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MQIDEYLAATSDNKPDHCDIDISRKAFWARPADEKMEIFAALRAEHPVSWQRPIEGAVVPDPDDPGFWAV VRHADIRQVSHDNRTFISGQGVMFDRLPPLFLEMALSFLAMDPPRHDKLRRLVNKAFTPRQITRIEDKID LVAKEVVDGFIADPTGEIEFMDRCASRLPLRMFCEMFGVPDHLEERTVEHVIGSVSWSDEEILAGRSAAD MQLESIGGLHQVAQEIIEMRRQQPGDDIISSLVHAEIDGQMLTDFEISSFFCLLSGAATDTTKTTLGHAV RALSLFPEQHAWLLEDFDNRIGTAVEEFIRWATPLLTFTRTAAVETELGGRRIMPGDRVVMIYQAGNFDE DVFDRPRELDLARSPNPHVSFGGGGVHYCLGANLARSMLRAELRELLLRITEFETDAPDMLATNFIHGLK RLPFRFTPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3992 | - | - | 100% (429) | hypothetical protein Mvan_3992 |
| M. vanbaalenii PYR-1 | Mvan_2234 | - | 3e-96 | 43.88% (417) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0012 | - | 3e-94 | 41.01% (417) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 1e-68 | 37.90% (409) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_2640 | - | 1e-119 | 50.12% (415) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 1e-68 | 37.90% (409) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-30 | 28.96% (328) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0611 | - | 1e-63 | 35.95% (395) | putative cytochrome P450 |
| M. marinum M | MMAR_3761 | cyp268A2 | 1e-122 | 50.24% (420) | cytochrome P450 268A2 Cyp268A2 |
| M. avium 104 | MAV_1734 | - | 1e-126 | 51.07% (419) | putative cytochrome P450 124 |
| M. smegmatis MC2 155 | MSMEG_4619 | - | 1e-122 | 51.47% (408) | putative cytochrome P450 126 |
| M. thermoresistible (build 8) | TH_2564 | - | 1e-103 | 44.90% (412) | PUTATIVE NikQ protein |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 3e-70 | 36.36% (407) | cytochrome P450 124A1, Cyp124A1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGS-LDFWALDDDVRDGAFAT
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGS-LDFWALDDDVRDGAFAT
MUL_1282|M.ulcerans_Agy99 MDLSTNLNTGLLPRVNGTPPPEVPLADIELGS-LEFWGRDDDFRDGAFAT
MMAR_3761|M.marinum_M --------MTAIS------ASVRPYDTIDLSS-RAFWASSASQRESSFSE
MAV_1734|M.avium_104 --------MAVLTGESGTDRSRRAYDEIDLSS-RAFWSGTAAERERSFAA
Mflv_2640|M.gilvum_PYR-GCK --------MTVTAHTPPAASAGRPYDPVDLSS-RAFWAGTADQREASFAQ
MSMEG_4619|M.smegmatis_MC2_155 --------MTVLPIT-------RPYDAVDLSS-RAFWATTAADREVAFAQ
Mvan_3992|M.vanbaalenii_PYR-1 --------MQIDEYLAATSDNKPDHCDIDISR-KAFWARPADEKMEIFAA
TH_2564|M.thermoresistible__bu --------MTTETTEPR--VDRPPFDPICIST-LEFWSKTAEEREPYFKI
MAB_0611|M.abscessus_ATCC_1997 ---------------MVQAQHPHLPDGIDFTD-PELFVHGIPERE--LAE
MLBr_02088|M.leprae_Br4923 ------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDP
: :
Mb2289|M.bovis_AF2122/97 LRREAPISFWPTIELPGFV--AGNGHWALTKYDDVFYASRHPDIFSSYPN
Rv2266|M.tuberculosis_H37Rv LRREAPISFWPTIELPGFV--AGNGHWALTKYDDVFYASRHPDIFSSYPN
MUL_1282|M.ulcerans_Agy99 LRREAPISFWPPIELAGLT--AGKGHWALTKHDDIHFASRHPEIFHSSPN
MMAR_3761|M.marinum_M LRAERPVSWHPPVEDALIQDPNDPGFWAVTRRADIVAVSRTNEVFLSGNG
MAV_1734|M.avium_104 LRAERPVSWHPPVEDSLLPDPTDPGFWAVTRRADIVTVSRNNDVFLSGHG
Mflv_2640|M.gilvum_PYR-GCK LREARPLSWHPPVEDALMPDADDPGFWAVTRHADIVEVSRNSEVFLSGKG
MSMEG_4619|M.smegmatis_MC2_155 LRAERPVSWHPPVEDALMHDPDDKGFWAVTRHADIVAISRDSETFLSGQG
Mvan_3992|M.vanbaalenii_PYR-1 LRAEHPVSWQRPIEGAVVPDPDDPGFWAVVRHADIRQVSHDNRTFISGQG
TH_2564|M.thermoresistible__bu LRDERPVSWHPPIEGTMMPPPVD-GVWAITRHEDIEYVSKNPQLFCSGQG
MAB_0611|M.abscessus_ATCC_1997 LRHTEPIWWNHTERG--VAGFDDDGFWVVSKHKDVKEVSLRCEVFSSEQN
MLBr_02088|M.leprae_Br4923 GTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLK
*. . . .. * .
Mb2289|M.bovis_AF2122/97 ITINDQT-----PELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIE
Rv2266|M.tuberculosis_H37Rv ITINDQT-----PELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIE
MUL_1282|M.ulcerans_Agy99 IVIHDQT-----PELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIE
MMAR_3761|M.marinum_M VLFENVP-----AELLEASQSFLAMDPPRHTKLRKLVSAAFTPRQVRRIE
MAV_1734|M.avium_104 VMFESIP-----AELLEASQSFLAMDPPRHTKLRKLAHAALSPRQVRRIE
Mflv_2640|M.gilvum_PYR-GCK VLFENVP-----EELLEASQSFLAMDPPRHTLIRKVVHAAFTPRQVRRIE
MSMEG_4619|M.smegmatis_MC2_155 VLFENVP-----QELLEASQSFLAMDAPRHTLIRKLVHSAFTPRQVARIE
Mvan_3992|M.vanbaalenii_PYR-1 VMFDRLP-----PLFLEMALSFLAMDPPRHDKLRRLVNKAFTPRQITRIE
TH_2564|M.thermoresistible__bu TQVEAIP-----PEMLVLAESFLSMDGEEHSSLRRLISSVFTPRRLSIIR
MAB_0611|M.abscessus_ATCC_1997 TAIPRYLPTTPRERIDATRLIMLNMDPPRHSRLRHIISRGFTPRAISRLR
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
. :: :* * :* : ::*: : :.
Mb2289|M.bovis_AF2122/97 AAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQ
Rv2266|M.tuberculosis_H37Rv AAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQ
MUL_1282|M.ulcerans_Agy99 ASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHE
MMAR_3761|M.marinum_M DSIKINAKGIVDELRMAGGG--VDFVEHCAKELPIRTLSDMVGIPEADRE
MAV_1734|M.avium_104 DSIKANAKAIVEELRAAGSG--CDFVDHCAKELPIRTLSDMMGIPESERE
Mflv_2640|M.gilvum_PYR-GCK DSIRANARDIVTELRAAGSG--VDFVSHCAKELPVRTLADMVGIPDSERH
MSMEG_4619|M.smegmatis_MC2_155 DSIKANAAAIVAELKAAGSG--VDFVDHCAKELPIRTLSDMVGIPEGERE
Mvan_3992|M.vanbaalenii_PYR-1 DKIDLVAKEVVDGFIADPTGE-IEFMDRCASRLPLRMFCEMFGVPDHLEE
TH_2564|M.thermoresistible__bu DQVNNQAKQIVDDFVKTKEG---DFVEQVAKKLPMWTIYEMVGLPPEKRD
MAB_0611|M.abscessus_ATCC_1997 DDLNARAQGIARAAAQLRHG---DFVEQVACELPLQAIAGLMGTPLDERE
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQF---DVIADLAFPLAVAVICRLLGVPYEDAP
: . : :.: * *.: : :.* *
Mb2289|M.bovis_AF2122/97 RIFHWTNVILGFGDPDLATD------FDEFMQVSADIGAYATALAEDRRV
Rv2266|M.tuberculosis_H37Rv RIFHWTNVILGFGDPDLATD------FDEFMQVSADIGAYATALAEDRRV
MUL_1282|M.ulcerans_Agy99 QIFHWTNVILGFGDPDLTTD------FDDFLQVSMAIGGYATALADDRRV
MMAR_3761|M.marinum_M RVAHAADALVSWADPRYLNGREP---LAVLFENQMYLHQVAASLAAERRD
MAV_1734|M.avium_104 RMAHATDALVSWADPEFLNGRPA---LEVLLENQMYLHQVVGDLATQRRE
Mflv_2640|M.gilvum_PYR-GCK AVADAADAMVSWGDPEYLDGRNP---LEVLFSSQMYLHQVALGLAAERRD
MSMEG_4619|M.smegmatis_MC2_155 KVAHAADALVSWADPIYLAGRHP---LEVLLENQMYLHQVANTLAAERRE
Mvan_3992|M.vanbaalenii_PYR-1 RTVEHVIGSVSWSDEEILAGRSA---ADMQLESIGGLHQVAQEIIEMRRQ
TH_2564|M.thermoresistible__bu ETTRHADGMVSWADPEVAAGREP---MQVILESLTALRETAMELADQRRA
MAB_0611|M.abscessus_ATCC_1997 QLFDWSNRLVGSSDG-----------EDDSAVASAELLMYAMGVAARKTA
MLBr_02088|M.leprae_Br4923 EFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRG
: * : : :
Mb2289|M.bovis_AF2122/97 NHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLA
Rv2266|M.tuberculosis_H37Rv NHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLA
MUL_1282|M.ulcerans_Agy99 NHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTISHGMLA
MMAR_3761|M.marinum_M RPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLKA
MAV_1734|M.avium_104 RPGDDLISSLVTAEVDGDRLEDAEVAAFFVLLSVAGNDTTRQTISHTLRA
Mflv_2640|M.gilvum_PYR-GCK NPGDDLFSSLVHAEVEGARLTDAEIAAFFVLLAVAGNDTTRQTTSHAIKA
MSMEG_4619|M.smegmatis_MC2_155 NPGNDLISALVHAEVDGDRLTDAEVAAFFVLLAVAGNDTTRQTTSHALKA
Mvan_3992|M.vanbaalenii_PYR-1 QPGDDIISSLVHAEIDGQMLTDFEISSFFCLLSGAATDTTKTTLGHAVRA
TH_2564|M.thermoresistible__bu EPTDDLMSQLVQAEVDGRRLTNDELGAFFVLLSVAGNDTTRNSTSIATMA
MAB_0611|M.abscessus_ATCC_1997 EPGADICTDLVNADIDGQKLSDDEFGFFVMLLAVAGNETTRNSITHGMHA
MLBr_02088|M.leprae_Br4923 TPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLA
*: : *: : .* * . :. ** *. :** *
Mb2289|M.bovis_AF2122/97 LSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTK
Rv2266|M.tuberculosis_H37Rv LSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTK
MUL_1282|M.ulcerans_Agy99 LSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGTK
MMAR_3761|M.marinum_M LTDFPSQKAWLLADFDTRIGTAVEELVRWATPVMTFRRTAAADFELGGQL
MAV_1734|M.avium_104 LTVFPDEKSWLLEDFDHRIGTAVEEFIRWASPVMTFRRTAAADVELGGQT
Mflv_2640|M.gilvum_PYR-GCK LTDHPEQRAWLTASFDDRIGGAVEEFIRWASPVMTFRRTAATDYVLGGQQ
MSMEG_4619|M.smegmatis_MC2_155 LTDFEDQRAWLMEDFDDRIGVAVEEMVRWASPVMTFRRTAAVDVELGGRQ
Mvan_3992|M.vanbaalenii_PYR-1 LSLFPEQHAWLLEDFDNRIGTAVEEFIRWATPLLTFTRTAAVETELGGRR
TH_2564|M.thermoresistible__bu LQEFPDQKELLLNDFDGHIHTAIEEFVRWATPVMTFRRTVTEDTVLRGQE
MAB_0611|M.abscessus_ATCC_1997 FTQFPEQWELYKKTRP---ETAADEIVRWATPVTSFQRTALEDTELGGVR
MLBr_02088|M.leprae_Br4923 MLRNPSQWK-ALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTT
: .: . :* :*: ..: : *. : :
Mb2289|M.bovis_AF2122/97 MAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGA
Rv2266|M.tuberculosis_H37Rv MAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGA
MUL_1282|M.ulcerans_Agy99 MAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLGA
MMAR_3761|M.marinum_M IRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVHFCLGA
MAV_1734|M.avium_104 ILAGEKVVMFYPSGNWDTEAFDHPERLNLGRDPNPHVGFGGGGLHFCLGA
Mflv_2640|M.gilvum_PYR-GCK IAAGEKVVMFYSSGNRDTAVFDRPDLLDLGRDPNPHLGFGGGGRHFCLGA
MSMEG_4619|M.smegmatis_MC2_155 IAAGEKVVMFYASGNWDTTVFDRPDVLDLGRKPNPHLGFGGGGRHFCLGA
Mvan_3992|M.vanbaalenii_PYR-1 IMPGDRVVMIYQAGNFDEDVFDRPRELDLARSPNPHVSFGGGGVHYCLGA
TH_2564|M.thermoresistible__bu LKQGDWVLLMYSSGNRDERAFTDPHKFDIRRKPNPHVAFGGGGPHYCMGA
MAB_0611|M.abscessus_ATCC_1997 IKKGQRVVMMYRSANFDEEVFENPFTFDIMRDPNPHVGFGGNGEHHCVGA
MLBr_02088|M.leprae_Br4923 LTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLGA
: *: : : :.* * : * :: * .. ::.*. . *.*:**
Mb2289|M.bovis_AF2122/97 NLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS----
Rv2266|M.tuberculosis_H37Rv NLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS----
MUL_1282|M.ulcerans_Agy99 NLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVAWSR---
MMAR_3761|M.marinum_M HLARAQLRAIFGELLVQLPDIQA-GDPVYVPGNFVHAIRSMPCTF-----
MAV_1734|M.avium_104 HVARAQLRAIFSELFRQLPGIQA-GEPTYLAGNFVHAIRAMPCTF-----
Mflv_2640|M.gilvum_PYR-GCK HVARAQLRAIIGELLTQLPDLAA-GEPSFVAGNFIHAVRRMPVTW-----
MSMEG_4619|M.smegmatis_MC2_155 HVARTQLRAIFGELLHQLPDIRA-GEPEYLQGNFVHAIRAMPCTFS----
Mvan_3992|M.vanbaalenii_PYR-1 NLARSMLRAELRELLLRITEFET-DAPDMLATNFIHGLKRLPFRFTPQ--
TH_2564|M.thermoresistible__bu FLAKMQLEAMFRELLFRAPTLRV-GEPSYLRSNFMRAVKSLPYTLD----
MAB_0611|M.abscessus_ATCC_1997 NLARMTINLMFNAIADHMPDLASAGEPDRLRSGWLNGVKHWEVDFCPAGY
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-----
:*: : : : . . :..:
Mb2289|M.bovis_AF2122/97 ----
Rv2266|M.tuberculosis_H37Rv ----
MUL_1282|M.ulcerans_Agy99 ----
MMAR_3761|M.marinum_M ----
MAV_1734|M.avium_104 ----
Mflv_2640|M.gilvum_PYR-GCK ----
MSMEG_4619|M.smegmatis_MC2_155 ----
Mvan_3992|M.vanbaalenii_PYR-1 ----
TH_2564|M.thermoresistible__bu ----
MAB_0611|M.abscessus_ATCC_1997 GRAS
MLBr_02088|M.leprae_Br4923 ----