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LVELSPSGGLFQFAFELGSALAARGERVELWTGPRPELASSQPGFTVRPVLPTWHPGDTGVHSRAFRLAR RGFRAGQLIFAWTVLSVRLLAARPHAVLWSQWRFAFEPMFVVAVSTLLRSSILGLIAHEPVPRSDAKDTS TAKAGALLTRAFRAAWRRLDVAFVLGPRTRDLAVTHWQPRCPVYVIPHGAEPGVRGGRSVRPVADTEPVV LFFGVWAKYKGIEVLLDAFARVRAELPESQLVLAGDVGADIDLPSVLDRAGQIGNVDARPGYVAIDDVAA LFDAARVVAVPYIRATQSGVAHLAFTFGRPVVSSAVGDLPEVIEDRVTGLLVEPDDADGLAAALVELLRN PSLAATLGAAGEQRVNDAWTTAAARVCDALAEAATVRSRKGD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5248 | - | - | 100% (393) | glycosyl transferase, group 1 |
| M. vanbaalenii PYR-1 | Mvan_5245 | - | 3e-13 | 31.03% (203) | glycosyl transferase, group 1 |
| M. vanbaalenii PYR-1 | Mvan_5246 | - | 5e-13 | 29.41% (204) | glycosyl transferase, group 1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0496 | - | 2e-11 | 31.73% (208) | mannosyltransferase |
| M. gilvum PYR-GCK | Mflv_1498 | - | 0.0 | 84.72% (386) | glycosyl transferase, group 1 |
| M. tuberculosis H37Rv | Rv0486 | - | 2e-11 | 31.73% (208) | mannosyltransferase |
| M. leprae Br4923 | MLBr_00886 | - | 2e-11 | 27.02% (248) | putative glycosyl transferase |
| M. abscessus ATCC 19977 | MAB_3366 | - | 5e-13 | 27.30% (381) | glycosyltransferase |
| M. marinum M | MMAR_3232 | - | 6e-11 | 25.40% (248) | glycosyltransferase |
| M. avium 104 | MAV_2755 | - | 1e-12 | 34.29% (175) | glycosyl transferase |
| M. smegmatis MC2 155 | MSMEG_6484 | - | 9e-15 | 27.70% (408) | glycosyl transferase |
| M. thermoresistible (build 8) | TH_0088 | - | 3e-12 | 26.25% (400) | glycosyl transferase |
| M. ulcerans Agy99 | MUL_3252 | pimA | 7e-11 | 29.03% (248) | alpha-mannosyltransferase PimA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5248|M.vanbaalenii_PYR-1 ---------MLVELSPSGGLFQFAFELGSALAARGERVELWTG-PRPELA
Mflv_1498|M.gilvum_PYR-GCK ---------MLVELSPSGGLFQFAFELGSALAACGQQVELWTG-PRPELE
MSMEG_6484|M.smegmatis_MC2_155 ---MRIALLSYRSKTHCGGQGVYVRHLSSGLAELGHDVEVFSGQPYPEGL
TH_0088|M.thermoresistible__bu ---MRIALLSYRSKTHCGGQGVYVRHLSRGLVELGHQVEVFSGQPYPEGL
MAV_2755|M.avium_104 -----------------------MRHLSHGLVELGHDVEVFSGQPYPDLL
Mb0496|M.bovis_AF2122/97 MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALL
Rv0486|M.tuberculosis_H37Rv MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALL
MLBr_00886|M.leprae_Br4923 ------MSRVLLVTNDFPPRRGGIQSYLG------------EFVDRLINI
MMAR_3232|M.marinum_M ------MSRVLLVTNDFPPRRGGIQSYLS------------EFVGRLVEA
MAB_3366|M.abscessus_ATCC_1997 ------MRILMVSWEYPPVVIGGLGRHVHHLS-----TELAAAGHDVVVL
MUL_3252|M.ulcerans_Agy99 ---MAHVSATMVGRLVRCPPRAAAGALMRIGMVCPYSFDVAGGVQSHVLQ
Mvan_5248|M.vanbaalenii_PYR-1 SSQPGFTVRPVLPTWHPGDTGVHSRAFRLARRGFRAGQLIFAWTV--LSV
Mflv_1498|M.gilvum_PYR-GCK SSQPGFTVRPVLPTWHPGDTGVHSRAFRLARRGIRAVQLIFAWMV--LSV
MSMEG_6484|M.smegmatis_MC2_155 DPRVTLTKVPSLDLYREPDP-FRVPHPREIRDGIDALELLTMWSAGFPEP
TH_0088|M.thermoresistible__bu DPRVKLTKVPSLDLYREPDP-FRIPRPSEIRDRIDLLELLTTWTAGFPEP
MAV_2755|M.avium_104 DPRVRLTEVPSLDLYREPDP-FRVPRPSEIRDSIDLLELLTTWTAGFPEP
Mb0496|M.bovis_AF2122/97 AVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPV
Rv0486|M.tuberculosis_H37Rv AVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPV
MLBr_00886|M.leprae_Br4923 GSHDVMVYAPQWTGADTFDNAAHDGGYQVVR---HPGTLMLPGPAVDARM
MMAR_3232|M.marinum_M GSHSITVYAPQWKGAQGYDDVARAAGYRVVR---HPSTLMLPVPTVDSRM
MAB_3366|M.abscessus_ATCC_1997 TRRPSGTDPSSHPTSDEISEGVRVVAAAEDPHDFDFGTDMMAWTLAMGHA
MUL_3252|M.ulcerans_Agy99 LAEVMRARGHEVSVLAPASP--HAALPDYVVSGGKAVPIPYNGSVARLRF
. .
Mvan_5248|M.vanbaalenii_PYR-1 RLLAAR--PHAVLWSQWR-FAFEPM----FVVAVSTLLRSSILGL----I
Mflv_1498|M.gilvum_PYR-GCK RLLVAR--PRAVLWSQWR-FTFEPM----FVVALSALLRSATLGL----I
MSMEG_6484|M.smegmatis_MC2_155 RTFTMR--AARILAARRDEFDVVHD----NQSLGTGLLKIEKLGLPVVAT
TH_0088|M.thermoresistible__bu KTFTMR--MARILAERRDEFDVVHD----NQSLGTGLLELADLGLPVVAT
MAV_2755|M.avium_104 RTFTLR--AARLLAGRTADFDVVHD----NQSLGTGLLSIAGSGLPVVAT
Mb0496|M.bovis_AF2122/97 VRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDI
Rv0486|M.tuberculosis_H37Rv VRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDI
MLBr_00886|M.leprae_Br4923 RRLIVDHGIDTVWFGSAAPLALLAP----CARKAGATRVLASTHG-----
MMAR_3232|M.marinum_M RRLIAQHDIDTVWFGAAAPLALLAP----RARQAGATRVLASTHG-----
MAB_3366|M.abscessus_ATCC_1997 MVRAGLALGLKGSGDWRPDVVHAHD-----WLVAHPAIALAEHFDVPLVS
MUL_3252|M.ulcerans_Agy99 GPATHRKVKKWLSEGDFDVLHLHEP-----NAPSLSMLALNIAEGPIVAT
.
Mvan_5248|M.vanbaalenii_PYR-1 AHEPVPRSDAKDTSTAKAG----------------------ALLTRAFRA
Mflv_1498|M.gilvum_PYR-GCK AHEPVPRSDAKDTSTAKGG----------------------EMLTRTFRA
MSMEG_6484|M.smegmatis_MC2_155 VHHPITRDKVVDVAAAKWWRKPLVRRWY-------------GFAEMQKKV
TH_0088|M.thermoresistible__bu VHHPITRDKVVEVAAAKWWRKPLVRRWY-------------GFAEMQKRV
MAV_2755|M.avium_104 VHHPITRDRVLDLAAARWWRKPLVRRWY-------------GFLAMQQEV
Mb0496|M.bovis_AF2122/97 VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRT
Rv0486|M.tuberculosis_H37Rv VHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRT
MLBr_00886|M.leprae_Br4923 --------HEVGWSMLP-------------------------VARSVLRR
MMAR_3232|M.marinum_M --------HEVGWSMLP-------------------------VARSVLRR
MAB_3366|M.abscessus_ATCC_1997 TLHATEAGRHSGWVSGRISR---------------------QVHSVEWWL
MUL_3252|M.ulcerans_Agy99 FHTSTTKSLTLTVFQSILR-------------------------PMHEKI
Mvan_5248|M.vanbaalenii_PYR-1 AW------RRLDVAFVLGPRTRDLAVTHWQPRCPVYVIPHGAEPGVRGGR
Mflv_1498|M.gilvum_PYR-GCK AW------QRLDVVFVLGPRTRDLAVSYWQPRCPVHVIPHGAEPGVRGGT
MSMEG_6484|M.smegmatis_MC2_155 AR------QIPELLTVSSSSAADIAADFGVTSDQLHIVPLGVNTELFKP-
TH_0088|M.thermoresistible__bu AR------RIPELITVSSSSAADISADFGVSPGQLHVVPLGVDTELFTP-
MAV_2755|M.avium_104 AR------HIPDLLTVSSSSAADIISDFGVSPEQLHVVPLGVNTELFKPG
Mb0496|M.bovis_AF2122/97 VGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPG
Rv0486|M.tuberculosis_H37Rv VGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPG
MLBr_00886|M.leprae_Br4923 IG------DVTDVVTFVSRYTRSRVTAAFGPRAALEYLPPGVDADRFRPD
MMAR_3232|M.marinum_M IG------DTTDIVTFVSRYTRSRFAPAFGPAASLEYLPPGVDTDRFRPD
MAB_3366|M.abscessus_ATCC_1997 AR------ESDSLITCSASMLDEVTQLFGPELPQVHVIRNGIDVTRWVFA
MUL_3252|M.ulcerans_Agy99 VG----------RIAVSDLARRWQMEALGS---DAVEIPNGVDVGSFASS
: * :
Mvan_5248|M.vanbaalenii_PYR-1 SVRPVAD-------TEPVVLFFGVW-AKYKGIEVLLDAFARVR-AELPES
Mflv_1498|M.gilvum_PYR-GCK AVRPVAD-------TGPVVLFFGVW-AKYKGIEVLLEAFDRVR-AEMPES
MSMEG_6484|M.smegmatis_MC2_155 AEQRVS---------GRIIAIASAD-VPLKGVSHLLHAVARLR-VER-NL
TH_0088|M.thermoresistible__bu SEHRVP---------GRIIAIASAD-VPLKGISHLLHAVARLR-AKR-NL
MAV_2755|M.avium_104 SGPRQP---------GRIIAIASAD-TPLKGVRTLLHAVARLR-TVR-DL
Mb0496|M.bovis_AF2122/97 DRRAARAALGLPVDER-VVAFVGRI-QPLKAPDIVLRAAAKLPGVRIIVA
Rv0486|M.tuberculosis_H37Rv DRRAARAALGLPVDER-VVAFVGRI-QPLKAPDIVLRAAAKLPGVRIIVA
MLBr_00886|M.leprae_Br4923 PASRAELRNRYRLGERPTVVCLARL-VPRKGQDMLIRALPSIR-QRADGA
MMAR_3232|M.marinum_M PAARAELRKRYQLGERPTVVCVSRL-VPRKGQDTLIKALPAIR-RRVDGA
MAB_3366|M.abscessus_ATCC_1997 PRPPADG-------TPPVLLFVGRL-EYEKGIHDAIAALPKIR-RAHPGT
MUL_3252|M.ulcerans_Agy99 SCLDGYPR------PGKTVLFLGRYDEPRKGMSVLLEALPKLV-ERFIDV
: . *. : * :
Mvan_5248|M.vanbaalenii_PYR-1 QLVLAGDVGADIDLPSVLDRAGQIGNVDARPGYVAIDDVAALFDAARVVA
Mflv_1498|M.gilvum_PYR-GCK QLVLAGDVGADVDLASVLDRAGRIGNVDARPGYVAIEDVPALFDAARVVA
MSMEG_6484|M.smegmatis_MC2_155 DLQLVSKLEPNGPTEKLIAELGISDIVHISSG-LSDQELAGLLASAEVAC
TH_0088|M.thermoresistible__bu DVQLVSKLEPNGPTEKLIAELGISDIVQASSG-LSDSELARLLASAEVAC
MAV_2755|M.avium_104 ELRLVAKVEPNGPTHKLIAELGISDIVHITSG-LSDAELAALFASAEVAC
Mb0496|M.bovis_AF2122/97 GGPSGSGLASPDGLVRLADELGISARVTFLPP-QSHTDLATLFRAADLVA
Rv0486|M.tuberculosis_H37Rv GGPSGSGLASPDGLVRLADELGISARVTFLPP-QSHTDLATLFRAADLVA
MLBr_00886|M.leprae_Br4923 ALMIVGGGPYLGTLRKLAQGCGVADHVIFAGG-VAAVEVPAHYTLADVFA
MMAR_3232|M.marinum_M ALVIVGGGPYLETLRKLARDCEVDEHVTFTGG-VPGEELPTHHAMADVFA
MAB_3366|M.abscessus_ATCC_1997 VLAVAGDGTQQDWLLEQARKYKVVKSVQFLGT-LDHSELLHWLHHADAIL
MUL_3252|M.ulcerans_Agy99 QLLIVGRGDED----ELRDEAGELAEHMRFLGQVDDAGKASAMRSADVYC
. *
Mvan_5248|M.vanbaalenii_PYR-1 VPYIR-------ATQSGVAHLAFTFGRPVVSSAVGDLPEVIE-DRVTGLL
Mflv_1498|M.gilvum_PYR-GCK VPYIR-------ATQSGVAHLAFTFGRPVVASNIGDLPEVIQ-DGVTGLL
MSMEG_6484|M.smegmatis_MC2_155 IPSLY-------EGFSLPAVEAMASGTPIVASRAGALPEVVGTDGSCARL
TH_0088|M.thermoresistible__bu IPSLY-------EGFSLPAVEAMASGTPIVASRAGALPEVLGPDGECARL
MAV_2755|M.avium_104 IPSLY-------EGFSLPAVEAMASGTPIVASRVGALPEVLGTDGACAEL
Mb0496|M.bovis_AF2122/97 VPSYS-------ESFGLVAVEAQACGTPVVAAAVGGLPVAVR-DGITGTL
Rv0486|M.tuberculosis_H37Rv VPSYS-------ESFGLVAVEAQACGTPVVAAAVGGLPVAVR-DGITGTL
MLBr_00886|M.leprae_Br4923 MPCRTRGGGMDVEGLGIVFLEASATGVPVIAGKSGGAPEAVQ-HNKTGLV
MMAR_3232|M.marinum_M MPCRTRGSGMDVEGLGIVFLEASASGVPVIAGESGGAPETVQ-HNKTGLV
MAB_3366|M.abscessus_ATCC_1997 LPSHY-------EPFGIVALEAAAAGTPLVTSTVGGLGEAVI-DGETGMS
MUL_3252|M.ulcerans_Agy99 APNTGG------ESFGIVLVEAMAAGTPVVASDLDAFRRVLR-DGEIGRL
* . * : * *:::. . .: . .
Mvan_5248|M.vanbaalenii_PYR-1 VEPDDADGLAAALVELLRNPS-LAATLGAAGEQRVND--AWTTAAARVCD
Mflv_1498|M.gilvum_PYR-GCK VDPEDVGGLTAAILTLLRDVS-FAARLGAAGERSVSD--AWSVAAARVRD
MSMEG_6484|M.smegmatis_MC2_155 VRPADVDELTAVLGELLDSPA-ERRRLGAAGRQRALDVFSWESVAAQTVA
TH_0088|M.thermoresistible__bu VPPADVDALTRVLGELLDSPH-QRSRLGAAGRQRALDVFSWESVAAQTVS
MAV_2755|M.avium_104 VPPADVDALTRALGELLDSPE-KRRSLGRAGRTRAVDVFSWEAVAAQTVR
Mb0496|M.bovis_AF2122/97 VSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLA
Rv0486|M.tuberculosis_H37Rv VSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLA
MLBr_00886|M.leprae_Br4923 VDGRSVNMVADAVTELLTDRD--RAAAMG-AAGRHWVTAEWR--WDTLAA
MMAR_3232|M.marinum_M VDGNSVDKVAGAVIEVLADRD--RAARMG-DAGRQWVTSQWR--WDTLAA
MAB_3366|M.abscessus_ATCC_1997 FAPRDVAGIAEAVTRTLDDPA-AAAERAVAARARLTADFDWATVADETAQ
MUL_3252|M.ulcerans_Agy99 VPVDDSDALAAALIEVLDSQE--LRERYVAAGTEAVRRYDWSVVASQIMR
. . : .: * *
Mvan_5248|M.vanbaalenii_PYR-1 ALAEAATVRSRKGD---------------------------
Mflv_1498|M.gilvum_PYR-GCK ALAAAETG-AGQGH---------------------------
MSMEG_6484|M.smegmatis_MC2_155 VYERAQNR--MGVKAC-------------------------
TH_0088|M.thermoresistible__bu IYERAIC----------------------------------
MAV_2755|M.avium_104 VYERAIARNAAGRAPC-------------------------
Mb0496|M.bovis_AF2122/97 SYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
Rv0486|M.tuberculosis_H37Rv SYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
MLBr_00886|M.leprae_Br4923 RLADLLCGNDSR-----------------------------
MMAR_3232|M.marinum_M RLAELLRGDDTGR----------------------------
MAB_3366|M.abscessus_ATCC_1997 VYLAAKRREREPLGRSVIVERPLPDR---------------
MUL_3252|M.ulcerans_Agy99 VYETVAGAGVKVQVAS-------------------------