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TAEDARVQSCPFLPDGYDFTDPDVLLEGVPVAEFAQLRRTAPVWWNAQQESIFDDGGYWVVSRHEDIKSI SRNSALWSTNAKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTPRAIAGMEAKLADSAR QIVGEAADKAGGNFVDDVATLLPLQAIADLIGVPEEDREKLFHWSNAIMNTDDPDFDSDPTIANAELMGY AYTMAEQRRRCPADDIVTRLVEADLDGDALGEVEFAFFVILLAVAGNETTRNAMTHGMNAFLDHPDQWEL FKRERPETAIDEIIRWATPVHCFQRTALDDVEIGGVTVARGQRVGLFYSSANFDEDVFDNPFNFDILRNP NPHLAFGGNGAHYCIGANLARMEIKLMFEAIADRLPDISKRAEPQRLRSGWINGVKDLQVAYR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1607 | - | - | 100% (414) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_3290 | - | e-138 | 58.27% (405) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1508 | - | e-134 | 55.28% (407) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3575c | cyp125 | 1e-140 | 56.40% (406) | cytochrome P450 125 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 1e-140 | 56.40% (406) | cytochrome P450 125 |
| M. leprae Br4923 | MLBr_02088 | - | 8e-41 | 30.72% (345) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0101 | - | 1e-135 | 55.64% (408) | cytochrome P450 |
| M. marinum M | MMAR_2783 | cyp125A6 | 1e-142 | 58.65% (416) | cytochrome P450 125A6 Cyp125A6 |
| M. avium 104 | MAV_2811 | - | 1e-143 | 58.41% (416) | putative cytochrome P450 124 |
| M. smegmatis MC2 155 | MSMEG_5853 | - | 0.0 | 79.76% (410) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_1263 | - | 0.0 | 78.50% (400) | PROBABLE CYTOCHROME P450 125 CYP125 |
| M. ulcerans Agy99 | MUL_4106 | cyp125A7 | 1e-139 | 56.02% (407) | cytochrome P450 125A7 Cyp125A7 |
| M. vanbaalenii PYR-1 | Mvan_5151 | - | 0.0 | 86.95% (406) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3575c|M.bovis_AF2122/97 ----------MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPV
Rv3545c|M.tuberculosis_H37Rv ----------MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPV
MUL_4106|M.ulcerans_Agy99 --------------------------MPCPNLPPGFDFTDPDIYAERLPV
MMAR_2783|M.marinum_M ------------------MPAAEPTATSVPNLPPGFDFTDPDIYAERLPV
MAV_2811|M.avium_104 ------------------MATVEPTTKPVPNLPPGFDFTDPDIYAERLPV
Mflv_1607|M.gilvum_PYR-GCK ------------------MTAEDARVQSCPFLPDGYDFTDPDVLLEGVPV
Mvan_5151|M.vanbaalenii_PYR-1 ------------------MTAT----QSCPFLPHGYDFTDPDVLLKGIPV
MSMEG_5853|M.smegmatis_MC2_155 ----------------------MATMNTCPFG-NGYDFTDPDVLFRGIPV
TH_1263|M.thermoresistible__bu MVGVERVPCHTKEVVAMSAAHSSPALGQSPFG-AGFDFTDPDVLLRGIPV
MAB_0101|M.abscessus_ATCC_1997 -------------------------MTTCPFT-PGFDFTDPDLIQHRIPA
MLBr_02088|M.leprae_Br4923 ------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLL
. . * : :
Mb3575c|M.bovis_AF2122/97 AEFAELRSAA---PIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHS-
Rv3545c|M.tuberculosis_H37Rv AEFAELRSAA---PIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHS-
MUL_4106|M.ulcerans_Agy99 EEFAELRSSE---PIWWDEQFPGQGGGFHDGGFWAITKLKDVKEVSRRS-
MMAR_2783|M.marinum_M AELAEMRRSA---PIWWNEQPTG-CGGFDDGGFWVVTKHKDVKEISLRS-
MAV_2811|M.avium_104 EELAEMRRVA---PIWWNEQPIG-AGGFDDGGFWVVTKHKDVKEVSLRS-
Mflv_1607|M.gilvum_PYR-GCK AEFAQLRRTA---PVWWNAQQES---IFDDGGYWVVSRHEDIKSISRNS-
Mvan_5151|M.vanbaalenii_PYR-1 TEFAELRRTA---PVWWNEQADS---IFDDGGYWVISRHEDVKAISRNS-
MSMEG_5853|M.smegmatis_MC2_155 EEFAVLRKTA---PVWWNQQGES---IFDDGGYWVISRHEDIKTISRDGG
TH_1263|M.thermoresistible__bu REFAELRKTA---PVWWCEQPET---IFGDTGYWVISRHEDIKNISRNS-
MAB_0101|M.abscessus_ATCC_1997 EEFAYLRKTE---PIWWNAQPRG-VAGFDDDGYWVVTKHADVKEVSRLN-
MLBr_02088|M.leprae_Br4923 LRLIDPGTRADPFPVYRALIDYG-PMQLPGMPLTVFSSFSDCDEALRHP-
.: *:: : . ..: * .
Mb3575c|M.bovis_AF2122/97 DVFSSYENGVIPRFKNDIAREDIEVQR-FVMLNMDAPHHTRLRKIISRGF
Rv3545c|M.tuberculosis_H37Rv DVFSSYENGVIPRFKNDIAREDIEVQR-FVMLNMDAPHHTRLRKIISRGF
MUL_4106|M.ulcerans_Agy99 DVFSSYENGVIPRFKNDIAREDIDVQR-FVMLNMDAPHHTRLRKIISRGF
MMAR_2783|M.marinum_M DVFSSLQKTALPRYKDGTVDEQIERGK-FVLLNMDAPQHTRLRKIVSRAF
MAV_2811|M.avium_104 DVFSSLQKTALPRYKDGTVAEQVERGK-FVLLNMDAPQHTRLRKIISRAF
Mflv_1607|M.gilvum_PYR-GCK ALWSTNAKGAVMRLPDGVTAEQLDLTK-ALLINHDAPEHTRLRKIVSRLF
Mvan_5151|M.vanbaalenii_PYR-1 TQWSTNTKGAVMRLPDGVTAEQLDLTK-ALLINHDAPEHTRLRKIVSRLF
MSMEG_5853|M.smegmatis_MC2_155 EVWSTNAKGAVMRLPDGVTAEQLDLTK-ALLINHDAPEHTRLRKLVSRLF
TH_1263|M.thermoresistible__bu DLWSTNRKGAVMVMPEGATPEQLELTK-ALLINHDPPEHTRLRKLVSRLF
MAB_0101|M.abscessus_ATCC_1997 EVFSNSVNTTVVRYNEDITAEQLEIQRENLLIDMDEPKHRILRRIVSPLF
MLBr_02088|M.leprae_Br4923 LSASDRLKATLAQQAIAAGAEPRPFYA-SSFMFLDPPDHTRLRKLVSKAF
* : .: * :: * *.* **:::* *
Mb3575c|M.bovis_AF2122/97 TPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGV
Rv3545c|M.tuberculosis_H37Rv TPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGV
MUL_4106|M.ulcerans_Agy99 TPRAIGRLHDELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGI
MMAR_2783|M.marinum_M TPRAVERLRDDLRERARRIVEAAAAEGRGDFVEQVSCELPLQAIAGLMGV
MAV_2811|M.avium_104 TPRAVERLRDDLRERARRIVEAAAAEGSGDFVEQVSCELPLQAIASLMGV
Mflv_1607|M.gilvum_PYR-GCK TPRAIAGMEAKLADSARQIVGEAADKAGGNFVDDVATLLPLQAIADLIGV
Mvan_5151|M.vanbaalenii_PYR-1 TPRAIAGMEDRLADAAREIVRSAAEKDSGDFVDDVAMMLPLQAIADLIGV
MSMEG_5853|M.smegmatis_MC2_155 TPRSVAALEEKLAVAAHDIVAEAKAEGSGNFVEDIAMKLPLLAIADLIGV
TH_1263|M.thermoresistible__bu TPRAVAELESKLAVAARDIVARARERGSGNFVEDIAMNLPLLAIADLIGV
MAB_0101|M.abscessus_ATCC_1997 TPKAVNGLHARLVERAHGIVEEAAEKSSGNFVSDIASVLPMHAIADLVGI
MLBr_02088|M.leprae_Br4923 APKVVQALEGDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGV
:*: : :. : . : . :.: ::: *.: .*. *:*:
Mb3575c|M.bovis_AF2122/97 PQEDRGKLFHWSNEMTG--------NEDPEYAHIDPKASSAELIGYAMKM
Rv3545c|M.tuberculosis_H37Rv PQEDRGKLFHWSNEMTG--------NEDPEYAHIDPKASSAELIGYAMKM
MUL_4106|M.ulcerans_Agy99 PQEDRGKLFDWSNEMTG--------TEDPEFAHIDAKASSVELIGYAMKM
MMAR_2783|M.marinum_M PQEDRKKLFHWSNEMVG--------DQDPEFATNDALTASVELIMYGMQM
MAV_2811|M.avium_104 PQEDRKKLFHWSNEMVG--------DQDPEFASNDAITASVELIMYGMQM
Mflv_1607|M.gilvum_PYR-GCK PEEDREKLFHWSNAIMN--------TDDPDFDS-DPTIANAELMGYAYTM
Mvan_5151|M.vanbaalenii_PYR-1 PEEDREKLFHWTNAIMN--------TDDPEFDA-DPTMANAELMGYAYSM
MSMEG_5853|M.smegmatis_MC2_155 PEADREKIFAWSNAIIN--------TDDPDFDS-DPTVANAELMGYAYTM
TH_1263|M.thermoresistible__bu PEEDREKVFHWSNCIIN--------TDDPDFDS-DPTAANAELMGYAYTM
MAB_0101|M.abscessus_ATCC_1997 PESDRQQVLDWTNQMFA--------YDDPAIGRDTATTATVSMLGYAYAM
MLBr_02088|M.leprae_Br4923 PYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
* * :. : : :* : . : * :
Mb3575c|M.bovis_AF2122/97 AEEKAKNPADDIVTQLIQADID---GEKLSDDEFGFFVVMLAVAGNETTR
Rv3545c|M.tuberculosis_H37Rv AEEKAKNPADDIVTQLIQADID---GEKLSDDEFGFFVVMLAVAGNETTR
MUL_4106|M.ulcerans_Agy99 AEEKAKNPGDDIVTQLIQADID---GEKLSDDEFGFFVVMLAVAGNETTR
MMAR_2783|M.marinum_M AADRAKNPGQDLVTKLVEADID---GHKLSDDEFGFFVILLAVAGNETTR
MAV_2811|M.avium_104 AADRAKNPGEDLVTKLVQADID---GHKLSDDEFGFFVILLAVAGNETTR
Mflv_1607|M.gilvum_PYR-GCK AEQRRRCPADDIVTRLVEADLD---GDALGEVEFAFFVILLAVAGNETTR
Mvan_5151|M.vanbaalenii_PYR-1 AEERRRCPADDIVTRLVQADID---GESLGEVEFAFFVILLAVAGNETTR
MSMEG_5853|M.smegmatis_MC2_155 AEERRRCPADDIVTRLVQADV---SGESLGEVEFAFFVILLAVAGNETTR
TH_1263|M.thermoresistible__bu AEQRRRHPQDDIVTRLVQADLEDGSGEALGEVEFAFFVILLAVAGNETTR
MAB_0101|M.abscessus_ATCC_1997 AEERQLNPQDDILTGLVRGAYD---DRPLTPLEFAYFVIQLMVAGNETSR
MLBr_02088|M.leprae_Br4923 VKCRRGTPGEDLISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTV
. : * :*::: *:. . * *: * ***:**:
Mb3575c|M.bovis_AF2122/97 NSITQGMMAFAEHPDQWELYKK--VRPETAADEIVRWATPVTAFQRTALR
Rv3545c|M.tuberculosis_H37Rv NSITQGMMAFAEHPDQWELYKK--VRPETAADEIVRWATPVTAFQRTALR
MUL_4106|M.ulcerans_Agy99 NSITQGMMAFADNPEQWELYKR--ERPGTAADEIVRWATPVTSFQRTALE
MMAR_2783|M.marinum_M NSITQGMMAFTDFPDQWELYKR--ERPVTTADEIVRWATPVTSFQRTALQ
MAV_2811|M.avium_104 NSITQGMMAFTDFPDQWELFKR--ERPATAADEIVRWATPVTSFQRTALQ
Mflv_1607|M.gilvum_PYR-GCK NAMTHGMNAFLDHPDQWELFKR--ERPETAIDEIIRWATPVHCFQRTALD
Mvan_5151|M.vanbaalenii_PYR-1 NAMTHGMNAFFDNPAQWELFKR--ERPETAIDEIIRWATPVHCFQRTALE
MSMEG_5853|M.smegmatis_MC2_155 NAITHGMNAFFENPDQWELFKR--ERPITAVDEIVRWATPVHCFQRTAVV
TH_1263|M.thermoresistible__bu NAMTHGMNAFFENPDQWELFKR--ERPETAIDEIVRWSTPVHCFQRTALA
MAB_0101|M.abscessus_ATCC_1997 NAITHGVLAFADNPAQWRLYRE--RRPSTAADEIIRWASPIIAFQRTALQ
MLBr_02088|M.leprae_Br4923 NLIANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAK
* :::.: *: * **. *. . :* :*: ..: : *.*
Mb3575c|M.bovis_AF2122/97 DYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGT
Rv3545c|M.tuberculosis_H37Rv DYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGT
MUL_4106|M.ulcerans_Agy99 DYELSGVQIKKGQRVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGT
MMAR_2783|M.marinum_M DYELSGVRIKKGQRVVMFYRSANFDEDVFDDPYTFNILRDPNPHVGFGGT
MAV_2811|M.avium_104 DYELSGVKIKKGQRVVMFYRSANFDEDVFDDPFTFNILRDPNPHVGFGGT
Mflv_1607|M.gilvum_PYR-GCK DVEIGGVTVARGQRVGLFYSSANFDEDVFDNPFNFDILRNPNPHLAFGGN
Mvan_5151|M.vanbaalenii_PYR-1 DVEVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPHLAFGGN
MSMEG_5853|M.smegmatis_MC2_155 DTEIGGVPIKAGQRAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGFGGN
TH_1263|M.thermoresistible__bu DVEIGGVTIREGERAGLFYSSANYDEEVFDRPFEFDILRDPNPHLGFGGH
MAB_0101|M.abscessus_ATCC_1997 DVELGGVQIRKDQRVGMFYASANFDEDVFDDPFAFNIERDPNPHLAFGGH
MLBr_02088|M.leprae_Br4923 DMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-V
* :. . : .: :: :** * *:. * *: * .. *:.*.
Mb3575c|M.bovis_AF2122/97 GAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQ
Rv3545c|M.tuberculosis_H37Rv GAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQ
MUL_4106|M.ulcerans_Agy99 GAHYCIGANLARMTINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQ
MMAR_2783|M.marinum_M GAHYCIGANLARMTIDLMFNAIADVMPDLESISQPERLRSGWLNGIKHWQ
MAV_2811|M.avium_104 GAHYCIGANLARMTIDLMFNAIADAMPDLESIGKPERLRSGWLNGIKHWQ
Mflv_1607|M.gilvum_PYR-GCK GAHYCIGANLARMEIKLMFEAIADRLPDISKRAEPQRLRSGWINGVKDLQ
Mvan_5151|M.vanbaalenii_PYR-1 GAHFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQ
MSMEG_5853|M.smegmatis_MC2_155 GAHYCIGANLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVKDLQ
TH_1263|M.thermoresistible__bu GAHYCIGANLARMEIKLIFNEIADQIPDIAKLSEPVRLRSGWLNGVKELR
MAB_0101|M.abscessus_ATCC_1997 GIHYCLGANLARLEIGIMFDALADRLPDLMPTGAPTRFRSGWINGVVALP
MLBr_02088|M.leprae_Br4923 GSHFCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALP
* *:*:** ***: : :. :: :*:: . . :.*:
Mb3575c|M.bovis_AF2122/97 VDYT----GRCPVAH
Rv3545c|M.tuberculosis_H37Rv VDYT----GRCPVAH
MUL_4106|M.ulcerans_Agy99 VDYT----GKCPVSH
MMAR_2783|M.marinum_M VDYHSDSSGKCPVAH
MAV_2811|M.avium_104 VDYHTNGSSKCPVAH
Mflv_1607|M.gilvum_PYR-GCK VAYR-----------
Mvan_5151|M.vanbaalenii_PYR-1 VAYR-----------
MSMEG_5853|M.smegmatis_MC2_155 VSYRG----------
TH_1263|M.thermoresistible__bu VSYVG----------
MAB_0101|M.abscessus_ATCC_1997 ANYHGSGPRG-----
MLBr_02088|M.leprae_Br4923 VQV------------
.