For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTIDLSSAADEFEHADVDTVVIFVDIAGFTAFTETHGDHRAAELADRFATTAARVLGPGDDMIKTLGDAV MITSSDPTAALAFLRRLHDETSRIDGFPLLRAGICAGPVVKRRGDVFGSTVNTAARLAAVAKPGQIVGNA EAAAALRATDLLAMTSLGPLRLRNVGALVEAFALDVGTRHQEHVDPICRMHVTTDAQPLTIAHEEDTYRF YFCSTACLRQFARRVGEVRTPSGNEDPPTTQSFVGEVAAHFGALASPPRARNAESTSPPANTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2823 | - | - | 100% (273) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_2243 | - | 2e-20 | 36.67% (150) | putative adenylate/guanylate cyclase |
| M. gilvum PYR-GCK | Mflv_3535 | - | 3e-10 | 32.28% (127) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1295 | - | 8e-20 | 36.25% (160) | adenylyl cyclase |
| M. tuberculosis H37Rv | Rv1264 | - | 8e-20 | 36.25% (160) | adenylyl cyclase |
| M. leprae Br4923 | MLBr_00201 | - | 7e-08 | 28.65% (171) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 8e-14 | 31.17% (154) | putative adenylate cyclase |
| M. marinum M | MMAR_1414 | cyaA_1 | 6e-38 | 42.79% (201) | adenylate cyclase, CyaA_1 |
| M. avium 104 | MAV_1415 | - | 1e-18 | 40.17% (117) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 3e-19 | 37.25% (153) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 3e-20 | 35.53% (152) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4470 | - | 8e-21 | 37.84% (148) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_3699 | - | 1e-124 | 83.90% (267) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2823|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3699|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1414|M.marinum_M --------------------------------------------------
MSMEG_5018|M.smegmatis_MC2_155 --------------------------------------------------
TH_1842|M.thermoresistible__bu --------------------------------------------------
Mb1295|M.bovis_AF2122/97 --------------------------------------------------
Rv1264|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4470|M.ulcerans_Agy99 --------------------------------------------------
MAV_1415|M.avium_104 --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00201|M.leprae_Br4923 MATQAAGLPGRIGAFVRWGIRTPWPLFSLSMLQSDIIGALFVLGFLRYGL
Mflv_2823|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3699|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1414|M.marinum_M --------------------------------------------------
MSMEG_5018|M.smegmatis_MC2_155 -------------------------------MVS-------------QQV
TH_1842|M.thermoresistible__bu --------------------------------MA-------------DDV
Mb1295|M.bovis_AF2122/97 -------------------------------MTD-------HVR---EAD
Rv1264|M.tuberculosis_H37Rv -------------------------------MTD-------HVR---EAD
MUL_4470|M.ulcerans_Agy99 -------------------------------MED-------SVDRAPEPA
MAV_1415|M.avium_104 -------------------------------MTSHDGLPALYVDDVHDGD
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00201|M.leprae_Br4923 PPQDRVELQDLPIRNLAISTLSVVVAFSTGFAVNLKLLMPVFRWQRRDNR
Mflv_2823|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3699|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1414|M.marinum_M --------------------------------------------------
MSMEG_5018|M.smegmatis_MC2_155 QPDIQPLLEGLDG----------------------------AARSQREEL
TH_1842|M.thermoresistible__bu DIEASGLLDDLTG----------------------------EAREQRAEL
Mb1295|M.bovis_AF2122/97 DANIDDLLGDLGG----------------------------TARAERAKL
Rv1264|M.tuberculosis_H37Rv DANIDDLLGDLGG----------------------------TARAERAKL
MUL_4470|M.ulcerans_Agy99 GQNTDDLLEGLEG----------------------------AARAERAEL
MAV_1415|M.avium_104 DRDIEDLLDGLQG----------------------------TARTERAEL
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00201|M.leprae_Br4923 LAEADPAATELARSRALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSA
Mflv_2823|M.gilvum_PYR-GCK --------------------------MTIDLSS----AADEFEHA-----
Mvan_3699|M.vanbaalenii_PYR-1 --------------------------MTIDPFS----AADEFEHA-----
MMAR_1414|M.marinum_M ------------------MNVSYPIRTSIIASSRYGRTHEVRTTA-----
MSMEG_5018|M.smegmatis_MC2_155 INWLLSRGISVDQIGQAITPMLLASRRVAGDDGTYVSAREISEQTGLDLD
TH_1842|M.thermoresistible__bu IAWLIERGYSIEEIRESVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLG
Mb1295|M.bovis_AF2122/97 VEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLE
Rv1264|M.tuberculosis_H37Rv VEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLE
MUL_4470|M.ulcerans_Agy99 IDWLFGQGITAAEIRTTNPPLLLATRHVIGDDGTYVSSREISETYGIDLD
MAV_1415|M.avium_104 VRWLLAQGITAEEIRTTNPPLLLATRHLIGDDGTYVSTREISETYGIDMA
MAB_4771|M.abscessus_ATCC_1997 ----------MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVE
MLBr_00201|M.leprae_Br4923 PIVALATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLR
:
Mflv_2823|M.gilvum_PYR-GCK ---DVDTVVIFVDIAGFTAFTETHGDHRAAELADRFATT---AARVLGPG
Mvan_3699|M.vanbaalenii_PYR-1 ---DVDSVVVFVDIAGFTAFTEAHGDHRAAELADRFATI---AARVLGPG
MMAR_1414|M.marinum_M ---ESGWTFGFVDLAGFTALTDAHGDQEAVTLVDRFETV---VAESLTAD
MSMEG_5018|M.smegmatis_MC2_155 LLQRLQRAMGLPAVEDPDAAVLLRADAEAVTFSQQFIDLGIDADQVVLIT
TH_1842|M.thermoresistible__bu LLQRMLRALGLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQMVQIA
Mb1295|M.bovis_AF2122/97 LLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVV
Rv1264|M.tuberculosis_H37Rv LLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVV
MUL_4470|M.ulcerans_Agy99 LLQRVQRAVGLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQIVLVV
MAV_1415|M.avium_104 LLQRVQRAIGLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQVVLVA
MAB_4771|M.abscessus_ATCC_1997 RARTLWVALGFAAADSDDEVAFTDAD---VSAIRTFAALGSATAANQQSQ
MLBr_00201|M.leprae_Br4923 LMLTWVPSTGVPVLAIVLAVVADKIALLHAVPEQLFSPILLLALAVLVVG
. . . *
Mflv_2823|M.gilvum_PYR-GCK DD----MIKTLGDAVMITSSDPTAALAFLRRLHDETSRIDGFPLLRAGI-
Mvan_3699|M.vanbaalenii_PYR-1 DE----MIKTLGDAVMITSSDPTAALAFLRRLHEQTRRIDGFPLLRAGI-
MMAR_1414|M.marinum_M DQ----LVKTIGDAVMLRFATPASAIAGARRIFARCTSGTGFPAPRAGL-
MSMEG_5018|M.smegmatis_MC2_155 RV----LAEGLSRAAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAP-
TH_1842|M.thermoresistible__bu AV----LSEGLAKAAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAP-
Mb1295|M.bovis_AF2122/97 RV----LAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVP-
Rv1264|M.tuberculosis_H37Rv RV----LAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVP-
MUL_4470|M.ulcerans_Agy99 RV----LAEGLSRAAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAP-
MAV_1415|M.avium_104 QV----LAEGLSRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAP-
MAB_4771|M.abscessus_ATCC_1997 IA----AARTLGQAMARLAEWQADLLTREVGGRLAAEGDDASAESSANA-
MLBr_00201|M.leprae_Br4923 LVSTWLVAMSIADPLRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFN
:. .
Mflv_2823|M.gilvum_PYR-GCK -CAGPVVK------RRGDVFGSTVNTAARLAAVAKPGQ----IVGNAEAA
Mvan_3699|M.vanbaalenii_PYR-1 -CAGAVVK------RRGDVFGSTVNTAARLAAVARPGQ----IVGNADAA
MMAR_1414|M.marinum_M -HHGPAVA------RGQDWFGATVNVAARVAAHSRGGQ----LLATRDVA
MSMEG_5018|M.smegmatis_MC2_155 -LLGPMIQDMLFVQLRHAMETEAVDASERAEGVPLPGARL-VTVAFADIV
TH_1842|M.thermoresistible__bu -LLGPMIQDLLLLQLRHAMETEAVSVTERAQGVPLPGARL-VSIAFADLV
Mb1295|M.bovis_AF2122/97 -LLGPMIQDMLFMQLRHMMETEAVNAGECAAGKPLPGARQ-VTVAFADLV
Rv1264|M.tuberculosis_H37Rv -LLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQ-VTVAFADLV
MUL_4470|M.ulcerans_Agy99 -LLGPMIQEMLFMQLRHMMETEAVNAGERAAGKPLPGARE-VSVAFADLV
MAV_1415|M.avium_104 -LLGPMIQQMLFMQLRHMMETEAVNAAERAAGKPLPGARQ-ITVAFADLV
MAB_4771|M.abscessus_ATCC_1997 -ATQTIAT---LTALQNYAWQRHLAAALHRANETGSTTRQ-LLVGFADMV
MLBr_00201|M.leprae_Br4923 DMVRELSERQRLRDLFGRYVGEDVARRALEHGTELGGQERDVAVLFVDLI
: : :
Mflv_2823|M.gilvum_PYR-GCK AALRATDLLAMTSLGPLR------LRNVGALV-EAFALDVGTRH-QEHVD
Mvan_3699|M.vanbaalenii_PYR-1 SALRGTDLLATTSLGSLR------LRNVGALV-EAFALDVGTRH-QEHVD
MMAR_1414|M.marinum_M ETARRAG-TRVAALGRVH------LRNVVAPM-ELYDLDVGAQIGGPLID
MSMEG_5018|M.smegmatis_MC2_155 GFTRLGEVVPPEQLEQLANSLAEATRDVVRPP-VRLIKTIGDAVMLVSPE
TH_1842|M.thermoresistible__bu GFTRLGEAVPPEELEQLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVD
Mb1295|M.bovis_AF2122/97 GFTQLGEVVSAEELGHLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPD
Rv1264|M.tuberculosis_H37Rv GFTQLGEVVSAEELGHLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPD
MUL_4470|M.ulcerans_Agy99 GFTKLGEVVSAEELGQLAGRLADLARELTAPP-VRFIKTIGDAVMLVCPD
MAV_1415|M.avium_104 GFTRIGEAVSPEELGQLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPE
MAB_4771|M.abscessus_ATCC_1997 GYTRLSRHLDPDELASLLETFETALTEAITTHGGWVIKNVGDEVMFAAAS
MLBr_00201|M.leprae_Br4923 GSTQLAETKPPTKVVHLLNEFFRVVVDTVGRHGGFVNKFQGDAALAIFGA
: : : : *
Mflv_2823|M.gilvum_PYR-GCK P--------------ICRMHVTTDAQPLTIAHEEDTYRFYFCST------
Mvan_3699|M.vanbaalenii_PYR-1 P--------------ICRMHVSTDAQSLTITHEEDTYRFYFCST------
MMAR_1414|M.marinum_M P--------------VCRMQVTSANAAGTLHHQGRKY--SFCSA------
MSMEG_5018|M.smegmatis_MC2_155 PAA-------LLDAVLNLVAATEADPEFPGLRVGLATGMAVSRAG-----
TH_1842|M.thermoresistible__bu PAE-------LLAAMLELIDGTGADQDFPRVRAGMATGMAVSRAG-----
Mb1295|M.bovis_AF2122/97 PAP-------LLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAG-----
Rv1264|M.tuberculosis_H37Rv PAP-------LLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAG-----
MUL_4470|M.ulcerans_Agy99 PAP-------LLDTVLNLVEVVDTDDAFPRLRAGVACGRAVSRAG-----
MAV_1415|M.avium_104 PRP-------LLDVVLKLVEAVDTDNEFPRLRAGVASGTAVSRAG-----
MAB_4771|M.abscessus_ATCC_1997 AAAG---ARIAVAMNTAITEAAQTIPDMPQIRVGLAYGQVLSRFG-----
MLBr_00201|M.leprae_Br4923 PIEHPDSAGAALSAARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQAR
. . ..
Mflv_2823|M.gilvum_PYR-GCK ------ACLRQFARRVGEVRTPSGNEDPPTTQSFVGEVAAHFGALASPPR
Mvan_3699|M.vanbaalenii_PYR-1 ------ACLRQFADRVGDMSTSSGDGDSQSIQSFLGEVAAPLGTLRSPTS
MMAR_1414|M.marinum_M ------GCIAEFATHPDRYATDK---------------------------
MSMEG_5018|M.smegmatis_MC2_155 ---DWFGSPVNLASRVTGVARPGTVLVAESTRQAIAAADDR--FRWSFAG
TH_1842|M.thermoresistible__bu ---DWYGSPVNLASRVTGVARPGSVLVAEATREAIGD-DER--FRWSFAG
Mb1295|M.bovis_AF2122/97 ---DWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAG
Rv1264|M.tuberculosis_H37Rv ---DWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAG
MUL_4470|M.ulcerans_Agy99 ---DWFGSPVNAASRITGVARPGTVLAADSVCDAIRDTAAGAGFEWSFAG
MAV_1415|M.avium_104 ---DWFGSPVNVASRVTAVARPGTVLVADSVWDVIGDNGE---FSGSFAG
MAB_4771|M.abscessus_ATCC_1997 ---DLYGTVVNIAARLTGVARPGTILLDDGAAAALGDDGEFSLRHLRGVR
MLBr_00201|M.leprae_Br4923 FEYTVIGDPVNEAARLTELAKLEDG-HVLASAIAVSGALDAEALCWNVGE
. : * :
Mflv_2823|M.gilvum_PYR-GCK ARNAESTSPPANTS-------------------------
Mvan_3699|M.vanbaalenii_PYR-1 GRGAAPMSTRSTSC-------------------------
MMAR_1414|M.marinum_M ---------------------------------------
MSMEG_5018|M.smegmatis_MC2_155 ARRLKGIKGDVKMFRARMRDQ------------------
TH_1842|M.thermoresistible__bu SRRLKGIKGEVKLYRARRAE-------------------
Mb1295|M.bovis_AF2122/97 PRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP
Rv1264|M.tuberculosis_H37Rv PRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP
MUL_4470|M.ulcerans_Agy99 PRRLKGIKNETKLFRVRRNLADLAADTATEGR-------
MAV_1415|M.avium_104 ARRLKGIKNEVKLFRVRRGG-------------------
MAB_4771|M.abscessus_ATCC_1997 VKGFSRLGSHVLRARKR----------------------
MLBr_00201|M.leprae_Br4923 IVELRGRTAPTQLARPLNLAVPEQITSEVTG--------