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MTVRAGENRLHSCWWALILVAALSVFVAATAAAFTGIFRSYVPVTLTSDRAGLVMENGARVKMRGVQVGR VAEIRGGTGPAELLLEIDPEQIARIPANVQAQISVTTAFGSKFVDLVPPEHPSTDRLAAGAVLMSTNVST EVNTVFENIVDLLDMVDPAKLNAVLSAIADAVRGQGPRMGEATTGLNEVLTALNARSDTIRGDWRSFKGF NDTYNAVAEDIVAILDGASTTSSTVVAHSAQLDTLLLNVTGFAESGTNLLTTSKDSLVDAVNTLAPTTAL LHKYDPIYTCWLQGATWFLENGGWDVWGGANGKSIQLDIALLAGNDPYRFPDNLPRIAAKGGPGGAPGCG SLPDATKNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVTRAVPEQPSIRQCIPGPAIGPVPYPGA PPYGAALYGPGGTPLWPGLPPAPPPPTQEGAPAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0363 | - | - | 100% (454) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_3982 | - | 0.0 | 72.12% (452) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4399 | - | e-157 | 60.36% (449) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0175 | mce1A | 2e-55 | 33.25% (403) | MCE-family protein MCE1A |
| M. gilvum PYR-GCK | Mflv_2101 | - | 1e-153 | 62.22% (442) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1966 | mce3A | 1e-175 | 70.71% (420) | MCE-family protein MCE3A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 9e-57 | 34.75% (400) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 2e-49 | 33.71% (353) | MCE-family protein |
| M. marinum M | MMAR_2882 | mce3A | 0.0 | 67.93% (449) | MCE-family protein Mce3A |
| M. avium 104 | MAV_2532 | - | 1e-139 | 61.56% (411) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0346 | - | 1e-165 | 63.82% (445) | virulence factor |
| M. thermoresistible (build 8) | TH_2548 | - | 1e-172 | 66.28% (430) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 1e-156 | 60.80% (449) | MCE-family protein Mce3A_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1966|M.tuberculosis_H37Rv ---MRRGPGRHRLHDAWWTLILFAVIGVAVLVTAVSFTGSLRSTVPVTLA
MMAR_2882|M.marinum_M ---MGRGPGKHRLHDAWWTVILFAAIVAAILVTTVSFTGTLRPHVAVTLT
Mvan_0363|M.vanbaalenii_PYR-1 ---MTVRAGENRLHSCWWALILVAALSVFVAATAAAFTGIFRSYVPVTLT
TH_2548|M.thermoresistible__bu -------------------VILVAAVTVFIVVTSAFFRGAFTATVPVTLS
Mflv_2101|M.gilvum_PYR-GCK -----MDD--DGLKPGWWTLILVAVFAVAIFVTYALFTGSLKSTVPVTLT
MUL_3918|M.ulcerans_Agy99 -----MDDRKEGLHPAWHTLILVLLFVAAMWVTYALFMGSLRSVVPVTLT
MAV_2532|M.avium_104 ----------------------------------------------MTLT
MSMEG_0346|M.smegmatis_MC2_155 ---MQPRFRDARIKPAWWTWILIAALGVFFFTTGSLFAGTFRSFVPVTLV
Mb0175|M.bovis_AF2122/97 MTTPGKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQLTML
MLBr_02589|M.leprae_Br4923 MTSSTKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSKLTML
MAB_4153c|M.abscessus_ATCC_199 -----MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKPITVV
:*:
Rv1966|M.tuberculosis_H37Rv ADRSGLVMDSGAKVMMRGVQVGRVAQIGRIEW-AQNGASLRLEIDPDQIR
MMAR_2882|M.marinum_M SERSGLVMDAGAKVMLRGVQVGRVRQID-----SNHGASLELEIDPDQIR
Mvan_0363|M.vanbaalenii_PYR-1 SDRAGLVMENGARVKMRGVQVGRVAEIRG----GTGPAELLLEIDPEQIA
TH_2548|M.thermoresistible__bu AERSGIILEPNAKVKMRGVEVGKVAHVEA----TGGAAQVRLELFPEQLA
Mflv_2101|M.gilvum_PYR-GCK SDRAGLVMETNAKVKLRGVQVGRVSDISVTGR-QDPTVALQLEIDPDQVQ
MUL_3918|M.ulcerans_Agy99 SERSGLVMETNAKVKLRGVQVGRVASIVGGGK-GATPVALTLEIDSDQIR
MAV_2532|M.avium_104 ADRSGLIMEPGAKVKLRGVQVGRVTSIHSGD-----PVTLRLELYPEQLQ
MSMEG_0346|M.smegmatis_MC2_155 SDRSGLVMETGAKVKLNGVEVGRVSEIRGGAS-G---VSLQLEIEPDQIR
Mb0175|M.bovis_AF2122/97 SARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDPRYIH
MLBr_02589|M.leprae_Br4923 ADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYPRYLS
MAB_4153c|M.abscessus_ATCC_199 SPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNAKDLR
: *:*:::: ..:: .*:::*:* : . . * : . :
Rv1966|M.tuberculosis_H37Rv YIPANVEAQISATTAFGAKFVDLVMPQNPSRARLSAGAVLHSKNVSTEIN
MMAR_2882|M.marinum_M YIPANVEAQISATTAFGAKFVDLVIPPTPSRARLAAGAVLHSKNVSTEIN
Mvan_0363|M.vanbaalenii_PYR-1 RIPANVQAQISVTTAFGSKFVDLVPPEHPSTDRLAAGAVLMSTNVSTEVN
TH_2548|M.thermoresistible__bu RIPANVMAEIDSTTAFGAKFVNLVYPDNPSEERLTAGAVLHADRVATEVN
Mflv_2101|M.gilvum_PYR-GCK YIPANVEAQIRATTIFGAKFVDLVFPDDPSNQRLEAGQVLQSRNVTTEVN
MUL_3918|M.ulcerans_Agy99 YIPANVQAEIRATTVFGAKFVDLIYPEDPSPQRLKAGQVLMSRNVTSEAN
MAV_2532|M.avium_104 YIPANVTAQITATTAFGGKYVDLQIPESPSPRRLAAGAVVRSRNVTTEVN
MSMEG_0346|M.smegmatis_MC2_155 FIPANVEARITATTAFGAKYVDLSYPDNPTGQHLAAGAVLRSRNVSTEVN
Mb0175|M.bovis_AF2122/97 LIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVTTEIN
MLBr_02589|M.leprae_Br4923 LIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVTTEIN
MAB_4153c|M.abscessus_ATCC_199 LIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVALEVN
**:*. . * ** **.* *.: * *: : . .: *: * *
Rv1966|M.tuberculosis_H37Rv TVFENVVDLLNMIDPLKLNAVLTAVADAVRGQGERIGQATTDLNEVLEAL
MMAR_2882|M.marinum_M TVFENVVDLLNMIDPLKLNAVLSAVAEGVRGQGERIGQATTDLNQVLQAL
Mvan_0363|M.vanbaalenii_PYR-1 TVFENIVDLLDMVDPAKLNAVLSAIADAVRGQGPRMGEATTGLNEVLTAL
TH_2548|M.thermoresistible__bu TVFENVVELIGMIDPAKLNAVLSATAEAVRGQGERIGEATTALSEVLQAV
Mflv_2101|M.gilvum_PYR-GCK TVFQNLVAVLDQVDAAKLNSTLSALADGVRGQGERIGRATTDANQVLLAL
MUL_3918|M.ulcerans_Agy99 TVFQNLVAVLDQIDPAKLNAALSALAEGLRGQGPLIGQATTDANQVLLEL
MAV_2532|M.avium_104 TVFQNLVAVLNQVDTPKLNAVLTALGDGLRGKGEALGEATTDLNEVLGAI
MSMEG_0346|M.smegmatis_MC2_155 TVFENLTDVLKMVDPAKLNAVLSALAEGFRGQGERMGQAITDANEVLMAI
Mb0175|M.bovis_AF2122/97 TLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTVLDDL
MLBr_02589|M.leprae_Br4923 TLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSVLDDV
MAB_4153c|M.abscessus_ATCC_199 TVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQYLDQL
*:*:.:. : :*. :** .*:* .:.. * * :*.. . . * :
Rv1966|M.tuberculosis_H37Rv NARGDTIGGNWRSLKNFTDTYDAAAQDILTILNAASTTSATVVNHSTQLD
MMAR_2882|M.marinum_M NARRDTLRQNWRSLRDFSNTYDAAARDILTILDAASTTSTTVVDHARSLD
Mvan_0363|M.vanbaalenii_PYR-1 NARSDTIRGDWRSFKGFNDTYNAVAEDIVAILDGASTTSSTVVAHSAQLD
TH_2548|M.thermoresistible__bu NDRSGLIREDWRAFKAFNDTYAAVAEDLLTVLDAASVTSETLVDHSAALD
Mflv_2101|M.gilvum_PYR-GCK NPRNETITEDLRALDQFNQTYSAAAQNILATLDAASTTSTTVVNQAKELD
MUL_3918|M.ulcerans_Agy99 NPRYETVTADLRAVKDFNDTFSAAAQDILDTLNALSTTSTTITGHSTQLD
MAV_2532|M.avium_104 NPRSETIRADSRALEGFSDTYSAAAHDIVTVLDAGSTTSATVSNNAQALD
MSMEG_0346|M.smegmatis_MC2_155 NPRQDTIREDWRAMGEVSAAYDHAADDIVKILDAGTTTAETVTSHRSELD
Mb0175|M.bovis_AF2122/97 NSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQAELD
MLBr_02589|M.leprae_Br4923 NSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQKDLD
MAB_4153c|M.abscessus_ATCC_199 NPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQQDLK
* : : : . : * ::. *: . : *: : *.
Rv1966|M.tuberculosis_H37Rv ALLLNAIGLSNAGTNLLGSSRDNLVGAADILAPTTSLLFKYNPEYTCFLQ
MMAR_2882|M.marinum_M SLLLNVIGLADTGTNLLANNRESLTTSINILEPTTNLLFKYNPEYTCLLQ
Mvan_0363|M.vanbaalenii_PYR-1 TLLLNVTGFAESGTNLLTTSKDSLVDAVNTLAPTTALLHKYDPIYTCWLQ
TH_2548|M.thermoresistible__bu ALLLSVTGFGRAGSGLLEESRDDLVTAARVLEPTTALLHRYSPSYTCLLQ
Mflv_2101|M.gilvum_PYR-GCK ALLLAAIGLSNSGIDLLAPNQANLIKAVNTLAPTTNLLHKYSPSYTCLLL
MUL_3918|M.ulcerans_Agy99 ALLLATIGLSNTGISLLAPNQANLIKAINALEPTTNLLYKYSPEYTCLLE
MAV_2532|M.avium_104 SLLLNVIGLSHSGIGLIGPNKDNLVHGVNLLESTTRLLMKYNPELTCTLL
MSMEG_0346|M.smegmatis_MC2_155 TLLLNVIGFGRAGVDLLAPSFTNLVNAVNGFAPTSDLLMKYQPEYTCLLD
Mb0175|M.bovis_AF2122/97 SALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELFCTIR
MLBr_02589|M.leprae_Br4923 QVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIFCTLR
MAB_4153c|M.abscessus_ATCC_199 ATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIPCTLQ
** . *:. : * . : ..: ** *.* * :
Rv1966|M.tuberculosis_H37Rv GAKWYLDNGGYAAWGG-----------ADGRTLQLDVALLFGND------
MMAR_2882|M.marinum_M GTKWYLDNGGYAAWGG-----------ADGRTLQLDVALLLGND------
Mvan_0363|M.vanbaalenii_PYR-1 GATWFLENGGWDVWGG-----------ANGKSIQLDIALLAGND------
TH_2548|M.thermoresistible__bu GAQLLLENGAYDVYGG-----------ADGRSLIFDVGLLPGND------
Mflv_2101|M.gilvum_PYR-GCK GAKHLLDEGGYEAPG------------GNGRTLVLDTSLSFGDD------
MUL_3918|M.ulcerans_Agy99 GAKYLLDHGGYEAPG------------GNGRSLVLDAALALGDD------
MAV_2532|M.avium_104 GSKYDAEFFGDVAGG------------HNGYSVTLDVALLLGDE------
MSMEG_0346|M.smegmatis_MC2_155 GSVSLLQNGHVDAFG------------GNGRSAIFDIGLLLGND------
Mb0175|M.bovis_AF2122/97 NFYDADPLAKAAAGGGNGYSLRTNSEILSGIGISLLSPLALATNGAAIGI
MLBr_02589|M.leprae_Br4923 NYHDIEPKVTSFLGG-NGYSINDHVELLSGLGFLLNPTSAISIIGAGV--
MAB_4153c|M.abscessus_ATCC_199 AISKALVTFTPLIGG-------------VRPGLFLTNSFPLGAP------
* : .
Rv1966|M.tuberculosis_H37Rv ------------------------------PYVYPDNLPVVAAKGGP--G
MMAR_2882|M.marinum_M ------------------------------PYVFPDNLPLVAARGGP--G
Mvan_0363|M.vanbaalenii_PYR-1 ------------------------------PYRFPDNLPRIAAKGGP--G
TH_2548|M.thermoresistible__bu ------------------------------LYEYPRHLPVVAAKGGP--G
Mflv_2101|M.gilvum_PYR-GCK ------------------------------PYQYPRHLPIIGAKGGP--G
MUL_3918|M.ulcerans_Agy99 ------------------------------PYRFPDNLPIIGAKGGP--G
MAV_2532|M.avium_104 ------------------------------AYRYPDNLPINGAKGGP--G
MSMEG_0346|M.smegmatis_MC2_155 ------------------------------PYHYPDDLPIVGAKGGP--G
Mb0175|M.bovis_AF2122/97 GLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARGGP--G
MLBr_02589|M.leprae_Br4923 -LSQGLLAP-------LG--LAGVVNGAANPYIYPENLPRVNARGGP--G
MAB_4153c|M.abscessus_ATCC_199 ------------------------------VYTYPDSLPIVNASGGPNCR
* :* ** * ***
Rv1966|M.tuberculosis_H37Rv GRPGCGPLPDATHNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVT
MMAR_2882|M.marinum_M GAPGCGSLPDATKNFPVRQLVTDTGWGTGLDIRPNPGIGHPCWADYLPVT
Mvan_0363|M.vanbaalenii_PYR-1 GAPGCGSLPDATKNFPVRQLVTNTGWGTGLDIRPNPGIGHPCWANYFPVT
TH_2548|M.thermoresistible__bu GRPGCGSLPDVAENFPVRKLITDTGWGTGLDIRPNPGIGSPCFANWFPVT
Mflv_2101|M.gilvum_PYR-GCK GKPGCGSLPKVAENWPVRNLVTNTGFGSGLDWRPNPGIAFPTYANYLPVT
MUL_3918|M.ulcerans_Agy99 GKPGCGSLPIVDNNWPVRNLVTNTGFGTGMDWRPNPGIGFPGWANYFPVT
MAV_2532|M.avium_104 GQPGCGSLPDVSKNFPLRYLVTNTGWGRGLDMRPNPGIGFPGYVDYLPVT
MSMEG_0346|M.smegmatis_MC2_155 GKPGCGSLPDVAKNFPVRQLVTNTGWGTGLDIRPNPGIGFPGWANYFPVT
Mb0175|M.bovis_AF2122/97 GAPGCWQPITRDLWP-APYLVMDTG------------------ASLAPYN
MLBr_02589|M.leprae_Br4923 GAPGCWQHITRDLWP-TPELVMDTG------------------NSIAPYN
MAB_4153c|M.abscessus_ATCC_199 GLPNIPTKMQNGSWFRSPFLVTDNAY-----------------IPYKPLE
* *. *: :.. *
Rv1966|M.tuberculosis_H37Rv RAVPEPPSIRQCIPGPAIG--PNP----------------------AAGE
MMAR_2882|M.marinum_M RAVPQPPSVRPCLPGPAIG--PNPGGPPYGAALYGPGGVPLWPGVPPAPT
Mvan_0363|M.vanbaalenii_PYR-1 RAVPEQPSIRQCIPGPAIGPVPYPGAPPYGAALYGPGGTPLWPGLPPAPP
TH_2548|M.thermoresistible__bu RAVPEPPSIRTCLPGPAIGPVPYPGAPPYGAPMYGPGGVPLWPGVPPAGP
Mflv_2101|M.gilvum_PYR-GCK RAVPEPPSVRNLFGGPAIGPIPYPGAPAYGAQLYAPDGTPLWPGLPPAPP
MUL_3918|M.ulcerans_Agy99 RGTPEPPSIRNLFGGPAPGPIPYPGAPPYGAELYAPDGTPLWPGLPPAPP
MAV_2532|M.avium_104 RGTPQPPSLR-HPGGTAPGPMPYPGAPPYGAPQYAPDGTPLYPGLPPAPP
MSMEG_0346|M.smegmatis_MC2_155 RGIPQPPIIRNLGGGPAPGPIPYPGAPPYGADLYADDGTPLWPGLPPAPP
Mb0175|M.bovis_AF2122/97 HMEVGSPYAVEYVWGRQVGDNTINP-------------------------
MLBr_02589|M.leprae_Br4923 HLDSGSPYAIEYVWGRQVGDNTINP-------------------------
MAB_4153c|M.abscessus_ATCC_199 ELQVNAPDTLQYLYNGAFAKRSEF--------------------------
. * . . .
Rv1966|M.tuberculosis_H37Rv QP------------------------------------------------
MMAR_2882|M.marinum_M EP--------------APIPEPLAPQQETETPSP----------------
Mvan_0363|M.vanbaalenii_PYR-1 PP--------------TQEGAPAP--------------------------
TH_2548|M.thermoresistible__bu EP--------------GPAQPDSNGQTPP---------------------
Mflv_2101|M.gilvum_PYR-GCK PG--APRDPGPRP-GSEPFVVPHPSQMQPTAVPYPFVPPPVPAQPGPPR-
MUL_3918|M.ulcerans_Agy99 PG--APRESGPTP-GSEPFVVPASAQAQPTPLP----PAPLPQEVAPSP-
MAV_2532|M.avium_104 PG--RPRDAGPPPAGSEPFTPPVPGAIQPTCGVLNQVCEPLPPPPNVPGP
MSMEG_0346|M.smegmatis_MC2_155 PSDQPPPDPNNPPPGAEPFVPPAPAAMTPTQ-------------------
Mb0175|M.bovis_AF2122/97 --------------------------------------------------
MLBr_02589|M.leprae_Br4923 --------------------------------------------------
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------------------