For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TDRAIDCLVNVHFGEAEAQPNWMLKVRDDYFKGPDSMFAPVDLAQLLDEMDEQGVQRAILMDSLASPSLT ACKFVQAKPDRFALAMGGINLLRPVRPLRELTAIVGELPVAYAAVGPSFWGEGQYPPSDAVYYPLYVKCA ELELALCINTGIPGPPIPGEVQHPMHLDRVCVRFPELRLCMIHGADPWWDVAIRLLLKYSNSRLMTSAWT PKRLPESLLHYMRTRGKNKVIFASDWPVLRMRRVVPEARALDLPADVLANYLYNNAQEFFFGEESGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3876 | - | - | 100% (278) | metal-dependent hydrolase |
| M. ulcerans Agy99 | MUL_4957 | - | 4e-25 | 28.91% (256) | hypothetical protein MUL_4957 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3540c | - | 5e-26 | 32.85% (207) | hypothetical protein Mb3540c |
| M. gilvum PYR-GCK | Mflv_4348 | - | 1e-130 | 76.73% (275) | amidohydrolase 2 |
| M. tuberculosis H37Rv | Rv3510c | - | 5e-26 | 32.85% (207) | hypothetical protein Rv3510c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4012 | - | 1e-161 | 97.84% (278) | metal-dependent hydrolase |
| M. avium 104 | MAV_1593 | - | 1e-138 | 83.33% (270) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2232 | - | 1e-130 | 78.89% (270) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_1218 | - | 1e-138 | 82.05% (273) | amidohydrolase family protein |
| M. vanbaalenii PYR-1 | Mvan_1996 | - | 1e-130 | 77.66% (273) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3876|M.ulcerans_Agy99 MTD----RAIDCLVNVHFGEAEAQPNWMLKVRDDYFKGPDSMFAPVDLAQ
MMAR_4012|M.marinum_M MTD----RAIDCLVNVHFGEAEAQPNWMLKVRDDYFKGPDSMFAPVDLAQ
MAV_1593|M.avium_104 --M----KAIDCLVNVHFGETEKQPTWMLKVRDDYFKGPASMFAPVELSE
TH_1218|M.thermoresistible__bu MTR----KVLDCLVNVHFGEAEMQPAWMEKVRDDYFKGPEAMFAPVDLAE
Mflv_4348|M.gilvum_PYR-GCK MSD----RVIDCLVNVHFGETANQPEFMLKVRDDYFKGPQSLYDQVELPA
Mvan_1996|M.vanbaalenii_PYR-1 MTH----KVIDCLVNVHFGETAKQPEFMLKVRDDYFKGPQSLYEQVELPA
MSMEG_2232|M.smegmatis_MC2_155 MTESPAGRAIDCLANVHFGETQNQPAFMTKVRDDYFKGPKSMYDPIDLGA
Mb3540c|M.bovis_AF2122/97 -------MTIDVWMQHPTQRFLHGDMFASLRR---WTGGSIPETDIPIEA
Rv3510c|M.tuberculosis_H37Rv -------MTIDVWMQHPTQRFLHGDMFASLRR---WTGGSIPETDIPIEA
.:* : . : * :.* : :
MUL_3876|M.ulcerans_Agy99 LLDEMDEQGVQRAILMDSLAS------PSLTACKFVQAKPDRFALAMGGI
MMAR_4012|M.marinum_M LLDEMDEQGVQRAILMDSLAS------PSITARKFVQAKPDRFALAMGGI
MAV_1593|M.avium_104 LIDEMDAQGVRKAILMDNLAK------PSVTARKFVEDKPERFALAMGGV
TH_1218|M.thermoresistible__bu LLDEMDEQGVQKAILMDNLSK------PSVTARKFVEARPDRFALAMGGV
Mflv_4348|M.gilvum_PYR-GCK LLDEMAEHGVEKAILMDNLVK------PSVTARKFAEERPDKFALAIGGV
Mvan_1996|M.vanbaalenii_PYR-1 LLDEMAEHGVEKAILMDNLVK------PSVTARKFVEERPDKFALAVGGV
MSMEG_2232|M.smegmatis_MC2_155 LLEEMDANGVERAILMDNLTK------PSVTARKFVEAHPERFALAMGGV
Mb3540c|M.bovis_AF2122/97 TVSSMDAGGVTLGLLSAWRGPNGQDLISNDAVAEWVRLYPNRFAG-LAAV
Rv3510c|M.tuberculosis_H37Rv TVSSMDAGGVTLGLLSAWRGPNGQDLISNDAVAEWVRLYPNRFAG-LAAV
:..* ** .:* .. :. ::.. *::** :..:
MUL_3876|M.ulcerans_Agy99 NLLRPVRPLRELTAIVGELPVAYAAVGPSFWGEGQYPPSDAVYYPLYVKC
MMAR_4012|M.marinum_M NLLRPVRPLRELTAIVGELPVAYAAVGPSFWGEGQYPPSDAVYYPLYAKC
MAV_1593|M.avium_104 NLLRPIPSLRELGAVVADLPVAYAAVGPSFWGDGQYPPSDAVYYPLYTKC
TH_1218|M.thermoresistible__bu NLLRPIPSLRELAAVAADLPVVYAVVGPSFWGDGQYPPSDAVYYPLYTKC
Mflv_4348|M.gilvum_PYR-GCK NLLRPMPSLRELSSVVADLPVAYAAVGPSFWGDGMYPPSDAVYYPLYTKC
Mvan_1996|M.vanbaalenii_PYR-1 NLLRPMPSLRELAAVVADLPVAYAAVGPSFWGDGMYPPSDAVYYPLYTKC
MSMEG_2232|M.smegmatis_MC2_155 NLLRPIPSLRELAAAVRDLPVAYAVVGPSFWGDGQYPPSDAVYYPLYTKC
Mb3540c|M.bovis_AF2122/97 DLDRPMAAVRELRRRVGEGFVGLRVV-PWLWG---APPTDRRYYPLFAEC
Rv3510c|M.tuberculosis_H37Rv DLDRPMAAVRELRRRVGEGFVGLRVV-PWLWG---APPTDRRYYPLFAEC
:* **: .:*** . : * .* * :** **:* ****:.:*
MUL_3876|M.ulcerans_Agy99 AELELALCINTGIPGPPIPGEVQHPM-HLDRVCVRFPELRLCMIHGADPW
MMAR_4012|M.marinum_M AELELALCINTGIPGPPIPGEVQHPM-HLDRVCVRFPELRLCMIHGADPW
MAV_1593|M.avium_104 AELELPLCVNTGIPGPPIPGEVQNPI-HLDRVCVRFPELKLCMIHGADPW
TH_1218|M.thermoresistible__bu AELELPLCVNTGIPGPPIPGEVQNPI-HLDRVCVRFPELRLCMIHGADPW
Mflv_4348|M.gilvum_PYR-GCK AELGLPLCINTGLPGPPIPGEVQNPI-HLDRVCVRFPELKLCMIHGADPW
Mvan_1996|M.vanbaalenii_PYR-1 AELELPLCINTGLPGPPIPGEVQNPI-HLDRVCVRFPELKLCMIHGADPW
MSMEG_2232|M.smegmatis_MC2_155 AELDLPLCVNTGLPGPPIPGEVQNPI-HLDRVCVRFPELRLCMIHGADPW
Mb3540c|M.bovis_AF2122/97 VQSAVPFCTQVGHTGPLRPSETGRPIPYIDQVALDFPELVIVCGHVGYPW
Rv3510c|M.tuberculosis_H37Rv VQSAVPFCTQVGHTGPLRPSETGRPIPYIDQVALDFPELVIVCGHVGYPW
.: :.:* :.* .** *.*. .*: ::*:*.: **** : * . **
MUL_3876|M.ulcerans_Agy99 WDVAIRLLLKYSNSRLMTSAWTPKRLPESLLHYMRTR-GKNKVIFASDWP
MMAR_4012|M.marinum_M WDVAIRLLLKYSNLRLMTSAWSPKRLPESLLHYMRTR-GKNKVIFASDWP
MAV_1593|M.avium_104 WDVAIRLLLKYANLRLMTSAWSPKRLPESLLHYMRTR-GQDKVIFASDWP
TH_1218|M.thermoresistible__bu WDIAIRLLIKYQNLRLMTSAWSPKRLPNSLLHYMRTR-GPNKVIFGSDWP
Mflv_4348|M.gilvum_PYR-GCK WDVAIRLLIKYANLRIMTSAWSPKRLPDSLLHYMRTR-GKNKVIFASDWP
Mvan_1996|M.vanbaalenii_PYR-1 WDVAIRLLIKYANLRIMTSAWSPKRLPDSLLHFMRTR-GKNKVIFASDWP
MSMEG_2232|M.smegmatis_MC2_155 WDIAIRMLIKYKNLRLMTSAWSPKRLPESLLHYMRTR-GPDKIIFASDFP
Mb3540c|M.bovis_AF2122/97 TEEMVAVARKHENVYIDTSAYTIKRLPGKLVRFMKTDTGQRKVLFGTNYP
Rv3510c|M.tuberculosis_H37Rv TEEMVAVARKHENVYIDTSAYTIKRLPGKLVRFMKTDTGQRKVLFGTNYP
: : : *: * : ***:: **** .*:::*:* * *::*.:::*
MUL_3876|M.ulcerans_Agy99 VLRMRRVVPEARALDLPADVLANYLYNNAQEFFFGE-ESGR--
MMAR_4012|M.marinum_M VLRMRRVVPEARALDLPADVLANYLYNNAQEFFFGE-ESRR--
MAV_1593|M.avium_104 VLKMHRVVPEAAGLDLPADVLENYLYNNAHEFFFGG-HKEG--
TH_1218|M.thermoresistible__bu VLTMRRVVPEAYALDLPSEVLDNYLYNNAAEFFFGGPEQER--
Mflv_4348|M.gilvum_PYR-GCK VLRQSRVVPEALALDLPPDVLDNYLYNNANDFFFGTDEQEI--
Mvan_1996|M.vanbaalenii_PYR-1 VLRQSRVVPEAVALDLPPDVLDNYLYNNANDFFFGAAEQEI--
MSMEG_2232|M.smegmatis_MC2_155 VLRMNRVVPEARALDLPPDVLDNYLYHNAAEFFFGGRQPQEF-
Mb3540c|M.bovis_AF2122/97 MIAHTHALTGLDELGLSDEARRDFLHGNAVRVFKLDPRGKVQT
Rv3510c|M.tuberculosis_H37Rv MIAHTHALTGLDELGLSDEARRDFLHGNAVRVFKLDPRGKVQT
:: :.:. *.*. :. ::*: ** .* .