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M. vanbaalenii PYR-1 Mvan_4246 (-)

annotation: alpha/beta hydrolase fold
coordinates: 4555594 - 4556460
length: 288

TEFESVWSDLQGVPFSQGYLDAGGVRTRYLHAGDPGKPALVFLHGSGGHAEAYVRNLEAHAEHFSTWSID
MLGHGYTDKPGHPLEIAHYVEHLAGFLDAIGASRAHISGESLGGWVAARFAADRPERVERLVLNTAGGSQ
ADPEVMKRIVTLSMAAAENPTWETVQARIKWLMADKTKDYDDIVASRQRVYRQPGFVNAMRDIMALQDPE
IRARNLLGTNEYGAITAPTLVVWTSDDPTADVKEGRRIASMIPGARFEVMPGCGHWPQYEDPKTFDRLHL
DFLLGRA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4246--100% (288)alpha/beta hydrolase fold
M. vanbaalenii PYR-1Mvan_0538-3e-4937.91% (277) alpha/beta hydrolase fold
M. vanbaalenii PYR-1Mvan_2912-4e-2629.59% (267) alpha/beta hydrolase fold

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3600cbphD9e-2530.29% (274) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD
M. gilvum PYR-GCKMflv_2400-1e-16294.10% (288) alpha/beta hydrolase fold
M. tuberculosis H37RvRv3569cbphD9e-2530.29% (274) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD
M. leprae Br4923MLBr_02269-3e-0924.24% (264) putative hydrolase
M. abscessus ATCC 19977MAB_3034-1e-2128.03% (264) hydrolase
M. marinum MMMAR_4778bphD_11e-14184.32% (287) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1
M. avium 104MAV_0877-1e-14584.67% (287) 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase
M. smegmatis MC2 155MSMEG_4867-1e-14886.16% (289) 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase
M. thermoresistible (build 8)TH_4528-1e-15087.59% (282) PUTATIVE alpha/beta hydrolase fold
M. ulcerans Agy99MUL_4140bphD1e-2631.52% (276) 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD

CLUSTAL 2.0.9 multiple sequence alignment


Mb3600c|M.bovis_AF2122/97           ----------------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV
Rv3569c|M.tuberculosis_H37Rv        ----------------MTATEELTFESTSRFAEVDVDG-PLKLHYHEAGV
MUL_4140|M.ulcerans_Agy99           ------------MTVTQSKTAEHTFESTSRYAEVDVDG-PLKLHYHEAGV
Mvan_4246|M.vanbaalenii_PYR-1       -----------MTEFESVWSDLQGVPFSQGYLDAGG----VRTRYLHAGD
Mflv_2400|M.gilvum_PYR-GCK          -----------MAEFESVWSDLQGVAFSQGYLDAGG----VRTRYLHAGD
TH_4528|M.thermoresistible__bu      -----------------VWSDLQGVAFTQGYLDAGG----VRTRYLHAGE
MSMEG_4867|M.smegmatis_MC2_155      MTSTAAAGTASAVEFESIWSDLQGVAFSQGYLDVPVGDRKIRTRYLHAGN
MMAR_4778|M.marinum_M               -----------MTDFESVWSDLQGVMFEQGYLTTAQG---VRTRYLRAGE
MAV_0877|M.avium_104                -----------MAEFESIWSDLQGVAFEQGYLD-AGG---IRTRYLRAGD
MAB_3034|M.abscessus_ATCC_1997      --------MNPPPRLLRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTI
MLBr_02269|M.leprae_Br4923          ---------------------------------------MINLAYEDRGT
                                                                             .        

Mb3600c|M.bovis_AF2122/97           G----------NDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQ
Rv3569c|M.tuberculosis_H37Rv        G----------NDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQ
MUL_4140|M.ulcerans_Agy99           G----------NDQTVVLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQ
Mvan_4246|M.vanbaalenii_PYR-1       P----------GKPALVFLHGSGGHAEAY---VRNLEAHAEHFSTWSIDM
Mflv_2400|M.gilvum_PYR-GCK          P----------ADPALVFLHGSGGHAEAY---VRNLEAHAEHFSTWSIDM
TH_4528|M.thermoresistible__bu      A----------DKPVLIFLHGSGGHAEAY---VRNLEAHAEHFSTWSIDM
MSMEG_4867|M.smegmatis_MC2_155      P----------QAPALLFLHGSGGHAEAY---VRNLAAHAEHFSTWSIDM
MMAR_4778|M.marinum_M               P----------DRPLLMLLHGSGGHAEAY---VRNLAAHAEHFWTWAIDM
MAV_0877|M.avium_104                P----------GKPVLVLLHGSGGHAEAY---VRNLAAHADHFWTWSIDM
MAB_3034|M.abscessus_ATCC_1997      HGYRRAYRIAGSGPVLLLIHGIGDNSATWD---SVHAQLAEHFTVIAPDL
MLBr_02269|M.leprae_Br4923          G------------EPVVFIAGRGGAGRTWQP-HQVPAFLAAGYRVITFDN
                                                   :::: * *  . ::          *  : . : * 

Mb3600c|M.bovis_AF2122/97           PGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRF
Rv3569c|M.tuberculosis_H37Rv        PGYGHSDKRAEHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRF
MUL_4140|M.ulcerans_Agy99           PGYGHSDKRAEHGQFNHYAARALKELFDQLGLGRVLLVGNSLGGGTAVRF
Mvan_4246|M.vanbaalenii_PYR-1       LGHGYTDKPGHPLEIAHYVEHLAG-FLDAIGASRAHISGESLGGWVAARF
Mflv_2400|M.gilvum_PYR-GCK          LGHGYTDKPGHPLEIPHYVDHLAA-FLDAIGARRAHISGESLGGWVAARI
TH_4528|M.thermoresistible__bu      LGHGYTDKPGHPLEVRHYVEHLAA-VLDAIGADRAHISGESLGGWVASRF
MSMEG_4867|M.smegmatis_MC2_155      LGHGYTDKPGHPLEVAHYVDHVIA-FLDTIGAQRAHISGESLGGWVAARV
MMAR_4778|M.marinum_M               LGHGYTDKPGHPLEIRHYVEHLMA-VLRAIGAQRASISGESLGGWVAARA
MAV_0877|M.avium_104                LGHGYTDKPGHPLEVRHYVEHLMT-VLRTIGVERASISGESLGGWVAARA
MAB_3034|M.abscessus_ATCC_1997      LGHGQSDKPRADYSVAAYANGMRD-LLAVLDIERVTVVGHSLGGGVAMQF
MLBr_02269|M.leprae_Br4923          RGIGATEN-TEGFTTQTMVADTAV-LIESLGAVPARIVGVSMGSFIAQEL
                                     * * :::          .      .:  :.   . : * *:*.  * . 

Mb3600c|M.bovis_AF2122/97           ALDYPARAGRLVLMGPGGLS------INLFAPDPTEGVKRLSKFSVA-PT
Rv3569c|M.tuberculosis_H37Rv        ALDYPARAGRLVLMGPGGLS------INLFAPDPTEGVKRLSKFSVA-PT
MUL_4140|M.ulcerans_Agy99           ALDYPDRAGRLVLMGPGGLS------INLFAPDPTEGVKRLGKFSVA-PT
Mvan_4246|M.vanbaalenii_PYR-1       AADRPERVERLVLNTAGGS---------QADPEVMKRIVTLSMAAAENPT
Mflv_2400|M.gilvum_PYR-GCK          AADRPERVDRLVLNTAGGS---------QADPEVMKRIITLSMAAAENPT
TH_4528|M.thermoresistible__bu      AIDRPDRLDRLVLNTAGGS---------QADPEVMKRIITLSMAAAENPS
MSMEG_4867|M.smegmatis_MC2_155      AVDHPDRVEKLVLNTAGGS---------QADPEVMKRIITLSMAAAENPT
MMAR_4778|M.marinum_M               AVDHPEAVERLVLNTAGGS---------QADPEVMARIVTLSMAAAENPT
MAV_0877|M.avium_104                AIDHPDVVDRLVLNTAGGS---------QADPVVMQRIIALSMAAAENPT
MAB_3034|M.abscessus_ATCC_1997      TYQFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDALGLLRLPMAMPM
MLBr_02269|M.leprae_Br4923          MVARPELVRAAVLMATRGR-------LDRTRQFFHAAEAEFHDSGIQLPS
                                        *      :*  . *                      :       * 

Mb3600c|M.bovis_AF2122/97           REN--LEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAG
Rv3569c|M.tuberculosis_H37Rv        REN--LEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMGKSFAG
MUL_4140|M.ulcerans_Agy99           REN--LEAFLRVMVYDQKLITPELVDQRFELARTPESLAATRAMGKSFAA
Mvan_4246|M.vanbaalenii_PYR-1       WET--VQARIKWLMADKTKDYDDIVASRQRVYRQPGFVNAMRDIMALQDP
Mflv_2400|M.gilvum_PYR-GCK          WDT--VQARIKWLMADKSKDYDDIVASRQRVYRQPGFANAMRDIMALQDP
TH_4528|M.thermoresistible__bu      WDT--VQARITWLMADKSKGYDDIVASRQKIYRQPGFVDAMRNIMALQDP
MSMEG_4867|M.smegmatis_MC2_155      WDT--VQARIKWLMADKSKDYDDIVASRQRVYRQPGFVAAMSDIMALQDP
MMAR_4778|M.marinum_M               WET--VQARIKWLMADKSKDYDDLVASRQRIYRQPGFVAAMRDIMALQDP
MAV_0877|M.avium_104                WET--VQARIKWLMADKSRDYDDLVASRQRVYRQPGFVAAMRDIMALQDP
MAB_3034|M.abscessus_ATCC_1997      LRLGGAVARATFGRASMARDIPDVLRVLADLPEPRASAAFTRTLRAVVDW
MLBr_02269|M.leprae_Br4923          GYN--AKVRLLENLSRKTLNDDVAVADWIAMFN----MWPIKSTPGLRCQ
                                           .                :     :                   

Mb3600c|M.bovis_AF2122/97           ADFEAGMMWREVY-RLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHV
Rv3569c|M.tuberculosis_H37Rv        ADFEAGMMWREVY-RLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHV
MUL_4140|M.ulcerans_Agy99           ADFELGMMWREVY-KLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHV
Mvan_4246|M.vanbaalenii_PYR-1       EIRARNLLGTNEYGAITAPTLVVWTSDDPTADVKEGRRIASMIPGARFEV
Mflv_2400|M.gilvum_PYR-GCK          EIRQRNLLGPNEYGAITAPTLVVWTSDDPTADVEEGRRIASMIPGARFEV
TH_4528|M.thermoresistible__bu      EIRARNLLGPEEYGAITAPTLVVWTSDDPTADVDEGKRIASMIPGARFEV
MSMEG_4867|M.smegmatis_MC2_155      QIRARNLLGQAEYGSITAPTLVVWTSDDPTADVAEGRRIASMIPGARFEV
MMAR_4778|M.marinum_M               QIRARNLLGPAEYGAIKAPTLVLWTSHDPTADVTEGRRIASMIPGARFEV
MAV_0877|M.avium_104                EIRARNILGPAEYGSIIAPTLVLWTSDDPTADVSEGRRIASMIPGARFEV
MAB_3034|M.abscessus_ATCC_1997      RGQVVTMLD-RCYLTESVPVQLIWGSDDLVIPVSHGHLAHAAMPGSALEI
MLBr_02269|M.leprae_Br4923          TDVAPQNNRLPAYRSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQ
                                                *     *. ::   .* .     .      :* .    

Mb3600c|M.bovis_AF2122/97           FGQCGHWVQVEKFDEFNKLTIEFLGGGR----------------------
Rv3569c|M.tuberculosis_H37Rv        FGQCGHWVQVEKFDEFNKLTIEFLGGGR----------------------
MUL_4140|M.ulcerans_Agy99           FGQCGHWAQVEKFDEFNRLTIDFLGGAR----------------------
Mvan_4246|M.vanbaalenii_PYR-1       MPGCGHWPQYEDPKTFDRLHLDFLLGRA----------------------
Mflv_2400|M.gilvum_PYR-GCK          MPGCGHWPQYEDPKTFDRLHLDFLLGRA----------------------
TH_4528|M.thermoresistible__bu      MPGCGHWPQYEDPATFNRLHIDFLLGRS----------------------
MSMEG_4867|M.smegmatis_MC2_155      MPGCGHWPQYEDPATFNALHLDFLLGR-----------------------
MMAR_4778|M.marinum_M               MSGCGHWPQYEDAKSFNRRHLDFLMGH-----------------------
MAV_0877|M.avium_104                MPGCGHWPQYEDAKTFNRLHLDFLLGR-----------------------
MAB_3034|M.abscessus_ATCC_1997      FDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRRLLRTGVTEHAI
MLBr_02269|M.leprae_Br4923          IPDAGHLGFFERPEAVNAAALQFFAGVKGEWP------------------
                                    :  .**    :    .     :*: .                        

Mb3600c|M.bovis_AF2122/97           ----------------------
Rv3569c|M.tuberculosis_H37Rv        ----------------------
MUL_4140|M.ulcerans_Agy99           ----------------------
Mvan_4246|M.vanbaalenii_PYR-1       ----------------------
Mflv_2400|M.gilvum_PYR-GCK          ----------------------
TH_4528|M.thermoresistible__bu      ----------------------
MSMEG_4867|M.smegmatis_MC2_155      ----------------------
MMAR_4778|M.marinum_M               ----------------------
MAV_0877|M.avium_104                ----------------------
MAB_3034|M.abscessus_ATCC_1997      SGAARTRMAVLDAMGTDERSAT
MLBr_02269|M.leprae_Br4923          ----------------------