For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTDTDLDARRLELLRRRLAGSGLREQDPAEPVAVAADPARGEFTDGQKRMWFVHSVDPSGVLLNVCLSYR ISGEVDLARLHDAVTAVARRHPVLRTTFAADEAGEPQRTVHDDLLPGWTVQDISELSEHARRLRLEVLAQ REFGTPFDLATESPLRITVARTAPAEYIMLLVVHHIAWDDGCWRVFFADLTRAYTGAELGPTPAPVVEPP TSDEDLRFWRSAMTDLPEPLELPGPHGSAVPTTWRCRRVTATLSADTVERVRVAAREAGATPYMVMLAAF GALLHRYTHADDVLIASPVLLRGPDSEDVIGYHGNSAVMRLRPQPMQTFTELLSRTRDFALDAFAHQQVN LDRVVRELNLDRRHGAERMTRVSFGFREPDGGGFSPPGVTCRRAELRGQITQLPLGLMVELHESGAVVEA EFLVEVLDDTLVTQMLDHYVVLLEAAVAQPDTVLSRLELMDGDDAEWLRRVSHGPEFDVPAATIGELIEA RTDLTPDTVAVVYEGRRYTYREINESANRVAHWLIGQGIGAEDRVAVLMDRSPELLITALGIIKAGAVYL PVDPSYPQDRMSFVLSDSDPTLVIREPVAGLDGHRTDNPTDDVRVRPLRPENAAYLIYTSGSTGQPKGVP VPHRPVAEYFVWFKDEYEISESDRLLQVASPSFDVSIGEIFGTLACGGRLVIPKPDGLTDVAYLTELLQR EGITAMHFVPSLLGLFLSLPGVNQWRTLERVPIGGEALPGELADRFHATFDALLHNFYGPTETIINTTRY KVEGTQGSRIVPIGTPKINTTVHLLDDALRPVPVGAIGEIYIGGGHVARGYHRRPALTAERFVADPFTVG GRLYRSGDLARRNADGDLEFVGRADDQVKIRGFRIELGEVAAAISVDPSVGQAVVLGQDLPGLGMSLVGY VTPAAGEDVDLARVRERVAAALPDYMTPAGYVVLDEIPITAHGKIDRAALPLPEITTATDYREPQTETEQ HLAQLFSELLGVARVGVDDSFFELGGHSLLATKLVSAVRSRCGVDMEIREIFELGTVARLAERVDELAAG GSAPLRPRLLAVPHDGPAPMSAAQLRQWFQYRIEGPGPVNNVPFAARFAGPCDVDALIEAVRDVVNRHES LRTTFCEIDGVPYQLVNAPDPGFPVRRDSGPDDAWLVGALDDERRRVFDLENQWPIRVAVLSIPGEHALS VVVHHIAADHWSGGVLFTELLTAYRARRAGEAPTWAPLPVQYADYAAWQSALLADDSGIVAAQRRYWTQQ LEGLSAETGLQPDLVRPSVPSGAADAVEFTLDAAIREKLVTLSREVGATEFMLLQAAVAVTLYKAGEGPD IPLGTPVAGRTESELDQLIGFFINILVLRNDLRDNPSLRDVGFRSREMALAAYAHQDLPFDQVVDAVSPV RSLSRNPLFGVVVHVREELPQDRVIATGSDGETTFTALEPTFDMAHADLSVNFFAGGNGYRGHVIYRTEL YTRATAERFAGWLSAVITAFADDPERHVDDVVIAEPVRPGDGAEAVLLDGAGHPVPVGVVADVHYAGAPD RRGDRARWTEDGRLQYVERVDHDLEAALAAVPGVAAAAVRTWEIGHRTAVVGYVVPAEPVDDPASFAETV RAAVAPESAPTSITVLDALPATRRALPAPRVGGPSEPARTDTEKALVGMLADVLVEVHDGTGIGRFDDFF ELGGDSILAVQLAARAKQAGLRLSARMVFEHPVVHDLAVALDTAKTPEVADVRHDPMSASGLTPEELAMV ATSWAAEQDGSP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_2696 | - | - | 100% (1762) | amino acid adenylation domain-containing protein |
M. gilvum PYR-GCK | Mflv_2697 | - | 2e-97 | 27.90% (1283) | amino acid adenylation domain-containing protein |
M. gilvum PYR-GCK | Mflv_2692 | - | 2e-80 | 27.80% (1043) | amino acid adenylation domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2401c | mbtE | 0.0 | 62.81% (1729) | peptide synthetase MBTE (peptide synthase) |
M. tuberculosis H37Rv | Rv2380c | mbtE | 0.0 | 62.81% (1729) | peptide synthetase MBTE (peptide synthase) |
M. leprae Br4923 | MLBr_01996 | nrp | 6e-25 | 27.19% (445) | putative peptide synthase |
M. abscessus ATCC 19977 | MAB_2122 | - | 0.0 | 42.91% (1566) | putative peptide synthetase MbtE |
M. marinum M | MMAR_3691 | mbtE | 0.0 | 43.49% (1529) | non-ribosomal peptide synthetase MbtE |
M. avium 104 | MAV_2013 | - | 0.0 | 65.34% (1529) | linear gramicidin synthetase subunit D |
M. smegmatis MC2 155 | MSMEG_4511 | - | 0.0 | 64.83% (1814) | linear gramicidin synthetase subunit B |
M. thermoresistible (build 8) | TH_3141 | - | 0.0 | 62.16% (1826) | PUTATIVE amino acid adenylation domain |
M. ulcerans Agy99 | MUL_3634 | mbtE | 0.0 | 43.43% (1529) | non-ribosomal peptide synthetase MbtE |
M. vanbaalenii PYR-1 | Mvan_3845 | - | 0.0 | 61.47% (1801) | amino acid adenylation domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu VTDTTETRPAGADDEARLALLRRRLSERGLSAQ---QTTGAAS---EDRL Mvan_3845|M.vanbaalenii_PYR-1 ---MTDIDTGALLDERRLELLRRRMQERGLSAG---TDTAEPAG-DTDVL MSMEG_4511|M.smegmatis_MC2_155 MTDIADTATAS-TVEARLELMRRKLAERGLAAGRAAAEGSAAAV-DPTVL Mflv_2696|M.gilvum_PYR-GCK -------MTDTDLDARRLELLRRRLAGSGLREQDPAEPVAVAADPARGEF MAV_2013|M.avium_104 --MTETTGAGTRLDDERLELLRRKLAERGLSRS------AGTARHDEPRM MMAR_3691|M.marinum_M -----MADDVRTLQDRRRELLRRRIAESGLAAEQSSDQPGICPG-ERYRL MUL_3634|M.ulcerans_Agy99 -----MADDVRTLQDRRRELLRRRIAESGLAAEQSSDQPRICPG-ERYRL MAB_2122|M.abscessus_ATCC_1997 -----MTGDQLSALDRRRELLRRRLAESGVAAQAVESAPRVQAG-ERRGL MLBr_01996|M.leprae_Br4923 ------------------------------------MTAPNTRRVDRVPL Mb2401c|M.bovis_AF2122/97 ------MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRI Rv2380c|M.tuberculosis_H37Rv ------MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRI TH_3141|M.thermoresistible__bu SDGQLRMWFVHQADPSGALLNICLSYRISGPVDLAALRGALDAVARRHPV Mvan_3845|M.vanbaalenii_PYR-1 TEGQLRMWFVHNADPSGALLNVCLSYRLSGEIDVARLHDAVGAVARRHRV MSMEG_4511|M.smegmatis_MC2_155 SDGQRRMWFVQGFDPSGVLLNVSLSYRLTGDIDAERMQAAVEAVARRHPI Mflv_2696|M.gilvum_PYR-GCK TDGQKRMWFVHSVDPSGVLLNVCLSYRISGEVDLARLHDAVTAVARRHPV MAV_2013|M.avium_104 SVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPV MMAR_3691|M.marinum_M SDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAI MUL_3634|M.ulcerans_Agy99 SDGQRRMWFLQTMDPDDVTLNICVAYRLTGLVDEDRLHTAVNDVVARHAI MAB_2122|M.abscessus_ATCC_1997 APGQRRMWFMQTKDPADTSLNICVAHRMRGALDQTRLRDAVAAVIRRHDV MLBr_01996|M.leprae_Br4923 SRSQQNIYNGMLQDNDPALYFIGKSYRFH-QLELSVFLAALEATILKNPG :: * . : ::*: :: : *: . :: Mb2401c|M.bovis_AF2122/97 LRTTY-----PVGDDGVAQPTVHADLRPGWTQYDLTDLS---QRAQRLRL Rv2380c|M.tuberculosis_H37Rv LRTTY-----PVGDDGVAQPTVHADLRPGWTQYDLTDLS---QRAQRLRL TH_3141|M.thermoresistible__bu LRTTY-----AADENGEPRPTVHAELRPGWTEHDLTDLADQSEQARRLRL Mvan_3845|M.vanbaalenii_PYR-1 LRTTYRTESTAAGDSGMPVPTVHTGLMPGWAEHDLSELS---ERARGLRL MSMEG_4511|M.smegmatis_MC2_155 LRTTF-----HADENGEPRAEVHDDLTPSWTTHDLSEKS---ERARKLRL Mflv_2696|M.gilvum_PYR-GCK LRTTF-----AADEAGEPQRTVHDDLLPGWTVQDISELS---EHARRLRL MAV_2013|M.avium_104 LHTTY-----DTTDEGDPRPVLRADLRPEWAEHDLSGLT---EQARRLRL MMAR_3691|M.marinum_M LRTTY-----GVDTEGEPYQVFSDDVEVGWRREDLTRLP---EAGHERQI MUL_3634|M.ulcerans_Agy99 LRTTY-----GVDTEGEPYQVFSDDVEVGWRREDLTRLP---EAGHEQQI MAB_2122|M.abscessus_ATCC_1997 LRTVY-----GVDSAGEPYQLFVEEFEVPWTAVDLTDLT---GDAQDRQV MLBr_01996|M.leprae_Br4923 QLCVL---------EAPSTEGDYPDLVPRLQFGDIVRVR--SDEQPQTDS . . . . *: Mb2401c|M.bovis_AF2122/97 EVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRV Rv2380c|M.tuberculosis_H37Rv EVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRV TH_3141|M.thermoresistible__bu EVLAQREFTAPFDLSVDSPLRITMIRTGADEHIMLLVAHHIAWDDGSWEV Mvan_3845|M.vanbaalenii_PYR-1 EVLAQREFGRPFDLGAESPLRITVIRTAPAEYVMLLVAHHIAWDDASWEV MSMEG_4511|M.smegmatis_MC2_155 EVLAQREFGTPFDLGTESPLRLTLIRTGPAEHVLLLVAHHIAWDDGSWRV Mflv_2696|M.gilvum_PYR-GCK EVLAQREFGTPFDLATESPLRITVARTAPAEYIMLLVVHHIAWDDGCWRV MAV_2013|M.avium_104 DVLAQRDFRRPFDLSKDSPLRVTAARLADDELMLLITAHHIAWDDGSWAP MMAR_3691|M.marinum_M ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEV MUL_3634|M.ulcerans_Agy99 ESLAADEFGRPFDLTNELPLRITVIRTRADELVLLLVVHHICWDDDSWEV MAB_2122|M.abscessus_ATCC_1997 RALADSEFGRPFDLAADRPLRVTLLRLGAEDFVVLLVVHHICWDDNSWEV MLBr_01996|M.leprae_Br4923 RDYDLMHAWSPDILAKPLVRYTVRTDKNGFVARLDVFTHHILVDGGAIRI . * * . : : .*** *. . Mb2401c|M.bovis_AF2122/97 FFTDLTQAYSRADL-GADLGPEHRPSAASGPDTTEADLNYWRAIMADPPE Rv2380c|M.tuberculosis_H37Rv FFTDLTQAYSRADL-GADLGPEHRPSAASGPDTTEADLNYWRAIMADPPE TH_3141|M.thermoresistible__bu FFDDLTRAYT-----GVDLGEELAPQLPPGPRDPDADLAYWREVLADPPE Mvan_3845|M.vanbaalenii_PYR-1 FFDDLTGAYV-----GEKLRPARRPVVAAGGSD-EDDVAYWRAVMADPPE MSMEG_4511|M.smegmatis_MC2_155 FFTDLTRAYS-----GEQLPETPR-VGAAAPDTTDEDLAYWREVMANPPE Mflv_2696|M.gilvum_PYR-GCK FFADLTRAYT-----GAELGPTPAPVVEP--PTSDEDLRFWRSAMTDLPE MAV_2013|M.avium_104 FFADLTRAYTAPG--DFDATPVVPDLSADPTAIRREDLDYWRPLMADLPE MMAR_3691|M.marinum_M FFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRPLPE MUL_3634|M.ulcerans_Agy99 FFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSVADVGYWAETLRPLPE MAB_2122|M.abscessus_ATCC_1997 FFAELSEYYHGRPVQGEAPQFMVVS--ADTEPSSDADLTYWRRALTPLPD MLBr_01996|M.leprae_Br4923 IEENLAHHLDTDN---RLEIPCIRQALDKLAEAHRREATKVEESLQRLAN : :*: : : .: Mb2401c|M.bovis_AF2122/97 PLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLA Rv2380c|M.tuberculosis_H37Rv PLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLA TH_3141|M.thermoresistible__bu PLELPGPHGSAVPSGWRSARDSVTLGADTARRVVELAQETGCTPYAVLLA Mvan_3845|M.vanbaalenii_PYR-1 PLELPGPTGSAVPTSWRSQRTTLRLDGETARRVTALADEVGATPYAVLLA MSMEG_4511|M.smegmatis_MC2_155 PLELPGPMGSVVPTGFRSQRSTVRLSAETVEKVTVLARETGATPYMVLLA Mflv_2696|M.gilvum_PYR-GCK PLELPGPHGSAVPTTWRCRRVTATLSADTVERVRVAAREAGATPYMVMLA MAV_2013|M.avium_104 PLELPGPNGSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMA MMAR_3691|M.marinum_M PPELPGVSG--ANPCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLA MUL_3634|M.ulcerans_Agy99 PPELPGVSG--ANPCRRAQRRVRPLPAGLFSRVEEFARKCSASPFMVLLA MAB_2122|M.abscessus_ATCC_1997 PLELPGAAS--TYSSRAARRLAVPMPAETAARIEEFAREHSATPFMVLLA MLBr_01996|M.leprae_Br4923 VVQRELADEVRNGGYGQVSNDAPGNAARGVLHESMIICGKAFDNIIALSE : . . : . .: Mb2401c|M.bovis_AF2122/97 AFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMS Rv2380c|M.tuberculosis_H37Rv AFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMS TH_3141|M.thermoresistible__bu VFGTLIFRYTHADDFLVATPVLNRDSGAEQRIGYYGNTVAMRLRPNAAMS Mvan_3845|M.vanbaalenii_PYR-1 VFGVLIHRYSHVDDFLVATPVLNRNGDTDDVIGYFGNTVAMRLRPHPAMT MSMEG_4511|M.smegmatis_MC2_155 AFGALIRRYTHTDDFLVATPVLNR--DTEDTIGYHGNTVAMRMRPRSDAG Mflv_2696|M.gilvum_PYR-GCK AFGALLHRYTHADDVLIASPVLLRGPDSEDVIGYHGNSAVMRLRPQPMQT MAV_2013|M.avium_104 AFAALVHRYTGSTDFLVAAPVLNRGAATENVIGYYGNTVVIRLRPQSHQS MMAR_3691|M.marinum_M AYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDT MUL_3634|M.ulcerans_Agy99 AYGVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDT MAB_2122|M.abscessus_ATCC_1997 AFGVLVHRYTGSRDFVTAIPVAERKSNAEKAIGYFGNTLLLRTVVNPDDS MLBr_01996|M.leprae_Br4923 TKQVPLN--ILVATAAVAVDASLRQSTEGLLVHAVDNRFGDPYLDVATCL . . : : . * : .* . Mb2401c|M.bovis_AF2122/97 FRELLTATRDIASGAFAHQRINLDRVVRELNPDR---RHGAERMTRVSFG Rv2380c|M.tuberculosis_H37Rv FRELLTATRDIASGAFAHQRINLDRVVRELNPDR---RHGAERMTRVSFG TH_3141|M.thermoresistible__bu FRDMLAQSRDTALGAFAHQGINLDRVVRELNPDR---RHGTERMTRVSFG Mvan_3845|M.vanbaalenii_PYR-1 FRDLLTQTRDTALGAFAHQRVGLDRMVRELNPDR---RHGAERMTRVSFG MSMEG_4511|M.smegmatis_MC2_155 FRDLVLQTRDVALGAFAHQRVNLDRVVRELNPDR---RHGAERMTRVSFG Mflv_2696|M.gilvum_PYR-GCK FTELLSRTRDFALDAFAHQQVNLDRVVRELNLDR---RHGAERMTRVSFG MAV_2013|M.avium_104 FRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR---RHGADRMTRVSFG MMAR_3691|M.marinum_M FTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFN MUL_3634|M.ulcerans_Agy99 FTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGMDLLVRLGFN MAB_2122|M.abscessus_ATCC_1997 FASHVAAVREVCLDAFGHQNVGIDEVVREVNPSRSIGHDGMDELVRLGFS MLBr_01996|M.leprae_Br4923 VNSVAHSIRFPPFASVQDVVRTLDRSYVKAIRLR---WLREEYYRRIYLA . . * .. . :* : * : *: : Mb2401c|M.bovis_AF2122/97 FREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAG-----VLVEA Rv2380c|M.tuberculosis_H37Rv FREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAG-----VLVEA TH_3141|M.thermoresistible__bu FRGPDRFGFTPPGVRCERAELRSHLTQLPLGVMIEFDPDPADP-GATVEI Mvan_3845|M.vanbaalenii_PYR-1 FRSRDRFGFTPPGVTCERADLRSHLTHLPLGIMVEFDPD-----EVVVEL MSMEG_4511|M.smegmatis_MC2_155 FREPDGGGFCPAGVRCERAELRGNHTQLPLGFMVEWEATG-----ATVEA Mflv_2696|M.gilvum_PYR-GCK FREPDGGGFSPPGVTCRRAELRGQITQLPLGLMVELHESG-----AVVEA MAV_2013|M.avium_104 QREPDGAGFCPPGVRCERGDLRGHFNQLPLSLMVELNRTPDGSGGGLVEA MMAR_3691|M.marinum_M MR-KSAGGLALDGVVVRQLGLGAVAAHLPLSLTIALDPDD-----VSVEF MUL_3634|M.ulcerans_Agy99 MR-KSAGGLALDGVVVRQLGLGAIAAHLPLSLTIALDPDD-----VSVEF MAB_2122|M.abscessus_ATCC_1997 MR-KDASGYRLEGVDVTQLDLAAVSAQLPLSLAIATESSG-----TIVEF MLBr_01996|M.leprae_Br4923 LNQTSHIEALTLNFIREPCAPGLRPFLSEVPTVTDIGPVEG------MTV . . .. : : Mb2401c|M.bovis_AF2122/97 EHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLRE Rv2380c|M.tuberculosis_H37Rv EHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLRE TH_3141|M.thermoresistible__bu EHLVEVIEPALGRQLLRHFVVLLEDALRRPDTPLSRLRLMDDADLAWLRD Mvan_3845|M.vanbaalenii_PYR-1 EHLVEIIEPGLARQLLDHYAVLIRSALDDPDTTLSGLQLMGDDDLEWLRA MSMEG_4511|M.smegmatis_MC2_155 EHLTEVLDAALAEQMLRHFTVLLDNALADPDRALWRLDLFTAEDTAWLTR Mflv_2696|M.gilvum_PYR-GCK EFLVEVLDDTLVTQMLDHYVVLLEAAVAQPDTVLSRLELMDGDDAEWLRR MAV_2013|M.avium_104 EYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACALMSDADAEWLRA MMAR_3691|M.marinum_M EYQQQLS-SVLVDQMLVHYLQLVDKALAEPERPLSSLDILGAGERDSVLA MUL_3634|M.ulcerans_Agy99 EYQQQLS-SVLVDQMLAHYLQLVDKALAEPERPLSSLDILGAGERDSVLA MAB_2122|M.abscessus_ATCC_1997 EYQTDVLPQWLVGQLLVHYQRLLADGLSRPEETLARLELFDAEEHSALLD MLBr_01996|M.leprae_Br4923 ACVLNEDERTLDLSIWNRVDLPQGKSCTRVAKRIAAALELMAAAWDQPIA : * .: : : : Mb2401c|M.bovis_AF2122/97 VSRGERFDTPVKTLVDLVNEQTTRT--PDATAVVYEGQHFTYHDLNEA-- Rv2380c|M.tuberculosis_H37Rv VSRGERFDTPVKTLVDLVNEQTTRT--PDATAVVYEGQHFTYHDLNEA-- TH_3141|M.thermoresistible__bu VSRGDRFDTPARTLPDLIESQVRQT--PDAVAVVYEGRHYSYRELNEA-- Mvan_3845|M.vanbaalenii_PYR-1 VSVGPTFDTPPATITDLIEAQVRRS--PDGTAVVYEGRHYTYREINEA-- MSMEG_4511|M.smegmatis_MC2_155 MATGEAFDTPAATLTDLVTQQAERT--PDATAVVYEGRHFTYREINES-- Mflv_2696|M.gilvum_PYR-GCK VSHGPEFDVPAATIGELIEARTDLT--PDTVAVVYEGRRYTYREINES-- MAV_2013|M.avium_104 VSTGEQFITPAATLSELVSRRAART--PDAVAVVYEGRTYTYRDIEEE-- MMAR_3691|M.marinum_M QSHGELVEMPATTMVKLLEATASAAGTATALALVSDEAELTYSELHRR-- MUL_3634|M.ulcerans_Agy99 QSHGELVEMPATTMVKLLEATASAAGTATALALVSDEAELTYSELHRR-- MAB_2122|M.abscessus_ATCC_1997 QSHGVLTRPSAATLVDLLDAAARAT--PEALAVVSDDVELTYELLQQR-- MLBr_01996|M.leprae_Br4923 MIVNEWFGISSDGALCLGNEVTQTTR-PLAPAWFLDPGGSVHLTVDKRRY . . * . : . * . : : :.. Mb2401c|M.bovis_AF2122/97 SNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSY Rv2380c|M.tuberculosis_H37Rv SNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSY TH_3141|M.thermoresistible__bu ANRVAHWLIGQGIGTEDRVAVLLDKSPELVITALGVLKAGAVYLPIDPTY Mvan_3845|M.vanbaalenii_PYR-1 ANRVAHWLIGEDVGAEDRVAVMLDKSPELVVTALGVLKAGAVYVPIDPAY MSMEG_4511|M.smegmatis_MC2_155 ANRLAHWLIGQGIGTEDRVAVLLEKSPELVITALGIVKAGAVYLPVDPTY Mflv_2696|M.gilvum_PYR-GCK ANRVAHWLIGQGIGAEDRVAVLMDRSPELLITALGIIKAGAVYLPVDPSY MAV_2013|M.avium_104 SNRVAHWLIERGVGTEDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTY MMAR_3691|M.marinum_M ANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAY MUL_3634|M.ulcerans_Agy99 ANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAY MAB_2122|M.abscessus_ATCC_1997 SNRFARWLVAQGAGTEDVIALQMSTSVEFIVAMLGVLKSGAAYMPIDPAL MLBr_01996|M.leprae_Br4923 VHPWIAWLVRGSVVPGDVLVFTDDNTDKTIDLLIACHLAGCGYSVCDTVA : *:: . . * : . : . : :. :* * *. Mb2401c|M.bovis_AF2122/97 PQDRLDFILADCDAKLVLRTPVRELAGYRSD-----DPTDADRIRPLRP- Rv2380c|M.tuberculosis_H37Rv PQDRLDFILADCDAKLVLRTPVRELAGYRSD-----DPTDADRIRPLRP- TH_3141|M.thermoresistible__bu PDDRLSFILGDCDARLVLREPVSDLDGQPTT-----DPTDTDRVRRLLP- Mvan_3845|M.vanbaalenii_PYR-1 PQDRLEFILGDCDAKVVVREPVTGLDGYRAD-----DPGDNDRRRPVGP- MSMEG_4511|M.smegmatis_MC2_155 PEDRLNYILSDSDPKIVLREFVTGLDDQPTT-----DPTDAERVRPLRP- Mflv_2696|M.gilvum_PYR-GCK PQDRMSFVLSDSDPTLVIREPVAGLDGHRTD-----NPTDDVRVRPLRP- MAV_2013|M.avium_104 PQDRLNFILGDADAKLVLREPVTDLADYPAT-----APT--ELLRPLTP- MMAR_3691|M.marinum_M PDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRP- MUL_3634|M.ulcerans_Agy99 PDERIDYLITDARPQTVIGRPELDVAERAAADNSDLPLSDGDRLRPLRP- MAB_2122|M.abscessus_ATCC_1997 PEERIEYLIADAKPRIVMRPQEFRVAEAAATGLGDAPITDADRLRPLLP- MLBr_01996|M.leprae_Br4923 EVPLRAKAITDHGGGVSARVIDVAATQLAVTPDNEQSKLADKLIKQAAQD : * : Mb2401c|M.bovis_AF2122/97 ----DNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLL Rv2380c|M.tuberculosis_H37Rv ----DNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLL TH_3141|M.thermoresistible__bu ----GNTAYLIYTSGTTGLPKGVPVPHRPVAEYFVWFKGDYQVDANDRLL Mvan_3845|M.vanbaalenii_PYR-1 ----YNTAYLIYTSGSTGLPKGVPVPHRPVAEYFVWFKGDYRVDAGDRML MSMEG_4511|M.smegmatis_MC2_155 ----DNTAYLIYTSGSTGLPKGVPVPHRPIAEYFVWFGGEYDVTNEDRLL Mflv_2696|M.gilvum_PYR-GCK ----ENAAYLIYTSGSTGQPKGVPVPHRPVAEYFVWFKDEYEISESDRLL MAV_2013|M.avium_104 ----QNTAYLIYTSGSTGLPKGVPVPHAPIAEYFVWFGDEYRIDETDRLL MMAR_3691|M.marinum_M ----GHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWL MUL_3634|M.ulcerans_Agy99 ----GHLAYVIYTSGSTGRPKGVAVSHHAIAEHVQGFVAEWTMTAEDRWL MAB_2122|M.abscessus_ATCC_1997 ----DNLAYVIYTSGSTGRPKGVAVAHAAIAEHVVSFTAEWSMTADDRML MLBr_01996|M.leprae_Br4923 ISLADKTAYIMPTSGSTGQPKLVQVSHGSLALFCDAVRNAYGWGAHDTIL : **:: ***:** ** * *.* .:* . . : * * Mb2401c|M.bovis_AF2122/97 QVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAM Rv2380c|M.tuberculosis_H37Rv QVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAM TH_3141|M.thermoresistible__bu QVASPSFDVSIAEIFGTLACGARLVIHRPGGLNDIGYLTALLQDEGITAM Mvan_3845|M.vanbaalenii_PYR-1 QVASPSFDISIAEVFGTLACGARLVIHRPGGLNDIGYLTALLRDEGITAM MSMEG_4511|M.smegmatis_MC2_155 QVASQSFDVSIGEIFGMLAAGARLVIPKPGGLTDIGYLTDLLRNEGITSM Mflv_2696|M.gilvum_PYR-GCK QVASPSFDVSIGEIFGTLACGGRLVIPKPDGLTDVAYLTELLQREGITAM MAV_2013|M.avium_104 QVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELLAREGITSM MMAR_3691|M.marinum_M QFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVL MUL_3634|M.ulcerans_Agy99 QFSSVSFDASLADIFVTLFLGAQLIVPKPDAFGDISYVADLISRRGVTVL MAB_2122|M.abscessus_ATCC_1997 QSTSVSFDASLADILCPLSLGAQLVIPKPNPFSDIGYVADLVRRRGVTVL MLBr_01996|M.leprae_Br4923 QCAPLTSDISVEEIFGGAICGSKLVRSTAMKTGDLAELARDIFVQRATVI * :. : * *: ::: *.::: . *:. :: : . * : Mb2401c|M.bovis_AF2122/97 HFVPSLLGLFLSLPGVSQWR---TLQRVPIGGEPLPGEVADKFHAT---F Rv2380c|M.tuberculosis_H37Rv HFVPSLLGLFLSLPGVSQWR---TLQRVPIGGEPLPGEVADKFHAT---F TH_3141|M.thermoresistible__bu HFVPSLLGLFLSLPGVNQWR---TLQRVPIGGEPLPGEVADKFHAT---F Mvan_3845|M.vanbaalenii_PYR-1 HFVPSLLGLFLSLPGVNQWR---TLQRVPIGGEALPGEVADKFRAT---F MSMEG_4511|M.smegmatis_MC2_155 HFVPSLLGLFLSLPGVNEWR---TLQRVPIGGEALPGEIADKFHAT---F Mflv_2696|M.gilvum_PYR-GCK HFVPSLLGLFLSLPGVNQWR---TLERVPIGGEALPGELADRFHAT---F MAV_2013|M.avium_104 HFVPSLLGLFLSLPGVSQWR---TLRRVPIGGEALPGEIADKFHAT---F MMAR_3691|M.marinum_M HLVPSMLSTLLLLPQVQQWR---QLRHVPVGGEALPGEVADRFAGY---F MUL_3634|M.ulcerans_Agy99 HLVPSMLSTLLLLPQVQQWR---QLRHVPVGGEALPGEVADRFAGY---F MAB_2122|M.abscessus_ATCC_1997 HMVPSLLGSVLLLPEARELR---GLRHVPVGGEALPGEVADKFATM---F MLBr_01996|M.leprae_Br4923 DLPTAVWHLLCDHSDAIDEINRSCLRQIVIGGEAVRPCAVDKWIDSGASQ .: .:: . . . : *.:: :***.: .*:: Mb2401c|M.bovis_AF2122/97 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQ Rv2380c|M.tuberculosis_H37Rv DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQ TH_3141|M.thermoresistible__bu DALLHNFYGPTETVINASRYKVEGKQGTRIVPIGRPKINTQLHLLDNALQ Mvan_3845|M.vanbaalenii_PYR-1 DALLHNFYGPTETVINATRFKVEGRQGTRIVPIGKPKINTAIHILDDALQ MSMEG_4511|M.smegmatis_MC2_155 DSLLHNFYGPTETVLNCTRYKVEGKQGARTVPIGKPKINTTIHLLDDALQ Mflv_2696|M.gilvum_PYR-GCK DALLHNFYGPTETIINTTRYKVEGTQGSRIVPIGTPKINTTVHLLDDALR MAV_2013|M.avium_104 DASLYNFYGPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRVYLLDNALQ MMAR_3691|M.marinum_M DAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLH MUL_3634|M.ulcerans_Agy99 DAELRNHYGPTEAVVCSTHMLVTGSHGARVVPIGVPNRNVYAYVLDEQLH MAB_2122|M.abscessus_ATCC_1997 DAELRNHYGPTEAVVCSTYMSVRGPQGNSIVPIGRPNQNVYAYVLDQALK MLBr_01996|M.leprae_Br4923 GISLMSTYGPTETTVVVTYLPIVCAP-------MTVESDARLRLGWPIVP . * . *****: : : : : :. : : Mb2401c|M.bovis_AF2122/97 PVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLA Rv2380c|M.tuberculosis_H37Rv PVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLA TH_3141|M.thermoresistible__bu PVPVGVIGEIYIGGTHVAHGYHRRPGLTAERFVADPFNPGGRLYRSGDLA Mvan_3845|M.vanbaalenii_PYR-1 PVPVGSIGEIYIGGTHVARGYHHRPGLTAERFVADPFTPGARMYRSGDLA MSMEG_4511|M.smegmatis_MC2_155 PVPVGVIGEIYIGGTHVAHGYHRRPGMTAERFVADPFNPGGRMYRSGDLA Mflv_2696|M.gilvum_PYR-GCK PVPVGAIGEIYIGGGHVARGYHRRPALTAERFVADPFTVGGRLYRSGDLA MAV_2013|M.avium_104 PVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSRGGRMYRSGDLA MMAR_3691|M.marinum_M PVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLV MUL_3634|M.ulcerans_Agy99 PVPDQVVGELYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLV MAB_2122|M.abscessus_ATCC_1997 LVPAGVVGELYLGGAQLARGYRARPVLTAERFVADPFGSGGRLYRTGDLV MLBr_01996|M.leprae_Br4923 NTVFIAFGELVIVGDLVSVGYLGIDSRNFG-TVTTTDGSCRRAFATADCV . .**: : * :: ** . :: . * : :.* . Mb2401c|M.bovis_AF2122/97 RRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDL Rv2380c|M.tuberculosis_H37Rv RRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDL TH_3141|M.thermoresistible__bu RRNADGDIEFVGRADEQVKIRGFRIELGDVAAAISVDPSVGQAVVVATDL Mvan_3845|M.vanbaalenii_PYR-1 RRNADGDIEFVGRADEQVKIRGFRIELGDVAAAITVDPSVGQAVVVVSDL MSMEG_4511|M.smegmatis_MC2_155 RRNADGDIEFVGRADEQVKIRGFRIELGEVSAAISVDPSVGQAVVVVSDL Mflv_2696|M.gilvum_PYR-GCK RRNADGDLEFVGRADDQVKIRGFRIELGEVAAAISVDPSVGQAVVLGQDL MAV_2013|M.avium_104 RRNANGDIEFVGRADEQVKIRGFRIELGEIAAAISVDPSVGQAVVLAMDL MMAR_3691|M.marinum_M RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLV-VAEE MUL_3634|M.ulcerans_Agy99 RRNHCGELEFVGRADEQVKIRGFRIELGEVESVITTHPAVRHCLV-VAEE MAB_2122|M.abscessus_ATCC_1997 RRNARGELEFVGRADEQVKVRGYRIELGEIEAVIGADPRVGHCVATVVDD MLBr_01996|M.leprae_Br4923 ILDDEGFPVFSGRKDAVVKISGKRVDTAELIRRISTDPNVSDVAVEVYNG : * * ** * **: * *:: .:: * ..* * . . : Mb2401c|M.bovis_AF2122/97 PRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVV- Rv2380c|M.tuberculosis_H37Rv PRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVV- TH_3141|M.thermoresistible__bu PNVGRSLVGYLTPVSGE---STDSVAVERIRARVAAALPEYMVPAAYVV- Mvan_3845|M.vanbaalenii_PYR-1 PNLGKSLVAYLTPADG------AGVDVDRIRTRVAAALPEYMTPAAYVV- MSMEG_4511|M.smegmatis_MC2_155 PSLGKSLVAYITPAAG-----ADHVDIERIRARVTAALPEYMVPAAYVE- Mflv_2696|M.gilvum_PYR-GCK PGLGMSLVGYVTPAAG------EDVDLARVRERVAAALPDYMTPAGYVV- MAV_2013|M.avium_104 PQLGKSLVGYVTPAQGAG---TETVDVERIRARVAAALPDYMTPAAYVV- MMAR_3691|M.marinum_M TEAGPMLAAYLVPA-------AAQVDLEEIRAHTAAAVPEYMVPGAFAV- MUL_3634|M.ulcerans_Agy99 TEAGPMLAAYLVPA-------AAQVDLEEIRAHTAAAVPEYMVPGAFAV- MAB_2122|M.abscessus_ATCC_1997 PQVGSLLAAYVVPAGG-----TREIDLDELRARAQEALPAYMVPTAFAV- MLBr_01996|M.leprae_Br4923 -RLGVWFETKLTREG---------VDDAAAATRSRLILASLGVSSFFVVG * : :. : : :. . :. Mb2401c|M.bovis_AF2122/97 LDEIPITAHGKIDR-AALPEPQIASDTEFRAPQTATERRLAQLFGELLG- Rv2380c|M.tuberculosis_H37Rv LDEIPITAHGKIDR-AALPEPQIASDTEFRAPQTATERRLAQLFGELLG- TH_3141|M.thermoresistible__bu LDEIPITTHGKIDR-AALPEPQIASMIEYREPATDTEREVARLFGDLLGR Mvan_3845|M.vanbaalenii_PYR-1 VDEIPITAHGKIDR-AALPEPEIAPTTEFREPAAGTEAHLAQLFAELLG- MSMEG_4511|M.smegmatis_MC2_155 LDEIPITTHGKIDR-RALPEPEITSTTRFREPSTDTERTVAGLFAELLE- Mflv_2696|M.gilvum_PYR-GCK LDEIPITAHGKIDR-AALPLPEITTATDYREPQTETEQHLAQLFSELLG- MAV_2013|M.avium_104 LDEIPITAHQKIDR-AALPQPQIGAGTEYRDPTTPTEHRIAQLFSGLLG- MMAR_3691|M.marinum_M IPEIPMTVSGKLDR-RALPAPTPIATRRYREPETATERWICSIFAQLFG- MUL_3634|M.ulcerans_Agy99 IPEIPMTVSGKLDR-RALPAPTPIATRRYREPETATERWICSIFAQLFG- MAB_2122|M.abscessus_ATCC_1997 IPEIPLTTSGKLDK-RALPTPDALTERAFRLPVTPTERRMCAIYSHLFG- MLBr_01996|M.leprae_Br4923 VPCIPRKPNGKIDRDNLLVMPQLVDSVQNYAGSGEGAAGLAEIWSRHLG- : ** . *:*: * * :. ::. : Mb2401c|M.bovis_AF2122/97 RDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALA Rv2380c|M.tuberculosis_H37Rv RDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALA TH_3141|M.thermoresistible__bu SERIGADDSFFDLGGHSLLATKLVAAVRSAFGVDIGVQDVFELGTVARLA Mvan_3845|M.vanbaalenii_PYR-1 HEKVGADDSFFDLGGHSLLATKLVAELRAGFGVDVEVRDIFENATIARLA MSMEG_4511|M.smegmatis_MC2_155 RDEVGADDSFFDLGGHSLLATKLVAAVRARCAVDVGVQDVFEHATVSGLA Mflv_2696|M.gilvum_PYR-GCK VARVGVDDSFFELGGHSLLATKLVSAVRSRCGVDMEIREIFELGTVARLA MAV_2013|M.avium_104 HERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFELATVGLLA MMAR_3691|M.marinum_M RQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLA MUL_3634|M.ulcerans_Agy99 RQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDVPTPAGLA MAB_2122|M.abscessus_ATCC_1997 KERVGLDDSFFELGGHSLLAARLVAQIRAQFGIDLTVRAVFDRPTPAGLA MLBr_01996|M.leprae_Br4923 -RAILPDSSLLDEGIGSVDLIRILPDTRRHLGRHLSLLDLISADNAANLT : :.*:: * *: :::. * . .: : ::. . *: Mb2401c|M.bovis_AF2122/97 G------------HIDTLDSDS----------ARPRLTRVDHDGPVRLSS Rv2380c|M.tuberculosis_H37Rv G------------HIDTLDSDS----------ARPRLTRVDHDGPVRLSS TH_3141|M.thermoresistible__bu G------------RIDELRSGSG-------GPLRPRLTPQHFDGPAPLSS Mvan_3845|M.vanbaalenii_PYR-1 A------------HLDTMGRATI-------GTRRPRLVAAPLDGPAPLSS MSMEG_4511|M.smegmatis_MC2_155 A------------HIEDLVASGA-------SSGRPAIVAVPHDGPLQMSA Mflv_2696|M.gilvum_PYR-GCK E------------RVDELAAGGS-------APLRPRLLAVPHDGPAPMSA MAV_2013|M.avium_104 E------------RVDQLSSGEL-------TGTRPKLIATAHDEPLPLSA MMAR_3691|M.marinum_M ARLVERFRNDFELDLDNLAADD---MPLDPKRARPGFVKSARPQRLPLSH MUL_3634|M.ulcerans_Agy99 ARLVERFRNDFELDLDNLAADD---MPLDPKQARPGFVKSARPQWLPLSH MAB_2122|M.abscessus_ATCC_1997 EQLVTYFREEFEIELDELDLDESDEMEAAPQDGRPDLVAAERPERLPLSS MLBr_01996|M.leprae_Br4923 A------------------------------------------------- Mb2401c|M.bovis_AF2122/97 SQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILR Rv2380c|M.tuberculosis_H37Rv SQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILR TH_3141|M.thermoresistible__bu SQLRSWFAYRVDGPSVVNNIPFAARLHGPVDVDALEAAIGDVIARHEILR Mvan_3845|M.vanbaalenii_PYR-1 SQLRSWFGYRIEGRSPVNNIPFAARLTGPCDVDAFVAAIRDVVERHAILR MSMEG_4511|M.smegmatis_MC2_155 AQLRQWFQFRIDGPNPVNNVPFAARLSGPCDVDALIAAVGDVVARHEILR Mflv_2696|M.gilvum_PYR-GCK AQLRQWFQYRIEGPGPVNNVPFAARFAGPCDVDALIEAVRDVVNRHESLR MAV_2013|M.avium_104 SQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDVVARHEILR MMAR_3691|M.marinum_M SQLAAWFQYRIEGAREEFNMPLALRFEGPLDSVALAAALNDVVARHEALR MUL_3634|M.ulcerans_Agy99 SQLAAWFQYRIEGAREEFNMPLALRFEGPLDSVALAAALNDVVARHEALR MAB_2122|M.abscessus_ATCC_1997 SQLSMWFECQMEGVTDIGNMWLALRFDGPLQTPALIAALNDVVARHEALR MLBr_01996|M.leprae_Br4923 -----------------------------AQTANVWMDVGTAAEIERDLA : . : . . * Mb2401c|M.bovis_AF2122/97 TVYREIGGVPHQIIQPPAE-VPVRCAAGSDAAWLRAELNNERGYVFDLET Rv2380c|M.tuberculosis_H37Rv TVYREIGGVPHQIIQPPAE-VPVRCAAGSDAAWLRAELNNERGYVFDLET TH_3141|M.thermoresistible__bu TVYREIDGVPYQIVLPTEP-VPVRRADGQGEQWLRAELDAERRHVFDLEN Mvan_3845|M.vanbaalenii_PYR-1 TTYREIDGVPYQIVNPISD-VPVRRARGEGEQWLQAELDRERKHTFDLEE MSMEG_4511|M.smegmatis_MC2_155 TTYREIDGAPYQIIHPPAP-VPVRQARGDGEDWVQAQLDAERRYCFDLET Mflv_2696|M.gilvum_PYR-GCK TTFCEIDGVPYQLVNAPDPGFPVRRDSGPDDAWLVGALDDERRRVFDLEN MAV_2013|M.avium_104 TRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDG MMAR_3691|M.marinum_M TNFDEHEGVPYQIVHPSRTVQLAVRAIDQDE--FDDVSTQLRRHVFTPES MUL_3634|M.ulcerans_Agy99 TNFDEHEGVPYQIVHPSRTVQLAVRAIDQDE--FDDVSTQLRRHVFTPES MAB_2122|M.abscessus_ATCC_1997 TNIAIHEGAPYQIVHPSRELAVPILRSSPEG--LSDTLAELRHHIFGLET MLBr_01996|M.leprae_Br4923 SLCRQRNATEFSVKQTRNS------------------------------- : .. ..: . Mb2401c|M.bovis_AF2122/97 DWPIRAALLSTPEQT-----------------------VLSLVVHHIAGD Rv2380c|M.tuberculosis_H37Rv DWPIRAALLSTPEQT-----------------------VLSLVVHHIAGD TH_3141|M.thermoresistible__bu ERPIRPAILSLRPDAGSPD----SPAGD--------VHVLSLVMHHIAGD Mvan_3845|M.vanbaalenii_PYR-1 DWPIRAAVFTVGAVSPASDGGAVSPASDGGAVDPASDHVLSVVIHHIAGD MSMEG_4511|M.smegmatis_MC2_155 DWPIRAAVLTTAEHH-----------------------VLSLVVHHIAAD Mflv_2696|M.gilvum_PYR-GCK QWPIRVAVLSIPGEH-----------------------ALSVVVHHIAAD MAV_2013|M.avium_104 ELPIRVAVLRVANAAEH---------------------VLSLVVHHIASD MMAR_3691|M.marinum_M GPLLQANLLVLGPDTH----------------------VLLLIVHHIVSD MUL_3634|M.ulcerans_Agy99 GPLLQANLLVLGPDTH----------------------VLLLIVHHIVSD MAB_2122|M.abscessus_ATCC_1997 ESLIRPAIIELSAQEH----------------------VLALVVHHIVVD MLBr_01996|M.leprae_Br4923 --HQKQAIVVLGASG-----------------------ILGTGFAQAVLD : :. * . : . * Mb2401c|M.bovis_AF2122/97 HWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAG- Rv2380c|M.tuberculosis_H37Rv HWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAG- TH_3141|M.thermoresistible__bu HWSATVLFTDLLTAYRARTAGQEPAWAPLPVQYADFGAWESELLAEETG- Mvan_3845|M.vanbaalenii_PYR-1 HWSGGVLFTDLVAAYRARKAGERPTWAPLPVQYTDYGAWQAELLSDDTG- MSMEG_4511|M.smegmatis_MC2_155 HWSGTVLFTDLLTAYHARHAGSAVELPPLPVQYADFAAWQAELLAGTDD- Mflv_2696|M.gilvum_PYR-GCK HWSGGVLFTELLTAYRARRAGEAPTWAPLPVQYADYAAWQSALLADDSG- MAV_2013|M.avium_104 HWSAGVLFADVMTAYRARRGGEAPSWAPLRVQYADYAAWQRTFLGDAGGQ MMAR_3691|M.marinum_M HASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESN--- MUL_3634|M.ulcerans_Agy99 HASLEIVFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESN--- MAB_2122|M.abscessus_ATCC_1997 HASFTVIVDDLIAAYRARLEGQAPQWDPQPVQYADYVLWQRDAFAPDSE- MLBr_01996|M.leprae_Br4923 LRQSGVLCPEVVLATRARLPEGDP---WTALQGVDGVRIERISFENGPGE . :: ::: * :** :* .* : : Mb2401c|M.bovis_AF2122/97 ---IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI Rv2380c|M.tuberculosis_H37Rv ---IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI TH_3141|M.thermoresistible__bu ---IAGPQREYWTRQLAGLPEETGLRPDFPRPPVPSGLAEAVEFTIDAAV Mvan_3845|M.vanbaalenii_PYR-1 ---IAGPQREYWIRQLADAPVESGLPLEFSRPRLPSGKGDAVEFTIDGQV MSMEG_4511|M.smegmatis_MC2_155 ---TIDEQRRYWTTQLAGLPEENGLYPDFPRPPVPTGDGAALDFSIDADT Mflv_2696|M.gilvum_PYR-GCK ---IVAAQRRYWTQQLEGLSAETGLQPDLVRPSVPSGAADAVEFTLDAAI MAV_2013|M.avium_104 ESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGESVDFHIDAAT MMAR_3691|M.marinum_M ---WGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR MUL_3634|M.ulcerans_Agy99 ---WGQTELDYWRDALAGLPDEISVATDRARPRVLGKRGEVVQFSVPAAR MAB_2122|M.abscessus_ATCC_1997 ---FGQAEVNFWRQQLAGVPTEIAVAHDRARPQILGKRGEVAKFVMEPER MLBr_01996|M.leprae_Br4923 ---LEALIRDTDAGTLVNGVGNTNMLVPYRELRLANVELVSAIVDICASY * . : : . : . : Mb2401c|M.bovis_AF2122/97 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANL Rv2380c|M.tuberculosis_H37Rv RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANL TH_3141|M.thermoresistible__bu REKLAGLCRDLGITEFMALQAAVAVVLHKAGSGSDIPLGTPVAGRSEPEL Mvan_3845|M.vanbaalenii_PYR-1 RRQITELCRELGITEFMLLQAAVAVTLAKVGGGLDIPLGTPVAGRSEAEL MSMEG_4511|M.smegmatis_MC2_155 RARLIALTRELGVTEFMLLQAAVAIALHKSGQGTDIPLGTPVAGRTAPEL Mflv_2696|M.gilvum_PYR-GCK REKLVTLSREVGATEFMLLQAAVAVTLYKAGEGPDIPLGTPVAGRTESEL MAV_2013|M.avium_104 RAKLADVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAEL MMAR_3691|M.marinum_M RAALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPAT MUL_3634|M.ulcerans_Agy99 RSALTQLAERNGATEFMLYQAALAVVLHKLGGGTDIALGSPVAARVEPAT MAB_2122|M.abscessus_ATCC_1997 RQALTRMAEQRGVTEFMVYQAALAVVLHRLGGGTDIVIGSPVAARVHPHV MLBr_01996|M.leprae_Br4923 STRLVHLSS-------FVVNADVTVPQVTDPRETPYPYAASKSLAELVVA : : : :: ::: .:. : Mb2401c|M.bovis_AF2122/97 DQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVE Rv2380c|M.tuberculosis_H37Rv DQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVE TH_3141|M.thermoresistible__bu DQLVGFFINILVLRNDLSGNPSLREVCRRAREMALAAYAHQDLPFDQVVD Mvan_3845|M.vanbaalenii_PYR-1 EQLVGFFVNFVVLRNDLRGNPTLREVLIRAREMALSAYSNQDVPFEQVVE MSMEG_4511|M.smegmatis_MC2_155 DALIGFFINIVVLRNDLSGNPSLREVLRRSREMALAAYQHQDLPFDRVVD Mflv_2696|M.gilvum_PYR-GCK DQLIGFFINILVLRNDLRDNPSLRDVGFRSREMALAAYAHQDLPFDQVVD MAV_2013|M.avium_104 DQLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVD MMAR_3691|M.marinum_M AQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVE MUL_3634|M.ulcerans_Agy99 AQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAHQELPIERLVE MAB_2122|M.abscessus_ATCC_1997 AKLVGLFANMVALRNDLSGDPSLRSVLERSRDATLNAHAHQELPIEKLVE MLBr_01996|M.leprae_Br4923 GSPSALDFTIVRLPRVLGEDYQLRNSSDILLSIVDACIALRAYPSATVTE .: ..: * * : **. . . . : * :.: Mb2401c|M.bovis_AF2122/97 AVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPT Rv2380c|M.tuberculosis_H37Rv AVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPT TH_3141|M.thermoresistible__bu AVSPVRTLARNPLFSVVVHVREQLPENRVIDHGPDG----DTTVTVLEPP Mvan_3845|M.vanbaalenii_PYR-1 AVNPPRTLARNPLFQVVVHVREQLPQRQMIDT--------DTEFTALEPT MSMEG_4511|M.smegmatis_MC2_155 AVSPVRSLSRNPLFGVVVHVRDDLPADQVIDDGGNG----ETRFTALEPT Mflv_2696|M.gilvum_PYR-GCK AVSPVRSLSRNPLFGVVVHVREELPQDRVIATGSDG----ETTFTALEPT MAV_2013|M.avium_104 SVSPVRSLSRNPLFQVVVHVRDHLSATRVIETAPVGGDGQDTVCTSLDPV MMAR_3691|M.marinum_M ALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRG----ETTVVPLPVN MUL_3634|M.ulcerans_Agy99 ALNPPRALSRNPLFQNMLNFRGEDWALVPRDLTGRG----ETTVVPLPVN MAB_2122|M.abscessus_ATCC_1997 AVNPVRSLSWNPLFQTMVNFRGADWGTAARDVTVSG----ETTVVPLPME MLBr_01996|M.leprae_Br4923 EVTTGRAAAKAILGVVSALARSGQLGSGISVVRGEA-------------- :.. *: : * * Mb2401c|M.bovis_AF2122/97 FDAAQADLSVNFFAC---------GDEYRGHVIYRTELYERATAQRFADW Rv2380c|M.tuberculosis_H37Rv FDAAQADLSVNFFAC---------GDEYRGHVIYRTELYERATAQRFADW TH_3141|M.thermoresistible__bu FDAAHADLSLNFFAAE-------DGGGYRGHVIYRPELYSRDTAQRFADW Mvan_3845|M.vanbaalenii_PYR-1 FDIAQADLSLNFLA---------DGTGYRGYLIYRPELYARRTIERLGRW MSMEG_4511|M.smegmatis_MC2_155 FDVAHADLSLNFFAQNGNGGRAGEPAGYKGTVIYRTELYEPATARRLIGW Mflv_2696|M.gilvum_PYR-GCK FDMAHADLSVNFFAG---------GNGYRGHVIYRTELYTRATAERFAGW MAV_2013|M.avium_104 FDMAHADLSVNFFGTDG-----AGDIGYNCHLIFRTDLYRRTTIERLAGW MMAR_3691|M.marinum_M FEVALLFLAIGMSVTP--------SGELDVQVIANADLYEPATVALIADA MUL_3634|M.ulcerans_Agy99 FEVALLFLAIGMSVTP--------SGELDVQVIANADLYEPATVALIADA MAB_2122|M.abscessus_ATCC_1997 VDVSYLDLNFALNVTP--------SGGLDVSVVANADLYDHETTRMIAQA MLBr_01996|M.leprae_Br4923 --VAYADFLSEFASD-------------------ELNMAEWKYRLDQSDW : : : . :: Mb2401c|M.bovis_AF2122/97 LVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAG----------- Rv2380c|M.tuberculosis_H37Rv LVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAG----------- TH_3141|M.thermoresistible__bu LGRVVTAFAERPDITLRELEIGAPGERRRILEEWG--------------- Mvan_3845|M.vanbaalenii_PYR-1 LPRVVAAFVDTPDRALGDVDIVSAEERQRVSQEWST-------------- MSMEG_4511|M.smegmatis_MC2_155 LHRIIDAFATDADTTLRDIAVIDADERTLLIEDWSRRAVPPA-------- Mflv_2696|M.gilvum_PYR-GCK LSAVITAFADDPERHVDDVVIAEPVRPG---------------------- MAV_2013|M.avium_104 LVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSRGAQPPRDRPRTIPE MMAR_3691|M.marinum_M LDAALAAFATTPDLPLSAVQLLPS-------------------------- MUL_3634|M.ulcerans_Agy99 LDAALAAFATTPDLPLSAVQLLPR-------------------------- MAB_2122|M.abscessus_ATCC_1997 LDTAFDAFVNNQESRVSEIVLLPA-------------------------- MLBr_01996|M.leprae_Br4923 AKRNPRRWS----------------------------------------- : Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 LLQASRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVGPGTLVG MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 LSTRRSIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVAT MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 VEAVDTMPGLPGVELLSLDDPQVRALVDRDDVDPRAGRLRPPHPDDPMYL MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 VFTSGSTGKPKGAVGTHRSMAARLDWQLRHYPPRTDDVRLAQASITFLEG MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 GMEMLAGLAAGATMILADDAEHRDPEALGELMHRHSVAQVTAVPSLVSAL MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 LDSRPDAVRSLSRLVCGGEPVSTSLLQRLVSVCDEADGGGPELLNNIGST MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -----------------------TARVYLLDDALKPVPVGVVGDVYYGGG Rv2380c|M.tuberculosis_H37Rv -----------------------TARVYLLDDALKPVPVGVVGDVYYGGG TH_3141|M.thermoresistible__bu -----------------------GGTVYVLDETLQPVPVGVVGDVYTAGP Mvan_3845|M.vanbaalenii_PYR-1 -----------------------GARVQVLDADLAPAPVGVFGDLYLSG- MSMEG_4511|M.smegmatis_MC2_155 -----------------LPQTEGATNVYVLDEWLEPVAIGVIGDVYYAGG Mflv_2696|M.gilvum_PYR-GCK ----------------------DGAEAVLLDGAGHPVPVGVVADVHYAGA MAV_2013|M.avium_104 ETSGAVSRGPLSPPNPLVGKPVPGAQAYLLDDGLRPVPVGVVGELYYAGD MMAR_3691|M.marinum_M -----------------------ADLAKLLAPPLPAGPAASP-------- MUL_3634|M.ulcerans_Agy99 -----------------------ADLAKLLAPPLPAGPAASQ-------- MAB_2122|M.abscessus_ATCC_1997 -----------------------DAMAQLMAPPAAAVEPVTT-------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 PAVGARLARPSETA-------------TRFVADPFAAQPGSRLYRNGERG Rv2380c|M.tuberculosis_H37Rv PAVGARLARPSETA-------------TRFVADPFAAQPGSRLYRNGERG TH_3141|M.thermoresistible__bu ALAAAHWTRAGVTA-------------TRLVADPVGNRPGARLYRTGDRA Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------GPFAQRHRTGDRA MSMEG_4511|M.smegmatis_MC2_155 AVDASAEAANGVAA-------------QRFVPNPFG---AGRLYRTGDRA Mflv_2696|M.gilvum_PYR-GCK PDRRGDRARWTEDGRLQYVERVDHDLEAALAAVPGVAAAAVRTWEIGHRT MAV_2013|M.avium_104 QLARGYWKRPGLTA-------------ARFVANPFGAEPGSRLYRSGDLA MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 VWK--------ADGQLELLAEIERLPTAQAAP------------------ Rv2380c|M.tuberculosis_H37Rv VWK--------ADGQLELLAEIERLPTAQAAP------------------ TH_3141|M.thermoresistible__bu RWI--------ADGVLEFVDAQP-PTIPAVRPDS---------------- Mvan_3845|M.vanbaalenii_PYR-1 RWD--------DDGRLEIAARAPGATVVEVAPPA---------------- MSMEG_4511|M.smegmatis_MC2_155 RWT--------PDGRLEPVTAGEPRLQAALEAVDGVAAAATRYWEN---- Mflv_2696|M.gilvum_PYR-GCK AVVGYVVPAEPVDDPASFAETVRAAVAPESAPTSITVLDALP-------- MAV_2013|M.avium_104 RWT--------EDGQLEFVGRSDHQVQVRGFRVELAEVEAALAGADGVAA MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------------------------- Rv2380c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3141|M.thermoresistible__bu -------------------------------------------------- Mvan_3845|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4511|M.smegmatis_MC2_155 ---------------------RSAPLLAAYVVADAAHAADPQFAEQVRTA Mflv_2696|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2013|M.avium_104 AAARTWEVHGGTSLAGYVVPQRPIADEAEKAAFAAQVRAEIAATLPGYMM MMAR_3691|M.marinum_M -------------------------------------------------- MUL_3634|M.ulcerans_Agy99 -------------------------------------------------- MAB_2122|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 -------------------------------VPAEPADTETERALAAILA Rv2380c|M.tuberculosis_H37Rv -------------------------------VPAEPADTETERALAAILA TH_3141|M.thermoresistible__bu -----------------------------GQRPGGPPATDTERALATLLA Mvan_3845|M.vanbaalenii_PYR-1 -----------------------------VEFE--EPRTDSERALAALLS MSMEG_4511|M.smegmatis_MC2_155 LPDEFAGAAITVVDDLTPAALTRPRVSATASGPFEAPATPTERAVAAMLV Mflv_2696|M.gilvum_PYR-GCK -------------------ATRRALPAPRVGGPSEPARTDTEKALVGMLA MAV_2013|M.avium_104 PSSLTVLDALPKTESGKLNRPGLPRPAVSTGGRTEPARTDTERALANVFA MMAR_3691|M.marinum_M --------------------------------PVAAGSAETERRLTAMLE MUL_3634|M.ulcerans_Agy99 --------------------------------PVAAGSAETERRLTAMLE MAB_2122|M.abscessus_ATCC_1997 --------------------------------PSVEGSEETKLVLISILE MLBr_01996|M.leprae_Br4923 -------------------------------------------------- Mb2401c|M.bovis_AF2122/97 DVLEVGEVG----RYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEH Rv2380c|M.tuberculosis_H37Rv DVLEVGEVG----RYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEH TH_3141|M.thermoresistible__bu EVLDTEVTG----RDDDFFSLGGDSILAVQLAARARDTGLKLTARMVFEH Mvan_3845|M.vanbaalenii_PYR-1 ELLATEEVG----RHDDFFGLGGDSVLAVQLAARARDTGLDLTARMVFEH MSMEG_4511|M.smegmatis_MC2_155 ELLGVTQVG----RHDDFFTLGGDSILAVQLAARARDAGVAMTARMVFEH Mflv_2696|M.gilvum_PYR-GCK DVLVEVHDGTGIGRFDDFFELGGDSILAVQLAARAKQAGLRLSARMVFEH MAV_2013|M.avium_104 ELLSTPEVG----RFDDFFALGGDSILSVQLASRARAAGLPVSPRMIFEN MMAR_3691|M.marinum_M ELLEITGID----RDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEH MUL_3634|M.ulcerans_Agy99 ELLEITGID----RDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEH MAB_2122|M.abscessus_ATCC_1997 ELLEISDVD----PEDNFFALGGDSVISIQWSTRAAERGLAMTPQMVFEC MLBr_01996|M.leprae_Br4923 -------------VIDAWFTLG----MMFEMRSYAEYPTMALGVESVAEL : :* ** : : : * : . : * Mb2401c|M.bovis_AF2122/97 PVLCELAAAVDAKP----------------------HVEAEPD------- Rv2380c|M.tuberculosis_H37Rv PVLCELAAAVDAKP----------------------HVEAEPD------- TH_3141|M.thermoresistible__bu PTLHELAAAVEAREAVEARETAEAGGAEAGGAESGGGADGAERGAAAGDS Mvan_3845|M.vanbaalenii_PYR-1 PRLAELAAALDS----------------------GAGAAAEQP------- MSMEG_4511|M.smegmatis_MC2_155 PVLSELAAAIDAAG----------------------EGSAAQD------- Mflv_2696|M.gilvum_PYR-GCK PVVHDLAVALDTAK-----------------------TPEVAD------- MAV_2013|M.avium_104 PTVQQLAAALDALG--------------------DNDSDGRLDDQP---- MMAR_3691|M.marinum_M MTIAELAAAVDAANGE---------------------PVVEAD------- MUL_3634|M.ulcerans_Agy99 MTIAELAAAVDAANGE---------------------PVVEAD------- MAB_2122|M.abscessus_ATCC_1997 ATIAQLAGAVDAADR----------------------VVTEGDSHL---- MLBr_01996|M.leprae_Br4923 AAPPESIRALLAHG------------------------------------ : *: : Mb2401c|M.bovis_AF2122/97 ---DKHHAPMSTSGLSPDELSALTASWDQWP---- Rv2380c|M.tuberculosis_H37Rv ---DKHHAPMSTSGLSPDELSALTASWDQWP---- TH_3141|M.thermoresistible__bu GNGAASHAPMSTSGLSAEQLSALTASWNPAGEDAP Mvan_3845|M.vanbaalenii_PYR-1 ---DTHHAPMSVSGLSEDELAALTASWG-TGE--- MSMEG_4511|M.smegmatis_MC2_155 ----VHHAPMEASGLSSDELAALTAAWGQSQDGKR Mflv_2696|M.gilvum_PYR-GCK ----VRHDPMSASGLTPEELAMVATSWAAEQDGSP MAV_2013|M.avium_104 --ADTRFEPMSTSGLSASDLAAVTQLWSSSREGTA MMAR_3691|M.marinum_M PPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS- MUL_3634|M.ulcerans_Agy99 PPPAQEYTPMSASGLAPDALAKLSASWLQQGSAS- MAB_2122|M.abscessus_ATCC_1997 VTPPVQSAPMSASGLSADALAELTASWQAQS---- MLBr_01996|M.leprae_Br4923 -----CSQPLKYTGR-------------------- *:. :*