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VTAPSLHEREHSAIDITSHDFWSRPFAQRDESFARLRAGDGLSWHAPFPSLFPMEEPGYWAVTRRADIAY VSQHPELFTSERGVALDPMPAEVQRFASFFLTMDPPQHTTYRRLISSAFTPRNVRQIEEQIQRNAVAIVD DLVGAGDIDFVADCSARLPMLTIMEMLGVPGADQPAVALAAEKLFSMSDDEYSSLEERAANTLNEIMLLS STGAELAKFRRAHPGDDLMTGIVNAEVDGQRLTDEEIGAFLILLASAGNDTTKQTTTHAMMALVENPQQR AWLMADFDGRIGAAVEEFVRWSSPVLQFARFATRDTEINGQPVAEGDKVGLFYCSANRDEAVFDNPAGFD LSRSPNPHLGFGGGGPHFCLGNQLAKAELRNLFRELLTRLKTVEFGEPDLLHSSFVHGVKRLPAHVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2234 | - | - | 100% (417) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3992 | - | 3e-96 | 43.88% (417) | hypothetical protein Mvan_3992 |
| M. vanbaalenii PYR-1 | Mvan_0012 | - | 2e-89 | 39.71% (408) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 6e-79 | 38.97% (408) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_2640 | - | 1e-112 | 49.51% (408) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 6e-79 | 38.97% (408) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 7e-40 | 32.82% (326) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0613 | - | 5e-64 | 34.37% (387) | putative cytochrome P450 |
| M. marinum M | MMAR_3761 | cyp268A2 | 1e-113 | 49.04% (416) | cytochrome P450 268A2 Cyp268A2 |
| M. avium 104 | MAV_1734 | - | 1e-106 | 46.81% (408) | putative cytochrome P450 124 |
| M. smegmatis MC2 155 | MSMEG_2558 | - | 0.0 | 78.80% (415) | NikQ protein |
| M. thermoresistible (build 8) | TH_3205 | - | 0.0 | 78.00% (409) | PUTATIVE NikQ protein |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 3e-78 | 38.61% (404) | cytochrome P450 124A1, Cyp124A1 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2558|M.smegmatis_MC2_155 --------MTVAS-----SAQAREYSPFDITS-HEFWSRPFAVRDETFAQ
TH_3205|M.thermoresistible__bu --------MTVAS-----TPETREHSPHDISS-RDFWSRPFAVRDETFAK
Mvan_2234|M.vanbaalenii_PYR-1 ---------MTAP-----SLHEREHSAIDITS-HDFWSRPFAQRDESFAR
MMAR_3761|M.marinum_M --------MTAIS------ASVRPYDTIDLSS-RAFWASSASQRESSFSE
MAV_1734|M.avium_104 --------MAVLTGESGTDRSRRAYDEIDLSS-RAFWSGTAAERERSFAA
Mflv_2640|M.gilvum_PYR-GCK --------MTVTAHTPPAASAGRPYDPVDLSS-RAFWAGTADQREASFAQ
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGS-LDFWALDDDVRDGAFAT
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGS-LDFWALDDDVRDGAFAT
MUL_1282|M.ulcerans_Agy99 MDLSTNLNTGLLPRVNGTPPPEVPLADIELGS-LEFWGRDDDFRDGAFAT
MAB_0613|M.abscessus_ATCC_1997 ------------------MVHPSLPAGFDFTD-PEIYAER--LPVEELKE
MLBr_02088|M.leprae_Br4923 ------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDP
: :
MSMEG_2558|M.smegmatis_MC2_155 LRAAEGLSWHQPLST--LFDVEEPGFWALTRRADIQFVSQHPELFTSAQG
TH_3205|M.thermoresistible__bu LRATDGVTWHAPLPT--IFDKVEPGFWAITRRADICHVSQHPELFTSTQG
Mvan_2234|M.vanbaalenii_PYR-1 LRAGDGLSWHAPFPS--LFPMEEPGYWAVTRRADIAYVSQHPELFTSERG
MMAR_3761|M.marinum_M LRAERPVSWHPPVEDALIQDPNDPGFWAVTRRADIVAVSRTNEVFLSGNG
MAV_1734|M.avium_104 LRAERPVSWHPPVEDSLLPDPTDPGFWAVTRRADIVTVSRNNDVFLSGHG
Mflv_2640|M.gilvum_PYR-GCK LREARPLSWHPPVEDALMPDADDPGFWAVTRHADIVEVSRNSEVFLSGKG
Mb2289|M.bovis_AF2122/97 LRREAPISFWPTIELPGFVAGN--GHWALTKYDDVFYASRHPDIFSSYPN
Rv2266|M.tuberculosis_H37Rv LRREAPISFWPTIELPGFVAGN--GHWALTKYDDVFYASRHPDIFSSYPN
MUL_1282|M.ulcerans_Agy99 LRREAPISFWPPIELAGLTAGK--GHWALTKHDDIHFASRHPEIFHSSPN
MAB_0613|M.abscessus_ATCC_1997 LRKTAPIWWQEQPDG--VGGFNDGGYWVVTKHKDVKEVSLRSDVFSSWEN
MLBr_02088|M.leprae_Br4923 GTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLK
. ..: * . .
MSMEG_2558|M.smegmatis_MC2_155 VALDPMPADVQKFAT-----FFLMMDPPEHTVYRRLISSAFTPRNVRRIE
TH_3205|M.thermoresistible__bu VALDPMPAELQQIAT-----FFLMMDPPQHTVYRRLISSAFTPRNVRRIE
Mvan_2234|M.vanbaalenii_PYR-1 VALDPMPAEVQRFAS-----FFLTMDPPQHTTYRRLISSAFTPRNVRQIE
MMAR_3761|M.marinum_M VLFENVPAELLEASQ-----SFLAMDPPRHTKLRKLVSAAFTPRQVRRIE
MAV_1734|M.avium_104 VMFESIPAELLEASQ-----SFLAMDPPRHTKLRKLAHAALSPRQVRRIE
Mflv_2640|M.gilvum_PYR-GCK VLFENVPEELLEASQ-----SFLAMDPPRHTLIRKVVHAAFTPRQVRRIE
Mb2289|M.bovis_AF2122/97 ITINDQTPELAEYFG-----SMIVLDDPRHQRLRSIVSRAFTPKVVARIE
Rv2266|M.tuberculosis_H37Rv ITINDQTPELAEYFG-----SMIVLDDPRHQRLRSIVSRAFTPKVVARIE
MUL_1282|M.ulcerans_Agy99 IVIHDQTPELAEYFG-----SMIVLDDPRHQRLRSIVSRAFTPKVVARIE
MAB_0613|M.abscessus_ATCC_1997 TAIPRFQDDITREAIELQRYVMLNMDAPHHTRLRKIISRGFTPRAIGRLR
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
: :: :* * * * : .::*: : :.
MSMEG_2558|M.smegmatis_MC2_155 EQIHANAVDVVDQLIGVG---NVDFVEACSAQLPMRTISDMLGVPKADQP
TH_3205|M.thermoresistible__bu EQIHANAVAIVDDLIGAG---NIDFVKACSARLPMLTICDMLGVPRSDHE
Mvan_2234|M.vanbaalenii_PYR-1 EQIQRNAVAIVDDLVGAG---DIDFVADCSARLPMLTIMEMLGVPGADQP
MMAR_3761|M.marinum_M DSIKINAKGIVDELRMAGG--GVDFVEHCAKELPIRTLSDMVGIPEADRE
MAV_1734|M.avium_104 DSIKANAKAIVEELRAAGS--GCDFVDHCAKELPIRTLSDMMGIPESERE
Mflv_2640|M.gilvum_PYR-GCK DSIRANARDIVTELRAAGS--GVDFVSHCAKELPVRTLADMVGIPDSERH
Mb2289|M.bovis_AF2122/97 AAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQ
Rv2266|M.tuberculosis_H37Rv AAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQ
MUL_1282|M.ulcerans_Agy99 ASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHE
MAB_0613|M.abscessus_ATCC_1997 DELNERAQEIAKAAAASG---TGDFVEQVSCELPLQAIAGLLGVPIEDRG
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVPYEDAP
: . : *.: : *.: : ::*:* :
MSMEG_2558|M.smegmatis_MC2_155 ALAKAAEKLFSMSDDEY---SSLEERAVATINEIMLISNTGVELAKFRRA
TH_3205|M.thermoresistible__bu AVAAAAEKLFSMSDDEY---SSLEERAADTVNEMLLLSNTGIELAKFRRK
Mvan_2234|M.vanbaalenii_PYR-1 AVALAAEKLFSMSDDEY---SSLEERAANTLNEIMLLSSTGAELAKFRRA
MMAR_3761|M.marinum_M RVAHAADALVSWADPRY---LNGREPLAVLFENQMYLHQVAASLAAERRD
MAV_1734|M.avium_104 RMAHATDALVSWADPEF---LNGRPALEVLLENQMYLHQVVGDLATQRRE
Mflv_2640|M.gilvum_PYR-GCK AVADAADAMVSWGDPEY---LDGRNPLEVLFSSQMYLHQVALGLAAERRD
Mb2289|M.bovis_AF2122/97 RIFHWTNVILGFGDP------DLATDFDEFMQVSADIGAYATALAEDRRV
Rv2266|M.tuberculosis_H37Rv RIFHWTNVILGFGDP------DLATDFDEFMQVSADIGAYATALAEDRRV
MUL_1282|M.ulcerans_Agy99 QIFHWTNVILGFGDP------DLTTDFDDFLQVSMAIGGYATALADDRRV
MAB_0613|M.abscessus_ATCC_1997 KLFNWSNEMTSYDDPEY---ADIDP-----AASSMEILAYSMEMAKQKAE
MLBr_02088|M.leprae_Br4923 EFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRG
. : : * . : :. :
MSMEG_2558|M.smegmatis_MC2_155 NPGDDLMTSIVNAEVDGH-RLTDEEIGAFLILLASAGNDTTKQTTTHAMM
TH_3205|M.thermoresistible__bu NPGDDLMTSIVNAEVDGH-RLTDEEIGAFMILLSSAGNDTTKQTTTHALM
Mvan_2234|M.vanbaalenii_PYR-1 HPGDDLMTGIVNAEVDGQ-RLTDEEIGAFLILLASAGNDTTKQTTTHAMM
MMAR_3761|M.marinum_M RPGDDLFSALVNAEVDGD-RLADADVAAFFVLLAVAGNDTTRQTISHGLK
MAV_1734|M.avium_104 RPGDDLISSLVTAEVDGD-RLEDAEVAAFFVLLSVAGNDTTRQTISHTLR
Mflv_2640|M.gilvum_PYR-GCK NPGDDLFSSLVHAEVEGA-RLTDAEIAAFFVLLAVAGNDTTRQTTSHAIK
Mb2289|M.bovis_AF2122/97 NHHDDLTSSLVEAEVDGE-RLSSREIASFFILLVVAGNETTRNAITHGVL
Rv2266|M.tuberculosis_H37Rv NHHDDLTSSLVEAEVDGE-RLSSREIASFFILLVVAGNETTRNAITHGVL
MUL_1282|M.ulcerans_Agy99 NHHGDLTTSLVEAEVDGE-RLSSSEIAMFFILLVVAGNETTRNTISHGML
MAB_0613|M.abscessus_ATCC_1997 NPGEDIVTTLINAEVEGEGKLSDDEFGFFVIMLAVAGNETSRNSITQGMM
MLBr_02088|M.leprae_Br4923 TPGEDLISRLIELDESGD-QLTEEEIIATCGLLLVAGHETTVNLIANAVL
*: : :: : .* :* . :. :* **::*: : :: :
MSMEG_2558|M.smegmatis_MC2_155 ALAAHPDQRDWLMADFDGRIGPAVEEFVRWATPVIQFARFATEDVEVAGQ
TH_3205|M.thermoresistible__bu ALAAHPEQRDWLMADFDNRIGPAIEEFVRYATPVLQFARFATADTEIAGQ
Mvan_2234|M.vanbaalenii_PYR-1 ALVENPQQRAWLMADFDGRIGAAVEEFVRWSSPVLQFARFATRDTEINGQ
MMAR_3761|M.marinum_M ALTDFPSQKAWLLADFDTRIGTAVEELVRWATPVMTFRRTAAADFELGGQ
MAV_1734|M.avium_104 ALTVFPDEKSWLLEDFDHRIGTAVEEFIRWASPVMTFRRTAAADVELGGQ
Mflv_2640|M.gilvum_PYR-GCK ALTDHPEQRAWLTASFDDRIGGAVEEFIRWASPVMTFRRTAATDYVLGGQ
Mb2289|M.bovis_AF2122/97 ALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGT
Rv2266|M.tuberculosis_H37Rv ALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGT
MUL_1282|M.ulcerans_Agy99 ALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGT
MAB_0613|M.abscessus_ATCC_1997 AFTQFPEQWELYKK---ERPETAADEIVRWATPVTSFQRTALEDTELDGV
MLBr_02088|M.leprae_Br4923 AMLRNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQT
*: *.: . :* :*: ..: : * * :
MSMEG_2558|M.smegmatis_MC2_155 TIRAGEKVGLFYCSANRDEAVFTDPQRFDLSRSPNPHLGFGGGGPHFCLG
TH_3205|M.thermoresistible__bu PIKAGDKLGLFYCSANRDESVFDDPHAFNLQRMPNPHVGFGGGGPHFCLG
Mvan_2234|M.vanbaalenii_PYR-1 PVAEGDKVGLFYCSANRDEAVFDNPAGFDLSRSPNPHLGFGGGGPHFCLG
MMAR_3761|M.marinum_M LIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVHFCLG
MAV_1734|M.avium_104 TILAGEKVVMFYPSGNWDTEAFDHPERLNLGRDPNPHVGFGGGGLHFCLG
Mflv_2640|M.gilvum_PYR-GCK QIAAGEKVVMFYSSGNRDTAVFDRPDLLDLGRDPNPHLGFGGGGRHFCLG
Mb2289|M.bovis_AF2122/97 KMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLG
Rv2266|M.tuberculosis_H37Rv KMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLG
MUL_1282|M.ulcerans_Agy99 KMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLG
MAB_0613|M.abscessus_ATCC_1997 KIKKGQRVVMMYRSANFDEDVFEDPFSFNIMRNPNPHMGFGGSGAHYCIG
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLG
: *: : : :.* * : * :: * .. ::.*. . *:*:*
MSMEG_2558|M.smegmatis_MC2_155 NQLAKTELRNLFRELLTRLKTIEFGE-PELLHSSFVHGIKRVPAYIR---
TH_3205|M.thermoresistible__bu NQLAKSELRNLFRELLTRLRTIEFGE-PEYLLSSFVHGIKRVPAYVQ---
Mvan_2234|M.vanbaalenii_PYR-1 NQLAKAELRNLFRELLTRLKTVEFGE-PDLLHSSFVHGVKRLPAHVR---
MMAR_3761|M.marinum_M AHLARAQLRAIFGELLVQLPDIQAGD-PVYVPGNFVHAIRSMPCTF----
MAV_1734|M.avium_104 AHVARAQLRAIFSELFRQLPGIQAGE-PTYLAGNFVHAIRAMPCTF----
Mflv_2640|M.gilvum_PYR-GCK AHVARAQLRAIIGELLTQLPDLAAGE-PSFVAGNFIHAVRRMPVTW----
Mb2289|M.bovis_AF2122/97 ANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS---
Rv2266|M.tuberculosis_H37Rv ANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS---
MUL_1282|M.ulcerans_Agy99 ANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVAWSR--
MAB_0613|M.abscessus_ATCC_1997 ANLARLTINLMFNAIADHMPNLAPAGDPKRLQSGWLNGIKHWQVDFTGAS
MLBr_02088|M.leprae_Br4923 AALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV----
:*: : : :: : . :..:
MSMEG_2558|M.smegmatis_MC2_155 ------
TH_3205|M.thermoresistible__bu ------
Mvan_2234|M.vanbaalenii_PYR-1 ------
MMAR_3761|M.marinum_M ------
MAV_1734|M.avium_104 ------
Mflv_2640|M.gilvum_PYR-GCK ------
Mb2289|M.bovis_AF2122/97 ------
Rv2266|M.tuberculosis_H37Rv ------
MUL_1282|M.ulcerans_Agy99 ------
MAB_0613|M.abscessus_ATCC_1997 GCPVLQ
MLBr_02088|M.leprae_Br4923 ------