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TSFAAEAAQQQEITFESTSRFAQVREDMRLHYHEAGDPESPTVVLLHGGGPGASSWSNFGKNIPVLAEHF HVLAVDQPGYGHSDKHTEHEQYNRYSATALLNLFDYLGIERAALVGNSLGGGTAVRFALDNGKRAGKLVL MGPGGLSVNLFSPDPTEGVKLLGKFAAEPTRENIEKFLRIMVFDQNMITPELVEERFQIASTPESLAATK AMGKSFAGADFELGMMWRDVYKLRQRVLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQLEKF DEFNKLTIDFLGGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5307 | - | - | 100% (295) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2898 | - | 6e-62 | 43.87% (269) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0592 | - | 2e-45 | 40.15% (259) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 1e-130 | 77.27% (286) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_1464 | - | 1e-162 | 95.55% (292) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 1e-130 | 77.27% (286) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_00862 | ephD | 9e-06 | 31.25% (64) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3810 | - | 6e-53 | 37.50% (288) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_5064 | bphD | 1e-129 | 78.17% (284) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_0592 | - | 1e-127 | 76.74% (288) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_6037 | - | 1e-139 | 84.67% (287) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. thermoresistible (build 8) | TH_1741 | - | 1e-143 | 82.55% (298) | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD |
| M. ulcerans Agy99 | MUL_4140 | bphD | 1e-130 | 78.17% (284) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5307|M.vanbaalenii_PYR-1 MTSFAAEAAQQQEITFESTSRFAQVR---EDMRLHYHEAGD---PESPTV
Mflv_1464|M.gilvum_PYR-GCK MTSFAAEAAQQQEITFESTSRYAQVR---EDMRLHYHEAGV---GNPKTV
TH_1741|M.thermoresistible__bu MTSYIQEAENQVEITFESTSRYAEVKAGDRDMRLHYHEAGI---GHAQKV
Mb3600c|M.bovis_AF2122/97 -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV---GNDQTV
Rv3569c|M.tuberculosis_H37Rv -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV---GNDQTV
MMAR_5064|M.marinum_M ---MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV---GNDQTV
MUL_4140|M.ulcerans_Agy99 ---MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV---GNDQTV
MAV_0592|M.avium_104 -------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGLSFKGTGRTV
MSMEG_6037|M.smegmatis_MC2_155 ------MVTATQEITFESTSRFADVQAGELAMRLHYHEAGD---PSAQTI
MAB_3810|M.abscessus_ATCC_1997 -----------MDVTYEGTKRELATDEG----TLRYHEAGT--AGEGEPL
MLBr_00862|M.leprae_Br4923 --------MPATQSIHKVPHQFVESPDG---VRLAIYQSGQ---PEGPAI
: .: . : * :::* :
Mvan_5307|M.vanbaalenii_PYR-1 VLLHGGGPGASSWSNFGKNIPVLAEHFHVLAVDQPGYGHSDKHTEHEQYN
Mflv_1464|M.gilvum_PYR-GCK VLLHGGGPGASSWSNFGRNIPVLAKHFHVLAVDQPGYGHSDKHTEHEQYN
TH_1741|M.thermoresistible__bu VLLHGGGPGASSWSNFGRNIAVLARHFHVIAVDQPGYGHSDKHTEHEQYN
Mb3600c|M.bovis_AF2122/97 VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
Rv3569c|M.tuberculosis_H37Rv VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFN
MMAR_5064|M.marinum_M VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MUL_4140|M.ulcerans_Agy99 VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFN
MAV_0592|M.avium_104 VLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYGLSDKRAEHGQFN
MSMEG_6037|M.smegmatis_MC2_155 VLLHGGGPGAASWSNFGRNIAVLAEHFHVLAVDQPGYGLSDKHTEHEQYN
MAB_3810|M.abscessus_ATCC_1997 ILLHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSDAVPGHPVLT
MLBr_00862|M.leprae_Br4923 VLVHGFPDSHVLWD---GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYT
:*:** . * : ::*.:*: : * * *. .
Mvan_5307|M.vanbaalenii_PYR-1 RY-SATALLNLFDYLGIE-RAALVGNSLGGGTAVRFALDNGKRAGKLVLM
Mflv_1464|M.gilvum_PYR-GCK RY-SATALLNLFDHLGIE-KAALVGNSLGGGTAVRFALDNGKRAGKLVLM
TH_1741|M.thermoresistible__bu RY-SATALLALFDHLGIE-RADLVGNSLGGGTAVRFALDHPKRAGRLVLM
Mb3600c|M.bovis_AF2122/97 RY-AAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRLVLM
Rv3569c|M.tuberculosis_H37Rv RY-AAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRLVLM
MMAR_5064|M.marinum_M HY-AARALKELFDQLGLG-RVPLVGNSLGGGTAVRFALDYPDRAGRLVLM
MUL_4140|M.ulcerans_Agy99 HY-AARALKELFDQLGLG-RVLLVGNSLGGGTAVRFALDYPDRAGRLVLM
MAV_0592|M.avium_104 RY-AARALNGLFEQLELG-RVPLVGNSLGGGTAVRFALDYPDKAGRLVLM
MSMEG_6037|M.smegmatis_MC2_155 RY-SAKAVRGLLDHLGVEGRVPLLGNSLGGGTAVRFALDYPDRAGKLVLM
MAB_3810|M.abscessus_ATCC_1997 ---AGASVIRFMDGLGIS-SAAVVGNSMGGVVGINLAIKHPDRITKLVTI
MLBr_00862|M.leprae_Br4923 MTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFT
. . .:: * . ::.:. *. .
Mvan_5307|M.vanbaalenii_PYR-1 GPGGLSVNLFSPDPTEGVKLLGK---------------FAAEPTRENIEK
Mflv_1464|M.gilvum_PYR-GCK GPGGLSVNLFSPDPTEGVKLLGR---------------FAAEPTRENIEK
TH_1741|M.thermoresistible__bu GPGGLSVNMFAPDPTEGVKLLAR---------------FNAEPTRENLEA
Mb3600c|M.bovis_AF2122/97 GPGGLSINLFAPDPTEGVKRLSK---------------FSVAPTRENLEA
Rv3569c|M.tuberculosis_H37Rv GPGGLSINLFAPDPTEGVKRLSK---------------FSVAPTRENLEA
MMAR_5064|M.marinum_M GPGGLSINLFAPDPTEGVKRLGK---------------FSVAPTRENLEA
MUL_4140|M.ulcerans_Agy99 GPGGLSINLFAPDPTEGVKRLGK---------------FSVAPTRENLEA
MAV_0592|M.avium_104 GPGGLSINLFAPDPTEGVKRLGK---------------FSAEPTRENLEA
MSMEG_6037|M.smegmatis_MC2_155 GPGGLSVNLFAPDPTEGVKALAK---------------FNVEPTRENLEA
MAB_3810|M.abscessus_ATCC_1997 G--GVGPNIFSPSPSEGLRLLQE---------------FTDNPDRDKLIR
MLBr_00862|M.leprae_Br4923 SVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVP
. * . : : .*:: . : :
Mvan_5307|M.vanbaalenii_PYR-1 FLRIMVFDQNMITPELVEERFQIASTPESLAATKAMG--KSFAG-----A
Mflv_1464|M.gilvum_PYR-GCK FLRIMVFDQAMITPELVEERFQIASTPESLAATKAMG--KSFAG-----A
TH_1741|M.thermoresistible__bu FLRIMVYDQSLITEELIDERFAIAATPESLAATRAMG--KSFMG-----P
Mb3600c|M.bovis_AF2122/97 FLRVMVYDKNLITPELVDQRFALASTPESLTATRAMG--KSFAG-----A
Rv3569c|M.tuberculosis_H37Rv FLRVMVYDKNLITPELVDQRFALASTPESLTATRAMG--KSFAG-----A
MMAR_5064|M.marinum_M FLRVMVYDQKLITPELVDQRFELARTPESLAATRAMG--KSFAA-----A
MUL_4140|M.ulcerans_Agy99 FLRVMVYDQKLITPELVDQRFELARTPESLAATRAMG--KSFAA-----A
MAV_0592|M.avium_104 FLRVMVYDQKLITDELIDERFALASTPESLAATRAMG--MSFAG-----A
MSMEG_6037|M.smegmatis_MC2_155 FLRIMVFDQKLITPELVEERFAIASTPESLAATRAMG--KSFAG-----A
MAB_3810|M.abscessus_ATCC_1997 WLNSMVWDPAVVTDELIEERWEAAINPDAHKTAQLMYGSKAFAMQQQFLA
MLBr_00862|M.leprae_Br4923 MVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPAN--YFR
: :. . : :::: .: : ::
Mvan_5307|M.vanbaalenii_PYR-1 DFELGMMWRDVYKLRQRVLLIWGREDRVNPLDGALVALKQIPRVQLHVFG
Mflv_1464|M.gilvum_PYR-GCK DFELGMMWRDVYKLRQRVLLIWGREDRVNPLDGALVALKQIPRVQLHVFG
TH_1741|M.thermoresistible__bu DFELGMMWRDAYKLRQRVLLIWGREDRVNPLDGALVALKQIPRVQLHVFG
Mb3600c|M.bovis_AF2122/97 DFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFG
Rv3569c|M.tuberculosis_H37Rv DFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFG
MMAR_5064|M.marinum_M DFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFG
MUL_4140|M.ulcerans_Agy99 DFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFG
MAV_0592|M.avium_104 DFELGMMWREVHRLRQPVLLIWGREDRVNPLDGALVALKTIARAQLHVFG
MSMEG_6037|M.smegmatis_MC2_155 DFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVAVKQIPRVQLHVFG
MAB_3810|M.abscessus_ATCC_1997 NADIPPYWAMMHKIKCPTLLTWGRDDRVSPPDMAIVPMRLIPNAELHIFP
MLBr_00862|M.leprae_Br4923 AFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIK
. :. . * . ** .. : :.. : :
Mvan_5307|M.vanbaalenii_PYR-1 QCGHWAQLEKFDEFNKLTIDFLGGG-------------------------
Mflv_1464|M.gilvum_PYR-GCK QCGHWAQLEKFDEFNKLTIDFLTN--------------------------
TH_1741|M.thermoresistible__bu QCGHWAQVEKFDEFNRLTIDFLEDGAKEAKS-------------------
Mb3600c|M.bovis_AF2122/97 QCGHWVQVEKFDEFNKLTIEFLGGGR------------------------
Rv3569c|M.tuberculosis_H37Rv QCGHWVQVEKFDEFNKLTIEFLGGGR------------------------
MMAR_5064|M.marinum_M QCGHWAQVEKFDEFNRLTIDFLGGAR------------------------
MUL_4140|M.ulcerans_Agy99 QCGHWAQVEKFDEFNRLTIDFLGGAR------------------------
MAV_0592|M.avium_104 QCGHWAQVEKFDEFNKLTIDFLGGA-------------------------
MSMEG_6037|M.smegmatis_MC2_155 QCGHWAQVEKFDEFNKLTIDFLGG--------------------------
MAB_3810|M.abscessus_ATCC_1997 NSGHWVMIEAKQAFEQTVVDFLRR--------------------------
MLBr_00862|M.leprae_Br4923 -AGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTL
.**: :. : : . ::
Mvan_5307|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1464|M.gilvum_PYR-GCK --------------------------------------------------
TH_1741|M.thermoresistible__bu --------------------------------------------------
Mb3600c|M.bovis_AF2122/97 --------------------------------------------------
Rv3569c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5064|M.marinum_M --------------------------------------------------
MUL_4140|M.ulcerans_Agy99 --------------------------------------------------
MAV_0592|M.avium_104 --------------------------------------------------
MSMEG_6037|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAY
Mvan_5307|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1464|M.gilvum_PYR-GCK --------------------------------------------------
TH_1741|M.thermoresistible__bu --------------------------------------------------
Mb3600c|M.bovis_AF2122/97 --------------------------------------------------
Rv3569c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5064|M.marinum_M --------------------------------------------------
MUL_4140|M.ulcerans_Agy99 --------------------------------------------------
MAV_0592|M.avium_104 --------------------------------------------------
MSMEG_6037|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFD
Mvan_5307|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1464|M.gilvum_PYR-GCK --------------------------------------------------
TH_1741|M.thermoresistible__bu --------------------------------------------------
Mb3600c|M.bovis_AF2122/97 --------------------------------------------------
Rv3569c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5064|M.marinum_M --------------------------------------------------
MUL_4140|M.ulcerans_Agy99 --------------------------------------------------
MAV_0592|M.avium_104 --------------------------------------------------
MSMEG_6037|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 RVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCT
Mvan_5307|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1464|M.gilvum_PYR-GCK --------------------------------------------------
TH_1741|M.thermoresistible__bu --------------------------------------------------
Mb3600c|M.bovis_AF2122/97 --------------------------------------------------
Rv3569c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5064|M.marinum_M --------------------------------------------------
MUL_4140|M.ulcerans_Agy99 --------------------------------------------------
MAV_0592|M.avium_104 --------------------------------------------------
MSMEG_6037|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQER
Mvan_5307|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1464|M.gilvum_PYR-GCK --------------------------------------------------
TH_1741|M.thermoresistible__bu --------------------------------------------------
Mb3600c|M.bovis_AF2122/97 --------------------------------------------------
Rv3569c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5064|M.marinum_M --------------------------------------------------
MUL_4140|M.ulcerans_Agy99 --------------------------------------------------
MAV_0592|M.avium_104 --------------------------------------------------
MSMEG_6037|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3810|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGIS
Mvan_5307|M.vanbaalenii_PYR-1 ----------------
Mflv_1464|M.gilvum_PYR-GCK ----------------
TH_1741|M.thermoresistible__bu ----------------
Mb3600c|M.bovis_AF2122/97 ----------------
Rv3569c|M.tuberculosis_H37Rv ----------------
MMAR_5064|M.marinum_M ----------------
MUL_4140|M.ulcerans_Agy99 ----------------
MAV_0592|M.avium_104 ----------------
MSMEG_6037|M.smegmatis_MC2_155 ----------------
MAB_3810|M.abscessus_ATCC_1997 ----------------
MLBr_00862|M.leprae_Br4923 RVLPQVLRSTARIRVI