For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TDIDTGALLDERRLELLRRRMQERGLSAGTDTAEPAGDTDVLTEGQLRMWFVHNADPSGALLNVCLSYRL SGEIDVARLHDAVGAVARRHRVLRTTYRTESTAAGDSGMPVPTVHTGLMPGWAEHDLSELSERARGLRLE VLAQREFGRPFDLGAESPLRITVIRTAPAEYVMLLVAHHIAWDDASWEVFFDDLTGAYVGEKLRPARRPV VAAGGSDEDDVAYWRAVMADPPEPLELPGPTGSAVPTSWRSQRTTLRLDGETARRVTALADEVGATPYAV LLAVFGVLIHRYSHVDDFLVATPVLNRNGDTDDVIGYFGNTVAMRLRPHPAMTFRDLLTQTRDTALGAFA HQRVGLDRMVRELNPDRRHGAERMTRVSFGFRSRDRFGFTPPGVTCERADLRSHLTHLPLGIMVEFDPDE VVVELEHLVEIIEPGLARQLLDHYAVLIRSALDDPDTTLSGLQLMGDDDLEWLRAVSVGPTFDTPPATIT DLIEAQVRRSPDGTAVVYEGRHYTYREINEAANRVAHWLIGEDVGAEDRVAVMLDKSPELVVTALGVLKA GAVYVPIDPAYPQDRLEFILGDCDAKVVVREPVTGLDGYRADDPGDNDRRRPVGPYNTAYLIYTSGSTGL PKGVPVPHRPVAEYFVWFKGDYRVDAGDRMLQVASPSFDISIAEVFGTLACGARLVIHRPGGLNDIGYLT ALLRDEGITAMHFVPSLLGLFLSLPGVNQWRTLQRVPIGGEALPGEVADKFRATFDALLHNFYGPTETVI NATRFKVEGRQGTRIVPIGKPKINTAIHILDDALQPVPVGSIGEIYIGGTHVARGYHHRPGLTAERFVAD PFTPGARMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAITVDPSVGQAVVVVSDLPNLGK SLVAYLTPADGAGVDVDRIRTRVAAALPEYMTPAAYVVVDEIPITAHGKIDRAALPEPEIAPTTEFREPA AGTEAHLAQLFAELLGHEKVGADDSFFDLGGHSLLATKLVAELRAGFGVDVEVRDIFENATIARLAAHLD TMGRATIGTRRPRLVAAPLDGPAPLSSSQLRSWFGYRIEGRSPVNNIPFAARLTGPCDVDAFVAAIRDVV ERHAILRTTYREIDGVPYQIVNPISDVPVRRARGEGEQWLQAELDRERKHTFDLEEDWPIRAAVFTVGAV SPASDGGAVSPASDGGAVDPASDHVLSVVIHHIAGDHWSGGVLFTDLVAAYRARKAGERPTWAPLPVQYT DYGAWQAELLSDDTGIAGPQREYWIRQLADAPVESGLPLEFSRPRLPSGKGDAVEFTIDGQVRRQITELC RELGITEFMLLQAAVAVTLAKVGGGLDIPLGTPVAGRSEAELEQLVGFFVNFVVLRNDLRGNPTLREVLI RAREMALSAYSNQDVPFEQVVEAVNPPRTLARNPLFQVVVHVREQLPQRQMIDTDTEFTALEPTFDIAQA DLSLNFLADGTGYRGYLIYRPELYARRTIERLGRWLPRVVAAFVDTPDRALGDVDIVSAEERQRVSQEWS TGARVQVLDADLAPAPVGVFGDLYLSGGPFAQRHRTGDRARWDDDGRLEIAARAPGATVVEVAPPAVEFE EPRTDSERALAALLSELLATEEVGRHDDFFGLGGDSVLAVQLAARARDTGLDLTARMVFEHPRLAELAAA LDSGAGAAAEQPDTHHAPMSVSGLSEDELAALTASWGTGE*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_3845 | - | - | 100% (1721) | amino acid adenylation domain-containing protein |
M. vanbaalenii PYR-1 | Mvan_1000 | - | e-148 | 28.44% (1505) | amino acid adenylation domain-containing protein |
M. vanbaalenii PYR-1 | Mvan_3844 | - | 2e-97 | 28.43% (1379) | amino acid adenylation domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2401c | mbtE | 0.0 | 66.69% (1711) | peptide synthetase MBTE (peptide synthase) |
M. gilvum PYR-GCK | Mflv_2696 | - | 0.0 | 61.47% (1801) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv2380c | mbtE | 0.0 | 66.69% (1711) | peptide synthetase MBTE (peptide synthase) |
M. leprae Br4923 | MLBr_01996 | nrp | 3e-26 | 27.42% (445) | putative peptide synthase |
M. abscessus ATCC 19977 | MAB_2122 | - | 0.0 | 40.78% (1758) | putative peptide synthetase MbtE |
M. marinum M | MMAR_3691 | mbtE | 0.0 | 41.13% (1758) | non-ribosomal peptide synthetase MbtE |
M. avium 104 | MAV_2013 | - | 0.0 | 62.46% (1569) | linear gramicidin synthetase subunit D |
M. smegmatis MC2 155 | MSMEG_4511 | - | 0.0 | 62.17% (1734) | linear gramicidin synthetase subunit B |
M. thermoresistible (build 8) | TH_3141 | - | 0.0 | 68.16% (1784) | PUTATIVE amino acid adenylation domain |
M. ulcerans Agy99 | MUL_3634 | mbtE | 0.0 | 41.18% (1758) | non-ribosomal peptide synthetase MbtE |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_3845|M.vanbaalenii_PYR-1 ---MTDIDTGALLDERRLELLRRRMQERGLSAG---TDTAEPAG-DTDVL TH_3141|M.thermoresistible__bu VTDTTETRPAGADDEARLALLRRRLSERGLSAQ---QTTGAAS---EDRL Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 MTDIADTATAS-TVEARLELMRRKLAERGLAAGRAAAEGSAAAV-DPTVL Mflv_2696|M.gilvum_PYR-GCK -------MTDTDLDARRLELLRRRLAGSGLREQDPAEPVAVAADPARGEF MAV_2013|M.avium_104 --MTETTGAGTRLDDERLELLRRKLAERGLSRS------AGTARHDEPRM MMAR_3691|M.marinum_M -----MADDVRTLQDRRRELLRRRIAESGLAAEQSSDQPGICPG-ERYRL MUL_3634|M.ulcerans_Agy99 -----MADDVRTLQDRRRELLRRRIAESGLAAEQSSDQPRICPG-ERYRL MAB_2122|M.abscessus_ATCC_1997 -----MTGDQLSALDRRRELLRRRLAESGVAAQAVESAPRVQAG-ERRGL MLBr_01996|M.leprae_Br4923 ------------------------------------MTAPNTRRVDRVPL Mvan_3845|M.vanbaalenii_PYR-1 TEGQLRMWFVHNADPSGALLNVCLSYRLSGEIDVARLHDAVGAVARRHRV TH_3141|M.thermoresistible__bu SDGQLRMWFVHQADPSGALLNICLSYRISGPVDLAALRGALDAVARRHPV Mb2401c|M.bovis_AF2122/97 ------MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRI Rv2380c|M.tuberculosis_H37Rv ------MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRI MSMEG_4511|M.smegmatis_MC2_155 SDGQRRMWFVQGFDPSGVLLNVSLSYRLTGDIDAERMQAAVEAVARRHPI Mflv_2696|M.gilvum_PYR-GCK TDGQKRMWFVHSVDPSGVLLNVCLSYRISGEVDLARLHDAVTAVARRHPV MAV_2013|M.avium_104 SVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPV MMAR_3691|M.marinum_M SDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAI MUL_3634|M.ulcerans_Agy99 SDGQRRMWFLQTMDPDDVTLNICVAYRLTGLVDEDRLHTAVNDVVARHAI MAB_2122|M.abscessus_ATCC_1997 APGQRRMWFMQTKDPADTSLNICVAHRMRGALDQTRLRDAVAAVIRRHDV MLBr_01996|M.leprae_Br4923 SRSQQNIYNGMLQDNDPALYFIGKSYRFH-QLELSVFLAALEATILKNPG :: * . : ::*: :: : *: . :: Mvan_3845|M.vanbaalenii_PYR-1 LRTTYRTESTAAGDSGMPVPTVHTGLMPGWAEHDLSELS---ERARGLRL TH_3141|M.thermoresistible__bu LRTTY-----AADENGEPRPTVHAELRPGWTEHDLTDLADQSEQARRLRL Mb2401c|M.bovis_AF2122/97 LRTTY-----PVGDDGVAQPTVHADLRPGWTQYDLTDLS---QRAQRLRL Rv2380c|M.tuberculosis_H37Rv LRTTY-----PVGDDGVAQPTVHADLRPGWTQYDLTDLS---QRAQRLRL MSMEG_4511|M.smegmatis_MC2_155 LRTTF-----HADENGEPRAEVHDDLTPSWTTHDLSEKS---ERARKLRL Mflv_2696|M.gilvum_PYR-GCK LRTTF-----AADEAGEPQRTVHDDLLPGWTVQDISELS---EHARRLRL MAV_2013|M.avium_104 LHTTY-----DTTDEGDPRPVLRADLRPEWAEHDLSGLT---EQARRLRL MMAR_3691|M.marinum_M LRTTY-----GVDTEGEPYQVFSDDVEVGWRREDLTRLP---EAGHERQI MUL_3634|M.ulcerans_Agy99 LRTTY-----GVDTEGEPYQVFSDDVEVGWRREDLTRLP---EAGHEQQI MAB_2122|M.abscessus_ATCC_1997 LRTVY-----GVDSAGEPYQLFVEEFEVPWTAVDLTDLT---GDAQDRQV MLBr_01996|M.leprae_Br4923 QLCVL---------EAPSTEGDYPDLVPRLQFGDIVRVR--SDEQPQTDS . . . . *: Mvan_3845|M.vanbaalenii_PYR-1 EVLAQREFGRPFDLGAESPLRITVIRTAPAEYVMLLVAHHIAWDDASWEV TH_3141|M.thermoresistible__bu EVLAQREFTAPFDLSVDSPLRITMIRTGADEHIMLLVAHHIAWDDGSWEV Mb2401c|M.bovis_AF2122/97 EVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRV Rv2380c|M.tuberculosis_H37Rv EVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRV MSMEG_4511|M.smegmatis_MC2_155 EVLAQREFGTPFDLGTESPLRLTLIRTGPAEHVLLLVAHHIAWDDGSWRV Mflv_2696|M.gilvum_PYR-GCK EVLAQREFGTPFDLATESPLRITVARTAPAEYIMLLVVHHIAWDDGCWRV MAV_2013|M.avium_104 DVLAQRDFRRPFDLSKDSPLRVTAARLADDELMLLITAHHIAWDDGSWAP MMAR_3691|M.marinum_M ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEV MUL_3634|M.ulcerans_Agy99 ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEV MAB_2122|M.abscessus_ATCC_1997 RALADSEFGRPFDLAADRPLRVTLLRLGAEDFVVLLVVHHICWDDNSWEV MLBr_01996|M.leprae_Br4923 RDYDLMHAWSPDILAKPLVRYTVRTDKNGFVARLDVFTHHILVDGGAIRI . * * . : : .*** *. . Mvan_3845|M.vanbaalenii_PYR-1 FFDDLTGAYV----------GEKLRPARRPVVAAGGSD-EDDVAYWRAVM TH_3141|M.thermoresistible__bu FFDDLTRAYT----------GVDLGEELAPQLPPGPRDPDADLAYWREVL Mb2401c|M.bovis_AF2122/97 FFTDLTQAYSRA-----DL-GADLGPEHRPSAASGPDTTEADLNYWRAIM Rv2380c|M.tuberculosis_H37Rv FFTDLTQAYSRA-----DL-GADLGPEHRPSAASGPDTTEADLNYWRAIM MSMEG_4511|M.smegmatis_MC2_155 FFTDLTRAYS----------GEQLPETPR-VGAAAPDTTDEDLAYWREVM Mflv_2696|M.gilvum_PYR-GCK FFADLTRAYT----------GAELGPTPAPVVEP--PTSDEDLRFWRSAM MAV_2013|M.avium_104 FFADLTRAYTAP-----G--DFDATPVVPDLSADPTAIRREDLDYWRPLM MMAR_3691|M.marinum_M FFGELSAAYNDL-----PINDPAAQFLSVEVLQNSAAPSVADVGYWAETL MUL_3634|M.ulcerans_Agy99 FFGELSAAYNDL-----PINDPAAQFLSVEVLQNSAAPSVADVGYWAETL MAB_2122|M.abscessus_ATCC_1997 FFAELSEYYHGR-----PVQGEAPQFMVVS--ADTEPSSDADLTYWRRAL MLBr_01996|M.leprae_Br4923 IEENLAHHLDTDNRLEIPCIRQALDKLAEAHRREATKVEESLQRLANVVQ : :*: Mvan_3845|M.vanbaalenii_PYR-1 ADPPEPLELPGPTGSAVPTSWRSQR----TTLRLDGETARRVTALADEVG TH_3141|M.thermoresistible__bu ADPPEPLELPGPHGSAVPSGWRSAR----DSVTLGADTARRVVELAQETG Mb2401c|M.bovis_AF2122/97 ADPPEPLELPGPAGTCVPTSWRAAR----ATLRLPADTAARVATMAKNTG Rv2380c|M.tuberculosis_H37Rv ADPPEPLELPGPAGTCVPTSWRAAR----ATLRLPADTAARVATMAKNTG MSMEG_4511|M.smegmatis_MC2_155 ANPPEPLELPGPMGSVVPTGFRSQR----STVRLSAETVEKVTVLARETG Mflv_2696|M.gilvum_PYR-GCK TDLPEPLELPGPHGSAVPTTWRCRR----VTATLSADTVERVRVAAREAG MAV_2013|M.avium_104 ADLPEPLELPGPNGSVVPSTWRAQR----AFAELPAEIVDRAAALARETG MMAR_3691|M.marinum_M RPLPEPPELPGVSG--ANPCRRAQR----RVRPLPAGLFSRVEDFARKCS MUL_3634|M.ulcerans_Agy99 RPLPEPPELPGVSG--ANPCRRAQR----RVRPLPAGLFSRVEEFARKCS MAB_2122|M.abscessus_ATCC_1997 TPLPDPLELPGAAS--TYSSRAARR----LAVPMPAETAARIEEFAREHS MLBr_01996|M.leprae_Br4923 RELADEVRNGGYGQVSNDAPGNAARGVLHESMIICGKAFDNIIALSETKQ .: . * . . * : . . : Mvan_3845|M.vanbaalenii_PYR-1 ATPYAVLLAVFGVLIHRYSHVDDFLVATPVLNRNGDTDDVIG-YFGNTVA TH_3141|M.thermoresistible__bu CTPYAVLLAVFGTLIFRYTHADDFLVATPVLNRDSGAEQRIG-YYGNTVA Mb2401c|M.bovis_AF2122/97 CTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIG-YFGNTVA Rv2380c|M.tuberculosis_H37Rv CTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIG-YFGNTVA MSMEG_4511|M.smegmatis_MC2_155 ATPYMVLLAAFGALIRRYTHTDDFLVATPVLNR--DTEDTIG-YHGNTVA Mflv_2696|M.gilvum_PYR-GCK ATPYMVMLAAFGALLHRYTHADDVLIASPVLLRGPDSEDVIG-YHGNSAV MAV_2013|M.avium_104 ATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAATENVIG-YYGNTVV MMAR_3691|M.marinum_M ASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALG-YFGNTLL MUL_3634|M.ulcerans_Agy99 ASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGALG-YFGNTLL MAB_2122|M.abscessus_ATCC_1997 ATPFMVLLAAFGVLVHRYTGSRDFVTAIPVAERKSNAEKAIG-YFGNTLL MLBr_01996|M.leprae_Br4923 VPLNILVATAAVAVDASLRQSTEGLLVHAVDNRFGDPYLDVATCLVNSVA . :: :. .: : : .* * . :. *: Mvan_3845|M.vanbaalenii_PYR-1 MRLRPHPAMTFRDLLTQTRDTALGAFAHQRVGLDRMVRELNPDR---RHG TH_3141|M.thermoresistible__bu MRLRPNAAMSFRDMLAQSRDTALGAFAHQGINLDRVVRELNPDR---RHG Mb2401c|M.bovis_AF2122/97 MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR---RHG Rv2380c|M.tuberculosis_H37Rv MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR---RHG MSMEG_4511|M.smegmatis_MC2_155 MRMRPRSDAGFRDLVLQTRDVALGAFAHQRVNLDRVVRELNPDR---RHG Mflv_2696|M.gilvum_PYR-GCK MRLRPQPMQTFTELLSRTRDFALDAFAHQQVNLDRVVRELNLDR---RHG MAV_2013|M.avium_104 IRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR---RHG MMAR_3691|M.marinum_M LRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDG MUL_3634|M.ulcerans_Agy99 LRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDG MAB_2122|M.abscessus_ATCC_1997 LRTVVNPDDSFASHVAAVREVCLDAFGHQNVGIDEVVREVNPSRSIGHDG MLBr_01996|M.leprae_Br4923 HSIRFPPFASVQDVVRTLDRSYVKAIRLRWLREEYYRRIYLALN----QT . . . : .: : * . . Mvan_3845|M.vanbaalenii_PYR-1 AERMTRVSFGFRSRDRFGFTPPGVTCERADLRSHLTHLPLGIMVEFDPD- TH_3141|M.thermoresistible__bu TERMTRVSFGFRGPDRFGFTPPGVRCERAELRSHLTQLPLGVMIEFDPDP Mb2401c|M.bovis_AF2122/97 AERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRA- Rv2380c|M.tuberculosis_H37Rv AERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRA- MSMEG_4511|M.smegmatis_MC2_155 AERMTRVSFGFREPDGGGFCPAGVRCERAELRGNHTQLPLGFMVEWEAT- Mflv_2696|M.gilvum_PYR-GCK AERMTRVSFGFREPDGGGFSPPGVTCRRAELRGQITQLPLGLMVELHES- MAV_2013|M.avium_104 ADRMTRVSFGQREPDGAGFCPPGVRCERGDLRGHFNQLPLSLMVELNRTP MMAR_3691|M.marinum_M MDLLVRLGFNMR-KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPD- MUL_3634|M.ulcerans_Agy99 MDLLVRLGFNMR-KSAGGLALDGVVVRQLGLGAIAAHLPLSLTIALDPD- MAB_2122|M.abscessus_ATCC_1997 MDELVRLGFSMR-KDASGYRLEGVDVTQLDLAAVSAQLPLSLAIATESS- MLBr_01996|M.leprae_Br4923 SHIEALTLNFIREPCAPGLRPFLSEVPTVTDIGPVEGMTVACVLNEDER- . . * * . :.:. : . Mvan_3845|M.vanbaalenii_PYR-1 ----EVVVELEHLVEIIEPGLARQLLDHYAVLIRSALDDPDTTLSGLQLM TH_3141|M.thermoresistible__bu ADP-GATVEIEHLVEVIEPALGRQLLRHFVVLLEDALRRPDTPLSRLRLM Mb2401c|M.bovis_AF2122/97 ----GVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALM Rv2380c|M.tuberculosis_H37Rv ----GVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALM MSMEG_4511|M.smegmatis_MC2_155 ----GATVEAEHLTEVLDAALAEQMLRHFTVLLDNALADPDRALWRLDLF Mflv_2696|M.gilvum_PYR-GCK ----GAVVEAEFLVEVLDDTLVTQMLDHYVVLLEAAVAQPDTVLSRLELM MAV_2013|M.avium_104 DGSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALM MMAR_3691|M.marinum_M ----DVSVEFEYQQQLS-SVLVDQMLVHYLQLVDKALAEPERPLSSLDIL MUL_3634|M.ulcerans_Agy99 ----DVSVEFEYQQQLS-SVLVDQMLAHYLQLVDKALAEPERPLSSLDIL MAB_2122|M.abscessus_ATCC_1997 ----GTIVEFEYQTDVLPQWLVGQLLVHYQRLLADGLSRPEETLARLELF MLBr_01996|M.leprae_Br4923 ----TLDLSIWNRVDLPQGKSCTRVAKRIAAALELMAAAWDQPIAMIVN- :. :: :: : : : : Mvan_3845|M.vanbaalenii_PYR-1 GDDDLEWLRAVSVGPTFDTPPATITDLIEAQVRRS--PDGTAVVYEGRHY TH_3141|M.thermoresistible__bu DDADLAWLRDVSRGDRFDTPARTLPDLIESQVRQT--PDAVAVVYEGRHY Mb2401c|M.bovis_AF2122/97 DERDAARLREVSRGERFDTPVKTLVDLVNEQTTRT--PDATAVVYEGQHF Rv2380c|M.tuberculosis_H37Rv DERDAARLREVSRGERFDTPVKTLVDLVNEQTTRT--PDATAVVYEGQHF MSMEG_4511|M.smegmatis_MC2_155 TAEDTAWLTRMATGEAFDTPAATLTDLVTQQAERT--PDATAVVYEGRHF Mflv_2696|M.gilvum_PYR-GCK DGDDAEWLRRVSHGPEFDVPAATIGELIEARTDLT--PDTVAVVYEGRRY MAV_2013|M.avium_104 SDADAEWLRAVSTGEQFITPAATLSELVSRRAART--PDAVAVVYEGRTY MMAR_3691|M.marinum_M GAGERDSVLAQSHGELVEMPATTMVKLLEATASAAGTATALALVSDEAEL MUL_3634|M.ulcerans_Agy99 GAGERDSVLAQSHGELVEMPATTMVKLLEATASAAGTATALALVSDEAEL MAB_2122|M.abscessus_ATCC_1997 DAEEHSALLDQSHGVLTRPSAATLVDLLDAAARAT--PEALAVVSDDVEL MLBr_01996|M.leprae_Br4923 -----EWFGISSDGALCLGNEVTQTTRPLAPAWFLDPGGSVHLTVDKRRY . : * * . :. : Mvan_3845|M.vanbaalenii_PYR-1 TYREINEAANRVAHWLIGEDVGAEDRVAVMLDKSPELVVTALGVLKAGAV TH_3141|M.thermoresistible__bu SYRELNEAANRVAHWLIGQGIGTEDRVAVLLDKSPELVITALGVLKAGAV Mb2401c|M.bovis_AF2122/97 TYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAV Rv2380c|M.tuberculosis_H37Rv TYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAV MSMEG_4511|M.smegmatis_MC2_155 TYREINESANRLAHWLIGQGIGTEDRVAVLLEKSPELVITALGIVKAGAV Mflv_2696|M.gilvum_PYR-GCK TYREINESANRVAHWLIGQGIGAEDRVAVLMDRSPELLITALGIIKAGAV MAV_2013|M.avium_104 TYRDIEEESNRVAHWLIERGVGTEDRVAVLLDKSPELVITALGVLKAGGV MMAR_3691|M.marinum_M TYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAA MUL_3634|M.ulcerans_Agy99 TYSELHRRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAA MAB_2122|M.abscessus_ATCC_1997 TYELLQQRSNRFARWLVAQGAGTEDVIALQMSTSVEFIVAMLGVLKSGAA MLBr_01996|M.leprae_Br4923 VHPWIA--------WLVRGSVVPGDVLVFTDDNTDKTIDLLIACHLAGCG : : *:: . . * : . : . : :. :* Mvan_3845|M.vanbaalenii_PYR-1 YVPIDPAYPQDRLEFILGDCDAKVVVREPVTGLDGYRAD-----DPGDND TH_3141|M.thermoresistible__bu YLPIDPTYPDDRLSFILGDCDARLVLREPVSDLDGQPTT-----DPTDTD Mb2401c|M.bovis_AF2122/97 YVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSD-----DPTDAD Rv2380c|M.tuberculosis_H37Rv YVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSD-----DPTDAD MSMEG_4511|M.smegmatis_MC2_155 YLPVDPTYPEDRLNYILSDSDPKIVLREFVTGLDDQPTT-----DPTDAE Mflv_2696|M.gilvum_PYR-GCK YLPVDPSYPQDRMSFVLSDSDPTLVIREPVAGLDGHRTD-----NPTDDV MAV_2013|M.avium_104 YLPVDPTYPQDRLNFILGDADAKLVLREPVTDLADYPAT-----APT--E MMAR_3691|M.marinum_M YLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSD MUL_3634|M.ulcerans_Agy99 YLPIDPAYPDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDGD MAB_2122|M.abscessus_ATCC_1997 YMPIDPALPEERIEYLIADAKPRIVMRPQEFRVAEAAATGLGDAPITDAD MLBr_01996|M.leprae_Br4923 YSVCDTVAEVPLRAKAITDHGGGVSARVIDVAATQLAVTPDNEQSKLADK * *. : * Mvan_3845|M.vanbaalenii_PYR-1 RRRPVGP-----YNTAYLIYTSGSTGLPKGVPVPHRPVAEYFVWFKGDYR TH_3141|M.thermoresistible__bu RVRRLLP-----GNTAYLIYTSGTTGLPKGVPVPHRPVAEYFVWFKGDYQ Mb2401c|M.bovis_AF2122/97 RIRPLRP-----DNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYD Rv2380c|M.tuberculosis_H37Rv RIRPLRP-----DNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYD MSMEG_4511|M.smegmatis_MC2_155 RVRPLRP-----DNTAYLIYTSGSTGLPKGVPVPHRPIAEYFVWFGGEYD Mflv_2696|M.gilvum_PYR-GCK RVRPLRP-----ENAAYLIYTSGSTGQPKGVPVPHRPVAEYFVWFKDEYE MAV_2013|M.avium_104 LLRPLTP-----QNTAYLIYTSGSTGLPKGVPVPHAPIAEYFVWFGDEYR MMAR_3691|M.marinum_M RLRPLRP-----GHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWT MUL_3634|M.ulcerans_Agy99 RLRPLRP-----GHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWT MAB_2122|M.abscessus_ATCC_1997 RLRPLLP-----DNLAYVIYTSGSTGRPKGVAVAHAAIAEHVVSFTAEWS MLBr_01996|M.leprae_Br4923 LIKQAAQDISLADKTAYIMPTSGSTGQPKLVQVSHGSLALFCDAVRNAYG : : **:: ***:** ** * *.* .:* . . : Mvan_3845|M.vanbaalenii_PYR-1 VDAGDRMLQVASPSFDISIAEVFGTLACGARLVIHRPGGLNDIGYLTALL TH_3141|M.thermoresistible__bu VDANDRLLQVASPSFDVSIAEIFGTLACGARLVIHRPGGLNDIGYLTALL Mb2401c|M.bovis_AF2122/97 VDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL Rv2380c|M.tuberculosis_H37Rv VDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL MSMEG_4511|M.smegmatis_MC2_155 VTNEDRLLQVASQSFDVSIGEIFGMLAAGARLVIPKPGGLTDIGYLTDLL Mflv_2696|M.gilvum_PYR-GCK ISESDRLLQVASPSFDVSIGEIFGTLACGGRLVIPKPDGLTDVAYLTELL MAV_2013|M.avium_104 IDETDRLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELL MMAR_3691|M.marinum_M MTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLI MUL_3634|M.ulcerans_Agy99 MTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLI MAB_2122|M.abscessus_ATCC_1997 MTADDRMLQSTSVSFDASLADILCPLSLGAQLVIPKPNPFSDIGYVADLV MLBr_01996|M.leprae_Br4923 WGAHDTILQCAPLTSDISVEEIFGGAICGSKLVRSTAMKTGDLAELARDI * ** :. : * *: ::: *.::: . *:. :: : Mvan_3845|M.vanbaalenii_PYR-1 RDEGITAMHFVPSLLGLFLSLPGVNQWR---TLQRVPIGGEALPGEVADK TH_3141|M.thermoresistible__bu QDEGITAMHFVPSLLGLFLSLPGVNQWR---TLQRVPIGGEPLPGEVADK Mb2401c|M.bovis_AF2122/97 RDEGITAMHFVPSLLGLFLSLPGVSQWR---TLQRVPIGGEPLPGEVADK Rv2380c|M.tuberculosis_H37Rv RDEGITAMHFVPSLLGLFLSLPGVSQWR---TLQRVPIGGEPLPGEVADK MSMEG_4511|M.smegmatis_MC2_155 RNEGITSMHFVPSLLGLFLSLPGVNEWR---TLQRVPIGGEALPGEIADK Mflv_2696|M.gilvum_PYR-GCK QREGITAMHFVPSLLGLFLSLPGVNQWR---TLERVPIGGEALPGELADR MAV_2013|M.avium_104 AREGITSMHFVPSLLGLFLSLPGVSQWR---TLRRVPIGGEALPGEIADK MMAR_3691|M.marinum_M SRRGVTVLHLVPSMLSTLLLLPQVQQWR---QLRHVPVGGEALPGEVADR MUL_3634|M.ulcerans_Agy99 SRRGVTVLHLVPSMLSTLLLLPQVQQWR---QLRHVPVGGEALPGEVADR MAB_2122|M.abscessus_ATCC_1997 RRRGVTVLHMVPSLLGSVLLLPEARELR---GLRHVPVGGEALPGEVADK MLBr_01996|M.leprae_Br4923 FVQRATVIDLPTAVWHLLCDHSDAIDEINRSCLRQIVIGGEAVRPCAVDK . * :.: .:: . . . : *.:: :***.: .*: Mvan_3845|M.vanbaalenii_PYR-1 FRAT---FDALLHNFYGPTETVINATRFKVEGRQGTRIVPIGKPKINTAI TH_3141|M.thermoresistible__bu FHAT---FDALLHNFYGPTETVINASRYKVEGKQGTRIVPIGRPKINTQL Mb2401c|M.bovis_AF2122/97 FHAT---FDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTM Rv2380c|M.tuberculosis_H37Rv FHAT---FDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTM MSMEG_4511|M.smegmatis_MC2_155 FHAT---FDSLLHNFYGPTETVLNCTRYKVEGKQGARTVPIGKPKINTTI Mflv_2696|M.gilvum_PYR-GCK FHAT---FDALLHNFYGPTETIINTTRYKVEGTQGSRIVPIGTPKINTTV MAV_2013|M.avium_104 FHAT---FDASLYNFYGPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRV MMAR_3691|M.marinum_M FAGY---FDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYA MUL_3634|M.ulcerans_Agy99 FAGY---FDAELRNHYGPTEAVVCSTHMLVTGSHGARVVPIGVPNRNVYA MAB_2122|M.abscessus_ATCC_1997 FATM---FDAELRNHYGPTEAVVCSTYMSVRGPQGNSIVPIGRPNQNVYA MLBr_01996|M.leprae_Br4923 WIDSGASQGISLMSTYGPTETTVVVTYLPIVCAP-------MTVESDARL : . * . *****: : : : : :. Mvan_3845|M.vanbaalenii_PYR-1 HILDDALQPVPVGSIGEIYIGGTHVARGYHHRPGLTAERFVADPFTPGAR TH_3141|M.thermoresistible__bu HLLDNALQPVPVGVIGEIYIGGTHVAHGYHRRPGLTAERFVADPFNPGGR Mb2401c|M.bovis_AF2122/97 HLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSR Rv2380c|M.tuberculosis_H37Rv HLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSR MSMEG_4511|M.smegmatis_MC2_155 HLLDDALQPVPVGVIGEIYIGGTHVAHGYHRRPGMTAERFVADPFNPGGR Mflv_2696|M.gilvum_PYR-GCK HLLDDALRPVPVGAIGEIYIGGGHVARGYHRRPALTAERFVADPFTVGGR MAV_2013|M.avium_104 YLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSRGGR MMAR_3691|M.marinum_M YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMR MUL_3634|M.ulcerans_Agy99 YVLDEQLHPVPDQVVGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMR MAB_2122|M.abscessus_ATCC_1997 YVLDQALKLVPAGVVGELYLGGAQLARGYRARPVLTAERFVADPFGSGGR MLBr_01996|M.leprae_Br4923 RLGWPIVPNTVFIAFGELVIVGDLVSVGYLGIDSRNFG-TVTTTDGSCRR : : . .**: : * :: ** . :: . * Mvan_3845|M.vanbaalenii_PYR-1 MYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAITVDPSVGQ TH_3141|M.thermoresistible__bu LYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAISVDPSVGQ Mb2401c|M.bovis_AF2122/97 MYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQ Rv2380c|M.tuberculosis_H37Rv MYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQ MSMEG_4511|M.smegmatis_MC2_155 MYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGEVSAAISVDPSVGQ Mflv_2696|M.gilvum_PYR-GCK LYRSGDLARRNADGDLEFVGRADDQVKIRGFRIELGEVAAAISVDPSVGQ MAV_2013|M.avium_104 MYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELGEIAAAISVDPSVGQ MMAR_3691|M.marinum_M LYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRH MUL_3634|M.ulcerans_Agy99 LYRTGDLVRRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRH MAB_2122|M.abscessus_ATCC_1997 LYRTGDLVRRNARGELEFVGRADEQVKVRGYRIELGEIEAVIGADPRVGH MLBr_01996|M.leprae_Br4923 AFATADCVILDDEGFPVFSGRKDAVVKISGKRVDTAELIRRISTDPNVSD : :.* . : * * ** * **: * *:: .:: * ..* * . Mvan_3845|M.vanbaalenii_PYR-1 AVVVVSDLPNLGKSLVAYLTPADG------AGVDVDRIRTRVAAALPEYM TH_3141|M.thermoresistible__bu AVVVATDLPNVGRSLVGYLTPVSGE---STDSVAVERIRARVAAALPEYM Mb2401c|M.bovis_AF2122/97 AVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYM Rv2380c|M.tuberculosis_H37Rv AVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYM MSMEG_4511|M.smegmatis_MC2_155 AVVVVSDLPSLGKSLVAYITPAAG-----ADHVDIERIRARVTAALPEYM Mflv_2696|M.gilvum_PYR-GCK AVVLGQDLPGLGMSLVGYVTPAAG------EDVDLARVRERVAAALPDYM MAV_2013|M.avium_104 AVVLAMDLPQLGKSLVGYVTPAQGAG---TETVDVERIRARVAAALPDYM MMAR_3691|M.marinum_M CLV-VAEETEAGPMLAAYLVPA-------AAQVDLEEIRAHTAAAVPEYM MUL_3634|M.ulcerans_Agy99 CLV-VAEETEAGPMLAAYLVPA-------AAQVDLEEIRAHTAAAVPEYM MAB_2122|M.abscessus_ATCC_1997 CVATVVDDPQVGSLLAAYVVPAGG-----TREIDLDELRARAQEALPAYM MLBr_01996|M.leprae_Br4923 VAVEVYNG-RLGVWFETKLTREG---------VDDAAAATRSRLILASLG . : * : :. : : :. Mvan_3845|M.vanbaalenii_PYR-1 TPAAYVV-VDEIPITAHGKIDR-AALPEPEIAPTTEFREPAAGTEAHLAQ TH_3141|M.thermoresistible__bu VPAAYVV-LDEIPITTHGKIDR-AALPEPQIASMIEYREPATDTEREVAR Mb2401c|M.bovis_AF2122/97 LPAAYVV-LDEIPITAHGKIDR-AALPEPQIASDTEFRAPQTATERRLAQ Rv2380c|M.tuberculosis_H37Rv LPAAYVV-LDEIPITAHGKIDR-AALPEPQIASDTEFRAPQTATERRLAQ MSMEG_4511|M.smegmatis_MC2_155 VPAAYVE-LDEIPITTHGKIDR-RALPEPEITSTTRFREPSTDTERTVAG Mflv_2696|M.gilvum_PYR-GCK TPAGYVV-LDEIPITAHGKIDR-AALPLPEITTATDYREPQTETEQHLAQ MAV_2013|M.avium_104 TPAAYVV-LDEIPITAHQKIDR-AALPQPQIGAGTEYRDPTTPTEHRIAQ MMAR_3691|M.marinum_M VPGAFAV-IPEIPMTVSGKLDR-RALPAPTPIATRRYREPETATERWICS MUL_3634|M.ulcerans_Agy99 VPGAFAV-IPEIPMTVSGKLDR-RALPAPTPIATRRYREPETATERWICS MAB_2122|M.abscessus_ATCC_1997 VPTAFAV-IPEIPLTTSGKLDK-RALPTPDALTERAFRLPVTPTERRMCA MLBr_01996|M.leprae_Br4923 VSSFFVVGVPCIPRKPNGKIDRDNLLVMPQLVDSVQNYAGSGEGAAGLAE . :. : ** . *:*: * * :. Mvan_3845|M.vanbaalenii_PYR-1 LFAELLG-HEKVGADDSFFDLGGHSLLATKLVAELRAGFGVDVEVRDIFE TH_3141|M.thermoresistible__bu LFGDLLGRSERIGADDSFFDLGGHSLLATKLVAAVRSAFGVDIGVQDVFE Mb2401c|M.bovis_AF2122/97 LFGELLG-RDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFE Rv2380c|M.tuberculosis_H37Rv LFGELLG-RDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFE MSMEG_4511|M.smegmatis_MC2_155 LFAELLE-RDEVGADDSFFDLGGHSLLATKLVAAVRARCAVDVGVQDVFE Mflv_2696|M.gilvum_PYR-GCK LFSELLG-VARVGVDDSFFELGGHSLLATKLVSAVRSRCGVDMEIREIFE MAV_2013|M.avium_104 LFSGLLG-HERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFE MMAR_3691|M.marinum_M IFAQLFG-RQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFD MUL_3634|M.ulcerans_Agy99 IFAQLFG-RQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFD MAB_2122|M.abscessus_ATCC_1997 IYSHLFG-KERVGLDDSFFELGGHSLLAARLVAQIRAQFGIDLTVRAVFD MLBr_01996|M.leprae_Br4923 IWSRHLG--RAILPDSSLLDEGIGSVDLIRILPDTRRHLGRHLSLLDLIS ::. : : :.*:: * *: :::. * . .: : ::. Mvan_3845|M.vanbaalenii_PYR-1 NATIARLAA------------HLDTMGRATI-------GTRRPRLVAAPL TH_3141|M.thermoresistible__bu LGTVARLAG------------RIDELRSGSG-------GPLRPRLTPQHF Mb2401c|M.bovis_AF2122/97 FATVTALAG------------HIDTLDSDS----------ARPRLTRVDH Rv2380c|M.tuberculosis_H37Rv FATVTALAG------------HIDTLDSDS----------ARPRLTRVDH MSMEG_4511|M.smegmatis_MC2_155 HATVSGLAA------------HIEDLVASGA-------SSGRPAIVAVPH Mflv_2696|M.gilvum_PYR-GCK LGTVARLAE------------RVDELAAGGS-------APLRPRLLAVPH MAV_2013|M.avium_104 LATVGLLAE------------RVDQLSSGEL-------TGTRPKLIATAH MMAR_3691|M.marinum_M APTPAGLAARLVERFRNDFELDLDNLAADD---MPLDPKRARPGFVKSAR MUL_3634|M.ulcerans_Agy99 VPTPAGLAARLVERFRNDFELDLDNLAADD---MPLDPKQARPGFVKSAR MAB_2122|M.abscessus_ATCC_1997 RPTPAGLAEQLVTYFREEFEIELDELDLDESDEMEAAPQDGRPDLVAAER MLBr_01996|M.leprae_Br4923 ADNAANLTAA-----------QTANVWMDVG---------TAAEIERDLA . *: : . : Mvan_3845|M.vanbaalenii_PYR-1 DGPAPLSSSQLRSWFGYRIEGRSPVNNIPFAARLTGPCDVDAFVAAIRDV TH_3141|M.thermoresistible__bu DGPAPLSSSQLRSWFAYRVDGPSVVNNIPFAARLHGPVDVDALEAAIGDV Mb2401c|M.bovis_AF2122/97 DGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDV Rv2380c|M.tuberculosis_H37Rv DGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDV MSMEG_4511|M.smegmatis_MC2_155 DGPLQMSAAQLRQWFQFRIDGPNPVNNVPFAARLSGPCDVDALIAAVGDV Mflv_2696|M.gilvum_PYR-GCK DGPAPMSAAQLRQWFQYRIEGPGPVNNVPFAARFAGPCDVDALIEAVRDV MAV_2013|M.avium_104 DEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDV MMAR_3691|M.marinum_M PQRLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPLDSVALAAALNDV MUL_3634|M.ulcerans_Agy99 PQWLPLSHSQLAAWFQYRIEGAREEFNMPLALRFEGPLDSVALAAALNDV MAB_2122|M.abscessus_ATCC_1997 PERLPLSSSQLSMWFECQMEGVTDIGNMWLALRFDGPLQTPALIAALNDV MLBr_01996|M.leprae_Br4923 SLCRQRNATEFSVKQTRNSHQKQAIVVLGASGILGTGFAQAVLDLRQSGV . ::: . . : : : .: .* Mvan_3845|M.vanbaalenii_PYR-1 VERHAILRTTYREIDGVPYQIVNPISD-VPVRRARGEGEQWLQAELDRER TH_3141|M.thermoresistible__bu IARHEILRTVYREIDGVPYQIVLPTEP-VPVRRADGQGEQWLRAELDAER Mb2401c|M.bovis_AF2122/97 VARHEILRTVYREIGGVPHQIIQPPAE-VPVRCAAGSDAAWLRAELNNER Rv2380c|M.tuberculosis_H37Rv VARHEILRTVYREIGGVPHQIIQPPAE-VPVRCAAGSDAAWLRAELNNER MSMEG_4511|M.smegmatis_MC2_155 VARHEILRTTYREIDGAPYQIIHPPAP-VPVRQARGDGEDWVQAQLDAER Mflv_2696|M.gilvum_PYR-GCK VNRHESLRTTFCEIDGVPYQLVNAPDPGFPVRRDSGPDDAWLVGALDDER MAV_2013|M.avium_104 VARHEILRTRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAER MMAR_3691|M.marinum_M VARHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDE--FDDVSTQLR MUL_3634|M.ulcerans_Agy99 VARHEALRTNFDEHEGVPYQIVHPSRTVQLAVRAIDQDE--FDDVSTQLR MAB_2122|M.abscessus_ATCC_1997 VARHEALRTNIAIHEGAPYQIVHPSRELAVPILRSSPEG--LSDTLAELR MLBr_01996|M.leprae_Br4923 LCPEVVLATRARLPEGDPWTALQGVDG----------------------- : . * * * * : Mvan_3845|M.vanbaalenii_PYR-1 KHTFDLEEDWPIRAAVFTVGAVSPASDGGAVSPASDGGAVDPASDHVLSV TH_3141|M.thermoresistible__bu RHVFDLENERPIRPAILSLRPDAGSPD----SPAGD--------VHVLSL Mb2401c|M.bovis_AF2122/97 GYVFDLETDWPIRAALLSTPEQT-----------------------VLSL Rv2380c|M.tuberculosis_H37Rv GYVFDLETDWPIRAALLSTPEQT-----------------------VLSL MSMEG_4511|M.smegmatis_MC2_155 RYCFDLETDWPIRAAVLTTAEHH-----------------------VLSL Mflv_2696|M.gilvum_PYR-GCK RRVFDLENQWPIRVAVLSIPGEH-----------------------ALSV MAV_2013|M.avium_104 RHCFELDGELPIRVAVLRVANAAEH---------------------VLSL MMAR_3691|M.marinum_M RHVFTPESGPLLQANLLVLGPDTH----------------------VLLL MUL_3634|M.ulcerans_Agy99 RHVFTPESGPLLQANLLVLGPDTH----------------------VLLL MAB_2122|M.abscessus_ATCC_1997 HHIFGLETESLIRPAIIELSAQEH----------------------VLAL MLBr_01996|M.leprae_Br4923 -----------VRIERISFENGPG----------------------ELEA :: : * Mvan_3845|M.vanbaalenii_PYR-1 VIHHIAGDHWSGGVLFTDLVAAYRARKAGERPTWAPLPVQYTDYGAWQAE TH_3141|M.thermoresistible__bu VMHHIAGDHWSATVLFTDLLTAYRARTAGQEPAWAPLPVQYADFGAWESE Mb2401c|M.bovis_AF2122/97 VVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Rv2380c|M.tuberculosis_H37Rv VVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA MSMEG_4511|M.smegmatis_MC2_155 VVHHIAADHWSGTVLFTDLLTAYHARHAGSAVELPPLPVQYADFAAWQAE Mflv_2696|M.gilvum_PYR-GCK VVHHIAADHWSGGVLFTELLTAYRARRAGEAPTWAPLPVQYADYAAWQSA MAV_2013|M.avium_104 VVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQRT MMAR_3691|M.marinum_M IVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRN MUL_3634|M.ulcerans_Agy99 IVHHIVSDHASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRN MAB_2122|M.abscessus_ATCC_1997 VVHHIVVDHASFTVIVDDLIAAYRARLEGQAPQWDPQPVQYADYVLWQRD MLBr_01996|M.leprae_Br4923 LIRDTDAGTLVNGVGNTNMLVPYRELRLANVELVSAIVDICASYSTRLVH :::. . : :::..*: . :.: Mvan_3845|M.vanbaalenii_PYR-1 LLSDDTG----IAGPQREYWIRQLADAPVESGLPLEFSRPRLPSGKGDAV TH_3141|M.thermoresistible__bu LLAEETG----IAGPQREYWTRQLAGLPEETGLRPDFPRPPVPSGLAEAV Mb2401c|M.bovis_AF2122/97 LLDDGAG----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV Rv2380c|M.tuberculosis_H37Rv LLDDGAG----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV MSMEG_4511|M.smegmatis_MC2_155 LLAGTDD----TIDEQRRYWTTQLAGLPEENGLYPDFPRPPVPTGDGAAL Mflv_2696|M.gilvum_PYR-GCK LLADDSG----IVAAQRRYWTQQLEGLSAETGLQPDLVRPSVPSGAADAV MAV_2013|M.avium_104 FLGDAGGQESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGESV MMAR_3691|M.marinum_M TFESN------WGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV MUL_3634|M.ulcerans_Agy99 TFESN------WGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVV MAB_2122|M.abscessus_ATCC_1997 AFAPDSE----FGQAEVNFWRQQLAGVPTEIAVAHDRARPQILGKRGEVA MLBr_01996|M.leprae_Br4923 LSSFVVN---------------ADVTVPQVTDPRETPYPYAASKSLAELV . . Mvan_3845|M.vanbaalenii_PYR-1 EFTIDGQVRRQITELCRELGITEFMLLQAAVAVTLAKVGGGLDIPLGTPV TH_3141|M.thermoresistible__bu EFTIDAAVREKLAGLCRDLGITEFMALQAAVAVVLHKAGSGSDIPLGTPV Mb2401c|M.bovis_AF2122/97 EFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPV Rv2380c|M.tuberculosis_H37Rv EFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPV MSMEG_4511|M.smegmatis_MC2_155 DFSIDADTRARLIALTRELGVTEFMLLQAAVAIALHKSGQGTDIPLGTPV Mflv_2696|M.gilvum_PYR-GCK EFTLDAAIREKLVTLSREVGATEFMLLQAAVAVTLYKAGEGPDIPLGTPV MAV_2013|M.avium_104 DFHIDAATRAKLADVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPV MMAR_3691|M.marinum_M QFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPV MUL_3634|M.ulcerans_Agy99 QFSVPAARRSALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPV MAB_2122|M.abscessus_ATCC_1997 KFVMEPERRQALTRMAEQRGVTEFMVYQAALAVVLHRLGGGTDIVIGSPV MLBr_01996|M.leprae_Br4923 VAGSPSALDFTIVRLPRVLGEDYQLRNSSDILLSIVDACIALRAYPSATV : : . * : .: : : : . .:.* Mvan_3845|M.vanbaalenii_PYR-1 AGRSEA--ELEQLVGFFVNFVVLRNDLRGNPTLREVLIRAREMALSAYSN TH_3141|M.thermoresistible__bu AGRSEP--ELDQLVGFFINILVLRNDLSGNPSLREVCRRAREMALAAYAH Mb2401c|M.bovis_AF2122/97 AGRSEA--NLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAH Rv2380c|M.tuberculosis_H37Rv AGRSEA--NLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAH MSMEG_4511|M.smegmatis_MC2_155 AGRTAP--ELDALIGFFINIVVLRNDLSGNPSLREVLRRSREMALAAYQH Mflv_2696|M.gilvum_PYR-GCK AGRTES--ELDQLIGFFINILVLRNDLRDNPSLRDVGFRSREMALAAYAH MAV_2013|M.avium_104 AGRTEA--ELDQLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAH MMAR_3691|M.marinum_M AARVEP--ATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAH MUL_3634|M.ulcerans_Agy99 AARVEP--ATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAH MAB_2122|M.abscessus_ATCC_1997 AARVHP--HVAKLVGLFANMVALRNDLSGDPSLRSVLERSRDATLNAHAH MLBr_01996|M.leprae_Br4923 TEEVTTGRAAAKAILGVVSALARSGQLGSGISVVRGEAVAYADFLSEFAS : . . : . . :. :* .. :: : * Mvan_3845|M.vanbaalenii_PYR-1 QDVPFEQVVEAVNPPRTLARNPLFQVVVHVREQLPQRQMIDT-------- TH_3141|M.thermoresistible__bu QDLPFDQVVDAVSPVRTLARNPLFSVVVHVREQLPENRVIDHGPDG---- Mb2401c|M.bovis_AF2122/97 QDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDG---- Rv2380c|M.tuberculosis_H37Rv QDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDG---- MSMEG_4511|M.smegmatis_MC2_155 QDLPFDRVVDAVSPVRSLSRNPLFGVVVHVRDDLPADQVIDDGGNG---- Mflv_2696|M.gilvum_PYR-GCK QDLPFDQVVDAVSPVRSLSRNPLFGVVVHVREELPQDRVIATGSDG---- MAV_2013|M.avium_104 QDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRDHLSATRVIETAPVGGDGQ MMAR_3691|M.marinum_M QELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRG---- MUL_3634|M.ulcerans_Agy99 QELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRG---- MAB_2122|M.abscessus_ATCC_1997 QELPIEKLVEAVNPVRSLSWNPLFQTMVNFRGADWGTAARDVTVSG---- MLBr_01996|M.leprae_Br4923 DELNMAEWKYRLDQSDWAKRNPRRWSVIDAWFTLG--------------- ::: : . :. ** ::. Mvan_3845|M.vanbaalenii_PYR-1 DTEFTALEPTFDIAQADLSLNFLA---------DGTGYRGYLIYRPELYA TH_3141|M.thermoresistible__bu DTTVTVLEPPFDAAHADLSLNFFAAE-------DGGGYRGHVIYRPELYS Mb2401c|M.bovis_AF2122/97 DTTLRVLEPTFDAAQADLSVNFFA---------CGDEYRGHVIYRTELYE Rv2380c|M.tuberculosis_H37Rv DTTLRVLEPTFDAAQADLSVNFFA---------CGDEYRGHVIYRTELYE MSMEG_4511|M.smegmatis_MC2_155 ETRFTALEPTFDVAHADLSLNFFAQNGNGGRAGEPAGYKGTVIYRTELYE Mflv_2696|M.gilvum_PYR-GCK ETTFTALEPTFDMAHADLSVNFFAG---------GNGYRGHVIYRTELYT MAV_2013|M.avium_104 DTVCTSLDPVFDMAHADLSVNFFGTDG-----AGDIGYNCHLIFRTDLYR MMAR_3691|M.marinum_M ETTVVPLPVNFEVALLFLAIGMSVTP--------SGELDVQVIANADLYE MUL_3634|M.ulcerans_Agy99 ETTVVPLPVNFEVALLFLAIGMSVTP--------SGELDVQVIANADLYE MAB_2122|M.abscessus_ATCC_1997 ETTVVPLPMEVDVSYLDLNFALNVTP--------SGGLDVSVVANADLYD MLBr_01996|M.leprae_Br4923 ---------------------------------MMFEMRSYAEYPTMALG . Mvan_3845|M.vanbaalenii_PYR-1 RRTIERLGRWLPRVVAAFVDTPDRALGDVDIVSAEERQRVSQEWST---- TH_3141|M.thermoresistible__bu RDTAQRFADWLGRVVTAFAERPDITLRELEIGAPGERRRILEEWG----- Mb2401c|M.bovis_AF2122/97 RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAG- Rv2380c|M.tuberculosis_H37Rv RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAG- MSMEG_4511|M.smegmatis_MC2_155 PATARRLIGWLHRIIDAFATDADTTLRDIAVIDADERTLLIEDWSRRAVP Mflv_2696|M.gilvum_PYR-GCK RATAERFAGWLSAVITAFADDPERHVDDVVIAEPVRPG------------ MAV_2013|M.avium_104 RTTIERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSRGAQP MMAR_3691|M.marinum_M PATVALIADALDAALAAFATTPDLPLSAVQLLPS---------------- MUL_3634|M.ulcerans_Agy99 PATVALIADALDAALAAFATTPDLPLSAVQLLPR---------------- MAB_2122|M.abscessus_ATCC_1997 HETTRMIAQALDTAFDAFVNNQESRVSEIVLLPA---------------- MLBr_01996|M.leprae_Br4923 VESVAELAAPPESIRALLAHGCSQPLKYTGR------------------- : : :. . : Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 PA------------------------------------------------ Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 PRDRPRTIPELLQASRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVD MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 RGVGPGTLVGLSTRRSIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLD MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 DVRPPVVVATVEAVDTMPGLPGVELLSLDDPQVRALVDRDDVDPRAGRLR MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 PPHPDDPMYLVFTSGSTGKPKGAVGTHRSMAARLDWQLRHYPPRTDDVRL MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 AQASITFLEGGMEMLAGLAAGATMILADDAEHRDPEALGELMHRHSVAQV MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 TAVPSLVSALLDSRPDAVRSLSRLVCGGEPVSTSLLQRLVSVCDEADGGG MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 ---------------------------------GARVQVLDADLAPAPVG TH_3141|M.thermoresistible__bu ---------------------------------GGTVYVLDETLQPVPVG Mb2401c|M.bovis_AF2122/97 ---------------------------------TARVYLLDDALKPVPVG Rv2380c|M.tuberculosis_H37Rv ---------------------------------TARVYLLDDALKPVPVG MSMEG_4511|M.smegmatis_MC2_155 ---------------------------LPQTEGATNVYVLDEWLEPVAIG Mflv_2696|M.gilvum_PYR-GCK --------------------------------DGAEAVLLDGAGHPVPVG MAV_2013|M.avium_104 PELLNNIGSTETSGAVSRGPLSPPNPLVGKPVPGAQAYLLDDGLRPVPVG MMAR_3691|M.marinum_M ---------------------------------ADLAKLLAPPLPAGPAA MUL_3634|M.ulcerans_Agy99 ---------------------------------ADLAKLLAPPLPAGPAA MAB_2122|M.abscessus_ATCC_1997 ---------------------------------DAMAQLMAPPAAAVEPV MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 VFGDLYLSG--------------------------------------GPF TH_3141|M.thermoresistible__bu VVGDVYTAGPALAAAHWTRAGVTA-------------TRLVADPVGNRPG Mb2401c|M.bovis_AF2122/97 VVGDVYYGGGPAVGARLARPSETA-------------TRFVADPFAAQPG Rv2380c|M.tuberculosis_H37Rv VVGDVYYGGGPAVGARLARPSETA-------------TRFVADPFAAQPG MSMEG_4511|M.smegmatis_MC2_155 VIGDVYYAGGAVDASAEAANGVAA-------------QRFVPNPFG---A Mflv_2696|M.gilvum_PYR-GCK VVADVHYAGAPDRRGDRARWTEDGRLQYVERVDHDLEAALAAVPGVAAAA MAV_2013|M.avium_104 VVGELYYAGDQLARGYWKRPGLTA-------------ARFVANPFGAEPG MMAR_3691|M.marinum_M SP------------------------------------------------ MUL_3634|M.ulcerans_Agy99 SQ------------------------------------------------ MAB_2122|M.abscessus_ATCC_1997 TT------------------------------------------------ MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 AQRHRTGDRARWD--------DDGRLEIAARAPGATVVEVAPPA------ TH_3141|M.thermoresistible__bu ARLYRTGDRARWI--------ADGVLEFVDAQP-PTIPAVRPDS------ Mb2401c|M.bovis_AF2122/97 SRLYRNGERGVWK--------ADGQLELLAEIERLPTAQAAP-------- Rv2380c|M.tuberculosis_H37Rv SRLYRNGERGVWK--------ADGQLELLAEIERLPTAQAAP-------- MSMEG_4511|M.smegmatis_MC2_155 GRLYRTGDRARWT--------PDGRLEPVTAGEPRLQAALEAVDGVAAAA Mflv_2696|M.gilvum_PYR-GCK VRTWEIGHRTAVVGYVVPAEPVDDPASFAETVRAAVAPESAPTSITVLDA MAV_2013|M.avium_104 SRLYRSGDLARWT--------EDGQLEFVGRSDHQVQVRGFRVELAEVEA MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 TRYWEN-------------------------RSAPLLAAYVVADAAHAAD Mflv_2696|M.gilvum_PYR-GCK LP------------------------------------------------ MAV_2013|M.avium_104 ALAGADGVAAAAARTWEVHGGTSLAGYVVPQRPIADEAEKAAFAAQVRAE MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 ---------------------------------------VEFE--EPRTD TH_3141|M.thermoresistible__bu ---------------------------------------GQRPGGPPATD Mb2401c|M.bovis_AF2122/97 -----------------------------------------VPAEPADTE Rv2380c|M.tuberculosis_H37Rv -----------------------------------------VPAEPADTE MSMEG_4511|M.smegmatis_MC2_155 PQFAEQVRTALPDEFAGAAITVVDDLTPAALTRPRVSATASGPFEAPATP Mflv_2696|M.gilvum_PYR-GCK -----------------------------ATRRALPAPRVGGPSEPARTD MAV_2013|M.avium_104 IAATLPGYMMPSSLTVLDALPKTESGKLNRPGLPRPAVSTGGRTEPARTD MMAR_3691|M.marinum_M ------------------------------------------PVAAGSAE MUL_3634|M.ulcerans_Agy99 ------------------------------------------PVAAGSAE MAB_2122|M.abscessus_ATCC_1997 ------------------------------------------PSVEGSEE MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 SERALAALLSELLATEEVG----RHDDFFGLGGDSVLAVQLAARARDTGL TH_3141|M.thermoresistible__bu TERALATLLAEVLDTEVTG----RDDDFFSLGGDSILAVQLAARARDTGL Mb2401c|M.bovis_AF2122/97 TERALAAILADVLEVGEVG----RYDDFFNLGGDSILATQVAARARDGGI Rv2380c|M.tuberculosis_H37Rv TERALAAILADVLEVGEVG----RYDDFFNLGGDSILATQVAARARDGGI MSMEG_4511|M.smegmatis_MC2_155 TERAVAAMLVELLGVTQVG----RHDDFFTLGGDSILAVQLAARARDAGV Mflv_2696|M.gilvum_PYR-GCK TEKALVGMLADVLVEVHDGTGIGRFDDFFELGGDSILAVQLAARAKQAGL MAV_2013|M.avium_104 TERALANVFAELLSTPEVG----RFDDFFALGGDSILSVQLASRARAAGL MMAR_3691|M.marinum_M TERRLTAMLEELLEITGID----RDENYFALGGDSIIAIKWSAQAGALGL MUL_3634|M.ulcerans_Agy99 TERRLTAMLEELLEITGID----RDENYFALGGDSIIAIKWSAQAGALGL MAB_2122|M.abscessus_ATCC_1997 TKLVLISILEELLEISDVD----PEDNFFALGGDSVISIQWSTRAAERGL MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 DLTARMVFEHPRLAELAAALDS----------------------GAGAAA TH_3141|M.thermoresistible__bu KLTARMVFEHPTLHELAAAVEAREAVEARETAEAGGAEAGGAESGGGADG Mb2401c|M.bovis_AF2122/97 PLTARMVFEHPVLCELAAAVDA----------------------KPHVEA Rv2380c|M.tuberculosis_H37Rv PLTARMVFEHPVLCELAAAVDA----------------------KPHVEA MSMEG_4511|M.smegmatis_MC2_155 AMTARMVFEHPVLSELAAAIDA-----------------------AGEGS Mflv_2696|M.gilvum_PYR-GCK RLSARMVFEHPVVHDLAVALDT------------------------AKTP MAV_2013|M.avium_104 PVSPRMIFENPTVQQLAAALDALGD-----------------NDSDGRLD MMAR_3691|M.marinum_M PFPPAMVFEHMTIAELAAAVDA---------------------ANGEPVV MUL_3634|M.ulcerans_Agy99 PFPPAMVFEHMTIAELAAAVDA---------------------ANGEPVV MAB_2122|M.abscessus_ATCC_1997 AMTPQMVFECATIAQLAGAVDA---------------------ADR-VVT MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 EQP----------DTHHAPMSVSGLSEDELAALTASWG-TGE--- TH_3141|M.thermoresistible__bu AERGAAAGDSGNGAASHAPMSTSGLSAEQLSALTASWNPAGEDAP Mb2401c|M.bovis_AF2122/97 EPD----------DKHHAPMSTSGLSPDELSALTASWDQWP---- Rv2380c|M.tuberculosis_H37Rv EPD----------DKHHAPMSTSGLSPDELSALTASWDQWP---- MSMEG_4511|M.smegmatis_MC2_155 AAQ----------DVHHAPMEASGLSSDELAALTAAWGQSQDGKR Mflv_2696|M.gilvum_PYR-GCK EVA----------DVRHDPMSASGLTPEELAMVATSWAAEQDGSP MAV_2013|M.avium_104 DQP---------ADTRFEPMSTSGLSASDLAAVTQLWSSSREGTA MMAR_3691|M.marinum_M EAD-------PPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS- MUL_3634|M.ulcerans_Agy99 EAD-------PPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS- MAB_2122|M.abscessus_ATCC_1997 EGDS----HLVTPPVQSAPMSASGLSADALAELTASWQAQS---- MLBr_01996|M.leprae_Br4923 ---------------------------------------------