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MMANASAETTFEHADTSGAIFFVDMSGDTALTEIHGDHVAAQFAEDFAVMANVALGPGDELTKTMGDAVM VASADAPAALAFLRRLGVAAGLAMGFPMLCAGVSAGTVVRRRGDVYGTTVNAAARLAALAAPGLIVIGRD VAAAAAPISAFPSQHSGW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3687 | - | - | 100% (159) | putative adenylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_3699 | - | 3e-40 | 58.99% (139) | putative adenylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | 3e-10 | 31.88% (138) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1295 | - | 1e-12 | 32.80% (125) | adenylyl cyclase |
| M. gilvum PYR-GCK | Mflv_2823 | - | 2e-39 | 57.86% (140) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1264 | - | 1e-12 | 32.80% (125) | adenylyl cyclase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4771 | - | 6e-13 | 35.25% (139) | putative adenylate cyclase |
| M. marinum M | MMAR_1414 | cyaA_1 | 5e-20 | 41.61% (137) | adenylate cyclase, CyaA_1 |
| M. avium 104 | MAV_1415 | - | 3e-14 | 34.43% (122) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 4e-13 | 33.07% (127) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 2e-14 | 33.09% (139) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4470 | - | 1e-13 | 34.33% (134) | adenylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1295|M.bovis_AF2122/97 MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
Rv1264|M.tuberculosis_H37Rv MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
MUL_4470|M.ulcerans_Agy99 MED-------SVDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGI
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
MSMEG_5018|M.smegmatis_MC2_155 MVS-------------QQVQPDIQPLLEGLDGAARSQREELINWLLSRGI
TH_1842|M.thermoresistible__bu -MA-------------DDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
Mvan_3687|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2823|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1414|M.marinum_M --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1295|M.bovis_AF2122/97 TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
Rv1264|M.tuberculosis_H37Rv TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
MUL_4470|M.ulcerans_Agy99 TAAEIRTTNPPLLLATRHVIGDDGTYVSSREISETYGIDLDLLQRVQRAV
MAV_1415|M.avium_104 TAEEIRTTNPPLLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQRAI
MSMEG_5018|M.smegmatis_MC2_155 SVDQIGQAITPMLLASRRVAGDDGTYVSAREISEQTGLDLDLLQRLQRAM
TH_1842|M.thermoresistible__bu SIEEIRESVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRMLRAL
Mvan_3687|M.vanbaalenii_PYR-1 ------------------MMMANASAETTFEHADTS-----------GAI
Mflv_2823|M.gilvum_PYR-GCK ------------------MTIDLSSAADEFEHADVD-----------TVV
MMAR_1414|M.marinum_M ------MNVSYPIRTSIIASSRYGRTHEVRTTAESG-----------WTF
MAB_4771|M.abscessus_ATCC_1997 -MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVERARTLWVAL
: ..
Mb1295|M.bovis_AF2122/97 GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSH
Rv1264|M.tuberculosis_H37Rv GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSH
MUL_4470|M.ulcerans_Agy99 GLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQIVLVVRVLAEGLSR
MAV_1415|M.avium_104 GLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQVVLVAQVLAEGLSR
MSMEG_5018|M.smegmatis_MC2_155 GLPAVEDPDAAVLLRADAEAVTFSQQFIDLGIDADQVVLITRVLAEGLSR
TH_1842|M.thermoresistible__bu GLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQMVQIAAVLSEGLAK
Mvan_3687|M.vanbaalenii_PYR-1 FFVDMSGDTALTEIHGDHVAAQFAEDFAVM---------ANVALGPGDEL
Mflv_2823|M.gilvum_PYR-GCK IFVDIAGFTAFTETHGDHRAAELADRFATT---------AARVLGPGDDM
MMAR_1414|M.marinum_M GFVDLAGFTALTDAHGDQEAVTLVDRFETV---------VAESLTADDQL
MAB_4771|M.abscessus_ATCC_1997 GFAAADSDDEVAFTDADVSAIRTFAALGSATAAN-----QQSQIAAARTL
: . . .* * : :
Mb1295|M.bovis_AF2122/97 AAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQL
Rv1264|M.tuberculosis_H37Rv AAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQL
MUL_4470|M.ulcerans_Agy99 AAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAPLLGPMIQEMLFMQL
MAV_1415|M.avium_104 AAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFMQL
MSMEG_5018|M.smegmatis_MC2_155 AAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAPLLGPMIQDMLFVQL
TH_1842|M.thermoresistible__bu AAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDLLLLQL
Mvan_3687|M.vanbaalenii_PYR-1 TKTMGDAVMVASADAPAALAFLRRLGVAAGLAMGFPMLCAGVSAGTVVRR
Mflv_2823|M.gilvum_PYR-GCK IKTLGDAVMITSSDPTAALAFLRRLHDETSRIDGFPLLRAGICAGPVVKR
MMAR_1414|M.marinum_M VKTIGDAVMLRFATPASAIAGARRIFARCTSGTGFPAPRAGLHHGPAVAR
MAB_4771|M.abscessus_ATCC_1997 GQAMARLAEWQADLLTREVGGRLAAEGDDASAESSANAATQTIATLTALQ
. . .
Mb1295|M.bovis_AF2122/97 RHMMETEAVNAGECAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH
Rv1264|M.tuberculosis_H37Rv RHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH
MUL_4470|M.ulcerans_Agy99 RHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELGQ
MAV_1415|M.avium_104 RHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEELGQ
MSMEG_5018|M.smegmatis_MC2_155 RHAMETEAVDASERAEGVPLPGARLVTVAFADIVGFTRLGEVVPPEQLEQ
TH_1842|M.thermoresistible__bu RHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPPEELEQ
Mvan_3687|M.vanbaalenii_PYR-1 RGDVYGTTVNAAARLAALAAPGL---------IVIGRDVAAAA-------
Mflv_2823|M.gilvum_PYR-GCK RGDVFGSTVNTAARLAAVAKPGQ---------IVGNAEAAAALRATDLLA
MMAR_1414|M.marinum_M GQDWFGATVNVAARVAAHSRGGQ---------LLATRDVAETARRAG-TR
MAB_4771|M.abscessus_ATCC_1997 NYAWQRHLAAALHRANETG-STTRQLLVGFADMVGYTRLSRHLDPDELAS
. . :: .
Mb1295|M.bovis_AF2122/97 LAGRLAGLARDLTAPPVWFIKT-IGDAVMLVCPDPAP----LLDTVLKLV
Rv1264|M.tuberculosis_H37Rv LAGRLAGLARDLTAPPVWFIKT-IGDAVMLVCPDPAP----LLDTVLKLV
MUL_4470|M.ulcerans_Agy99 LAGRLADLARELTAPPVRFIKT-IGDAVMLVCPDPAP----LLDTVLNLV
MAV_1415|M.avium_104 LANRLAILARDVTVPPVRFVKT-IGDAVMFVCPEPRP----LLDVVLKLV
MSMEG_5018|M.smegmatis_MC2_155 LANSLAEATRDVVRPPVRLIKT-IGDAVMLVSPEPAA----LLDAVLNLV
TH_1842|M.thermoresistible__bu LAARLADLAREVAEPPVRFIKT-IGDAVMLVSVDPAE----LLAAMLELI
Mvan_3687|M.vanbaalenii_PYR-1 -------------APISAFP-----SQHSG-W------------------
Mflv_2823|M.gilvum_PYR-GCK MTSLGPLRLRNVGALVEAFALD-VGTRHQE-HVDPIC----RMHVTTDAQ
MMAR_1414|M.marinum_M VAALGRVHLRNVVAPMELYDLD-VGAQIGGPLIDPVC----RMQVTSANA
MAB_4771|M.abscessus_ATCC_1997 LLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAMNTAIT
Mb1295|M.bovis_AF2122/97 EVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLV
Rv1264|M.tuberculosis_H37Rv EVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLV
MUL_4470|M.ulcerans_Agy99 EVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARPGTVLA
MAV_1415|M.avium_104 EAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARPGTVLV
MSMEG_5018|M.smegmatis_MC2_155 AATEADPEFPGLRVGLATGMAVSRAGDWFGSPVNLASRVTGVARPGTVLV
TH_1842|M.thermoresistible__bu DGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARPGSVLV
Mvan_3687|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2823|M.gilvum_PYR-GCK PLTIAHEEDTYRFYFCST-----------ACLRQFARRVGEVRTPSGNED
MMAR_1414|M.marinum_M AGTLHHQGR--KYSFCSA-----------GCIAEFATHPDRYATDK----
MAB_4771|M.abscessus_ATCC_1997 EAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARPGTILL
Mb1295|M.bovis_AF2122/97 ADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGG
Rv1264|M.tuberculosis_H37Rv ADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGG
MUL_4470|M.ulcerans_Agy99 ADSVCDAIRDTAAGAGFEWSFAGPRRLKGIKNETKLFRVRRNLADLAADT
MAV_1415|M.avium_104 ADSVWDVIGDNGE---FSGSFAGARRLKGIKNEVKLFRVRRGG-------
MSMEG_5018|M.smegmatis_MC2_155 AESTRQAIAAADDR--FRWSFAGARRLKGIKGDVKMFRARMRDQ------
TH_1842|M.thermoresistible__bu AEATREAIGD-DER--FRWSFAGSRRLKGIKGEVKLYRARRAE-------
Mvan_3687|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2823|M.gilvum_PYR-GCK PPTTQSFVGEVAAHFGALASPPRARNAESTSPPANTS-------------
MMAR_1414|M.marinum_M --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 DDGAAAALGDDGEFSLRHLRGVRVKGFSRLGSHVLRARKR----------
Mb1295|M.bovis_AF2122/97 AAQDDDLAGSSP
Rv1264|M.tuberculosis_H37Rv AAQDDDLAGSSP
MUL_4470|M.ulcerans_Agy99 ATEGR-------
MAV_1415|M.avium_104 ------------
MSMEG_5018|M.smegmatis_MC2_155 ------------
TH_1842|M.thermoresistible__bu ------------
Mvan_3687|M.vanbaalenii_PYR-1 ------------
Mflv_2823|M.gilvum_PYR-GCK ------------
MMAR_1414|M.marinum_M ------------
MAB_4771|M.abscessus_ATCC_1997 ------------