For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
NHYQGHRKVRPAWWSLALCAALALIIFICWSLFAGTFRSYVPVTLTSERSGLVMEPGAKVKLRGVEVGRV GDIRHGAQAASLQLQIFPDQISHIPANVEAQVRATTIFGAKYVDLVYPEQPSGQRLAAGAELVSRNVSIE VNTVFDNLVHLLEHIDPAKLNAVLNAWAEAVRGRGERIGEAITASNQVLASVNPLMPTVQRDWQSLQGFA DTYAEAAPDILDILQGASTTSATITSHADDLDRLLLSTMGFSQTGTDLLSSTRDSFPEAVNILAPTTALL LKYSPEYTCLLQGAKLALDRGWYDAAGGNGKSIVLDAGLTWATDPYRYPDHLPKVAATGGADGKPGCGSL PDVSKNWPVRHLVTDTGYGTGLDLRPNPGIAHPWWGNFLPVTRAVPEPPSLRGMGPPAIGPVPYPGSPPY GGSLYGPDGLPLWAAPPPGMPPPPVPGVPNPPPPYGTGIPPQSHPAPNP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4399 | - | - | 100% (470) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0363 | - | e-157 | 60.36% (449) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4604 | - | e-157 | 57.75% (471) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0604 | mce2A | 2e-67 | 39.95% (368) | MCE-family protein MCE2A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 1e-154 | 59.78% (450) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-136 | 58.12% (425) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 1e-63 | 36.86% (388) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 4e-56 | 34.40% (375) | MCE-family protein |
| M. marinum M | MMAR_4051 | mce3A_1 | 1e-154 | 57.96% (471) | MCE-family protein Mce3A_1 |
| M. avium 104 | MAV_2532 | - | 1e-129 | 53.88% (425) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-158 | 59.26% (459) | virulence factor |
| M. thermoresistible (build 8) | TH_4174 | - | 1e-141 | 56.25% (448) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-153 | 57.54% (471) | MCE-family protein Mce3A_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4399|M.vanbaalenii_PYR-1 ---MNHYQGHRKVRPAWWSLALCAALALIIFICWSLFAGTFRSYVPVTLT
TH_4174|M.thermoresistible__bu --------------LGWWAAIMITVVAGMVFVCSTLFAGTFRRYVPVSLT
MMAR_4051|M.marinum_M -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
Mflv_2101|M.gilvum_PYR-GCK -----MDD--DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKSTVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
Mb0604|M.bovis_AF2122/97 -MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTPKTELTMV
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
MAB_4153c|M.abscessus_ATCC_199 -----MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
:::
Mvan_4399|M.vanbaalenii_PYR-1 SERSGLVMEPGAKVKLRGVEVGRVGDIRHGAQA----ASLQLQIFPDQIS
TH_4174|M.thermoresistible__bu ADRTGLVLEKGAKVRMRGVDVGRVGAIEGGAAP----VRLELEIFPDKLS
MMAR_4051|M.marinum_M SERSGLVMETNAKVKLRGVQVGRVASIVGGGKGA-TPVALTLEIDSDQIR
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGKGA-TPVALTLEIDSDQIR
Mflv_2101|M.gilvum_PYR-GCK SDRAGLVMETNAKVKLRGVQVGRVSDISVTGRQD-PTVALQLEIDPDQVQ
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSGD-----PVTLRLELYPEQLQ
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIRGGASG----VSLQLEIEPDQIR
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEWAQ-NGASLRLEIDPDQIR
Mb0604|M.bovis_AF2122/97 ASRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLDVNPRYIS
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNAKDLR
: *:**::: ..*: .*:.:*:* * . : * : . :
Mvan_4399|M.vanbaalenii_PYR-1 HIPANVEAQVRATTIFGAKYVDLVYPEQPSGQRLAAGAELVSRNVSIEVN
TH_4174|M.thermoresistible__bu FIPSNVEAEIKATTAFGAKYVELIPPPAPSQARLAAGMTVHSRNVATEVN
MMAR_4051|M.marinum_M YIPANVQAEIRATTVFGAKFVDLVYPQDPSPQRLKAGQVLMSRNVTSEAN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
Mflv_2101|M.gilvum_PYR-GCK YIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSRNVTTEVN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
Mb0604|M.bovis_AF2122/97 LIPVNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVGSVTTEFN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
** *. . : .:* ** * * : * * : . : *: * *
Mvan_4399|M.vanbaalenii_PYR-1 TVFDNLVHLLEHIDPAKLNAVLNAWAEAVRGRGERIGEAITASNQVLASV
TH_4174|M.thermoresistible__bu TVFQNLVAVLDQIDVAKLNATLSALADGVRGRGESIGQATTAVSETLRQL
MMAR_4051|M.marinum_M TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
Mflv_2101|M.gilvum_PYR-GCK TVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDANQVLLAL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
Mb0604|M.bovis_AF2122/97 TLFETITSIAEKVDPIELNATLSAVAQAPDGLGGKFGESIVNGNQILAQL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
*:*:.:. : :* :** .*.* .:. * * :*.. . .. * :
Mvan_4399|M.vanbaalenii_PYR-1 NPLMPTVQRDWQSLQGFADTYAEAAPDILDILQGASTTSATITSHADDLD
TH_4174|M.thermoresistible__bu NVRIDSMAQGWRSFKGFTDAYGMAAEDILAILDAAATTADTVEARSSQLD
MMAR_4051|M.marinum_M NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITSHSTQLD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
Mflv_2101|M.gilvum_PYR-GCK NPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVVNQAKELD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
Mb0604|M.bovis_AF2122/97 NPRLPQLGYDVRRLADLGEVYVDASPDLWSFLQNALTTARTLTSQQRDLD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
* . : . : :: :: *: . : *: . *.
Mvan_4399|M.vanbaalenii_PYR-1 RLLLSTMGFSQTGTDLLSSTRDSFPEAVNILAPTTALLLKYSPEYTCLLQ
TH_4174|M.thermoresistible__bu ALLLSTIGMANIGTELLGSTRDDFVTAVNEARPTTDLLLKYDPVYTCLLV
MMAR_4051|M.marinum_M ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
Mflv_2101|M.gilvum_PYR-GCK ALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSPSYTCLLL
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
Mb0604|M.bovis_AF2122/97 AALLAATGAGNTGEDVFARGGPYLARAAADLVPTATLLDTYSPELFCMIR
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
** . * .. * :. : . ..: ** *.* * :
Mvan_4399|M.vanbaalenii_PYR-1 GAKLALDRGWYDAAG-GNGKS-----------------------------
TH_4174|M.thermoresistible__bu GAKLYLDKGGYDALG-GNGRT-----------------------------
MMAR_4051|M.marinum_M GAKYLLDHGGYEAPG-GNGRS-----------------------------
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPG-GNGRS-----------------------------
Mflv_2101|M.gilvum_PYR-GCK GAKHLLDEGGYEAPG-GNGRT-----------------------------
MAV_2532|M.avium_104 GSKYDAEFFGDVAGG-HNGYS-----------------------------
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFG-GNGRS-----------------------------
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGGADGRT-----------------------------
Mb0604|M.bovis_AF2122/97 NFHDAAPKVADAVGGNGYS-------------------------------
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGGNGYSINDHVELLSGLGFLLNPTSAISIIGAGVLSQ
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIGGVRPG-------------------------------
* .
Mvan_4399|M.vanbaalenii_PYR-1 -----IVLDAGLTWATDPYRYPDHLPKVAATGGA--DGKPGCGSLPDVSK
TH_4174|M.thermoresistible__bu -----LVADTTLLFGDDPYRYPEHLPIHNAKGGP--GGKPGCGSLPDVEQ
MMAR_4051|M.marinum_M -----LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCGSLPIVDN
MUL_3918|M.ulcerans_Agy99 -----LVLDAALALGDDPYRFPDNLPIIGAKGGP--GGKPGCGSLPIVDN
Mflv_2101|M.gilvum_PYR-GCK -----LVLDTSLSFGDDPYQYPRHLPIIGAKGGP--GGKPGCGSLPKVAE
MAV_2532|M.avium_104 -----VTLDVALLLGDEAYRYPDNLPINGAKGGP--GGQPGCGSLPDVSK
MSMEG_0346|M.smegmatis_MC2_155 -----AIFDIGLLLGNDPYHYPDDLPIVGAKGGP--GGKPGCGSLPDVAK
Rv1966|M.tuberculosis_H37Rv -----LQLDVALLFGNDPYVYPDNLPVVAAKGGP--GGRPGCGPLPDATH
Mb0604|M.bovis_AF2122/97 -----LAAAGTILGAPNPYVYPDNLPRVNAHGGP--GGRPGCWQTITREL
MLBr_02589|M.leprae_Br4923 GLLAPLGLAGVVNGAANPYIYPENLPRVNARGGP--GGAPGCWQHITRDL
MAB_4153c|M.abscessus_ATCC_199 -----LFLTNSFPLGAPVYTYPDSLPIVNASGGPNCRGLPNIPTKMQNGS
. . * :* ** * **. * *.
Mvan_4399|M.vanbaalenii_PYR-1 NWPVRHLVTDTGYGTGLDLRPNPGIAHPWWGNFLPVTRAVPEPPSLR-GM
TH_4174|M.thermoresistible__bu NFPVRKLVTDTGFGSGTDIRTNPGIGHPWFINFFPATRAVPEHPYVL-GE
MMAR_4051|M.marinum_M NWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLF
MUL_3918|M.ulcerans_Agy99 NWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVTRGTPEPPSIRNLF
Mflv_2101|M.gilvum_PYR-GCK NWPVRNLVTNTGFGSGLDWRPNPGIAFPTYANYLPVTRAVPEPPSVRNLF
MAV_2532|M.avium_104 NFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLPVTRGTPQPPSLR-HP
MSMEG_0346|M.smegmatis_MC2_155 NFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFPVTRGIPQPPIIRNLG
Rv1966|M.tuberculosis_H37Rv NFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRAVPEPPSIRQCI
Mb0604|M.bovis_AF2122/97 WP-APYLVMDTG--ASLAPYNHVELGQPMFTEYVWGRQYGENTINP----
MLBr_02589|M.leprae_Br4923 WP-TPELVMDTG--NSIAPYNHLDSGSPYAIEYVWGRQVGDNTINP----
MAB_4153c|M.abscessus_ATCC_199 WFRSPFLVTDNAY-IPYKPLEELQVNAPDTLQYLYNGAFAKRSEF-----
** :.. . * ::. .
Mvan_4399|M.vanbaalenii_PYR-1 GPPAIGPVPYPGSPPYGGSLYGPDGLPLWAAPPPGMPPP-PVPGVPNPPP
TH_4174|M.thermoresistible__bu GPPAPGPSP---SIPHG-PVAAP-----VPAPPVGQSSP-PEPTTDEPTP
MMAR_4051|M.marinum_M GGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPAPPPG--APRESGPTP
MUL_3918|M.ulcerans_Agy99 GGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPAPPPG--APRESGPTP
Mflv_2101|M.gilvum_PYR-GCK GGPAIGPIPYPGAPAYGAQLYAPDGTPLWPGLPPAPPPG--APRDPGPRP
MAV_2532|M.avium_104 GGTAPGPMPYPGAPPYGAPQYAPDGTPLYPGLPPAPPPG--RPRDAGPPP
MSMEG_0346|M.smegmatis_MC2_155 GGPAPGPIPYPGAPPYGADLYADDGTPLWPGLPPAPPPSDQPPPDPNNPP
Rv1966|M.tuberculosis_H37Rv PGPAIGPNPAAGEQP-----------------------------------
Mb0604|M.bovis_AF2122/97 --------------------------------------------------
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4399|M.vanbaalenii_PYR-1 ----PYGTGIPPQSHPAPNP-----------------
TH_4174|M.thermoresistible__bu ----RTQSGQP--------------------------
MMAR_4051|M.marinum_M -GSEPFVVPAPAQAQPTPLP----PAPLPQEVAPSP-
MUL_3918|M.ulcerans_Agy99 -GSEPFVVPASAQAQPTPLP----PAPLPQEVAPSP-
Mflv_2101|M.gilvum_PYR-GCK -GSEPFVVPHPSQMQPTAVPYPFVPPPVPAQPGPPR-
MAV_2532|M.avium_104 AGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVPGP
MSMEG_0346|M.smegmatis_MC2_155 PGAEPFVPPAPAAMTPTQ-------------------
Rv1966|M.tuberculosis_H37Rv -------------------------------------
Mb0604|M.bovis_AF2122/97 -------------------------------------
MLBr_02589|M.leprae_Br4923 -------------------------------------
MAB_4153c|M.abscessus_ATCC_199 -------------------------------------