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AGNTSTPGTTVTSRLLNILGAFDERHKNLTLSELARRAGLPIATTHRLAAELVAGSALQRRADGQYVVGR LIWNAGLLAPVEGQLRQVAEPFLHDVYAATLATVHLAVRDGDEVLYLERMMGRTSVPIVSAVGSRLPMHC TGVGKVLLAHAPEDVKHRVFATLTRITPYTIVSPTVLSSQMQRIHREGVATTSEEMSLGACSLAVPVIRQ TDDAVVAAIAVVVPTLKRDRQRLLGALQVAARGIGRLL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0559 | - | - | 100% (249) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_2889 | - | 9e-32 | 36.07% (244) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_4411 | - | 2e-31 | 32.91% (237) | regulatory proteins, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 1e-15 | 28.12% (224) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0531 | - | 1e-115 | 98.60% (215) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 1e-15 | 28.12% (224) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0077 | - | 6e-28 | 34.14% (249) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 5e-15 | 27.78% (252) | transcriptional regulatory protein |
| M. avium 104 | MAV_3024 | - | 8e-29 | 35.29% (238) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_2600 | - | 1e-95 | 71.97% (239) | regulatory protein |
| M. thermoresistible (build 8) | TH_3251 | - | 3e-30 | 36.03% (247) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 1e-12 | 35.35% (198) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
Mvan_0559|M.vanbaalenii_PYR-1 -----------------MAGNTSTPGTTVTSRLLNILGAFDERHKNLTLS
Mflv_0531|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2600|M.smegmatis_MC2_155 -----------------MADDSSP---TVASRLLAVVGAFDERHRSLSLT
MAB_0077|M.abscessus_ATCC_1997 ----------------MTITADSATPSAVIDRVSLLLDAFDGPGR-LTLA
MAV_3024|M.avium_104 ------------------MPAPAETPTAVIDRISLVLDAFDGPGR-LTLA
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFDGPGR-LTLA
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRAT--AKSPCGLA
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADLGK-AGVT
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVRL
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVRL
Mvan_0559|M.vanbaalenii_PYR-1 ELARRAGLPIATTHRLAAELVAGSALQRR-ADGQYVVGRLIWNAGLLAPV
Mflv_0531|M.gilvum_PYR-GCK -MARRAGLPIATTHRLAAELVAGSALQRR-ADGQYVVGRLVWNAGLLAPV
MSMEG_2600|M.smegmatis_MC2_155 EIARRAGIPLSTAHRLTGTLVEGGALQRR-DDGRYVIGRLIWQAGLLAPV
MAB_0077|M.abscessus_ATCC_1997 QLVRRTGLPRSSVHRMLERLVQLRWLRR--DGRDYELGTRLVELGSLAVH
MAV_3024|M.avium_104 QIVRRTGLPRSSAHRMLERLVQLRWLRR--SGRDYELGMRLVELGSLAVH
TH_3251|M.thermoresistible__bu QVVRRTGLPRSSAHRMLERLVQLRWLRR--DGRDYELGMRLVELGSLAVH
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLGRD-EDGRWGLGPAITELA--AHV
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
: . *: ::. *: * : : :* : . .
Mb1748|M.bovis_AF2122/97 G--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv G--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Mvan_0559|M.vanbaalenii_PYR-1 EGQLRQVAEPFLHDVYAATLATVHLAVRDGDEVLYLERMMGRTSVPIVSA
Mflv_0531|M.gilvum_PYR-GCK EGQLRQVAEPFLYDVYAATLATVHLAVRDGDEVLYLERMMGRTSVPIVSA
MSMEG_2600|M.smegmatis_MC2_155 EGPLRHVAEPYLHDVYAATMATVHLGVRDGDEVLYLLRIRGRASVPIVST
MAB_0077|M.abscessus_ATCC_1997 QDRLHAAALPMLHELHRATGLVVHLSILDGADVVYLEKIGAGIGAAVATR
MAV_3024|M.avium_104 QDRLVRAATPLLVELHRATGLVVHLAVLDGPDVVYLEKVGDRLNSVIPSR
TH_3251|M.thermoresistible__bu QDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPTR
MUL_1967|M.ulcerans_Agy99 DDPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
: : ..* : :
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALPSRLAPLTANTITDRAALRDE
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALPSRLAPLTANTITDRAALRDE
Mvan_0559|M.vanbaalenii_PYR-1 VGSRLPMHCTGVGKVLLAHAP-EDVKHRVFATLTRITPYTIVSPTVLSSQ
Mflv_0531|M.gilvum_PYR-GCK VGSRLPMHCTGVGKVLLAHAP-EDVKDRVFATLTRITPYTIVSPTVLSSQ
MSMEG_2600|M.smegmatis_MC2_155 VGSRLPLYCTGVGKVLLAHAP-EDVAERVLSGLRPVTPKTITQPAMLRQQ
MAB_0077|M.abscessus_ATCC_1997 IGGRQPAHCTASGKAILAYR---AQILDGCTALARKTRYSIGSAAQLRPE
MAV_3024|M.avium_104 VGGRQPAHCTAVGKAILAYR---DEATD-LDLGARPTKYSISSAPQLAAE
TH_3251|M.thermoresistible__bu VGGRRPANCAAVGKAILAYAE-DDGVLSGTGPLPRNTKYSISDPARLRAE
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSD------------PATQQAVLPTAKFTDRV
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVGATLDSFTENTIVTIDALEAQ
:* * . . .*.:** :
Mb1748|M.bovis_AF2122/97 LNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPAQRFYGR
Rv1719|M.tuberculosis_H37Rv LNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPAQRFYGR
Mvan_0559|M.vanbaalenii_PYR-1 MQRIHREGVATTSEEMSLGACSLAVPVI-RQTDDAVVAAIAVVVPTLKRD
Mflv_0531|M.gilvum_PYR-GCK MQRIHREGVATTSEEMSLGACSLAVPVI-RQTDDAVVAAIAVVVPTLKRD
MSMEG_2600|M.smegmatis_MC2_155 LRRVRDDGIATTSEEMSLGACSLAVPVT-RASDHTVVAAIGVVVPSLKRD
MAB_0077|M.abscessus_ATCC_1997 LDKVRGHGVAFDREELQQGIGCVAAPIG-SIGDAVAAVSVCGPMTRMTFD
MAV_3024|M.avium_104 LAKVRAHGVAFEREESLLGFGCVAAPIG-GPGEAAAAVSVCGPLQRMALD
TH_3251|M.thermoresistible__bu LAKVRAHGVAFDREESLPGIGCVAAPIG-DPGEAVAAISVCGPMNQMAFD
MUL_1967|M.ulcerans_Agy99 LAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVAAISVSGPIDRIGRR
MMAR_4423|M.marinum_M LAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAAALSVSGPAYRLPAA
: : * * * * .:.. : .. :: :
Mb1748|M.bovis_AF2122/97 E-AELAGALLAWVSKVDAWFNGTEDRK-----------------------
Rv1719|M.tuberculosis_H37Rv E-AELAGALLAWVSKVDAWFNGTEDRK-----------------------
Mvan_0559|M.vanbaalenii_PYR-1 R-QRLLGALQVAARGIGRLL------------------------------
Mflv_0531|M.gilvum_PYR-GCK R-QRLLGALQVAARGIGRLL------------------------------
MSMEG_2600|M.smegmatis_MC2_155 R-QRLIQALQGAARGIGRVL------------------------------
MAB_0077|M.abscessus_ATCC_1997 --QRLAAPVRMTAMGIWRNVENGPSRVAPTLQPIRPLRCGPAASSTG-RE
MAV_3024|M.avium_104 --QRLAAPVRMTAMGVWRNVEGGPQRVAPTLQRLRPLP--PMRPQHP-VP
TH_3251|M.thermoresistible__bu --HRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQSLSHSA
MUL_1967|M.ulcerans_Agy99 PGARWAADLLAAADELARRL------------------------------
MMAR_4423|M.marinum_M DFEEVAQQTIAAADAVSRGLGWTDRIS-----------------------
. . : .
Mb1748|M.bovis_AF2122/97 ---------------------
Rv1719|M.tuberculosis_H37Rv ---------------------
Mvan_0559|M.vanbaalenii_PYR-1 ---------------------
Mflv_0531|M.gilvum_PYR-GCK ---------------------
MSMEG_2600|M.smegmatis_MC2_155 ---------------------
MAB_0077|M.abscessus_ATCC_1997 MNSPALQYA------------
MAV_3024|M.avium_104 KPRPALQYA------------
TH_3251|M.thermoresistible__bu LSHPAQSHPARSHRADTRRFA
MUL_1967|M.ulcerans_Agy99 ---------------------
MMAR_4423|M.marinum_M ---------------------