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M. avium 104 MAV_0592 (-)

annotation: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
coordinates: 576520 - 577401
length: 293

MTATEELTFESTSRFAEVDVDGPLKLHYHEAGLSFKGTGRTVVLLHGGGPGAASWTNFGRNIPVLARHFH
VLAVDQPGYGLSDKRAEHGQFNRYAARALNGLFEQLELGRVPLVGNSLGGGTAVRFALDYPDKAGRLVLM
GPGGLSINLFAPDPTEGVKRLGKFSAEPTRENLEAFLRVMVYDQKLITDELIDERFALASTPESLAATRA
MGMSFAGADFELGMMWREVHRLRQPVLLIWGREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFD
EFNKLTIDFLGGA

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. avium 104 MAV_0592 - - 100% (293) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
M. avium 104 MAV_3016 - 2e-55 40.15% (274) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
M. avium 104 MAV_2517 - 7e-48 41.51% (265) 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3600c bphD 1e-150 89.38% (292) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD
M. gilvum PYR-GCK Mflv_1464 - 1e-127 76.22% (286) alpha/beta hydrolase fold
M. tuberculosis H37Rv Rv3569c bphD 1e-150 89.38% (292) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_3810 - 3e-52 36.30% (292) putative hydrolase, alpha/beta fold
M. marinum M MMAR_5064 bphD 1e-146 87.59% (290) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD
M. smegmatis MC2 155 MSMEG_6037 - 1e-137 79.93% (294) 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase
M. thermoresistible (build 8) TH_1741 - 1e-129 77.97% (286) 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD
M. ulcerans Agy99 MUL_4140 bphD 1e-145 87.24% (290) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD
M. vanbaalenii PYR-1 Mvan_5307 - 1e-127 76.74% (288) alpha/beta hydrolase fold

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1464|M.gilvum_PYR-GCK          MTSFAAEAAQQQEITFESTSRYAQVR---EDMRLHYHEAGV---GNPKTV
Mvan_5307|M.vanbaalenii_PYR-1       MTSFAAEAAQQQEITFESTSRFAQVR---EDMRLHYHEAGD---PESPTV
TH_1741|M.thermoresistible__bu      MTSYIQEAENQVEITFESTSRYAEVKAGDRDMRLHYHEAGI---GHAQKV
Mb3600c|M.bovis_AF2122/97           -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV---GNDQTV
Rv3569c|M.tuberculosis_H37Rv        -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV---GNDQTV
MMAR_5064|M.marinum_M               ---MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV---GNDQTV
MUL_4140|M.ulcerans_Agy99           ---MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV---GNDQTV
MAV_0592|M.avium_104                -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGLSFKGTGRTV
MSMEG_6037|M.smegmatis_MC2_155      ------MVTATQEITFESTSRFADVQAGELAMRLHYHEAGD---PSAQTI
MAB_3810|M.abscessus_ATCC_1997      -----------MDVTYEGTKRELATDEG----TLRYHEAGT--AGEGEPL
                                                : *:*.*.*   .        *:*****         :

Mflv_1464|M.gilvum_PYR-GCK          VLLHGGGPGASSWSNFGRNIPVLAKHFHVLAVDQPGYGHSDKHTEHEQYN
Mvan_5307|M.vanbaalenii_PYR-1       VLLHGGGPGASSWSNFGKNIPVLAEHFHVLAVDQPGYGHSDKHTEHEQYN
TH_1741|M.thermoresistible__bu      VLLHGGGPGASSWSNFGRNIAVLARHFHVIAVDQPGYGHSDKHTEHEQYN
Mb3600c|M.bovis_AF2122/97           VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
Rv3569c|M.tuberculosis_H37Rv        VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
MMAR_5064|M.marinum_M               VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MUL_4140|M.ulcerans_Agy99           VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MAV_0592|M.avium_104                VLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYGLSDKRAEHGQFN
MSMEG_6037|M.smegmatis_MC2_155      VLLHGGGPGAASWSNFGRNIAVLAEHFHVLAVDQPGYGLSDKHTEHEQYN
MAB_3810|M.abscessus_ATCC_1997      ILLHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSDAVPGHPVLT
                                    :****.***.:.* *:  *: *:*.:**. .:: **:* **  . *   .

Mflv_1464|M.gilvum_PYR-GCK          RYSATALLNLFDHLGIE-KAALVGNSLGGGTAVRFALDNGKRAGKLVLMG
Mvan_5307|M.vanbaalenii_PYR-1       RYSATALLNLFDYLGIE-RAALVGNSLGGGTAVRFALDNGKRAGKLVLMG
TH_1741|M.thermoresistible__bu      RYSATALLALFDHLGIE-RADLVGNSLGGGTAVRFALDHPKRAGRLVLMG
Mb3600c|M.bovis_AF2122/97           RYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRLVLMG
Rv3569c|M.tuberculosis_H37Rv        RYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRLVLMG
MMAR_5064|M.marinum_M               HYAARALKELFDQLGLG-RVPLVGNSLGGGTAVRFALDYPDRAGRLVLMG
MUL_4140|M.ulcerans_Agy99           HYAARALKELFDQLGLG-RVLLVGNSLGGGTAVRFALDYPDRAGRLVLMG
MAV_0592|M.avium_104                RYAARALNGLFEQLELG-RVPLVGNSLGGGTAVRFALDYPDKAGRLVLMG
MSMEG_6037|M.smegmatis_MC2_155      RYSAKAVRGLLDHLGVEGRVPLLGNSLGGGTAVRFALDYPDRAGKLVLMG
MAB_3810|M.abscessus_ATCC_1997      --AGASVIRFMDGLGIS-SAAVVGNSMGGVVGINLAIKHPDRITKLVTIG
                                      :. ::  ::: * :   . ::***:** ..:.:*:.   :  :** :*

Mflv_1464|M.gilvum_PYR-GCK          PGGLSVNLFSPDPTEGVKLLGRFAAEPTRENIEKFLRIMVFDQAMITPEL
Mvan_5307|M.vanbaalenii_PYR-1       PGGLSVNLFSPDPTEGVKLLGKFAAEPTRENIEKFLRIMVFDQNMITPEL
TH_1741|M.thermoresistible__bu      PGGLSVNMFAPDPTEGVKLLARFNAEPTRENLEAFLRIMVYDQSLITEEL
Mb3600c|M.bovis_AF2122/97           PGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPEL
Rv3569c|M.tuberculosis_H37Rv        PGGLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRVMVYDKNLITPEL
MMAR_5064|M.marinum_M               PGGLSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLRVMVYDQKLITPEL
MUL_4140|M.ulcerans_Agy99           PGGLSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLRVMVYDQKLITPEL
MAV_0592|M.avium_104                PGGLSINLFAPDPTEGVKRLGKFSAEPTRENLEAFLRVMVYDQKLITDEL
MSMEG_6037|M.smegmatis_MC2_155      PGGLSVNLFAPDPTEGVKALAKFNVEPTRENLEAFLRIMVFDQKLITPEL
MAB_3810|M.abscessus_ATCC_1997      --GVGPNIFSPSPSEGLRLLQEFTDNPDRDKLIRWLNSMVWDPAVVTDEL
                                      *:. *:*:*.*:**:: * .*   * *:::  :*. **:*  ::* **

Mflv_1464|M.gilvum_PYR-GCK          VEERFQIASTPESLAATKAMG--KSFAG-----ADFELGMMWRDVYKLRQ
Mvan_5307|M.vanbaalenii_PYR-1       VEERFQIASTPESLAATKAMG--KSFAG-----ADFELGMMWRDVYKLRQ
TH_1741|M.thermoresistible__bu      IDERFAIAATPESLAATRAMG--KSFMG-----PDFELGMMWRDAYKLRQ
Mb3600c|M.bovis_AF2122/97           VDQRFALASTPESLTATRAMG--KSFAG-----ADFEAGMMWREVYRLRQ
Rv3569c|M.tuberculosis_H37Rv        VDQRFALASTPESLTATRAMG--KSFAG-----ADFEAGMMWREVYRLRQ
MMAR_5064|M.marinum_M               VDQRFELARTPESLAATRAMG--KSFAA-----ADFELGMMWREVYKLRQ
MUL_4140|M.ulcerans_Agy99           VDQRFELARTPESLAATRAMG--KSFAA-----ADFELGMMWREVYKLRQ
MAV_0592|M.avium_104                IDERFALASTPESLAATRAMG--MSFAG-----ADFELGMMWREVHRLRQ
MSMEG_6037|M.smegmatis_MC2_155      VEERFAIASTPESLAATRAMG--KSFAG-----ADFELGMMWREVYKLRQ
MAB_3810|M.abscessus_ATCC_1997      IEERWEAAINPDAHKTAQLMYGSKAFAMQQQFLANADIPPYWAMMHKIKC
                                    :::*:  * .*::  ::: *    :*       .: :    *   :::: 

Mflv_1464|M.gilvum_PYR-GCK          RVLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQLEKFDEFNK
Mvan_5307|M.vanbaalenii_PYR-1       RVLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQLEKFDEFNK
TH_1741|M.thermoresistible__bu      RVLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQVEKFDEFNR
Mb3600c|M.bovis_AF2122/97           PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNK
Rv3569c|M.tuberculosis_H37Rv        PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNK
MMAR_5064|M.marinum_M               PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNR
MUL_4140|M.ulcerans_Agy99           PVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNR
MAV_0592|M.avium_104                PVLLIWGREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNK
MSMEG_6037|M.smegmatis_MC2_155      PVLLIWGREDRVNPLDGALVAVKQIPRVQLHVFGQCGHWAQVEKFDEFNK
MAB_3810|M.abscessus_ATCC_1997      PTLLTWGRDDRVSPPDMAIVPMRLIPNAELHIFPNSGHWVMIEAKQAFEQ
                                     .** ***:***.* * *:*.:: *...:**:* :.***. :*  : *::

Mflv_1464|M.gilvum_PYR-GCK          LTIDFLTN-------
Mvan_5307|M.vanbaalenii_PYR-1       LTIDFLGGG------
TH_1741|M.thermoresistible__bu      LTIDFLEDGAKEAKS
Mb3600c|M.bovis_AF2122/97           LTIEFLGGGR-----
Rv3569c|M.tuberculosis_H37Rv        LTIEFLGGGR-----
MMAR_5064|M.marinum_M               LTIDFLGGAR-----
MUL_4140|M.ulcerans_Agy99           LTIDFLGGAR-----
MAV_0592|M.avium_104                LTIDFLGGA------
MSMEG_6037|M.smegmatis_MC2_155      LTIDFLGG-------
MAB_3810|M.abscessus_ATCC_1997      TVVDFLRR-------
                                     .::**

species	id	gene	e-value	identity (len)	annotation
M. avium 104	MAV_0592	-	-	100% (293)	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
M. avium 104	MAV_3016	-	2e-55	40.15% (274)	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
M. avium 104	MAV_2517	-	7e-48	41.51% (265)	2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase