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PDRTYRVIQWMTGDVGQVGIRHFAASPVFDLVGVLVHSKDKVGRDAGEIAGIAPIGVAATDDVDAVVALD ADCVFYTPIIMDVDTVCRLLRSGKNVVTTAGFFHPSKDFREAGEQIRAACADGATSFHGGGIHPGYAGDL LPLTLARVMSRIDTINLYEVVDVLKDAPIDHIDWMGFGKDKTAFLAEPTILGLGLPFFAQSMYMIADGLG VTIDDVSAADIDVATAVADIPHRDGAIPKGTVAAQRHEWTAWVDGKPLIVFHAIYVTAGPDMLDPAWDWG ETRYEIVIDGDTPTELTLKGVRQPDGTMAHPGYTWTAMGAVNAIPDVCDGPPGWRTHLDLGLVRPRGLVR P*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1766 | - | - | 100% (352) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_2027 | - | 1e-54 | 38.15% (346) | dihydrodipicolinate reductase |
| M. gilvum PYR-GCK | Mflv_1767 | - | 8e-50 | 36.59% (358) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1088 | - | 5e-54 | 40.62% (357) | hypothetical protein Mb1088 |
| M. tuberculosis H37Rv | Rv1059 | - | 6e-54 | 40.62% (357) | hypothetical protein Rv1059 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0258c | - | 2e-43 | 35.71% (364) | putative dihydropicolinate reductase |
| M. marinum M | MMAR_5280 | - | 1e-56 | 40.35% (347) | hypothetical protein MMAR_5280 |
| M. avium 104 | MAV_0353 | - | 4e-59 | 41.93% (353) | hypothetical protein MAV_0353 |
| M. smegmatis MC2 155 | MSMEG_5286 | dapB | 7e-51 | 37.39% (345) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. thermoresistible (build 8) | TH_1493 | - | 8e-56 | 37.46% (355) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4353 | - | 7e-52 | 38.62% (347) | hypothetical protein MUL_4353 |
| M. vanbaalenii PYR-1 | Mvan_4981 | - | 0.0 | 86.65% (352) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1766|M.gilvum_PYR-GCK -MPDRTYRVIQWMTGDVGQVGIRHFAASPVFDLVGVLVHSKDKVGRDAGE
Mvan_4981|M.vanbaalenii_PYR-1 -MSQRTYRVIQWMTGDVGRVGVRHFAENPVFDLVGVLVHSKDKVGRDAGE
MSMEG_5286|M.smegmatis_MC2_155 ----MALRVVQWATGGVGMAAIKGVLEHPALELVGCWVHSEGKAGRDVGE
TH_1493|M.thermoresistible__bu ----MTFRVVQWATGGVGIAAIKGVLEHPELELVGCWVHSPDKAGRDVGE
Mb1088|M.bovis_AF2122/97 --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
Rv1059|M.tuberculosis_H37Rv --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
MMAR_5280|M.marinum_M MSGPAKLRVIQWATGGVGKAAIECILNHPQLELAGCWVHSAAKHGLDVGT
MUL_4353|M.ulcerans_Agy99 MSGPAKLRVIQWATGGVGKAAIECILNHPQLELAGCWVHSAAKHGLDVGT
MAV_0353|M.avium_104 MSSPSKLRVIQWASGGVGKAAIQCVLNHPRLELAGCWVHSAEKNGVDVGR
MAB_0258c|M.abscessus_ATCC_199 --MSDKYPVIVWGTGVVGKLVIRELLDHPVFELAAVLVHDPAKDGVDVGT
*: * :* ** :. . * ::*.. **. * * *.*
Mflv_1766|M.gilvum_PYR-GCK IAGIAPIGVAATDDVDAVVALDADCVFYTP----IIMDVDTVCRLLRSGK
Mvan_4981|M.vanbaalenii_PYR-1 IAGTGPIGVAATDDVDAVMALDADCVFYTP----IIMDVDTVCRLLRTGK
MSMEG_5286|M.smegmatis_MC2_155 IIGTEPLGVETTRDIDDILGLDADAVIYAP----LLPNPEEVAALLRSGK
TH_1493|M.thermoresistible__bu IIGAEPLGITATNSIDDILALDADAVIYAP----LLPDPDEVAALLRSGK
Mb1088|M.bovis_AF2122/97 IIGSPPLGVIATNSIDDVLALDADAVIYAP----LLPSVDEVAALLRSGK
Rv1059|M.tuberculosis_H37Rv IIGSPPLGVIATNSIDDVLALDADAVIYAP----LLPSVDEVAALLRSGK
MMAR_5280|M.marinum_M IIGAARLGVTATNDVDELLALDADCVMYSP----LVADEQDVKAILRSGK
MUL_4353|M.ulcerans_Agy99 IIGAARFGVTATNDVDELLALDADCVMYSP----QVADEQDVKAILRSGK
MAV_0353|M.avium_104 IIGTQELGVTASTSVDEVLALDADCVVYSP----LIPNDDEVIAILRSGK
MAB_0258c|M.abscessus_ATCC_199 LVGSHPTGLAATTDIDAALGTEGTVAYFGPTAQYALENIDNMSRALRSGH
: * *: :: .:* :. :. . : * : . : : **:*:
Mflv_1766|M.gilvum_PYR-GCK NVVTTAG--FFHPSKDFREAGEQIRAACADGATSFHGGGIHPGYAGDLLP
Mvan_4981|M.vanbaalenii_PYR-1 NVVTTAG--FFHPSRDFREAGEQIRAACGDGGASFHGGGIHPGYAGDLLP
MSMEG_5286|M.smegmatis_MC2_155 NVVTPVG--WVYP--SERQG-APLREAALAGNATLHGTGIAPGGISEKFP
TH_1493|M.thermoresistible__bu NVVTPLG--WFYP--TEKQA-APLRAAALEGGATLHGTGIAPGGISEKLP
Mb1088|M.bovis_AF2122/97 NVVTPLG--WFYP--SEKEA-APLEVAAQAGNATLHGAGIGPGAVTELFP
Rv1059|M.tuberculosis_H37Rv NVVTPLG--WFYP--SEKEA-APLEVAAQAGNATLHGAGIGPGAVTELFP
MMAR_5280|M.marinum_M NVVTPVG--WVYPDLSKPRV-KAVADAAVAGGVTLHGSGIHPGGITERFP
MUL_4353|M.ulcerans_Agy99 NVFTPVG--WVYPDLSKPRV-KAVADAAVAGGVTLHGSGIHPGGITERFP
MAV_0353|M.avium_104 NVVTPVG--WVYPDPGNPRH-RAVADAALESGVTLHGSGIHPGGITERFP
MAB_0258c|M.abscessus_ATCC_199 NIVSTAMTPWVYPQVCPPEMLADIQHACEAGQTSCFTTGIDPGFANDLFP
*:.:. :.:* . : *. . .: . ** ** : :*
Mflv_1766|M.gilvum_PYR-GCK LTLARVMSRIDTINLYEVVDVLK-DAPIDHIDWMGFGKDKTAFLAEPTIL
Mvan_4981|M.vanbaalenii_PYR-1 LTLARVMSRIDSIHVYEVVDVVK-DAPVDHIDWMGFGKDKDAFLAEPTIL
MSMEG_5286|M.smegmatis_MC2_155 LLFSVFSTGVTFVRAEEFSDLRTYDAPDVLRHVMGFGEVPDKALSGP-MQ
TH_1493|M.thermoresistible__bu LMFSALATGVTFVRAEEFSDLRTYDAPDVVRHVMGFGDTPEKALSGP-MQ
Mb1088|M.bovis_AF2122/97 LLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP-MQ
Rv1059|M.tuberculosis_H37Rv LLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP-MQ
MMAR_5280|M.marinum_M LMVSSLSSAITHVRAEEFSDIRTYNAPDVVRDIMGFGVPPAQAMQGP-MA
MUL_4353|M.ulcerans_Agy99 LMVSSLSSAITHVRAEEFSDIRTYNAPDVVRDIMGFGVPHAQAMQGP-MA
MAV_0353|M.avium_104 LMVSSLSSAVTHVRAEEFSDIRTYNAPDVVRHIMGFGGTPEEATGGP-MA
MAB_0258c|M.abscessus_ATCC_199 MTLLGVGGRVDSVLVQELLDYQYYNGDFSTPMGLGAPMDQPAVLEIP---
: . . : : *. * .. :* *
Mflv_1766|M.gilvum_PYR-GCK GLGLPFFAQSMYMIADGLGVTIDDVSAADIDVATAVAD---IPHRDGAIP
Mvan_4981|M.vanbaalenii_PYR-1 GLGLPFFAQSMYMIADGLGLTIDEVTAADIEAATAVEA---IPHAEGAIP
MSMEG_5286|M.smegmatis_MC2_155 KLLDGGFMQAVKMCVDQFGFAADPKIRSRQEIAVATAP---IDSPLGAIQ
TH_1493|M.thermoresistible__bu KLLDGGFIQAVRMCVDKIGFAADPQVRSRQEIAVATAP---IESPIGVIE
Mb1088|M.bovis_AF2122/97 KILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAP---IDSPIGVIE
Rv1059|M.tuberculosis_H37Rv KILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAP---IDSPIGVIE
MMAR_5280|M.marinum_M ALLESGFKMSVRMIADHMGFHIDPTIRATHEIAVATSD---IASDVLPIA
MUL_4353|M.ulcerans_Agy99 ALLESGFKMSVRMIANHMGFHIDPMIRATHEIAVATSD---IASDVLPIA
MAV_0353|M.avium_104 GLLDGGFKQSVRMIADHMGFRIDPNIRTIQDVAVATAD---IDYDPFPIT
MAB_0258c|M.abscessus_ATCC_199 EVLILAWGHTIPMIADAVGVKLDKIDTVYEKWATPTEISYGSAPNTGTIP
: : :: : .: .*. * . *... *
Mflv_1766|M.gilvum_PYR-GCK KGTVAAQRHEWTAWVDGKPLIVFHAIYVTAGPDMLDPAWDWG--ETRYEI
Mvan_4981|M.vanbaalenii_PYR-1 KGTVAAQRHEWTAWVDGRPLIVFHAIYVSAGPDLLDPPWDWG--DTRYEI
MSMEG_5286|M.smegmatis_MC2_155 PGQVAGRRFHWEALRGEQ-VVVRVTVNWLMGEENLDPPWTFGPQGQRYEM
TH_1493|M.thermoresistible__bu PGQVAGRRFHWEALAGDE-VVVRVTVNWLMGEEDLDPPWDFGPAGQRYEI
Mb1088|M.bovis_AF2122/97 PGQVAGRRFHWEALVEDT-VVVQIAVNWLMGSENLDPPWSFGPAGERYEI
Rv1059|M.tuberculosis_H37Rv PGQVAGRRFHWEALVEDT-VVVQIAVNWLMGSENLDPPWSFGPAGERYEI
MMAR_5280|M.marinum_M AGTVAGRKFRWQALADGK-PVITAAVNWLMGQADMDPDWSFGERGERFEI
MUL_4353|M.ulcerans_Agy99 ADTVAGRKFRWQTLADGK-PVITAAVNWLMGQADMHPDWSFGERGERFEI
MAV_0353|M.avium_104 AGTVAARRFRWQALVDGE-PVITAAVNWLMGEQNLDPAWDFGGRGERFEV
MAB_0258c|M.abscessus_ATCC_199 AGHCAAVRFEIRGWVGGEPKIVIEHVNRITNDTAPQWPRAQSVDNDAYRI
. *. :.. :: : . . . :.:
Mflv_1766|M.gilvum_PYR-GCK VIDGDTPTELTLKGVRQ---PDGTMAHPGYTWTAMGAVNAIPDVCDGPPG
Mvan_4981|M.vanbaalenii_PYR-1 VIDGAPPTELTLKGVRQ---PDGALSHPGYEWTAMAAINAIPAVCDAPPG
MSMEG_5286|M.smegmatis_MC2_155 QVCGNPDFDVVIKGFQGEVGETGPE--PGVVATAAHCVNSIPAVCAAEPG
TH_1493|M.thermoresistible__bu EVRGNPDFTVTINGFQSEPGDHGPE--AGIVATAAHCVNSVPAVCAADPG
Mb1088|M.bovis_AF2122/97 EVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAG
Rv1059|M.tuberculosis_H37Rv EVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAG
MMAR_5280|M.marinum_M EVTGDPSVSLVFKGLQPTSIAEGLQRNPGVVATANHCVNAIPVVCAADPG
MUL_4353|M.ulcerans_Agy99 EITGNPSVSLVFKGLQPTSITEGLQRNPGVVATANHCANAIPVVCAADPG
MAV_0353|M.avium_104 EITGDPDVSLTFKGLQPETIAEGLVKNPGVVVTANHCVNAIPDVCAAAPG
MAB_0258c|M.abscessus_ATCC_199 EIKGSPNITQETVFRDE---RSGDGAIGGCLATGMRAINAIPAVIDAKPG
: * . * * *. . *::* . . .*
Mflv_1766|M.gilvum_PYR-GCK WRTHLDLGLVRPRGLVRP-----
Mvan_4981|M.vanbaalenii_PYR-1 WLNHLDLGLIRPRGLVRP-----
MSMEG_5286|M.smegmatis_MC2_155 IATYLDLPLFSAKAAPHLR----
TH_1493|M.thermoresistible__bu LLTYLDMPLISGRAAPRLT----
Mb1088|M.bovis_AF2122/97 IQSFFDLPLITGRAAPGLAR---
Rv1059|M.tuberculosis_H37Rv IQSFFDLPLITGRAAPGLAR---
MMAR_5280|M.marinum_M IATYLDLPLFAGRPARASRGLER
MUL_4353|M.ulcerans_Agy99 IATYLDLPLFAGRPARASRGLER
MAV_0353|M.avium_104 IKTYLDLPLFAGRPAPGLATS--
MAB_0258c|M.abscessus_ATCC_199 FLTPLDLPLIAGRGTIRI-----
. :*: *. :