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EDSVDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGITAAEIRTTNPPLLLATRHVIGDDGTYVS SREISETYGIDLDLLQRVQRAVGLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQIVLVVRVLAEGL SRAAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAPLLGPMIQEMLFMQLRHMMETEAVNAGERAAGK PLPGAREVSVAFADLVGFTKLGEVVSAEELGQLAGRLADLARELTAPPVRFIKTIGDAVMLVCPDPAPLL DTVLNLVEVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARPGTVLAADSVCDAIRDTAA GAGFEWSFAGPRRLKGIKNETKLFRVRRNLADLAADTATEGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4470 | - | - | 100% (393) | adenylate cyclase |
| M. ulcerans Agy99 | MUL_4940 | cyaA | e-100 | 52.50% (360) | adenylate cyclase, CyaA |
| M. ulcerans Agy99 | MUL_1633 | - | 3e-11 | 28.95% (190) | hypothetical protein MUL_1633 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1295 | - | 1e-171 | 81.28% (374) | adenylyl cyclase |
| M. gilvum PYR-GCK | Mflv_2243 | - | 1e-125 | 60.87% (368) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1264 | - | 1e-172 | 81.55% (374) | adenylyl cyclase |
| M. leprae Br4923 | MLBr_01399 | - | 1e-11 | 33.09% (136) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 6e-21 | 27.13% (317) | putative adenylate cyclase |
| M. marinum M | MMAR_4173 | - | 0.0 | 99.49% (393) | adenylate cyclase |
| M. avium 104 | MAV_1415 | - | 1e-164 | 77.60% (375) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 1e-131 | 65.83% (360) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 1e-125 | 63.71% (361) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | 1e-126 | 61.81% (364) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4470|M.ulcerans_Agy99 MED-------SVDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGI
MMAR_4173|M.marinum_M MED-------SVDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGI
Mb1295|M.bovis_AF2122/97 MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
Rv1264|M.tuberculosis_H37Rv MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
Mflv_2243|M.gilvum_PYR-GCK --------------------METSGLLDGLEGAARAERAELIGWLLDRGV
Mvan_4452|M.vanbaalenii_PYR-1 --------------MAEDLDLETSELLDGLEGDARGERAELIRWLVGRGV
TH_1842|M.thermoresistible__bu --------------MADDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
MSMEG_5018|M.smegmatis_MC2_155 -------------MVSQQVQPDIQPLLEGLDGAARSQREELINWLLSRGI
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
MUL_4470|M.ulcerans_Agy99 TAAEIRTTNPPLLLATRHVIGDDGTYVSSREISETYGIDLDLLQRVQRAV
MMAR_4173|M.marinum_M TAAEIRTTNPPLLLATRHVIGDDGTYVSSREISETYGIDLDLLQRVQRAV
Mb1295|M.bovis_AF2122/97 TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
Rv1264|M.tuberculosis_H37Rv TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
MAV_1415|M.avium_104 TAEEIRTTNPPLLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQRAI
Mflv_2243|M.gilvum_PYR-GCK AVDEIRGNPAPMLLASRRVIGDDGEYVSARQAADRAGVELELFERIQRAM
Mvan_4452|M.vanbaalenii_PYR-1 GIDQIRGNPAPMLLASRRVIGDDGLYVSARQAAANAGVDLELFERIQRAM
TH_1842|M.thermoresistible__bu SIEEIRESVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRMLRAL
MSMEG_5018|M.smegmatis_MC2_155 SVDQIGQAITPMLLASRRVAGDDGTYVSAREISEQTGLDLDLLQRLQRAM
MAB_4771|M.abscessus_ATCC_1997 -MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVERARTLWVAL
MLBr_01399|M.leprae_Br4923 -----------------MPPSAKSTYPGQVEGAPHDGTPSAPQEPDEDTV
: : * . ::
MUL_4470|M.ulcerans_Agy99 GLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQ-IVLVVRVLAEGLS
MMAR_4173|M.marinum_M GLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQ-IVLVVRVLAEGLS
Mb1295|M.bovis_AF2122/97 GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQ-VVLVVRVLAEGLS
Rv1264|M.tuberculosis_H37Rv GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQ-VVLVVRVLAEGLS
MAV_1415|M.avium_104 GLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQ-VVLVAQVLAEGLS
Mflv_2243|M.gilvum_PYR-GCK GLPRVEDPDAEVFLRADAEAAKFTRDFLDVGIGLDE-LVQITRLLGDGLA
Mvan_4452|M.vanbaalenii_PYR-1 GLPRVDDADAQVFLRADAEAAKFTRDFLDAGIDPDE-LVQITRLLGDGLS
TH_1842|M.thermoresistible__bu GLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQ-MVQIAAVLSEGLA
MSMEG_5018|M.smegmatis_MC2_155 GLPAVEDPDAAVLLRADAEAVTFSQQFIDLGIDADQ-VVLITRVLAEGLS
MAB_4771|M.abscessus_ATCC_1997 GFAAADSDDEVAFTDADVSAIRTFAALGSATAANQQSQIAAARTLGQAMA
MLBr_01399|M.leprae_Br4923 TVP------APALIRRSSVSMPNAAQWLHTTNRSPR-LVAMVRRARRLLP
. . . : . : . :.
MUL_4470|M.ulcerans_Agy99 RAAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAPLLGPMIQEMLFMQ
MMAR_4173|M.marinum_M RAAEVMRYTALEAIMHPGVTELDIAKGSKALVSQIAPLLGPMIQEMLFMQ
Mb1295|M.bovis_AF2122/97 HAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ
Rv1264|M.tuberculosis_H37Rv HAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ
MAV_1415|M.avium_104 RAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFMQ
Mflv_2243|M.gilvum_PYR-GCK RAAEAMRYAALAAVIRPAATELETAKASEELVGNVAPLLGPMIQEVLLLQ
Mvan_4452|M.vanbaalenii_PYR-1 RAAEAMRYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEVLLLQ
TH_1842|M.thermoresistible__bu KAAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDLLLLQ
MSMEG_5018|M.smegmatis_MC2_155 RAAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAPLLGPMIQDMLFVQ
MAB_4771|M.abscessus_ATCC_1997 RLAEWQ-----ADLLTREVGGRLAAEGDDASAESSANAATQTIATLTALQ
MLBr_01399|M.leprae_Br4923 GDPDFGDPLSTAGEGGP----RAAARAADRLLGDRG--AASREVSLSVLQ
.: *. . : :*
MUL_4470|M.ulcerans_Agy99 LRHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELG
MMAR_4173|M.marinum_M LRHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELG
Mb1295|M.bovis_AF2122/97 LRHMMETEAVNAGECAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELG
Rv1264|M.tuberculosis_H37Rv LRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELG
MAV_1415|M.avium_104 LRHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEELG
Mflv_2243|M.gilvum_PYR-GCK LRHAIETEAINATERAEGQHLPGARLVTIGFADLVGFTRLGEALPPEDLE
Mvan_4452|M.vanbaalenii_PYR-1 LRHAIETEAVNATERAEGQHLPGARLVTIGFADLVGFTRLGEAVPPEDLE
TH_1842|M.thermoresistible__bu LRHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPPEELE
MSMEG_5018|M.smegmatis_MC2_155 LRHAMETEAVDASERAEGVPLPGARLVTVAFADIVGFTRLGEVVPPEQLE
MAB_4771|M.abscessus_ATCC_1997 N-YAWQRHLAAALHRAN-ETGSTTRQLLVGFADMVGYTRLSRHLDPDELA
MLBr_01399|M.leprae_Br4923 VWQALTEAIARR---------PVNPEVTLVFTDLVGFSGWSLQAGDEATL
. : : *:*:**:: . :
MUL_4470|M.ulcerans_Agy99 QLAGRLADLARELTAPP-VRFIKTIGDAVMLVCPDPAP----LLDTVLNL
MMAR_4173|M.marinum_M QLAGRLADLARELTAPP-VRFIKTIGDAVMLVCPDPAP----LLDTVLNL
Mb1295|M.bovis_AF2122/97 HLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLKL
Rv1264|M.tuberculosis_H37Rv HLAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLKL
MAV_1415|M.avium_104 QLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPEPRP----LLDVVLKL
Mflv_2243|M.gilvum_PYR-GCK RLAQRLADLTREIAVAP-VRFIKTIGDEVMLVSPEPAP----LLETMLRL
Mvan_4452|M.vanbaalenii_PYR-1 QLSQRLADMTREFAVAP-VRFIKTIGDEVMLVSPEPAP----LLDTLLRL
TH_1842|M.thermoresistible__bu QLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVDPAE----LLAAMLEL
MSMEG_5018|M.smegmatis_MC2_155 QLANSLAEATRDVVRPP-VRLIKTIGDAVMLVSPEPAA----LLDAVLNL
MAB_4771|M.abscessus_ATCC_1997 SLLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAMNTAI
MLBr_01399|M.leprae_Br4923 ALLRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPSVAVQ-AVLAATEA
* . . .:* :** :* . .. :
MUL_4470|M.ulcerans_Agy99 VEVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARPGTVL
MMAR_4173|M.marinum_M VEVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARPGTVL
Mb1295|M.bovis_AF2122/97 VEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVL
Rv1264|M.tuberculosis_H37Rv VEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVL
MAV_1415|M.avium_104 VEAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARPGTVL
Mflv_2243|M.gilvum_PYR-GCK VEETEGDDDFPRLRAGVATGMAVSRAGDWFGSPVNLAARMTGAARPGTVL
Mvan_4452|M.vanbaalenii_PYR-1 VDETEDDDDFPRLRAGVATGLAVSRAGDWFGSPVNLAARVTGAARPGSVL
TH_1842|M.thermoresistible__bu IDGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARPGSVL
MSMEG_5018|M.smegmatis_MC2_155 VAATEADPEFPGLRVGLATGMAVSRAGDWFGSPVNLASRVTGVARPGTVL
MAB_4771|M.abscessus_ATCC_1997 TEAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARPGTIL
MLBr_01399|M.leprae_Br4923 MKSVEVGGYTPRIRVGIHTGRPQRLAADWLGVDVNIAARVMERATKGGIM
. * :*.*: * .* * ** *:*: * * ::
MUL_4470|M.ulcerans_Agy99 AADSVCDAIRDTAAGAG--FEWSFAGPRRLKGIKN---ETKLFRVRRNLA
MMAR_4173|M.marinum_M AADSVCDAVRDTAAGAG--FEWSFAGPRRLKGIKN---ETKLFRVRRNLA
Mb1295|M.bovis_AF2122/97 VADSVREALGDAPEADG--FQWSFAGPRRLRGIRG---DVRLFRVRRGAT
Rv1264|M.tuberculosis_H37Rv VADSVREALGDAPEADG--FQWSFAGPRRLRGIRG---DVRLFRVRRGAT
MAV_1415|M.avium_104 VADSVWDVIGDNGE-----FSGSFAGARRLKGIKN---EVKLFRVRRGG-
Mflv_2243|M.gilvum_PYR-GCK VAEAAREAIGE-DDR----FAWSFAGAKHLKGIKS---DVKSFRARWAPA
Mvan_4452|M.vanbaalenii_PYR-1 VAEATREAIGE-DER----FTWSFAGGKHLKGFKS---DVKTFRARRTTN
TH_1842|M.thermoresistible__bu VAEATREAIGD-DER----FRWSFAGSRRLKGIKG---EVKLYRARRAE-
MSMEG_5018|M.smegmatis_MC2_155 VAESTRQAIAAADDR----FRWSFAGARRLKGIKG---DVKMFRARMRDQ
MAB_4771|M.abscessus_ATCC_1997 LDDGAAAALGDDGE-----FSLRHLRGVRVKGFSRL--GSHVLRARKR--
MLBr_01399|M.leprae_Br4923 ISGPTLDLIPQSDLKELGIITRRVRKPMFTSKFTGIPPDMVIYRIKARRE
. : : : * :
MUL_4470|M.ulcerans_Agy99 DLAADTATEGR-------
MMAR_4173|M.marinum_M DLAADTATEGR-------
Mb1295|M.bovis_AF2122/97 RTGSGGAAQDDDLAGSSP
Rv1264|M.tuberculosis_H37Rv RTGSGGAAQDDDLAGSSP
MAV_1415|M.avium_104 ------------------
Mflv_2243|M.gilvum_PYR-GCK DSH---------------
Mvan_4452|M.vanbaalenii_PYR-1 L-----------------
TH_1842|M.thermoresistible__bu ------------------
MSMEG_5018|M.smegmatis_MC2_155 ------------------
MAB_4771|M.abscessus_ATCC_1997 ------------------
MLBr_01399|M.leprae_Br4923 LTASDETAQTNSLT----