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SEAAAPVCRRRARLPLLSGTRCSVGFMFESLFDVGVGASEAELRAAVERCERLKSQAAAAQARATALWAA KRRAAEQAGGVPAAKRGKGLASEVALARHDAPVLGNRHLGFAQALVEEMPHTLAALECGALSEWRATLIV RESACLSVEHRRALDEELCGDVSRLAGWGNKRIEAEAKTIAARLDAAAVVDHTEKAAADCAVTCRPAPNN MVYVTLRLPLTRGVGIYAACKRAADTTFDGRPRGQVMTDTVYERVTGRPADTPVPVALNLVMADTTLAGD DDELGWLDGYGPVPAGFCRALIGNAVADAHAHADADAEVDAEVKATLRRLYRHPTSGQLVAMESRARIFP KGLGMLLQRRDRTCRTPYCDAPIRHHDHATPDRAGGPTSALNGLGECEACNYAKEAPGWTVTTGDVDGAH TADFETPTGAVYRSTAPPLPGPPVRRRLSLLEGRLSIDLVTFDAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3614 | - | - | 100% (466) | hypothetical protein Mvan_3614 |
| M. vanbaalenii PYR-1 | Mvan_5297 | - | 0.0 | 94.76% (439) | hypothetical protein Mvan_5297 |
| M. vanbaalenii PYR-1 | Mvan_2657 | - | 0.0 | 97.60% (333) | hypothetical protein Mvan_2657 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1413c | - | 1e-138 | 58.82% (442) | hypothetical protein Mb1413c |
| M. gilvum PYR-GCK | Mflv_2586 | - | 0.0 | 76.66% (437) | hypothetical protein Mflv_2586 |
| M. tuberculosis H37Rv | Rv1378c | - | 1e-138 | 58.82% (442) | hypothetical protein Rv1378c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1907 | - | 1e-115 | 52.87% (401) | hypothetical protein MAB_1907 |
| M. marinum M | MMAR_1584 | - | 1e-135 | 59.56% (413) | hypothetical protein MMAR_1584 |
| M. avium 104 | MAV_3980 | - | 1e-133 | 60.84% (406) | hypothetical protein MAV_3980 |
| M. smegmatis MC2 155 | MSMEG_6025 | - | 1e-158 | 64.49% (445) | hypothetical protein MSMEG_6025 |
| M. thermoresistible (build 8) | TH_0334 | - | 2e-12 | 25.63% (394) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 7e-05 | 24.41% (381) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3614|M.vanbaalenii_PYR-1 ---------------------MSEAAAPVCRRRARLPLLSGTRCSVGFMF
Mflv_2586|M.gilvum_PYR-GCK ------------------------------------------------MF
MSMEG_6025|M.smegmatis_MC2_155 --------------------------------------MSVRGCSVWHMF
Mb1413c|M.bovis_AF2122/97 MGNLDLLLHLSGRIVKGCRPLGSVALARCGPAVRWPWWPRPAILEHMFDL
Rv1378c|M.tuberculosis_H37Rv MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPRWPRPAILEHMFDL
MMAR_1584|M.marinum_M ------------------------------------------------MF
MAV_3980|M.avium_104 --------------------------------------------------
MAB_1907|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3614|M.vanbaalenii_PYR-1 ESLFDVGVGASEAELRAAVERCERLKSQAAAAQARATALWAAKRRAAE-Q
Mflv_2586|M.gilvum_PYR-GCK ESLFDIDEGASQAELRAVVERCERLKSAAAAAQARATALWAAKRAAAE-E
MSMEG_6025|M.smegmatis_MC2_155 ESLFDIDPQASEAELRDRIEQFERMKSAAAAAQATASVLWEQKRRAAE-A
Mb1413c|M.bovis_AF2122/97 VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNE-A
Rv1378c|M.tuberculosis_H37Rv VSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNE-A
MMAR_1584|M.marinum_M ESLAAVDPAADQAALVERIAELETVKSAAAAGQARAAAALDTARRAAE-S
MAV_3980|M.avium_104 ---MAVDPAAGESALIERISELETLKCAAAAAQARAAAALDAARRAAE-A
MAB_1907|M.abscessus_ATCC_1997 --MLPLDPATRAAQLVDRIAELERVKAAAAAEQAHAAVLLDRARREEE-A
TH_0334|M.thermoresistible__bu -----MFESLDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPEDDT
MUL_1813|M.ulcerans_Agy99 ---------------MERAREASRREAAAAAERLDVVGALFVLRCRES-G
. :. *.. . . * .
Mvan_3614|M.vanbaalenii_PYR-1 AGGVPAAKRGKGLASEVALARHDAPVLGNRHLGFAQALVEEMPHTLAALE
Mflv_2586|M.gilvum_PYR-GCK AAGVPVRRRGKGLASEVALARRDAPVKGGQHLGFAKALMGEMPHTWAALE
MSMEG_6025|M.smegmatis_MC2_155 AAGIPASRRGRGLATEVALARRESPNAGGRHLGLAHALVDELPHTLAALR
Mb1413c|M.bovis_AF2122/97 DAGVPARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
Rv1378c|M.tuberculosis_H37Rv DAGVPARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALE
MMAR_1584|M.marinum_M AAGVPAARRGRGLANEIALARRDSPARGSRHLGFAKALVHEMPHTLAALE
MAV_3980|M.avium_104 AAGVPAARRGRGVASEVALARRDSPARGGRHLGFAKALVHEMPHTLAALE
MAB_1907|M.abscessus_ATCC_1997 ANGVPRRRQGAGVATEIALARQDSPARGSRHLGFAKALVNEMPHTLAALE
TH_0334|M.thermoresistible__bu ERANWAIDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFA
MUL_1813|M.ulcerans_Agy99 DRAEWATDTWEAVGAQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFR
. : ::: * . : . * * : .:*:. .:
Mvan_3614|M.vanbaalenii_PYR-1 CGALS-EWRATLIVRESACLSVEHRRALDEELCGDVSRLAGWGNKRIEAE
Mflv_2586|M.gilvum_PYR-GCK CGALS-EWRATLIVRESACLSVEDRRRLDEELCADVSRFEGWGNKRVEAE
MSMEG_6025|M.smegmatis_MC2_155 CGALS-EWRATLIARESACLSPELRRELDAELSADPSRFDGWGDARVAAE
Mb1413c|M.bovis_AF2122/97 VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
Rv1378c|M.tuberculosis_H37Rv VGRLS-EWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAA
MMAR_1584|M.marinum_M CGLLS-EWRATLIVRESACLDIEHRRELDAELCGDPSGLEGMGDARVAAA
MAV_3980|M.avium_104 CGALS-EWRATLIVRESACLDAEDRRALDAELCADPAGLSGMGDARVAAA
MAB_1907|M.abscessus_ATCC_1997 CGALS-EWRATILVRETAYLAVEDRQKIDVEMCAETSRLRGLGDTRLAAE
TH_0334|M.thermoresistible__bu AGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNER
MUL_1813|M.ulcerans_Agy99 AEDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVA
:. . ::: * : :* :.. . :
Mvan_3614|M.vanbaalenii_PYR-1 AKTIAARLDAAAVVDHTEKAAADCAVTCRPAPNN--MVYVTLRLPLTRGV
Mflv_2586|M.gilvum_PYR-GCK AKKIAARLDVAAVVERVDRAAAQARVSCRPAPNG--MVYFTVLLPLAQGI
MSMEG_6025|M.smegmatis_MC2_155 AKKIACRLNIDAVLDRSAKAEKDRRVTIRPAPDA--MTKLTVLLPLKQGV
Mb1413c|M.bovis_AF2122/97 ARAIAYRLDAQAVVERAARAETERTVTIRPAPDT--MTWVTALLPVARGV
Rv1378c|M.tuberculosis_H37Rv ARAIAYRLDAQAVVERAARAETERTVTIRPAPDT--MTWVTALLPVARGV
MMAR_1584|M.marinum_M AKAIAYRLDPHAVVDRAAKAERERTVTIRPAPDT--MTYLTALLPVAQGI
MAV_3980|M.avium_104 AKAIAYRLDPHAVVERAAKAENDRTVTIRPAPDT--MTYLTALLPVAQGV
MAB_1907|M.abscessus_ATCC_1997 AKRLAYRLDAQAVVRRARRAESERRVSLRPAPDT--MTYLTALLPVKQGV
TH_0334|M.thermoresistible__bu IDMWVERFDPTGVREPRSPGE-DRYVVVTPAGQG--MVDVSARLTFEAGF
MUL_1813|M.ulcerans_Agy99 VDQVVADVDRDVVRRVAEAAD-GRFVDVDVIADGSGLAALAGSVLATAGR
. .: * . * : :. .: : *
Mvan_3614|M.vanbaalenii_PYR-1 GIYAACKRAADTTFD--GRPRGQVMTDTVYERVTGR--------------
Mflv_2586|M.gilvum_PYR-GCK GMYAALKHHADTTFD--GRSRGQVMADTAFERITGR--------------
MSMEG_6025|M.smegmatis_MC2_155 AVYAALHQAAMVNAD--DRNRGQVMADTLVERVTGR--------------
Mb1413c|M.bovis_AF2122/97 SVYAALKRAADTTFD--DRTRGQVMADTLVERVTGQ--------------
Rv1378c|M.tuberculosis_H37Rv SVYAALKRAADTTFD--DRTRGQVMADTLVERVTGQ--------------
MMAR_1584|M.marinum_M SVYAALRRAADTRCD--GRSRGQVMADTLVERVTGR--------------
MAV_3980|M.avium_104 SVYAALRREADTRGD--GRPRGQVMADTLVERVTGR--------------
MAB_1907|M.abscessus_ATCC_1997 AVYAALKRTADASMDP-VRGQGQIMADTLVERVTGV--------------
TH_0334|M.thermoresistible__bu AFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPA
MUL_1813|M.ulcerans_Agy99 AFDRRLDELANTVCAADPRTREQRRADAVGALVAGSDRLACGCTSADCTA
.. . * . * * :*: *
Mvan_3614|M.vanbaalenii_PYR-1 --PADTPVPVALNLVMADTTLAGDDDELGWLDGYG-PVPAGFCRALIGNA
Mflv_2586|M.gilvum_PYR-GCK --SAGTAVPVALNLVMADTTLAGDDDCPGWLDGYG-PVPAGFCRALTGDA
MSMEG_6025|M.smegmatis_MC2_155 --PAHAPVPVNLNLVMADTTLFGEDDQPGWVQGYG-PVPAEVARRMVADA
Mb1413c|M.bovis_AF2122/97 --PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYG-PIPAAVARNLVRDA
Rv1378c|M.tuberculosis_H37Rv --PAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYG-PIPAAVARNLVRDA
MMAR_1584|M.marinum_M --DAAVPTPIAVNLVLTDESLLGADSAPADVCGYG-PIPAAVARTMVADA
MAV_3980|M.avium_104 --RSTVPTPVAVNLVLSDETLLGGADAPGEISGYG-PIPAAVARRMVANA
MAB_1907|M.abscessus_ATCC_1997 --SAAAAVPVGVNITVSDEALLGGGDEPATITGHG-LVPAAVARRLISEA
TH_0334|M.thermoresistible__bu DPADTAATRLVINVIAEQATVEGRSDNPGYLPGYG-AVPASILRAKAATA
MUL_1813|M.ulcerans_Agy99 A-ARSAPSKVVIHVVADQSTVDGTGHTPAVLLGAEGLIPASLIAELAKVA
.. : ::: : :: . . : * :** . *
Mvan_3614|M.vanbaalenii_PYR-1 VADAHAHADADAEVDAEVKATLRRLYRHPTSGQLVAMESRARIFPKGLGM
Mflv_2586|M.gilvum_PYR-GCK VADKGAR------------ATLRRLYRHPRSGQLVAMESRARLFPKGLAT
MSMEG_6025|M.smegmatis_MC2_155 TLDENTK------------AAVRRLFRHPKSGQLVAMESRSRIFPKGLAT
Mb1413c|M.bovis_AF2122/97 VADTRSR------------ATLRRLYRHPRSGALVAMESRARRFPKGLAA
Rv1378c|M.tuberculosis_H37Rv VADTRSR------------ATLRRLYRHPRSGALVAMESRARRFPKGLAA
MMAR_1584|M.marinum_M VADGRSR------------ATLRRLYAHPRAGALVAMESRARLFPRGLAA
MAV_3980|M.avium_104 AADPRSR------------ATLRRLYAHPRAGALVAMESRARLFPQGLAR
MAB_1907|M.abscessus_ATCC_1997 VS-AEAK------------VLVRRLYRRCTTGALVKAESRSRLFPRGLAE
TH_0334|M.thermoresistible__bu TLRPVAL---------------------PQPCAEAGYRP-----SAALTR
MUL_1813|M.ulcerans_Agy99 TLRPLMR---------------------PSGRPESGYAP-----SAGLAE
. . . .*
Mvan_3614|M.vanbaalenii_PYR-1 LLQRRDRTCRTPYCDAP--IRHHDHATPDRAGGPTSALNGLGECEACNYA
Mflv_2586|M.gilvum_PYR-GCK LIDRRDQTCRTPYCDAP--IRHHDHATPDRAGGKTSAENGLGECAACNYA
MSMEG_6025|M.smegmatis_MC2_155 FIGLRDQTCRTPYCDAL--IRHRDHAVPHHDGGPTTAHNGLGTCEACNYA
Mb1413c|M.bovis_AF2122/97 FIGLRDQRCRMPYCDAP--IRHRDHAQPHHRGGPTTATNGLGSCERCNYV
Rv1378c|M.tuberculosis_H37Rv FIGLRDQRCRMPYCDAP--IRHRDHAQPHHRGGPTTATNGLGSCERCNYV
MMAR_1584|M.marinum_M FIELRDQRCRTPYCDAP--IRHRDHARPWAKGGPTTADNGLGSCERCNYA
MAV_3980|M.avium_104 FIGLRDQRCRTPYCDAP--IRHRDHAQPWADGGATSAGNGLGLCEHCNYV
MAB_1907|M.abscessus_ATCC_1997 LIDLRDQTCRTPYCDAP--IRHHDHVVGSMRGGPTALDNGQGLCERCNYV
TH_0334|M.thermoresistible__bu FIRCRDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQ
MUL_1813|M.ulcerans_Agy99 FVRCRDLTCRARGCDQPAVCCDLDHTVAYGDGGHTHASNLKCLCRKHHLL
:: ** ** ** . **. * * * *
Mvan_3614|M.vanbaalenii_PYR-1 KEAPGWT--------VTTGDV-DGAHTADFETP--------TGAVYRSTA
Mflv_2586|M.gilvum_PYR-GCK KEAPGWQ--------VSAGTQ-DGSHTARWVTP--------TGAVHYSIA
MSMEG_6025|M.smegmatis_MC2_155 KEAPGWS--------VIITETSDGEHIAEYVTP--------TGAVYRSTA
Mb1413c|M.bovis_AF2122/97 KEAPGWR--------VSTDTDETGRHTAEFTTP--------TGMYYHCTA
Rv1378c|M.tuberculosis_H37Rv KEAPGWR--------VSTDTDETGRHTAEFTTP--------TGMYYHCTA
MMAR_1584|M.marinum_M KEAYGWR--------VETSMHETHTHTAEFTTP--------TGTSYRSGA
MAV_3980|M.avium_104 KETSGWT--------VSAGVDETHTHTALFTTP--------TGQTYRSTA
MAB_1907|M.abscessus_ATCC_1997 KETAGWN--------VAP-VPGADRHTVEFTTP--------TGTAYRSTA
TH_0334|M.thermoresistible__bu AELR--------------FTHDQHKHQSS----------CLPAYFQRPHG
MUL_1813|M.ulcerans_Agy99 KTFWGWRDLQLPDGTVIWLLPDGHTYVTTPGSALLFPNLCVPTGELPPIV
: .
Mvan_3614|M.vanbaalenii_PYR-1 PPLPGPP-------------------VRRRLSLLEGRLSIDLVTFDAA--
Mflv_2586|M.gilvum_PYR-GCK PALPGPP-------------------VRRRISDTEGRLSIDLITFDKPDA
MSMEG_6025|M.smegmatis_MC2_155 PPLPGRP-------------------VRHTLSLVETGLTIDLVTFDAA--
Mb1413c|M.bovis_AF2122/97 PPLPGPL-------------------EID-VSQVEARIGVALTHLHAA--
Rv1378c|M.tuberculosis_H37Rv PPLPGPL-------------------EID-VSQVEARIGVALTHLHAA--
MMAR_1584|M.marinum_M P--PRVQ-------------------TVT-ASELEVRVGISLAR-HAA--
MAV_3980|M.avium_104 P--PRAP-------------------AIT-MSTVEVRVAVAFAR-HAA--
MAB_1907|M.abscessus_ATCC_1997 PPLP----------------------------------------------
TH_0334|M.thermoresistible__bu PATRRPP-------------------SARGLREAVPRQGVDPRRVSGQ--
MUL_1813|M.ulcerans_Agy99 GTAGKPPRWPSGEDADPCPNPRTKPGESHRHRAPMQSQGTGSRRRRPRRP
Mvan_3614|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2586|M.gilvum_PYR-GCK A-------------------------------------------------
MSMEG_6025|M.smegmatis_MC2_155 --------------------------------------------------
Mb1413c|M.bovis_AF2122/97 --------------------------------------------------
Rv1378c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1584|M.marinum_M --------------------------------------------------
MAV_3980|M.avium_104 --------------------------------------------------
MAB_1907|M.abscessus_ATCC_1997 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 VRHPGAGNRSRRAAALLAATSLGTCQIPRRIAPRPGPSRSSRGCTDSGTR
Mvan_3614|M.vanbaalenii_PYR-1 ----------------
Mflv_2586|M.gilvum_PYR-GCK ----------------
MSMEG_6025|M.smegmatis_MC2_155 ----------------
Mb1413c|M.bovis_AF2122/97 ----------------
Rv1378c|M.tuberculosis_H37Rv ----------------
MMAR_1584|M.marinum_M ----------------
MAV_3980|M.avium_104 ----------------
MAB_1907|M.abscessus_ATCC_1997 ----------------
TH_0334|M.thermoresistible__bu ----------------
MUL_1813|M.ulcerans_Agy99 MGESSMSARPRACVAG