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MTTAVPTHRDIDLSDRNFWARPHEERDAAFAVLRRENPVPWSRPADSDLLPPEQNLKGFWSLTKHEDIRY ASRHPEIFSSAEGITVEDFPVEIRMMSQSFIAMDAPRHTQLRGITLDAFKPRNMLRLQDWIQGHARDLIS EISHLGEGDFVDLVSVKLPGRIFGSFFGLPPGELHEKTINAAQRTLGWTDPEVRGDLTAVELFVGAVMDL HETVTTLLPERRANPGDDLLSWMVQAEFDGEKMTDDELKAFFTLLAVAANDTTRHASAHAILAFSQFPDQ RDLLVADVEGRVDTAVEEVLRWASPLVHMRRTAVQDVTLRGSEIKAGDKVVLWYSSANRDEDIFEDPFKF DIARNPNPHIAFGGGGPHFCLGAALARTMLRSLLTEVYTRIPDISAPEPRYQVANFINGINSLPATWTPE RR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0012 | - | - | 100% (422) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 7e-98 | 45.28% (413) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3992 | - | 3e-94 | 41.01% (417) | hypothetical protein Mvan_3992 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 5e-94 | 44.31% (413) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_2640 | - | 1e-104 | 45.34% (408) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 5e-94 | 44.31% (413) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-32 | 30.96% (323) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0613 | - | 4e-66 | 35.11% (393) | putative cytochrome P450 |
| M. marinum M | MMAR_3761 | cyp268A2 | 3e-98 | 43.06% (418) | cytochrome P450 268A2 Cyp268A2 |
| M. avium 104 | MAV_1734 | - | 1e-100 | 43.52% (409) | putative cytochrome P450 124 |
| M. smegmatis MC2 155 | MSMEG_4619 | - | 1e-103 | 46.21% (409) | putative cytochrome P450 126 |
| M. thermoresistible (build 8) | TH_2564 | - | 1e-104 | 43.31% (411) | PUTATIVE NikQ protein |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 7e-91 | 43.10% (413) | cytochrome P450 124A1, Cyp124A1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2640|M.gilvum_PYR-GCK --------MTVTAHTPPAASAGRPYDPVDLSSRAFWAGTADQREASFAQL
MSMEG_4619|M.smegmatis_MC2_155 --------MTVLPIT-------RPYDAVDLSSRAFWATTAADREVAFAQL
MMAR_3761|M.marinum_M --------MTAIS------ASVRPYDTIDLSSRAFWASSASQRESSFSEL
MAV_1734|M.avium_104 --------MAVLTGESGTDRSRRAYDEIDLSSRAFWSGTAAERERSFAAL
TH_2564|M.thermoresistible__bu --------MTTETTEPR--VDRPPFDPICISTLEFWSKTAEEREPYFKIL
Mvan_0012|M.vanbaalenii_PYR-1 --------MTTAVP---------THRDIDLSDRNFWARPHEERDAAFAVL
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
MUL_1282|M.ulcerans_Agy99 MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATL
MAB_0613|M.abscessus_ATCC_1997 --------------------MVHPSLPAGFDFTDPEIYAERLPVEELKEL
MLBr_02088|M.leprae_Br4923 -----------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLL
. : *
Mflv_2640|M.gilvum_PYR-GCK REARPLSWHP--PVEDALMP----DADDPGFWAVTRHADIVEVSRNSEVF
MSMEG_4619|M.smegmatis_MC2_155 RAERPVSWHP--PVEDALMH----DPDDKGFWAVTRHADIVAISRDSETF
MMAR_3761|M.marinum_M RAERPVSWHP--PVEDALIQ----DPNDPGFWAVTRRADIVAVSRTNEVF
MAV_1734|M.avium_104 RAERPVSWHP--PVEDSLLP----DPTDPGFWAVTRRADIVTVSRNNDVF
TH_2564|M.thermoresistible__bu RDERPVSWHP--PIEGTMMP----PPVD-GVWAITRHEDIEYVSKNPQLF
Mvan_0012|M.vanbaalenii_PYR-1 RRENPVPWSR--PADSDLLPP---EQNLKGFWSLTKHEDIRYASRHPEIF
Mb2289|M.bovis_AF2122/97 RREAPISFWP--TIELPGFV------AGNGHWALTKYDDVFYASRHPDIF
Rv2266|M.tuberculosis_H37Rv RREAPISFWP--TIELPGFV------AGNGHWALTKYDDVFYASRHPDIF
MUL_1282|M.ulcerans_Agy99 RREAPISFWP--PIELAGLT------AGKGHWALTKHDDIHFASRHPEIF
MAB_0613|M.abscessus_ATCC_1997 RKTAPIWWQE--QPDGVGGF------NDGGYWVVTKHKDVKEVSLRSDVF
MLBr_02088|M.leprae_Br4923 RLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSA
* * .: *
Mflv_2640|M.gilvum_PYR-GCK LSGKGVLFENVPEELLEASQS-----FLAMDPPRHTLIRKVVHAAFTPRQ
MSMEG_4619|M.smegmatis_MC2_155 LSGQGVLFENVPQELLEASQS-----FLAMDAPRHTLIRKLVHSAFTPRQ
MMAR_3761|M.marinum_M LSGNGVLFENVPAELLEASQS-----FLAMDPPRHTKLRKLVSAAFTPRQ
MAV_1734|M.avium_104 LSGHGVMFESIPAELLEASQS-----FLAMDPPRHTKLRKLAHAALSPRQ
TH_2564|M.thermoresistible__bu CSGQGTQVEAIPPEMLVLAES-----FLSMDGEEHSSLRRLISSVFTPRR
Mvan_0012|M.vanbaalenii_PYR-1 SSAEGITVEDFPVEIRMMSQS-----FIAMDAPRHTQLRGITLDAFKPRN
Mb2289|M.bovis_AF2122/97 SSYPNITINDQTPELAEYFGS-----MIVLDDPRHQRLRSIVSRAFTPKV
Rv2266|M.tuberculosis_H37Rv SSYPNITINDQTPELAEYFGS-----MIVLDDPRHQRLRSIVSRAFTPKV
MUL_1282|M.ulcerans_Agy99 HSSPNIVIHDQTPELAEYFGS-----MIVLDDPRHQRLRSIVSRAFTPKV
MAB_0613|M.abscessus_ATCC_1997 SSWENTAIPRFQDDITREAIELQRYVMLNMDAPHHTRLRKIISRGFTPRA
MLBr_02088|M.leprae_Br4923 SDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKV
. . :: :* * :* : : *:
Mflv_2640|M.gilvum_PYR-GCK VRRIEDSIRANARDIVTELRAAGSGV--DFVSHCAKELPVRTLADMVGIP
MSMEG_4619|M.smegmatis_MC2_155 VARIEDSIKANAAAIVAELKAAGSGV--DFVDHCAKELPIRTLSDMVGIP
MMAR_3761|M.marinum_M VRRIEDSIKINAKGIVDELRMAGGGV--DFVEHCAKELPIRTLSDMVGIP
MAV_1734|M.avium_104 VRRIEDSIKANAKAIVEELRAAGSGC--DFVDHCAKELPIRTLSDMMGIP
TH_2564|M.thermoresistible__bu LSIIRDQVNNQAKQIVDDFVKTKEG---DFVEQVAKKLPMWTIYEMVGLP
Mvan_0012|M.vanbaalenii_PYR-1 MLRLQDWIQGHARDLISEISHLGEG---DFVDLVSVKLPGRIFGSFFGLP
Mb2289|M.bovis_AF2122/97 VARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIP
Rv2266|M.tuberculosis_H37Rv VARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIP
MUL_1282|M.ulcerans_Agy99 VARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIP
MAB_0613|M.abscessus_ATCC_1997 IGRLRDELNERAQEIAKAAAASGTG---DFVEQVSCELPLQAIAGLLGVP
MLBr_02088|M.leprae_Br4923 VQALEGDIAALVDSLLDKGAAAGQF---DVIADLAFPLAVAVICRLLGVP
: :. : . : *.: : *. : :.*:*
Mflv_2640|M.gilvum_PYR-GCK DSE-RHAVADAADAMVSWGDPEYLDGRNP---LEVLFSSQMYLHQVALGL
MSMEG_4619|M.smegmatis_MC2_155 EGE-REKVAHAADALVSWADPIYLAGRHP---LEVLLENQMYLHQVANTL
MMAR_3761|M.marinum_M EAD-RERVAHAADALVSWADPRYLNGREP---LAVLFENQMYLHQVAASL
MAV_1734|M.avium_104 ESE-RERMAHATDALVSWADPEFLNGRPA---LEVLLENQMYLHQVVGDL
TH_2564|M.thermoresistible__bu PEK-RDETTRHADGMVSWADPEVAAGREP---MQVILESLTALRETAMEL
Mvan_0012|M.vanbaalenii_PYR-1 PGELHEKTINAAQRTLGWTDPEVRGDLTA---VELFVGAVMDLHETVTTL
Mb2289|M.bovis_AF2122/97 KAD-HQRIFHWTNVILGFGDPDLATD------FDEFMQVSADIGAYATAL
Rv2266|M.tuberculosis_H37Rv KAD-HQRIFHWTNVILGFGDPDLATD------FDEFMQVSADIGAYATAL
MUL_1282|M.ulcerans_Agy99 EED-HEQIFHWTNVILGFGDPDLTTD------FDDFLQVSMAIGGYATAL
MAB_0613|M.abscessus_ATCC_1997 IED-RGKLFNWSNEMTSYDDPEYADIDP--------AASSMEILAYSMEM
MLBr_02088|M.leprae_Br4923 YED-APEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
. : ** : :
Mflv_2640|M.gilvum_PYR-GCK AAERRDNPGDDLFSSLVHAEVEGA-RLTDAEIAAFFVLLAVAGNDTTRQT
MSMEG_4619|M.smegmatis_MC2_155 AAERRENPGNDLISALVHAEVDGD-RLTDAEVAAFFVLLAVAGNDTTRQT
MMAR_3761|M.marinum_M AAERRDRPGDDLFSALVNAEVDGD-RLADADVAAFFVLLAVAGNDTTRQT
MAV_1734|M.avium_104 ATQRRERPGDDLISSLVTAEVDGD-RLEDAEVAAFFVLLSVAGNDTTRQT
TH_2564|M.thermoresistible__bu ADQRRAEPTDDLMSQLVQAEVDGR-RLTNDELGAFFVLLSVAGNDTTRNS
Mvan_0012|M.vanbaalenii_PYR-1 LPERRANPGDDLLSWMVQAEFDGE-KMTDDELKAFFTLLAVAANDTTRHA
Mb2289|M.bovis_AF2122/97 AEDRRVNHHDDLTSSLVEAEVDGE-RLSSREIASFFILLVVAGNETTRNA
Rv2266|M.tuberculosis_H37Rv AEDRRVNHHDDLTSSLVEAEVDGE-RLSSREIASFFILLVVAGNETTRNA
MUL_1282|M.ulcerans_Agy99 ADDRRVNHHGDLTTSLVEAEVDGE-RLSSSEIAMFFILLVVAGNETTRNT
MAB_0613|M.abscessus_ATCC_1997 AKQKAENPGEDIVTTLINAEVEGEGKLSDDEFGFFVIMLAVAGNETSRNS
MLBr_02088|M.leprae_Br4923 VKCRRGTPGEDLISRLIELDESGD-QLTEEEIIATCGLLLVAGHETTVNL
: *: : :: : .* :: . :. :* **.::*: :
Mflv_2640|M.gilvum_PYR-GCK TSHAIKALTDHPEQRAWLTASFDDRIGGAVEEFIRWASPVMTFRRTAATD
MSMEG_4619|M.smegmatis_MC2_155 TSHALKALTDFEDQRAWLMEDFDDRIGVAVEEMVRWASPVMTFRRTAAVD
MMAR_3761|M.marinum_M ISHGLKALTDFPSQKAWLLADFDTRIGTAVEELVRWATPVMTFRRTAAAD
MAV_1734|M.avium_104 ISHTLRALTVFPDEKSWLLEDFDHRIGTAVEEFIRWASPVMTFRRTAAAD
TH_2564|M.thermoresistible__bu TSIATMALQEFPDQKELLLNDFDGHIHTAIEEFVRWATPVMTFRRTVTED
Mvan_0012|M.vanbaalenii_PYR-1 SAHAILAFSQFPDQRDLLVADVEGRVDTAVEEVLRWASPLVHMRRTAVQD
Mb2289|M.bovis_AF2122/97 ITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQD
Rv2266|M.tuberculosis_H37Rv ITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQD
MUL_1282|M.ulcerans_Agy99 ISHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQD
MAB_0613|M.abscessus_ATCC_1997 ITQGMMAFTQFPEQWELYKK---ERPETAADEIVRWATPVTSFQRTALED
MLBr_02088|M.leprae_Br4923 IANAVLAMLRNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKD
: *: .: . :* :*: ..: : *. *
Mflv_2640|M.gilvum_PYR-GCK YVLGGQQIAAGEKVVMFYSSGNRDTAVFDRPDLLDLGRDPNPHLGFGGGG
MSMEG_4619|M.smegmatis_MC2_155 VELGGRQIAAGEKVVMFYASGNWDTTVFDRPDVLDLGRKPNPHLGFGGGG
MMAR_3761|M.marinum_M FELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGG
MAV_1734|M.avium_104 VELGGQTILAGEKVVMFYPSGNWDTEAFDHPERLNLGRDPNPHVGFGGGG
TH_2564|M.thermoresistible__bu TVLRGQELKQGDWVLLMYSSGNRDERAFTDPHKFDIRRKPNPHVAFGGGG
Mvan_0012|M.vanbaalenii_PYR-1 VTLRGSEIKAGDKVVLWYSSANRDEDIFEDPFKFDIARNPNPHIAFGGGG
Mb2289|M.bovis_AF2122/97 IELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGG
Rv2266|M.tuberculosis_H37Rv IELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGG
MUL_1282|M.ulcerans_Agy99 VDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGG
MAB_0613|M.abscessus_ATCC_1997 TELDGVKIKKGQRVVMMYRSANFDEDVFEDPFSFNIMRNPNPHMGFGGSG
MLBr_02088|M.leprae_Br4923 MTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-
: : *: : : :.* * : * :: * .. ::.*. .
Mflv_2640|M.gilvum_PYR-GCK RHFCLGAHVARAQLRAIIGELLTQLPDLAAGE-PSFVAGNFIHAVRRMPV
MSMEG_4619|M.smegmatis_MC2_155 RHFCLGAHVARTQLRAIFGELLHQLPDIRAGE-PEYLQGNFVHAIRAMPC
MMAR_3761|M.marinum_M VHFCLGAHLARAQLRAIFGELLVQLPDIQAGD-PVYVPGNFVHAIRSMPC
MAV_1734|M.avium_104 LHFCLGAHVARAQLRAIFSELFRQLPGIQAGE-PTYLAGNFVHAIRAMPC
TH_2564|M.thermoresistible__bu PHYCMGAFLAKMQLEAMFRELLFRAPTLRVGE-PSYLRSNFMRAVKSLPY
Mvan_0012|M.vanbaalenii_PYR-1 PHFCLGAALARTMLRSLLTEVYTRIPDISAPE-PRYQVANFINGINSLPA
Mb2289|M.bovis_AF2122/97 AHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPV
Rv2266|M.tuberculosis_H37Rv AHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPV
MUL_1282|M.ulcerans_Agy99 AHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPV
MAB_0613|M.abscessus_ATCC_1997 AHYCIGANLARLTINLMFNAIADHMPNLAPAGDPKRLQSGWLNGIKHWQV
MLBr_02088|M.leprae_Br4923 SHFCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPV
*:*:** :*: : : : * : :..:
Mflv_2640|M.gilvum_PYR-GCK TW----------
MSMEG_4619|M.smegmatis_MC2_155 TFS---------
MMAR_3761|M.marinum_M TF----------
MAV_1734|M.avium_104 TF----------
TH_2564|M.thermoresistible__bu TLD---------
Mvan_0012|M.vanbaalenii_PYR-1 TWTPERR-----
Mb2289|M.bovis_AF2122/97 TWS---------
Rv2266|M.tuberculosis_H37Rv TWS---------
MUL_1282|M.ulcerans_Agy99 AWSR--------
MAB_0613|M.abscessus_ATCC_1997 DFTGASGCPVLQ
MLBr_02088|M.leprae_Br4923 QV----------