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MMGMLDGRVAVITGAGRGIGREHALLFAAQGAAVVVNDLGGSNTGEGADAGPAHEVVAEITANGGRAVAN TDSVADWDGAKRVVQQAIDEFGRLDVLVNNAGILRDAFIAGMAEDQWDAVINVHLKGHFAMLHHAAAYWK EQSKAGEQPTAAVINTASGSGVTLPNAGQANYGAAKAGIAALTLIAAEELERYGVRVNAIAPIARTRLTL ATPGMGALMAEPDDGELDLFAPANISPLVGYLASEKCPVTGKVYAVQGGAISLLQGWQDVETIETDKVWE LDDIAARLPGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2341 | - | - | 100% (291) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5264 | - | 4e-77 | 53.45% (290) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0106 | - | 8e-54 | 43.57% (280) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3578c | - | 4e-76 | 52.82% (284) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1492 | - | 1e-76 | 54.80% (281) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3548c | - | 3e-76 | 52.82% (284) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 3e-23 | 33.08% (260) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_2948c | - | 1e-133 | 79.65% (285) | short chain dehydrogenase |
| M. marinum M | MMAR_5036 | - | 2e-79 | 55.87% (281) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0612 | - | 4e-77 | 54.08% (294) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5999 | - | 4e-79 | 56.58% (281) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3887 | - | 1e-75 | 54.45% (281) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4110 | - | 1e-78 | 55.16% (281) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2341|M.vanbaalenii_PYR-1 ---------------------------------------------MMGML
MAB_2948c|M.abscessus_ATCC_199 -------------------------------------------------M
Mflv_1492|M.gilvum_PYR-GCK ----------------------------------------------MGLL
MSMEG_5999|M.smegmatis_MC2_155 ----------------------------------------------MGLL
TH_3887|M.thermoresistible__bu ----------------------------------------------MGIV
MAV_0612|M.avium_104 ----------------------------------------------MGVV
Mb3578c|M.bovis_AF2122/97 ----------------------------------------------MGLV
Rv3548c|M.tuberculosis_H37Rv ----------------------------------------------MGLV
MMAR_5036|M.marinum_M ----------------------------------------------MGLL
MUL_4110|M.ulcerans_Agy99 ----------------------------------------------MGLL
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
:
Mvan_2341|M.vanbaalenii_PYR-1 DGRVAVITGAGRGIGREHALLFAAQG-------AAVVVNDLGGSNTGEGA
MAB_2948c|M.abscessus_ATCC_199 EGRVAVITGAGRGIGREHALLFAREG-------ASVVVNDLGGSNEGEGA
Mflv_1492|M.gilvum_PYR-GCK DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MSMEG_5999|M.smegmatis_MC2_155 DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
TH_3887|M.thermoresistible__bu DGRVVIVTGAGNGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MAV_0612|M.avium_104 DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
Mb3578c|M.bovis_AF2122/97 DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
Rv3548c|M.tuberculosis_H37Rv DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MMAR_5036|M.marinum_M DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MUL_4110|M.ulcerans_Agy99 DGRVVIVTGAGGGIGRAHALAFAVEG-------ARVVVNDIGVGLDGSPA
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
* :: : : : * * . :*.: * ..
Mvan_2341|M.vanbaalenii_PYR-1 DAG-PAHEVVAEITANGGRAVANTDSVADWDGAKRVVQQAIDEFG-RLDV
MAB_2948c|M.abscessus_ATCC_199 DAG-PAHQVVDEIVSAGGKAVANTDNIATWDGAAGLIEQAISEFG-GLDV
Mflv_1492|M.gilvum_PYR-GCK GGGSAAQTVVDEIIAAGGEAVTSGANVADWGQAEGLIQTAVDAFG-GLDV
MSMEG_5999|M.smegmatis_MC2_155 SGGSAAQTVVDEIVAAGGEAVANGSNVADWAQAESLVQTAVDTFG-GLDV
TH_3887|M.thermoresistible__bu SGGSAAQAVVDEIKAAGGEAVANGSNVADWAQAEELVKTAIDTYG-GLDV
MAV_0612|M.avium_104 SGGSAAQSVVDEITAAGGEAVADGSNVADWDQAAGLIQTAVETFG-GLDV
Mb3578c|M.bovis_AF2122/97 SGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYG-GVDV
Rv3548c|M.tuberculosis_H37Rv SGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYG-GVDV
MMAR_5036|M.marinum_M GGGSAAHGVVDEITAAGGEAVANGSDVSNWQQAADLISTAVDTFG-GLDV
MUL_4110|M.ulcerans_Agy99 GGGSAAHGVVDEITAAGGEAVANGSDVSNWQQAADLISTAVDTFG-GLDV
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
. :: :: . .* . : : . *:. :. :.
Mvan_2341|M.vanbaalenii_PYR-1 LVNNAGILRDAFIAGMAE---DQWDAVINVHLKGHFAMLHHAAAYWKEQS
MAB_2948c|M.abscessus_ATCC_199 VVNNAGILRDGFIAGMDE---SQWDSVLTVHLKGHFSVLRHAATYWKSQS
Mflv_1492|M.gilvum_PYR-GCK LVNNAGIVRDRMFANTSE---EEFDAVTAVHLKGHFATMRHAAAYWRAKS
MSMEG_5999|M.smegmatis_MC2_155 LVNNAGIVRDRMFANTSE---EEFDAVVAVHLKGHFATMKHAAAYWRAKS
TH_3887|M.thermoresistible__bu LVNNAGIVRDRMIANTSE---EEFDAVVAVHLKGHFATTRHAAAYWRGLA
MAV_0612|M.avium_104 LVNNAGIVRDRMIANTSE---EEFDAVIAVHLKGHFATMRHAAAYWRGLS
Mb3578c|M.bovis_AF2122/97 LVNNAGIVRDRMIANTSE---EEFDAVIAVHLKGHFATMRHAASHWRGLS
Rv3548c|M.tuberculosis_H37Rv LVNNAGIVRDRMIANTSE---EEFDAVIAVHLKGHFATMRHAASHWRGLS
MMAR_5036|M.marinum_M LVNNAGIVRDRMMANTSE---EEFDAVIAVHLKGHFATMRHAASYWRGLS
MUL_4110|M.ulcerans_Agy99 LVNNAGIVRDRMMANTSE---EEFDAVIAVHLKGHFATMRHAASYWRGLS
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
:.... : :: : ::. . *..: : . . :
Mvan_2341|M.vanbaalenii_PYR-1 KAGEQ----PTAAVINTASGSGVTLPNAGQANYGAAKAGIAALTLIAAEE
MAB_2948c|M.abscessus_ATCC_199 KDGSQ----PNAAVVNTASGSGLTVPNAGQANYGAAKAGIAALTLVAAEE
Mflv_1492|M.gilvum_PYR-GCK KAGDT----VDARIINTSSGAGLQG-SVGQANYSAAKAGIAALTLVAAAE
MSMEG_5999|M.smegmatis_MC2_155 KAGET----VDARIINTSSGAGLQG-SVGQANYSAAKAGIAALTLVAAAE
TH_3887|M.thermoresistible__bu KEGKA----VDARIINTSSGAGLQG-SVGQGNYSAAKAGIAALTLVAAAE
MAV_0612|M.avium_104 KAGKA----VDGRIINTSSGAGLQG-SVGQGNYSAAKAGIATLTLVGAAE
Mb3578c|M.bovis_AF2122/97 KAGKAPKD-IDARIINTSSGAGLQG-SVGQGNYSAAKAGIAALTLVGAAE
Rv3548c|M.tuberculosis_H37Rv KAGKAPKD-IDARIINTSSGAGLQG-SVGQGNYSAAKAGIAALTLVGAAE
MMAR_5036|M.marinum_M KAGKA----VDARIINTSSGAGLQG-SVGQANYSAAKAGIAALTLVGAAE
MUL_4110|M.ulcerans_Agy99 KVGKA----VDARIINTSSGAGLQG-SVGQANYSAAKAGIAALTLVGAAE
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
. : :*:. . . * :.:: : .* *
Mvan_2341|M.vanbaalenii_PYR-1 LE-----RYG---VRVNAIAPIARTRLTLATP----------------GM
MAB_2948c|M.abscessus_ATCC_199 LE-----RYG---VRVNAIAPIARTRLTLATP----------------GM
Mflv_1492|M.gilvum_PYR-GCK MG-----RYG---VSVNAIAPSARTRMTETV------------------F
MSMEG_5999|M.smegmatis_MC2_155 MG-----RYG---VTVNAIAPSARTRMTETV------------------F
TH_3887|M.thermoresistible__bu LG-----RYG---VTVNAIAPSARTRMTETV------------------F
MAV_0612|M.avium_104 MG-----RYG---VTVNAIAPSARTRMTETV------------------F
Mb3578c|M.bovis_AF2122/97 MR-----RYG---VTVNAIAPAARTRMTETV------------------F
Rv3548c|M.tuberculosis_H37Rv MR-----RYG---VTVNAIAPAARTRMTETV------------------F
MMAR_5036|M.marinum_M MG-----RYG---VTVNAIAPAARTRMTETV------------------F
MUL_4110|M.ulcerans_Agy99 MG-----RYG---VTVNAIAPAARTRMTETV------------------F
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
* * : ::. * * ::*
Mvan_2341|M.vanbaalenii_PYR-1 GALMAEPDDGELDLFAPANISP---LVGYLASEKCP-VTGKVYAVQGGA-
MAB_2948c|M.abscessus_ATCC_199 GALMGEPEDGEVDLFSPANISP---LVAYLASEKCP-LSGKVFAVQGGA-
Mflv_1492|M.gilvum_PYR-GCK ADMMATQDKD-FDAMAPENVSP---LVVWLGSVESRDVTGKMFEVEGGK-
MSMEG_5999|M.smegmatis_MC2_155 ADMMATQDQE-FDAMAPENISP---IVVWLGSAEARDVTGKMFEVEGGK-
TH_3887|M.thermoresistible__bu AEMMATQDQE-FDSMAPENISP---LVVWLGSAESKDVSGRVFEVEGGK-
MAV_0612|M.avium_104 AEMMATQDQD-FDAMAPENVSP---LVVWLGSAEARDVTGKVFEVEGGK-
Mb3578c|M.bovis_AF2122/97 AEVMAKPQEG-FDAMAPENVSP---LVVWLGSAESRDVTGKVFEVEGGI-
Rv3548c|M.tuberculosis_H37Rv AEMMAKPQEG-FDAMAPENVSP---LVVWLGSAESRDVTGKVFEVEGGI-
MMAR_5036|M.marinum_M AEMMAKPDEG-FDAMAPENVSP---LVVWLASAEAGAVTGKVFEVEGGV-
MUL_4110|M.ulcerans_Agy99 AEMMAKPDEG-FDAMAPENVSP---LVVWLASAEAGAVTGKVFEVEGGV-
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
::. :. * . *: . :. * . . *:: :..
Mvan_2341|M.vanbaalenii_PYR-1 ISLLQGWQDVETIETDKVWELDDIAARLPGA-------------------
MAB_2948c|M.abscessus_ATCC_199 ISELAGWHDVKTIETEDIWQIDDIAVRLP---------------------
Mflv_1492|M.gilvum_PYR-GCK IRVAEGWAHGPEIDKGARWDPAELGPVVGDLLAKARTPVPVYGA------
MSMEG_5999|M.smegmatis_MC2_155 IRIAEGWAHGPEIDKGARWDPAELGPVVADLLAKARPAVPVYGA------
TH_3887|M.thermoresistible__bu VRVAEGWAHGPEADKGARWDPAELGPVVRDLLAKARQPVPVYGAXXAPPS
MAV_0612|M.avium_104 IRVAEGWAHGPQIDKGARWDPAELGPVVADLLGKARPPVPVYGA------
Mb3578c|M.bovis_AF2122/97 IRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA------
Rv3548c|M.tuberculosis_H37Rv IRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLAKSRPPVPVYGA------
MMAR_5036|M.marinum_M IRVAEGWAHGPEVDKGAKWDPAELRLVVADLLAKSRPSVPVYGA------
MUL_4110|M.ulcerans_Agy99 IRVAEGWAHGPEVDKGAKWDPAELRLVVADLLAKSRPSVPVYGA------
MLBr_02565|M.leprae_Br4923 IAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
: * . . : :
Mvan_2341|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2948c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1492|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5999|M.smegmatis_MC2_155 --------------------------------------------------
TH_3887|M.thermoresistible__bu TACSRSTSALSLRQLVANV-------------------------------
MAV_0612|M.avium_104 --------------------------------------------------
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5036|M.marinum_M --------------------------------------------------
MUL_4110|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 IPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQA
Mvan_2341|M.vanbaalenii_PYR-1 ----
MAB_2948c|M.abscessus_ATCC_199 ----
Mflv_1492|M.gilvum_PYR-GCK ----
MSMEG_5999|M.smegmatis_MC2_155 ----
TH_3887|M.thermoresistible__bu ----
MAV_0612|M.avium_104 ----
Mb3578c|M.bovis_AF2122/97 ----
Rv3548c|M.tuberculosis_H37Rv ----
MMAR_5036|M.marinum_M ----
MUL_4110|M.ulcerans_Agy99 ----
MLBr_02565|M.leprae_Br4923 MLGA