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AETCTHYRTASIDGLDVFYREAGDRSNPTLLLLHGFPSSSHMFRNLITALADDYHLVAPDHIGFGQSSMP SVNQFTYSFDRLTDITEKLIDRLGLGRFAIYIHDYGAPIGLRIASSRPERITGIITQSGNAYTEGFTPFW DRLFAHAKDRGANEDAVRDYFTPETTKWQYTHGVPADRLDRIAPETWLLDQAGLDRKGNDAIQLQLFWDY QFNLDGYPKFQEYFRVHQPPLLVTWGRNDEIFGAAGAEAFKRDLPDGEFHLLDTGHFALETHGDEIAGHI RDFLGRQEGLIRE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4733 | - | - | 100% (294) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 1e-16 | 27.12% (295) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_3998 | - | 2e-14 | 38.33% (120) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 1e-16 | 36.52% (115) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4848 | - | 1e-74 | 49.31% (290) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1833c | - | 1e-16 | 36.52% (115) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-09 | 31.07% (103) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 1e-16 | 33.33% (141) | epoxide hydrolase EphA |
| M. marinum M | MMAR_2710 | - | 1e-16 | 36.07% (122) | haloalkane dehalogenase |
| M. avium 104 | MAV_2130 | - | 2e-16 | 36.21% (116) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_0117 | - | 3e-80 | 51.76% (284) | hydrolase |
| M. thermoresistible (build 8) | TH_0992 | ephA | 7e-15 | 35.59% (118) | PROBABLE EPOXIDE HYDROLASE EPHA (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_3052 | - | 2e-16 | 35.04% (117) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4848|M.gilvum_PYR-GCK -------------------------MTVVHHRIDTVDG----HQVFYREA
MSMEG_0117|M.smegmatis_MC2_155 --------------------------MNIHHRYATIDG----QRIFYRAA
Mvan_4733|M.vanbaalenii_PYR-1 -----------------------MAETCTHYRTASIDG----LDVFYREA
Mb1864c|M.bovis_AF2122/97 ---------MSIDFTPDP-----QLYPFESRWFDSSRG-----RIHYVDE
Rv1833c|M.tuberculosis_H37Rv ---------MSIDFTPDP-----QLYPFESRWFDSSRG-----RIHYVDE
MMAR_2710|M.marinum_M -----MGRQFTPDFTPDP-----KLYPFASRWFDSSRG-----RLHYIDE
MUL_3052|M.ulcerans_Agy99 -----MGRQFTPDFTPDP-----KLYPFASRWFDSSRG-----RLHYIDE
MAV_2130|M.avium_104 MPVHAEELNMHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDE
MAB_0528c|M.abscessus_ATCC_199 ---------------------MTDAAVDIRERDIATNG----VHLRIVEA
TH_0992|M.thermoresistible__bu -------------------------VITPSERSVETNG----VRLRLVEA
MLBr_00862|M.leprae_Br4923 ------------------MPATQSIHKVPHQFVESPDG----VRLAIYQS
:
Mflv_4848|M.gilvum_PYR-GCK GDPDAPVIVLLHGFPTSSFMFRNLIPELADR-YRVIAPDYLGFGYSDAPT
MSMEG_0117|M.smegmatis_MC2_155 GPADAPPIVLLHGFPTSSFMFRDLIPLLARN-HRVIAPDHLGFGFSDAPS
Mvan_4733|M.vanbaalenii_PYR-1 GDRSNPTLLLLHGFPSSSHMFRNLITALADD-YHLVAPDHIGFGQSSMPS
Mb1864c|M.bovis_AF2122/97 G--TGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPS
Rv1833c|M.tuberculosis_H37Rv G--TGPPILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPS
MMAR_2710|M.marinum_M G--DGPPILLCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSEHPG
MUL_3052|M.ulcerans_Agy99 S--DGPPILLCHGNPTWSFLYRHIIVALRDH-FRCIAPDYLGFGLSEHPG
MAV_2130|M.avium_104 GPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPDLIGFGRSDKPS
MAB_0528c|M.abscessus_ATCC_199 GEPGQPAVILSHGFPELAYSWRHQIPALAAAGYHVIAPDQRGYGRSSMPA
TH_0992|M.thermoresistible__bu GERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSAPE
MLBr_00862|M.leprae_Br4923 GQPEGPAIVLVHGFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPK
. * ::* ** * : : * : : * * * *. *
Mflv_4848|M.gilvum_PYR-GCK VEDFDYTFDALTDSVAGLLTQLGIRR-YAIYVQDYGAPVGWRLALRD--P
MSMEG_0117|M.smegmatis_MC2_155 ADEFDYTFDALADLTEGLLTHLGIVR-YAIYVQDYGAPIGWRLALRH--P
Mvan_4733|M.vanbaalenii_PYR-1 VNQFTYSFDRLTDITEKLIDRLGLGR-FAIYIHDYGAPIGLRIASSR--P
Mb1864c|M.bovis_AF2122/97 GFG--YQIDEHARVIGEFVDHLGLDR-YLSMGQDWGGPISMAVAVER--A
Rv1833c|M.tuberculosis_H37Rv GFG--YQIDEHARVIGEFVDHLGLDR-YLSMGQDWGGPISMAVAVER--A
MMAR_2710|M.marinum_M TFG--YKVDEHAQVVGEFVDHLGLDN-YLTMGQDWGGPISMAVAVER--A
MUL_3052|M.ulcerans_Agy99 TFG--YKVDEHAQVVGEFVDHLGLDN-YLTMGQDWGGPISMAVAVER--A
MAV_2130|M.avium_104 RIED-YSYQRHVDWVVSWFEHLNLSD-VTLFVQDWGSLIGLRIAAEQ--P
MAB_0528c|M.abscessus_ATCC_199 HIDD-YNIEALSDDLLGILDDVGAGK-ATFVGHDWGAVVTWHTALAV--P
TH_0992|M.thermoresistible__bu AIEA-YDITRLTADLMGLLDDIGAEK-AAFIGHDWGALVVWNAALLY--P
MLBr_00862|M.leprae_Br4923 PVSA-YTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGAS
* . :. :*:*. .
Mflv_4848|M.gilvum_PYR-GCK AAITAIITQNGN--------------------------------------
MSMEG_0117|M.smegmatis_MC2_155 EAISAIVTQNGN--------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 ERITGIITQSGN--------------------------------------
Mb1864c|M.bovis_AF2122/97 DRVRGVVLGNTW--------------------------------------
Rv1833c|M.tuberculosis_H37Rv DRVRGVVLGNTW--------------------------------------
MMAR_2710|M.marinum_M ERVRGIVLGNTW--------------------------------------
MUL_3052|M.ulcerans_Agy99 ERVRGIVLGNTW--------------------------------------
MAV_2130|M.avium_104 DRVGRLVVANGF--------------------------------------
MAB_0528c|M.abscessus_ATCC_199 ERVSGVVGLSVP--------------------------------------
TH_0992|M.thermoresistible__bu DRVAAVAGLSVP--------------------------------------
MLBr_00862|M.leprae_Br4923 DRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLF
: . .
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2710|M.marinum_M --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0992|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYP
Mflv_4848|M.gilvum_PYR-GCK ------------------------------------------------GY
MSMEG_0117|M.smegmatis_MC2_155 ------------------------------------------------GY
Mvan_4733|M.vanbaalenii_PYR-1 ------------------------------------------------AY
Mb1864c|M.bovis_AF2122/97 ------------------------------------------------FW
Rv1833c|M.tuberculosis_H37Rv ------------------------------------------------FW
MMAR_2710|M.marinum_M ------------------------------------------------FW
MUL_3052|M.ulcerans_Agy99 ------------------------------------------------FW
MAV_2130|M.avium_104 ------------------------------------------------LP
MAB_0528c|M.abscessus_ATCC_199 ------------------------------------------------FT
TH_0992|M.thermoresistible__bu ------------------------------------------------PV
MLBr_00862|M.leprae_Br4923 ANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLW
Mflv_4848|M.gilvum_PYR-GCK NDGFVAEGWQPAWD------------YQREQTPETEAALRGILTFETTRM
MSMEG_0117|M.smegmatis_MC2_155 VEGFVDGFWSTVWD------------YHREQTPQTEAAIRTALDPESVKW
Mvan_4733|M.vanbaalenii_PYR-1 TEGFTP-FWDRLFA------------HAKDRG-ANEDAVRDYFTPETTKW
Mb1864c|M.bovis_AF2122/97 PADTLA---MKAFS------------RVMSSPPVQYAILRRNFFVERLIP
Rv1833c|M.tuberculosis_H37Rv PADTLA---MKAFS------------RVMSSPPVQYAILRRNFFVERLIP
MMAR_2710|M.marinum_M PADTLT---MKAFS------------TVMSSLPMQYAILHHNFFVERLIP
MUL_3052|M.ulcerans_Agy99 PADTLT---MKAFS------------TVMSSLPMQYAILHHNFFVERLIP
MAV_2130|M.avium_104 TAQRRT---PPAFY------------AWR-----AFARYSPVLPAGRIVS
MAB_0528c|M.abscessus_ATCC_199 RRSQVP--PTQAWNKLFG-DNFFYILYFQEPGVADADLNRDPATTMRRMM
TH_0992|M.thermoresistible__bu PRSLTR--PTEAFRALVGEDNFFYILYFQEPGVADAELDGDPARTMRRMF
MLBr_00862|M.leprae_Br4923 RRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTF
Mflv_4848|M.gilvum_PYR-GCK QYTAGVPDP--SVVSPD-----TWHHDFALLSRPGNDRIQLKLFLDYSTN
MSMEG_0117|M.smegmatis_MC2_155 QYVTGVADE--SLVSPD-----TWNHDAAQLARPGNDVIQLKLFADYATN
Mvan_4733|M.vanbaalenii_PYR-1 QYTHGVPADRLDRIAPE-----TWLLDQAGLDRKGNDAIQLQLFWDYQFN
Mb1864c|M.bovis_AF2122/97 AGTEHRPSS---AVMAH-----YRAVQPNAAARRGVAEMPKQILAARPLL
Rv1833c|M.tuberculosis_H37Rv AGTEHRPSS---AVMAH-----YRAVQPNAAARRGVAEMPKQILAARPLL
MMAR_2710|M.marinum_M AGTTHRPSS---AVMEH-----YRGVQPTASARVGVAEMPKQILAARPLL
MUL_3052|M.ulcerans_Agy99 AGTTHRPSS---AVMEH-----YRGVQPTASARVGVAEMPKQILAARPLL
MAV_2130|M.avium_104 VGTVRRVSS---KVRAG-----YDAPFPDKTYQAGARAFPQLVPTSPADP
MAB_0528c|M.abscessus_ATCC_199 AGMAR-IDGAT-MIAPGPAGFVERMPDPGELPEWLSQDELDHYITEFART
TH_0992|M.thermoresistible__bu GGLTSDPDAAHRMLQPGPAGFIDRLPEPEALPDWLTAEELDHYIAEFTRT
MLBr_00862|M.leprae_Br4923 GDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASG
:
Mflv_4848|M.gilvum_PYR-GCK PKIYP-----------ALHDYLRAS--GVPLLAVWGD-------------
MSMEG_0117|M.smegmatis_MC2_155 PPLYP-----------TLHEYLRTS--GVPVLAVWGR-------------
Mvan_4733|M.vanbaalenii_PYR-1 LDGYP-----------KFQEYFRVH--QPPLLVTWGR-------------
Mb1864c|M.bovis_AF2122/97 ARLAR-----------EVPATLG----TKPTLLIWGM-------------
Rv1833c|M.tuberculosis_H37Rv ARLAR-----------EVPATLG----TKPTLLIWGM-------------
MMAR_2710|M.marinum_M ARLAS-----------EVPAQLG----TKPALLVWGM-------------
MUL_3052|M.ulcerans_Agy99 ARLAS-----------EVPAQLG----TKPALLVWGM-------------
MAV_2130|M.avium_104 AIPANR----------KAWEALGRW--EKPFLAIFGA-------------
MAB_0528c|M.abscessus_ATCC_199 GFTGGLNWYRNFDRNWALTERLAGANVVVPSLFIAGA-------------
TH_0992|M.thermoresistible__bu GFTGGLNWYRNMDRNWELTEHLAGATITAPALFLAGA-------------
MLBr_00862|M.leprae_Br4923 GVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPP
* : .
Mflv_4848|M.gilvum_PYR-GCK --KDPFFGPD--GARAFAKDAVDSEIHLIDGGHFLLES------------
MSMEG_0117|M.smegmatis_MC2_155 --NDPIFGPD--GARAFEKDATDAEIHLLDGGHFLLET------------
Mvan_4733|M.vanbaalenii_PYR-1 --NDEIFGAA--GAEAFKRDLPDGEFHLLDTGHFALET------------
Mb1864c|M.bovis_AF2122/97 --KDVAFRPKTIIPRLSATFPDHVLVELPNAKHFIQED------------
Rv1833c|M.tuberculosis_H37Rv --KDVAFRPKTIIPRLSATFPDHVLVELPNAKHFIQED------------
MMAR_2710|M.marinum_M --KDFAFRPEPMLARMRAVFADHVLVELPEAKHFIQED------------
MUL_3052|M.ulcerans_Agy99 --KDFAFRPEPMLARMRAVFADHILVELPEAKHLIQED------------
MAV_2130|M.avium_104 --RDPILGHADSPLIKHIPGAAGQPHARINASHFIQED------------
MAB_0528c|M.abscessus_ATCC_199 --ADPVLGFTDHAGSAKYRTDNRGDLLIDGAGHWIQQE------------
TH_0992|M.thermoresistible__bu --ADPVLGFMRPERATEVAVGPYRQVLLDGAGHWVQQE------------
MLBr_00862|M.leprae_Br4923 EEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLS
* : *
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2710|M.marinum_M --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0992|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTA
Mflv_4848|M.gilvum_PYR-GCK ---------------------ELTRVANLIRDFLERRL------------
MSMEG_0117|M.smegmatis_MC2_155 ---------------------HVDEVAGLIDSFLDRKVS-----------
Mvan_4733|M.vanbaalenii_PYR-1 ---------------------HGDEIAGHIRDFLGRQEGLIRE-------
Mb1864c|M.bovis_AF2122/97 ---------------------APDRIAAAIIERFG---------------
Rv1833c|M.tuberculosis_H37Rv ---------------------APDRIAAAIIERFG---------------
MMAR_2710|M.marinum_M ---------------------APDEIAAAIIARFG---------------
MUL_3052|M.ulcerans_Agy99 ---------------------APDEIAAAIIARFG---------------
MAV_2130|M.avium_104 ---------------------RGPELAERILSWQQALL------------
MAB_0528c|M.abscessus_ATCC_199 ---------------------RPLEVNAALLAFLREVVH-----------
TH_0992|M.thermoresistible__bu ---------------------RPQEVNAALIDFLRGLELQ----------
MLBr_00862|M.leprae_Br4923 KQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYAL
.: :
Mflv_4848|M.gilvum_PYR-GCK --------------------
MSMEG_0117|M.smegmatis_MC2_155 --------------------
Mvan_4733|M.vanbaalenii_PYR-1 --------------------
Mb1864c|M.bovis_AF2122/97 --------------------
Rv1833c|M.tuberculosis_H37Rv --------------------
MMAR_2710|M.marinum_M --------------------
MUL_3052|M.ulcerans_Agy99 --------------------
MAV_2130|M.avium_104 --------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------
TH_0992|M.thermoresistible__bu --------------------
MLBr_00862|M.leprae_Br4923 YGISRVLPQVLRSTARIRVI