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MSQRTYRVIQWMTGDVGRVGVRHFAENPVFDLVGVLVHSKDKVGRDAGEIAGTGPIGVAATDDVDAVMAL DADCVFYTPIIMDVDTVCRLLRTGKNVVTTAGFFHPSRDFREAGEQIRAACGDGGASFHGGGIHPGYAGD LLPLTLARVMSRIDSIHVYEVVDVVKDAPVDHIDWMGFGKDKDAFLAEPTILGLGLPFFAQSMYMIADGL GLTIDEVTAADIEAATAVEAIPHAEGAIPKGTVAAQRHEWTAWVDGRPLIVFHAIYVSAGPDLLDPPWDW GDTRYEIVIDGAPPTELTLKGVRQPDGALSHPGYEWTAMAAINAIPAVCDAPPGWLNHLDLGLIRPRGLV RP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4981 | - | - | 100% (352) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_4692 | - | 1e-57 | 39.02% (346) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_4980 | - | 2e-53 | 37.75% (355) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1088 | - | 1e-57 | 40.90% (357) | hypothetical protein Mb1088 |
| M. gilvum PYR-GCK | Mflv_1766 | - | 0.0 | 86.65% (352) | dihydrodipicolinate reductase |
| M. tuberculosis H37Rv | Rv1059 | - | 1e-57 | 40.90% (357) | hypothetical protein Rv1059 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0258c | - | 3e-47 | 37.09% (364) | putative dihydropicolinate reductase |
| M. marinum M | MMAR_4411 | - | 2e-55 | 39.71% (350) | hypothetical protein MMAR_4411 |
| M. avium 104 | MAV_0353 | - | 4e-56 | 39.54% (349) | hypothetical protein MAV_0353 |
| M. smegmatis MC2 155 | MSMEG_5286 | dapB | 6e-54 | 38.19% (343) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. thermoresistible (build 8) | TH_1493 | - | 1e-59 | 39.15% (355) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4353 | - | 1e-50 | 36.60% (347) | hypothetical protein MUL_4353 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4981|M.vanbaalenii_PYR-1 -MSQRTYRVIQWMTGDVGRVGVRHFAENPVFDLVGVLVHSKDKVGRDAGE
Mflv_1766|M.gilvum_PYR-GCK -MPDRTYRVIQWMTGDVGQVGIRHFAASPVFDLVGVLVHSKDKVGRDAGE
MSMEG_5286|M.smegmatis_MC2_155 ----MALRVVQWATGGVGMAAIKGVLEHPALELVGCWVHSEGKAGRDVGE
TH_1493|M.thermoresistible__bu ----MTFRVVQWATGGVGIAAIKGVLEHPELELVGCWVHSPDKAGRDVGE
Mb1088|M.bovis_AF2122/97 --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
Rv1059|M.tuberculosis_H37Rv --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
MMAR_4411|M.marinum_M ----MGLRVVQWATGSVGVAAIKGVLEHPELELVGCWVYSEAKSGVDVGE
MAV_0353|M.avium_104 MSSPSKLRVIQWASGGVGKAAIQCVLNHPRLELAGCWVHSAEKNGVDVGR
MUL_4353|M.ulcerans_Agy99 MSGPAKLRVIQWATGGVGKAAIECILNHPQLELAGCWVHSAAKHGLDVGT
MAB_0258c|M.abscessus_ATCC_199 --MSDKYPVIVWGTGVVGKLVIRELLDHPVFELAAVLVHDPAKDGVDVGT
*: * :* ** :. . * ::*.. *:. * * *.*
Mvan_4981|M.vanbaalenii_PYR-1 IAGTGPIGVAATDDVDAVMALDADCVFYTP----IIMDVDTVCRLLRTGK
Mflv_1766|M.gilvum_PYR-GCK IAGIAPIGVAATDDVDAVVALDADCVFYTP----IIMDVDTVCRLLRSGK
MSMEG_5286|M.smegmatis_MC2_155 IIGTEPLGVETTRDIDDILGLDADAVIYAP----LLPNPEEVAALLRSGK
TH_1493|M.thermoresistible__bu IIGAEPLGITATNSIDDILALDADAVIYAP----LLPDPDEVAALLRSGK
Mb1088|M.bovis_AF2122/97 IIGSPPLGVIATNSIDDVLALDADAVIYAP----LLPSVDEVAALLRSGK
Rv1059|M.tuberculosis_H37Rv IIGSPPLGVIATNSIDDVLALDADAVIYAP----LLPSVDEVAALLRSGK
MMAR_4411|M.marinum_M IIGTPPLGVITTNSVDEILALDADAVIYAP----LMPSVDEVAALLHSGK
MAV_0353|M.avium_104 IIGTQELGVTASTSVDEVLALDADCVVYSP----LIPNDDEVIAILRSGK
MUL_4353|M.ulcerans_Agy99 IIGAARFGVTATNDVDELLALDADCVMYSP----QVADEQDVKAILRSGK
MAB_0258c|M.abscessus_ATCC_199 LVGSHPTGLAATTDIDAALGTEGTVAYFGPTAQYALENIDNMSRALRSGH
: * *: :: .:* :. :. . : * : . : : *::*:
Mvan_4981|M.vanbaalenii_PYR-1 NVVTTAG--FFHPSRDFREAGEQIRAACGDGGASFHGGGIHPGYAGDLLP
Mflv_1766|M.gilvum_PYR-GCK NVVTTAG--FFHPSKDFREAGEQIRAACADGATSFHGGGIHPGYAGDLLP
MSMEG_5286|M.smegmatis_MC2_155 NVVTPVG--WVYP--SERQG-APLREAALAGNATLHGTGIAPGGISEKFP
TH_1493|M.thermoresistible__bu NVVTPLG--WFYP--TEKQA-APLRAAALEGGATLHGTGIAPGGISEKLP
Mb1088|M.bovis_AF2122/97 NVVTPLG--WFYP--SEKEA-APLEVAAQAGNATLHGAGIGPGAVTELFP
Rv1059|M.tuberculosis_H37Rv NVVTPLG--WFYP--SEKEA-APLEVAAQAGNATLHGAGIGPGAVTELFP
MMAR_4411|M.marinum_M NVVTPLG--WFYP--TEKEA-APLEVAAQSGNATLHGAGIGPGAATELFP
MAV_0353|M.avium_104 NVVTPVG--WVYPDPGNPRH-RAVADAALESGVTLHGSGIHPGGITERFP
MUL_4353|M.ulcerans_Agy99 NVFTPVG--WVYPDLSKPRV-KAVADAAVAGGVTLHGSGIHPGGITERFP
MAB_0258c|M.abscessus_ATCC_199 NIVSTAMTPWVYPQVCPPEMLADIQHACEAGQTSCFTTGIDPGFANDLFP
*:.:. :.:* . : *. . .: . ** ** : :*
Mvan_4981|M.vanbaalenii_PYR-1 LTLARVMSRIDSIHVYEVVDVVK-DAPVDHIDWMGFGKDKDAFLAEPTIL
Mflv_1766|M.gilvum_PYR-GCK LTLARVMSRIDTINLYEVVDVLK-DAPIDHIDWMGFGKDKTAFLAEPTIL
MSMEG_5286|M.smegmatis_MC2_155 LLFSVFSTGVTFVRAEEFSDLRTYDAPDVLRHVMGFGEVPDKALSGP-MQ
TH_1493|M.thermoresistible__bu LMFSALATGVTFVRAEEFSDLRTYDAPDVVRHVMGFGDTPEKALSGP-MQ
Mb1088|M.bovis_AF2122/97 LLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP-MQ
Rv1059|M.tuberculosis_H37Rv LLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP-MQ
MMAR_4411|M.marinum_M LLLSVMSTGVTFVRSEEFSDLRTYGAPDVLRYVMGFGGTPDSALTGP-MQ
MAV_0353|M.avium_104 LMVSSLSSAVTHVRAEEFSDIRTYNAPDVVRHIMGFGGTPEEATGGP-MA
MUL_4353|M.ulcerans_Agy99 LMVSSLSSAITHVRAEEFSDIRTYNAPDVVRDIMGFGVPHAQAMQGP-MA
MAB_0258c|M.abscessus_ATCC_199 MTLLGVGGRVDSVLVQELLDYQYYNGDFSTPMGLGAPMDQPAVLEIP---
: . . : : *. * .. :* *
Mvan_4981|M.vanbaalenii_PYR-1 GLGLPFFAQSMYMIADGLGLTIDEVTAADIEAATAVEA---IPHAEGAIP
Mflv_1766|M.gilvum_PYR-GCK GLGLPFFAQSMYMIADGLGVTIDDVSAADIDVATAVAD---IPHRDGAIP
MSMEG_5286|M.smegmatis_MC2_155 KLLDGGFMQAVKMCVDQFGFAADPKIRSRQEIAVATAP---IDSPLGAIQ
TH_1493|M.thermoresistible__bu KLLDGGFIQAVRMCVDKIGFAADPQVRSRQEIAVATAP---IESPIGVIE
Mb1088|M.bovis_AF2122/97 KILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAP---IDSPIGVIE
Rv1059|M.tuberculosis_H37Rv KILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAP---IDSPIGVIE
MMAR_4411|M.marinum_M KLLDGGFMQSVRLCVDRLGFAADPQIRTSQEVAVATSP---IESPIGVIE
MAV_0353|M.avium_104 GLLDGGFKQSVRMIADHMGFRIDPNIRTIQDVAVATAD---IDYDPFPIT
MUL_4353|M.ulcerans_Agy99 ALLESGFKMSVRMIANHMGFHIDPMIRATHEIAVATSD---IASDVLPIA
MAB_0258c|M.abscessus_ATCC_199 EVLILAWGHTIPMIADAVGVKLDKIDTVYEKWATPTEISYGSAPNTGTIP
: : :: : .: .*. * . *... *
Mvan_4981|M.vanbaalenii_PYR-1 KGTVAAQRHEWTAWVDGRPLIVFHAIYVSAGPDLLDPPWDWG--DTRYEI
Mflv_1766|M.gilvum_PYR-GCK KGTVAAQRHEWTAWVDGKPLIVFHAIYVTAGPDMLDPAWDWG--ETRYEI
MSMEG_5286|M.smegmatis_MC2_155 PGQVAGRRFHWEALRGEQ-VVVRVTVNWLMGEENLDPPWTFGPQGQRYEM
TH_1493|M.thermoresistible__bu PGQVAGRRFHWEALAGDE-VVVRVTVNWLMGEEDLDPPWDFGPAGQRYEI
Mb1088|M.bovis_AF2122/97 PGQVAGRRFHWEALVEDT-VVVQIAVNWLMGSENLDPPWSFGPAGERYEI
Rv1059|M.tuberculosis_H37Rv PGQVAGRRFHWEALVEDT-VVVQIAVNWLMGSENLDPPWSFGPAGERYEI
MMAR_4411|M.marinum_M PGQVAGRRFHWEAVVGDT-AVVEITVNWLMGEENLDPPWSFGPAGERYEI
MAV_0353|M.avium_104 AGTVAARRFRWQALVDGE-PVITAAVNWLMGEQNLDPAWDFGGRGERFEV
MUL_4353|M.ulcerans_Agy99 ADTVAGRKFRWQTLADGK-PVITAAVNWLMGQADMHPDWSFGERGERFEI
MAB_0258c|M.abscessus_ATCC_199 AGHCAAVRFEIRGWVGGEPKIVIEHVNRITNDTAPQWPRAQSVDNDAYRI
. *. :.. :: : . . . :.:
Mvan_4981|M.vanbaalenii_PYR-1 VIDGAPPTELTLKGVRQ---PDGALSHPGYEWTAMAAINAIPAVCDAPPG
Mflv_1766|M.gilvum_PYR-GCK VIDGDTPTELTLKGVRQ---PDGTMAHPGYTWTAMGAVNAIPDVCDGPPG
MSMEG_5286|M.smegmatis_MC2_155 QVCGNPDFDVVIKGFQGEVGETGPE--PGVVATAAHCVNSIPAVCAAEPG
TH_1493|M.thermoresistible__bu EVRGNPDFTVTINGFQSEPGDHGPE--AGIVATAAHCVNSVPAVCAADPG
Mb1088|M.bovis_AF2122/97 EVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAG
Rv1059|M.tuberculosis_H37Rv EVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAG
MMAR_4411|M.marinum_M EVRGHPDAFVTIKGWQPDSVAAGLQSNPGIVATAAHCVNAVPATCAAPAG
MAV_0353|M.avium_104 EITGDPDVSLTFKGLQPETIAEGLVKNPGVVVTANHCVNAIPDVCAAAPG
MUL_4353|M.ulcerans_Agy99 EITGNPSVSLVFKGLQPTSITEGLQRNPGVVATANHCANAIPVVCAADPG
MAB_0258c|M.abscessus_ATCC_199 EIKGSPNITQETVFRDE---RSGDGAIGGCLATGMRAINAIPAVIDAKPG
: * . * * *. . *::* . . .*
Mvan_4981|M.vanbaalenii_PYR-1 WLNHLDLGLIRPRGLVRP-----
Mflv_1766|M.gilvum_PYR-GCK WRTHLDLGLVRPRGLVRP-----
MSMEG_5286|M.smegmatis_MC2_155 IATYLDLPLFSAKAAPHLR----
TH_1493|M.thermoresistible__bu LLTYLDMPLISGRAAPRLT----
Mb1088|M.bovis_AF2122/97 IQSFFDLPLITGRAAPGLAR---
Rv1059|M.tuberculosis_H37Rv IQSFFDLPLITGRAAPGLAR---
MMAR_4411|M.marinum_M IQSFFDLPLITGRAAPELSN---
MAV_0353|M.avium_104 IKTYLDLPLFAGRPAPGLATS--
MUL_4353|M.ulcerans_Agy99 IATYLDLPLFAGRPARASRGLER
MAB_0258c|M.abscessus_ATCC_199 FLTPLDLPLIAGRGTIRI-----
. :*: *. :