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FESMFDVDETASQAELRAAVERLERLKSQAAAAQARATALWAAKRQLAEESAGVRAHHRGKGLASEVALA RRDAPVKGNQHLGFAKALVNEMPHTLAALESGVLSEWRANLIVRESACLSVEHRRQLDAELCADASGLEG WGNRRIEAEAKKIAARLDAAALVERARKAPEQRCVSCRPAPDNMLYVTVLLPMTHGVAVYAACNRAADTT FDGRTRDQVMADTIYERVTGRSAAEPVSVALNLVMADTTLFGDDEAPGWAQGYGPVPAAVVRDLVSDAVT DAKAKATLRRLYRHPKSGQLVAMESRSWLFPKGLATFIGLRDQSCRTPYCDAPIRHHDHAVPDREGGPTS ALNGLGECQACNYAKEAPGWHVTTTDTDGEHTATFCTPTGAKYFSIAPPAPGTPVSRRSIVEGELSIDIV TFLAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4725 | - | - | 100% (426) | hypothetical protein Mvan_4725 |
| M. vanbaalenii PYR-1 | Mvan_5297 | - | 0.0 | 74.65% (430) | hypothetical protein Mvan_5297 |
| M. vanbaalenii PYR-1 | Mvan_3614 | - | e-180 | 73.12% (439) | hypothetical protein Mvan_3614 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1413c | - | 1e-145 | 61.89% (433) | hypothetical protein Mb1413c |
| M. gilvum PYR-GCK | Mflv_2586 | - | 1e-179 | 74.06% (424) | hypothetical protein Mflv_2586 |
| M. tuberculosis H37Rv | Rv1378c | - | 1e-145 | 61.89% (433) | hypothetical protein Rv1378c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1907 | - | 1e-117 | 54.80% (396) | hypothetical protein MAB_1907 |
| M. marinum M | MMAR_1584 | - | 1e-143 | 63.59% (401) | hypothetical protein MMAR_1584 |
| M. avium 104 | MAV_3980 | - | 1e-136 | 61.17% (412) | hypothetical protein MAV_3980 |
| M. smegmatis MC2 155 | MSMEG_6025 | - | 1e-158 | 65.89% (428) | hypothetical protein MSMEG_6025 |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-13 | 25.32% (387) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 8e-21 | 24.50% (453) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4725|M.vanbaalenii_PYR-1 ------------------------------------------------MF
Mflv_2586|M.gilvum_PYR-GCK ------------------------------------------------MF
MSMEG_6025|M.smegmatis_MC2_155 --------------------------------------MSVRGCSVWHMF
Mb1413c|M.bovis_AF2122/97 MGNLDLLLHLSGRIVKGCRPLGSVALARCGPAVRWPWWPRPAILEHMFDL
Rv1378c|M.tuberculosis_H37Rv MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAILEHMFDL
MMAR_1584|M.marinum_M ------------------------------------------------MF
MAV_3980|M.avium_104 --------------------------------------------------
MAB_1907|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 ------------------------------------------------MD
Mvan_4725|M.vanbaalenii_PYR-1 ESMFDVDETASQAELRAAVERLERLKSQAAAAQARATALWAAKRQLAEES
Mflv_2586|M.gilvum_PYR-GCK ESLFDIDEGASQAELRAVVERCERLKSAAAAAQARATALWAAKRAAAEEA
MSMEG_6025|M.smegmatis_MC2_155 ESLFDIDPQASEAELRDRIEQFERMKSAAAAAQATASVLWEQKRRAAEAA
Mb1413c|M.bovis_AF2122/97 VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEAD
Rv1378c|M.tuberculosis_H37Rv VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEAD
MMAR_1584|M.marinum_M ESLAAVDPAADQAALVERIAELETVKSAAAAGQARAAAALDTARRAAESA
MAV_3980|M.avium_104 ---MAVDPAAGESALIERISELETLKCAAAAAQARAAAALDAARRAAEAA
MAB_1907|M.abscessus_ATCC_1997 --MLPLDPATRAAQLVDRIAELERVKAAAAAEQAHAAVLLDRARREEEAA
TH_0334|M.thermoresistible__bu -----MFESLDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPEDDT
MUL_2679|M.ulcerans_Agy99 QHIIEYVFDTDDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHG-
. : :. *.. . * * .
Mvan_4725|M.vanbaalenii_PYR-1 AGVRAHHRGKG-LASEVALARRDAPVKGNQHLGFAKALVNEMPHTLAALE
Mflv_2586|M.gilvum_PYR-GCK AGVPVRRRGKG-LASEVALARRDAPVKGGQHLGFAKALMGEMPHTWAALE
MSMEG_6025|M.smegmatis_MC2_155 AGIPASRRGRG-LATEVALARRESPNAGGRHLGLAHALVDELPHTLAALR
Mb1413c|M.bovis_AF2122/97 AGVPARRRGRG-VASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
Rv1378c|M.tuberculosis_H37Rv AGVPARRRGRG-VASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
MMAR_1584|M.marinum_M AGVPAARRGRG-LANEIALARRDSPARGSRHLGFAKALVHEMPHTLAALE
MAV_3980|M.avium_104 AGVPAARRGRG-VASEVALARRDSPARGGRHLGFAKALVHEMPHTLAALE
MAB_1907|M.abscessus_ATCC_1997 NGVPRRRQGAG-VATEIALARQDSPARGSRHLGFAKALVNEMPHTLAALE
TH_0334|M.thermoresistible__bu ERANWAIDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFA
MUL_2679|M.ulcerans_Agy99 NREDWVADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFR
:. *:: * . : . .* * : .:*: * :
Mvan_4725|M.vanbaalenii_PYR-1 SGVLS-EWRANLIVRESACLSVEHRRQLDAELCADASGLEGWGNRRIEAE
Mflv_2586|M.gilvum_PYR-GCK CGALS-EWRATLIVRESACLSVEDRRRLDEELCADVSRFEGWGNKRVEAE
MSMEG_6025|M.smegmatis_MC2_155 CGALS-EWRATLIARESACLSPELRRELDAELSADPSRFDGWGDARVAAE
Mb1413c|M.bovis_AF2122/97 VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
Rv1378c|M.tuberculosis_H37Rv VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
MMAR_1584|M.marinum_M CGLLS-EWRATLIVRESACLDIEHRRELDAELCGDPSGLEGMGDARVAAA
MAV_3980|M.avium_104 CGALS-EWRATLIVRESACLDAEDRRALDAELCADPAGLSGMGDARVAAA
MAB_1907|M.abscessus_ATCC_1997 CGALS-EWRATILVRETAYLAVEDRQKIDVEMCAETSRLRGLGDTRLAAE
TH_0334|M.thermoresistible__bu AGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNER
MUL_2679|M.ulcerans_Agy99 AGGIDFRLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATE
* :. . :: * : :* :. . . :
Mvan_4725|M.vanbaalenii_PYR-1 AKKIAARLDAAALVERARKAPEQRCVSCRPAPDNMLYVTVLLPMTHGVAV
Mflv_2586|M.gilvum_PYR-GCK AKKIAARLDVAAVVERVDRAAAQARVSCRPAPNGMVYFTVLLPLAQGIGM
MSMEG_6025|M.smegmatis_MC2_155 AKKIACRLNIDAVLDRSAKAEKDRRVTIRPAPDAMTKLTVLLPLKQGVAV
Mb1413c|M.bovis_AF2122/97 ARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSV
Rv1378c|M.tuberculosis_H37Rv ARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSV
MMAR_1584|M.marinum_M AKAIAYRLDPHAVVDRAAKAERERTVTIRPAPDTMTYLTALLPVAQGISV
MAV_3980|M.avium_104 AKAIAYRLDPHAVVERAAKAENDRTVTIRPAPDTMTYLTALLPVAQGVSV
MAB_1907|M.abscessus_ATCC_1997 AKRLAYRLDAQAVVRRARRAESERRVSLRPAPDTMTYLTALLPVKQGVAV
TH_0334|M.thermoresistible__bu IDMWVERFDPTGVRE-PRSPGEDRYVVVTPAGQGMVDVSARLTFEAGFAF
MUL_2679|M.ulcerans_Agy99 VDRVVAKFDRDAVRR-SRRDAADRYVDCAPLEPGMALVNRQVFSATAEAL
. ::: .: : * * * .. : . ..
Mvan_4725|M.vanbaalenii_PYR-1 YAACNRAADTTFD--GRTRDQVMADTIYERVTGR----------------
Mflv_2586|M.gilvum_PYR-GCK YAALKHHADTTFD--GRSRGQVMADTAFERITGR----------------
MSMEG_6025|M.smegmatis_MC2_155 YAALHQAAMVNAD--DRNRGQVMADTLVERVTGR----------------
Mb1413c|M.bovis_AF2122/97 YAALKRAADTTFD--DRTRGQVMADTLVERVTGQ----------------
Rv1378c|M.tuberculosis_H37Rv YAALKRAADTTFD--DRTRGQVMADTLVERVTGQ----------------
MMAR_1584|M.marinum_M YAALRRAADTRCD--GRSRGQVMADTLVERVTGR----------------
MAV_3980|M.avium_104 YAALRREADTRGD--GRPRGQVMADTLVERVTGR----------------
MAB_1907|M.abscessus_ATCC_1997 YAALKRTADASMDP-VRGQGQIMADTLVERVTGV----------------
TH_0334|M.thermoresistible__bu XTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADP
MUL_2679|M.ulcerans_Agy99 ARRLDELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAG
. * . * * **: *
Mvan_4725|M.vanbaalenii_PYR-1 SAAEPVSVALNLVMADTTLFGDDEAPGWAQGYGPVPAAVVRDLVSDAVTD
Mflv_2586|M.gilvum_PYR-GCK SAGTAVPVALNLVMADTTLAGDDDCPGWLDGYGPVPAGFCRALTGDAVAD
MSMEG_6025|M.smegmatis_MC2_155 PAHAPVPVNLNLVMADTTLFGEDDQPGWVQGYGPVPAEVARRMVADATLD
Mb1413c|M.bovis_AF2122/97 PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVAD
Rv1378c|M.tuberculosis_H37Rv PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVAD
MMAR_1584|M.marinum_M DAAVPTPIAVNLVLTDESLLGADSAPADVCGYGPIPAAVARTMVADAVAD
MAV_3980|M.avium_104 RSTVPTPVAVNLVLSDETLLGGADAPGEISGYGPIPAAVARRMVANAAAD
MAB_1907|M.abscessus_ATCC_1997 SAAAAVPVGVNITVSDEALLGGGDEPATITGHGLVPAAVARRLISEAVS-
TH_0334|M.thermoresistible__bu ADTAATRLVINVIAEQATVEGRSDNPGYLPGYGAVPASILRAKAATATLR
MUL_2679|M.ulcerans_Agy99 APQQPSRVVIHVVAGCQTVDGAGEAPGVLPGDGIIPAEIVRELAKSAKLQ
. : ::: :: . *. * * :** . * *
Mvan_4725|M.vanbaalenii_PYR-1 AKAKATLRRLYRHPKSGQLVAMESRSWLFPKGLATFIGLRDQSCRTPYCD
Mflv_2586|M.gilvum_PYR-GCK KGARATLRRLYRHPRSGQLVAMESRARLFPKGLATLIDRRDQTCRTPYCD
MSMEG_6025|M.smegmatis_MC2_155 ENTKAAVRRLFRHPKSGQLVAMESRSRIFPKGLATFIGLRDQTCRTPYCD
Mb1413c|M.bovis_AF2122/97 TRSRATLRRLYRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCD
Rv1378c|M.tuberculosis_H37Rv TRSRATLRRLYRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCD
MMAR_1584|M.marinum_M GRSRATLRRLYAHPRAGALVAMESRARLFPRGLAAFIELRDQRCRTPYCD
MAV_3980|M.avium_104 PRSRATLRRLYAHPRAGALVAMESRARLFPQGLARFIGLRDQRCRTPYCD
MAB_1907|M.abscessus_ATCC_1997 AEAKVLVRRLYRRCTTGALVKAESRSRLFPRGLAELIDLRDQTCRTPYCD
TH_0334|M.thermoresistible__bu PVALPQPCAEAGYRPS--------------AALTRFIRCRDLTCRFPGCD
MUL_2679|M.ulcerans_Agy99 PMSTP-ILAETGYVPS--------------PALMDFVRARDLTCRAPGCD
: : .* :: ** ** * **
Mvan_4725|M.vanbaalenii_PYR-1 APIRHH--DHAVPDREGGPTSALNGLGECQACNYAKEAPGWHVTTTDT-D
Mflv_2586|M.gilvum_PYR-GCK APIRHH--DHATPDRAGGKTSAENGLGECAACNYAKEAPGWQVSAGTQ-D
MSMEG_6025|M.smegmatis_MC2_155 ALIRHR--DHAVPHHDGGPTTAHNGLGTCEACNYAKEAPGWSVIITETSD
Mb1413c|M.bovis_AF2122/97 APIRHR--DHAQPHHRGGPTTATNGLGSCERCNYVKEAPGWRVSTDTDET
Rv1378c|M.tuberculosis_H37Rv APIRHR--DHAQPHHRGGPTTATNGLGSCERCNYVKEAPGWRVSTDTDET
MMAR_1584|M.marinum_M APIRHR--DHARPWAKGGPTTADNGLGSCERCNYAKEAYGWRVETSMHET
MAV_3980|M.avium_104 APIRHR--DHAQPWADGGATSAGNGLGLCEHCNYVKETSGWTVSAGVDET
MAB_1907|M.abscessus_ATCC_1997 APIRHH--DHVVGSMRGGPTALDNGQGLCERCNYVKETAGWNVAP-VPGA
TH_0334|M.thermoresistible__bu APAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRFTHDQHKHQSS
MUL_2679|M.ulcerans_Agy99 RPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWGWHDEQLPDAT
**. * * * *
Mvan_4725|M.vanbaalenii_PYR-1 GEHTAT-----FCTPTG----AKYFSIAPPAPGTPVSRR-SIVEGELSID
Mflv_2586|M.gilvum_PYR-GCK GSHTAR-----WVTPTG----AVHYSIAPALPGPPVRRRISDTEGRLSID
MSMEG_6025|M.smegmatis_MC2_155 GEHIAE-----YVTPTG----AVYRSTAPPLPGRPVRHTLSLVETGLTID
Mb1413c|M.bovis_AF2122/97 GRHTAE-----FTTPTG----MYYHCTAPPLPGPLEIDV-SQVEARIGVA
Rv1378c|M.tuberculosis_H37Rv GRHTAE-----FTTPTG----MYYHCTAPPLPGPLEIDV-SQVEARIGVA
MMAR_1584|M.marinum_M HTHTAE-----FTTPTG----TSYRSGAP--PRVQTVTA-SELEVRVGIS
MAV_3980|M.avium_104 HTHTAL-----FTTPTG----QTYRSTAP--PRAPAITM-STVEVRVAVA
MAB_1907|M.abscessus_ATCC_1997 DRHTVE-----FTTPTG----TAYRSTAPPLP------------------
TH_0334|M.thermoresistible__bu ---CLP---AYFQRP---------HGPATRRPPSARG-----LR-----E
MUL_2679|M.ulcerans_Agy99 VIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPRSEATGSLRKPRRDD
* :. *
Mvan_4725|M.vanbaalenii_PYR-1 IVTFLAA-----------------
Mflv_2586|M.gilvum_PYR-GCK LITFDKPDAA--------------
MSMEG_6025|M.smegmatis_MC2_155 LVTFDAA-----------------
Mb1413c|M.bovis_AF2122/97 LTHLHAA-----------------
Rv1378c|M.tuberculosis_H37Rv LTHLHAA-----------------
MMAR_1584|M.marinum_M LAR-HAA-----------------
MAV_3980|M.avium_104 FAR-HAA-----------------
MAB_1907|M.abscessus_ATCC_1997 ------------------------
TH_0334|M.thermoresistible__bu AVPRQGVDP-------RRVSGQ--
MUL_2679|M.ulcerans_Agy99 AQTRPNSRPKLGRTHCDRTQPQHD