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RIARHISELIGNTPLVQLNSVVPPGAGTVAAKIEYLNPGGSSKDRIAIKMIDAAEASGELKPGGTIVEPT SGNTGVGLAIVAQQRGYKCIFVCPDKVSEDKQNVLRAYGADVVVCPTAVAPEDPASYYSVSNRLVEEIDG AWKPDQYSNPMGPESHYETTGPEIWADTDGKVTHFVAGVGTGGTITGAGRYLKEVSGGRVKVIGVDPEGS VYSGGTGRPYLVEGVGEDFWPAAYDPSVPDEIIAVSDADSFDMTRRLAREEALLVGGSCGMAAVAAIKVA EREGPDALVVVLLPDGGRGYLSKIFNDAWMSSYGFLRSRLDGSVEESTVGDVLRGKSGALPDLVHTHPSE TVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVADHMGPPLPLIGVGE LVSTAAKALRESDAVMVVEEGKPVGVLTRHDLLGYLSEGNARR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4674 | - | - | 100% (464) | cystathionine beta-synthase |
| M. vanbaalenii PYR-1 | Mvan_4291 | - | 5e-46 | 37.42% (302) | cysteine synthases |
| M. vanbaalenii PYR-1 | Mvan_5856 | - | 5e-35 | 32.05% (312) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1106 | cbs | 0.0 | 87.50% (464) | cystathionine beta-synthase CBS (Serine sulfhydrase) |
| M. gilvum PYR-GCK | Mflv_2043 | - | 0.0 | 94.58% (461) | cystathionine beta-synthase |
| M. tuberculosis H37Rv | Rv1077 | cbs | 0.0 | 87.50% (464) | cystathionine beta-synthase CBS (Serine sulfhydrase) |
| M. leprae Br4923 | MLBr_02396 | cysM2 | 0.0 | 85.00% (460) | cystathionine beta-synthase |
| M. abscessus ATCC 19977 | MAB_1195 | - | 0.0 | 84.83% (468) | cystathionine beta-synthase |
| M. marinum M | MMAR_4390 | cbs | 0.0 | 86.85% (464) | cystathionine beta-synthase CBS |
| M. avium 104 | MAV_1201 | - | 0.0 | 86.30% (460) | cystathionine beta-synthase |
| M. smegmatis MC2 155 | MSMEG_5270 | - | 0.0 | 91.36% (463) | cystathionine beta-synthase |
| M. thermoresistible (build 8) | TH_1371 | - | 0.0 | 86.27% (466) | cystathionine beta-synthase |
| M. ulcerans Agy99 | MUL_0203 | cbs | 0.0 | 86.21% (464) | cystathionine beta-synthase CBS |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4390|M.marinum_M MRIAQHISDLIGGTPLVRLNAVVPAGIGTVAAKVEYLNPGGSSKDRIAIK
MUL_0203|M.ulcerans_Agy99 MRIAQHISDLIGGTPLVRLNAVVPAGIGTVAAKVEYLNPGGSSKDRIAIK
MAV_1201|M.avium_104 MRIAQHISDLIGGTPLVRLNSVVPDGAGIVAAKVEYLNPGGSSKDRIAVR
Mb1106|M.bovis_AF2122/97 MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVK
Rv1077|M.tuberculosis_H37Rv MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVK
MLBr_02396|M.leprae_Br4923 MRIAQHISDLIGGTPLVRLNSVVPAGTGVVAAKVEYFNSGGSSKDRIAAK
Mvan_4674|M.vanbaalenii_PYR-1 MRIARHISELIGNTPLVQLNSVVPPGAGTVAAKIEYLNPGGSSKDRIAIK
Mflv_2043|M.gilvum_PYR-GCK MRIARHISELIGNTPLVQLNSVVPPGAGTVVAKVEYLNPGGSSKDRIAIK
MSMEG_5270|M.smegmatis_MC2_155 MRIARHISELIGNTPLVQLNSVVPEGAGLVAAKIEYLNPGGSSKDRIALK
TH_1371|M.thermoresistible__bu MRYARHVSELIGNTPLVQLNSVVPEGAGMVLAKIEYLNPGGSSKDRIAVK
MAB_1195|M.abscessus_ATCC_1997 MRIAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAVK
** *:*:*:***.****:**:*** * . * **:**:*.********* :
MMAR_4390|M.marinum_M MIDAAEASGALRPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
MUL_0203|M.ulcerans_Agy99 MIDAAEASGALRPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
MAV_1201|M.avium_104 MIDAAEASGALKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVGE
Mb1106|M.bovis_AF2122/97 MIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSE
Rv1077|M.tuberculosis_H37Rv MIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSE
MLBr_02396|M.leprae_Br4923 MIDAAEASGQLKPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVCPDKVSE
Mvan_4674|M.vanbaalenii_PYR-1 MIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
Mflv_2043|M.gilvum_PYR-GCK MIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
MSMEG_5270|M.smegmatis_MC2_155 MIEAAEVSGELKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVSE
TH_1371|M.thermoresistible__bu MIEDAEKRGLLKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVSE
MAB_1195|M.abscessus_ATCC_1997 MIEAAEEAGLLKPGGTIVEPTSGNTGVGLALVAQRKGYHCVFVCPDKVSE
**: ** * *:******************:***::**:*:*******.*
MMAR_4390|M.marinum_M DKRNVLRAYGAEVVVCPTAVPPEDPDSYYSVSDRLVREIDGAWKPDQYAN
MUL_0203|M.ulcerans_Agy99 DKRNVLRAYGAEVVVCPTAVPPEDPDSYYSVSDRLVREIDGAWKPDQYAN
MAV_1201|M.avium_104 DKRNVLMAYGAEVVVCPTAVPPEHPDSYYSVSDRLVTEIEGAWKPDQYAN
Mb1106|M.bovis_AF2122/97 DKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYAN
Rv1077|M.tuberculosis_H37Rv DKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYAN
MLBr_02396|M.leprae_Br4923 DKRNVLLAYGAEVVVCPTAVPPDDPDSYYSVSDRLVAKIDGAWKPDQYAN
Mvan_4674|M.vanbaalenii_PYR-1 DKQNVLRAYGADVVVCPTAVAPEDPASYYSVSNRLVEEIDGAWKPDQYSN
Mflv_2043|M.gilvum_PYR-GCK DKQNVLRAYGAEVVVCPTAVAPDDPASYYSVSNRLVSEIDGAWKPDQYSN
MSMEG_5270|M.smegmatis_MC2_155 DKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSNRLVTEIEGAWKPDQYSN
TH_1371|M.thermoresistible__bu DKQNVLRAYGAEVVVCPTAVPPEHPDSYYSVSDRLTREIDGAWKPDQYSN
MAB_1195|M.abscessus_ATCC_1997 DKRNVLRAYGAEVVVCPTAVPPEHPDSYYNVSDRLVREIEGAWKPDQYSN
**:*** ****:********.*..* ***.**:**. .*:********:*
MMAR_4390|M.marinum_M PEGPASHYATTGPEIWADTDGKITHFVAGIGTGGTITGAGRYLKEVSG--
MUL_0203|M.ulcerans_Agy99 PEGPASHYATTGPEIWADTDGKITHFVAGIGTGGTITGAGCYLKEVSG--
MAV_1201|M.avium_104 PEGPASHYATTGPEIWADTDGKVTHFVAGIGTGGTITGAGRYLKEVSG--
Mb1106|M.bovis_AF2122/97 PEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSG--
Rv1077|M.tuberculosis_H37Rv PEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSG--
MLBr_02396|M.leprae_Br4923 PAGPASHYETTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYLKEVSG--
Mvan_4674|M.vanbaalenii_PYR-1 PMGPESHYETTGPEIWADTDGKVTHFVAGVGTGGTITGAGRYLKEVSG--
Mflv_2043|M.gilvum_PYR-GCK PMGPESHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSG--
MSMEG_5270|M.smegmatis_MC2_155 QMGPESHYETTGPEIWADTEGKITHFVAGVGTGGTITGTGRYLKEVSG--
TH_1371|M.thermoresistible__bu QMGPQSHYETTGPEIWNDTDGKVTHFVAGVGTGGTITGAGRYLKEVSGRR
MAB_1195|M.abscessus_ATCC_1997 PNGPASHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGGR
** *** ******* **:*::******:********.* *******
MMAR_4390|M.marinum_M --GKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPAVPDEIIAV
MUL_0203|M.ulcerans_Agy99 --GKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPATYDHAVPDEIIAV
MAV_1201|M.avium_104 --GRVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPQAYDRTVPDEIIAV
Mb1106|M.bovis_AF2122/97 --GRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
Rv1077|M.tuberculosis_H37Rv --GRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
MLBr_02396|M.leprae_Br4923 --GLVRIIGADPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPMVPDQIIAV
Mvan_4674|M.vanbaalenii_PYR-1 --GRVKVIGVDPEGSVYSGGTGRPYLVEGVGEDFWPAAYDPSVPDEIIAV
Mflv_2043|M.gilvum_PYR-GCK --GRVKVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSVPDEIIAV
MSMEG_5270|M.smegmatis_MC2_155 --GKVKVIGADPEGSVYSGGTGRPYLVEGVGEDFWPTAYDPSVPDEIIAV
TH_1371|M.thermoresistible__bu PEGPVRVVGADPEGSVYSGGTGRPYLVEGVGEDFWPSVYDPSVPDEIIAV
MAB_1195|M.abscessus_ATCC_1997 AIGEVKIVGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPSVVDEVIAV
* *:::*.**********:*************** .** * *::***
MMAR_4390|M.marinum_M SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
MUL_0203|M.ulcerans_Agy99 SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
MAV_1201|M.avium_104 SDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAGPDALVVVLLPD
Mb1106|M.bovis_AF2122/97 SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPD
Rv1077|M.tuberculosis_H37Rv SDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPD
MLBr_02396|M.leprae_Br4923 SDSDSFNMTRRLAREEAMLVGGSCGMAVVAALQVAEEAGPAALVVVLLPD
Mvan_4674|M.vanbaalenii_PYR-1 SDADSFDMTRRLAREEALLVGGSCGMAAVAAIKVAEREGPDALVVVLLPD
Mflv_2043|M.gilvum_PYR-GCK SDADSFDMTRRLAREEALLVGGSCGMAAVAAIRVAEREGPDALVVVLLPD
MSMEG_5270|M.smegmatis_MC2_155 SDADSFEMTRRLAREEALLVGGSCGMAVVAAIEVARKAGPDAVVVVLLPD
TH_1371|M.thermoresistible__bu SDADSFEMTRRLAREEGLLVGGSCGMAVVAANKVALEAGPDAVVVVLLPD
MAB_1195|M.abscessus_ATCC_1997 SDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEKVGPDGLVVVLLPD
**:***:*********.:*********.*** .:* . ** .::******
MMAR_4390|M.marinum_M GGRGYMSKIFNDAWMSSYGFLRSRLDGRTDASTVGDVLRRKSGALPALVH
MUL_0203|M.ulcerans_Agy99 GGRGYMSKIFNDAWMSSYGFLRSRLDGRTDTSTVGDVLRRKSGALPALVH
MAV_1201|M.avium_104 GGRGYMAKIFNDAWMSSYGFLRTRLDGSTDQSRVGDVLRRKSGELPDLVH
Mb1106|M.bovis_AF2122/97 GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVH
Rv1077|M.tuberculosis_H37Rv GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVH
MLBr_02396|M.leprae_Br4923 GGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGALPDLVH
Mvan_4674|M.vanbaalenii_PYR-1 GGRGYLSKIFNDAWMSSYGFLRSRLDGSVEESTVGDVLRGKSGALPDLVH
Mflv_2043|M.gilvum_PYR-GCK GGRGYLSKIFNDGWMSSYGFLRTRLDGSVQESTVGDVLRGKSGALPALVH
MSMEG_5270|M.smegmatis_MC2_155 GGRGYLSKIFNDAWMSSYGFLRTRLDGSVEK-TVGDVLRGKSGALPDLVH
TH_1371|M.thermoresistible__bu GGRGYLSKIFNDEWMSSYGFLRTPLDGKVHQPTVGDVLRGKSGELPDLVH
MAB_1195|M.abscessus_ATCC_1997 GGRGYLSKVFNDAWMSSYGFLRSRLDGSVSEPTVGDVLRGKSGALPDLVH
*****::*:*** *********: *** . ****** *** ** ***
MMAR_4390|M.marinum_M THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MUL_0203|M.ulcerans_Agy99 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MAV_1201|M.avium_104 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Mb1106|M.bovis_AF2122/97 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Rv1077|M.tuberculosis_H37Rv THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
MLBr_02396|M.leprae_Br4923 THPSETVRDAIGILREYAVSQIPVVGAEPPVMAGEVVGSVSERELLSAVF
Mvan_4674|M.vanbaalenii_PYR-1 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
Mflv_2043|M.gilvum_PYR-GCK THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERDLVSAVF
MSMEG_5270|M.smegmatis_MC2_155 THPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
TH_1371|M.thermoresistible__bu THPSETIRDAINILREYGVSQMPVVGAEPPVMAGEVAGSVTERELLSAVY
MAB_1195|M.abscessus_ATCC_1997 THPSETVRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVF
******:**** *****.***:**************.***:**:*:***:
MMAR_4390|M.marinum_M SGKAKLADAVSQHMSPPLKLIGAGELVGVAGKALRDWDALMVVEEGKPVG
MUL_0203|M.ulcerans_Agy99 SGKAKLADAVSQHMSPPLKLIGAGELVGVAGKALRDWDALMVVEEGKPVG
MAV_1201|M.avium_104 EGRAKLADAVSLHMSPPLPMIGAGESVSAAGKALRDWDALMVVEEGKPVG
Mb1106|M.bovis_AF2122/97 EGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVG
Rv1077|M.tuberculosis_H37Rv EGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVG
MLBr_02396|M.leprae_Br4923 EGRASLADAVSEHMGPPLRLIGDGELVSVAGEALRDSDALMVVEKGKLVG
Mvan_4674|M.vanbaalenii_PYR-1 EGRAKLADAVADHMGPPLPLIGVGELVSTAAKALRESDAVMVVEEGKPVG
Mflv_2043|M.gilvum_PYR-GCK EGRAKLADAVAQHMSPPLPLIGAGELVSAAAKTLRECDAVMVVEEGKPAG
MSMEG_5270|M.smegmatis_MC2_155 EGRAKLADAVAEHMSPPLPLIGAGELVSTAAKTLRESDAVMVVEDGKPVG
TH_1371|M.thermoresistible__bu EGRAKLTDAVAEHMGAPLPLIGAGEPVQAAAKMLRECDAVMVVEEGKPAG
MAB_1195|M.abscessus_ATCC_1997 EGRAQLADAVAQHMSPPLPLVGSGEPLSTAGSMLRDTDAVMVVDEGKPVG
.*:*.*:***: **..** ::* ** : .*.. **: **:***:.** .*
MMAR_4390|M.marinum_M VITRYDLLGFLSEG----ALRR
MUL_0203|M.ulcerans_Agy99 VITRYDLLGFLSEG----ALRR
MAV_1201|M.avium_104 VITRYDLLGFLSEGPRGSGGRR
Mb1106|M.bovis_AF2122/97 VITRYDLLGFLSEG----AGRR
Rv1077|M.tuberculosis_H37Rv VITRYDLLGFLSEG----AGRR
MLBr_02396|M.leprae_Br4923 VITRYDLLGFLSEG----APLR
Mvan_4674|M.vanbaalenii_PYR-1 VLTRHDLLGYLSEG----NARR
Mflv_2043|M.gilvum_PYR-GCK VLTRHDLLGYLSDS----SPGH
MSMEG_5270|M.smegmatis_MC2_155 VLTRHDLLGFLSEG----GYRH
TH_1371|M.thermoresistible__bu VLTRHDLLGFLSES----TAAH
MAB_1195|M.abscessus_ATCC_1997 VITRHDLLGFVSSGR---GVRH
*:**:****::*.. :