALRR
MLBr_02396|M.leprae_Br4923 EALRDSDALMVVEKGKLVGVITRYDLLGFLSEG----APLR
MSMEG_5270|M.smegmatis_MC2_155 KTLRESDAVMVVEDGKPVGVLTRHDLLGFLSEG----GYRH
TH_1449|M.thermoresistible__bu -----------------------------------------