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MNVSYPIRTSIIASSRYGRTHEVRTTAESGWTFGFVDLAGFTALTDAHGDQEAVTLVDRFETVVAESLTA DDQLVKTIGDAVMLRFATPASAIAGARRIFARCTSGTGFPAPRAGLHHGPAVARGQDWFGATVNVAARVA AHSRGGQLLATRDVAETARRAGTRVAALGRVHLRNVVAPMELYDLDVGAQIGGPLIDPVCRMQVTSANAA GTLHHQGRKYSFCSAGCIAEFATHPDRYATDK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1414 | cyaA_1 | - | 100% (242) | adenylate cyclase, CyaA_1 |
| M. marinum M | MMAR_4173 | - | 2e-15 | 33.33% (153) | adenylate cyclase |
| M. marinum M | MMAR_0157 | cyaA | 4e-14 | 29.49% (156) | adenylate cyclase, CyaA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1295 | - | 5e-16 | 33.33% (162) | adenylyl cyclase |
| M. gilvum PYR-GCK | Mflv_2823 | - | 4e-38 | 42.79% (201) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1264 | - | 5e-16 | 33.33% (162) | adenylyl cyclase |
| M. leprae Br4923 | MLBr_01399 | - | 8e-10 | 30.33% (122) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 2e-12 | 35.48% (124) | putative adenylate cyclase |
| M. avium 104 | MAV_1415 | - | 1e-15 | 36.59% (123) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 7e-16 | 36.15% (130) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 1e-16 | 34.39% (157) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4470 | - | 1e-15 | 33.33% (153) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_3699 | - | 6e-39 | 44.33% (203) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2823|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3699|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1414|M.marinum_M --------------------------------------------------
Mb1295|M.bovis_AF2122/97 MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
Rv1264|M.tuberculosis_H37Rv MTD-------HVR---EADDANIDDLLGDLGGTARAERAKLVEWLLEQGI
MUL_4470|M.ulcerans_Agy99 MED-------SVDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGI
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
MSMEG_5018|M.smegmatis_MC2_155 MVS-------------QQVQPDIQPLLEGLDGAARSQREELINWLLSRGI
TH_1842|M.thermoresistible__bu -MA-------------DDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
Mflv_2823|M.gilvum_PYR-GCK -----------------MTIDLSS----AADEFEHA--------DVDTVV
Mvan_3699|M.vanbaalenii_PYR-1 -----------------MTIDPFS----AADEFEHA--------DVDSVV
MMAR_1414|M.marinum_M ---------MNVSYPIRTSIIASSRYGRTHEVRTTA--------ESGWTF
Mb1295|M.bovis_AF2122/97 TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
Rv1264|M.tuberculosis_H37Rv TPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAV
MUL_4470|M.ulcerans_Agy99 TAAEIRTTNPPLLLATRHVIGDDGTYVSSREISETYGIDLDLLQRVQRAV
MAV_1415|M.avium_104 TAEEIRTTNPPLLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQRAI
MSMEG_5018|M.smegmatis_MC2_155 SVDQIGQAITPMLLASRRVAGDDGTYVSAREISEQTGLDLDLLQRLQRAM
TH_1842|M.thermoresistible__bu SIEEIRESVSPMLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRMLRAL
MAB_4771|M.abscessus_ATCC_1997 -MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVERARTLWVAL
MLBr_01399|M.leprae_Br4923 -----------------MPPSAKSTYPGQVEGAPHDG------TPSAPQE
:
Mflv_2823|M.gilvum_PYR-GCK IFVDIAGFTAFTETHGDHRAAELADRFATT---AARVLGPGDDMIKTLGD
Mvan_3699|M.vanbaalenii_PYR-1 VFVDIAGFTAFTEAHGDHRAAELADRFATI---AARVLGPGDEMIKTLGD
MMAR_1414|M.marinum_M GFVDLAGFTALTDAHGDQEAVTLVDRFETV---VAESLTADDQLVKTIGD
Mb1295|M.bovis_AF2122/97 GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSH
Rv1264|M.tuberculosis_H37Rv GLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSH
MUL_4470|M.ulcerans_Agy99 GLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQIVLVVRVLAEGLSR
MAV_1415|M.avium_104 GLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQVVLVAQVLAEGLSR
MSMEG_5018|M.smegmatis_MC2_155 GLPAVEDPDAAVLLRADAEAVTFSQQFIDLGIDADQVVLITRVLAEGLSR
TH_1842|M.thermoresistible__bu GLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQMVQIAAVLSEGLAK
MAB_4771|M.abscessus_ATCC_1997 GFAAADSDDEVAFTDAD---VSAIRTFAALGSATAANQQSQIAAARTLGQ
MLBr_01399|M.leprae_Br4923 PDEDTVTVPAPALIRRSSVSMPNAAQWLHTTNRSPRLVAMVRRARRLLPG
. . : . :
Mflv_2823|M.gilvum_PYR-GCK AVMITSSDPTAALAFLRRLHDETSRIDGFPLLRAGICAGPVVK------R
Mvan_3699|M.vanbaalenii_PYR-1 AVMITSSDPTAALAFLRRLHEQTRRIDGFPLLRAGICAGAVVK------R
MMAR_1414|M.marinum_M AVMLRFATPASAIAGARRIFARCTSGTGFPAPRAGLHHGPAVA------R
Mb1295|M.bovis_AF2122/97 AAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQL
Rv1264|M.tuberculosis_H37Rv AAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQL
MUL_4470|M.ulcerans_Agy99 AAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAPLLGPMIQEMLFMQL
MAV_1415|M.avium_104 AAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFMQL
MSMEG_5018|M.smegmatis_MC2_155 AAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAPLLGPMIQDMLFVQL
TH_1842|M.thermoresistible__bu AAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDLLLLQL
MAB_4771|M.abscessus_ATCC_1997 AMARLAEWQADLLTREVGGRLAAEGDDASAESSANAATQTIAT---LTAL
MLBr_01399|M.leprae_Br4923 DPDFGDPLSTAGEGGPR----AAARAADRLLGDRGAAS-----------R
Mflv_2823|M.gilvum_PYR-GCK RGDVFGSTVNTAARLAAVAKPGQ---IVGNAEAAAALRATDLLAMTSLGP
Mvan_3699|M.vanbaalenii_PYR-1 RGDVFGSTVNTAARLAAVARPGQ---IVGNADAASALRGTDLLATTSLGS
MMAR_1414|M.marinum_M GQDWFGATVNVAARVAAHSRGGQ---LLATRDVAETARRAG-TRVAALGR
Mb1295|M.bovis_AF2122/97 RHMMETEAVNAGECAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH
Rv1264|M.tuberculosis_H37Rv RHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH
MUL_4470|M.ulcerans_Agy99 RHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELGQ
MAV_1415|M.avium_104 RHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEELGQ
MSMEG_5018|M.smegmatis_MC2_155 RHAMETEAVDASERAEGVPLPGARLVTVAFADIVGFTRLGEVVPPEQLEQ
TH_1842|M.thermoresistible__bu RHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPPEELEQ
MAB_4771|M.abscessus_ATCC_1997 QNYAWQRHLAAALHRANETGSTTRQLLVGFADMVGYTRLSRHLDPDELAS
MLBr_01399|M.leprae_Br4923 EVSLSVLQVWQALTEAIARRPVNPEVTLVFTDLVGFSGWSLQAGDEATLA
: : : .
Mflv_2823|M.gilvum_PYR-GCK LR------LRNVGALV-EAFALDVGTRH-QEHVDP-----------ICRM
Mvan_3699|M.vanbaalenii_PYR-1 LR------LRNVGALV-EAFALDVGTRH-QEHVDP-----------ICRM
MMAR_1414|M.marinum_M VH------LRNVVAPM-ELYDLDVGAQIGGPLIDP-----------VCRM
Mb1295|M.bovis_AF2122/97 LAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLKLV
Rv1264|M.tuberculosis_H37Rv LAGRLAGLARDLTAPP-VWFIKTIGDAVMLVCPDPAP----LLDTVLKLV
MUL_4470|M.ulcerans_Agy99 LAGRLADLARELTAPP-VRFIKTIGDAVMLVCPDPAP----LLDTVLNLV
MAV_1415|M.avium_104 LANRLAILARDVTVPP-VRFVKTIGDAVMFVCPEPRP----LLDVVLKLV
MSMEG_5018|M.smegmatis_MC2_155 LANSLAEATRDVVRPP-VRLIKTIGDAVMLVSPEPAA----LLDAVLNLV
TH_1842|M.thermoresistible__bu LAARLADLAREVAEPP-VRFIKTIGDAVMLVSVDPAE----LLAAMLELI
MAB_4771|M.abscessus_ATCC_1997 LLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAMNTAIT
MLBr_01399|M.leprae_Br4923 LLRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPSVAVQ-AVLAATEAM
: . :* ..
Mflv_2823|M.gilvum_PYR-GCK HVTTDAQPLTIAHEEDTYRFYFCST----ACLRQFARRVGEVRTPSGNED
Mvan_3699|M.vanbaalenii_PYR-1 HVSTDAQSLTITHEEDTYRFYFCST----ACLRQFADRVGDMSTSSGDGD
MMAR_1414|M.marinum_M QVTSANAAGTLHHQGRKY--SFCSA----GCIAEFATHPDRYATDK----
Mb1295|M.bovis_AF2122/97 EVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLV
Rv1264|M.tuberculosis_H37Rv EVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLV
MUL_4470|M.ulcerans_Agy99 EVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARPGTVLA
MAV_1415|M.avium_104 EAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARPGTVLV
MSMEG_5018|M.smegmatis_MC2_155 AATEADPEFPGLRVGLATGMAVSRAGDWFGSPVNLASRVTGVARPGTVLV
TH_1842|M.thermoresistible__bu DGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARPGSVLV
MAB_4771|M.abscessus_ATCC_1997 EAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARPGTILL
MLBr_01399|M.leprae_Br4923 KSVEVGGYTPRIRVGIHTGRPQRLAADWLGVDVNIAARVMERATKGGIMI
. : . : * :
Mflv_2823|M.gilvum_PYR-GCK PPTTQSFVGEVAAHFG-----ALASPPRARNAESTSPPANTS--------
Mvan_3699|M.vanbaalenii_PYR-1 SQSIQSFLGEVAAPLG-----TLRSPTSGRGAAPMSTRSTSC--------
MMAR_1414|M.marinum_M --------------------------------------------------
Mb1295|M.bovis_AF2122/97 ADSVREALGDAPEADG-----FQWSFAGPRRLRGIRGDVRLFRVRRGATR
Rv1264|M.tuberculosis_H37Rv ADSVREALGDAPEADG-----FQWSFAGPRRLRGIRGDVRLFRVRRGATR
MUL_4470|M.ulcerans_Agy99 ADSVCDAIRDTAAGAG-----FEWSFAGPRRLKGIKNETKLFRVRRNLAD
MAV_1415|M.avium_104 ADSVWDVIGDNGE--------FSGSFAGARRLKGIKNEVKLFRVRRGG--
MSMEG_5018|M.smegmatis_MC2_155 AESTRQAIAAADDR-------FRWSFAGARRLKGIKGDVKMFRARMRDQ-
TH_1842|M.thermoresistible__bu AEATREAIGD-DER-------FRWSFAGSRRLKGIKGEVKLYRARRAE--
MAB_4771|M.abscessus_ATCC_1997 DDGAAAALGDDGEFSL-----RHLRGVRVKGFSRLGSHVLRARKR-----
MLBr_01399|M.leprae_Br4923 SGPTLDLIPQSDLKELGIITRRVRKPMFTSKFTGIPPDMVIYRIKARREL
Mflv_2823|M.gilvum_PYR-GCK -----------------
Mvan_3699|M.vanbaalenii_PYR-1 -----------------
MMAR_1414|M.marinum_M -----------------
Mb1295|M.bovis_AF2122/97 TGSGGAAQDDDLAGSSP
Rv1264|M.tuberculosis_H37Rv TGSGGAAQDDDLAGSSP
MUL_4470|M.ulcerans_Agy99 LAADTATEGR-------
MAV_1415|M.avium_104 -----------------
MSMEG_5018|M.smegmatis_MC2_155 -----------------
TH_1842|M.thermoresistible__bu -----------------
MAB_4771|M.abscessus_ATCC_1997 -----------------
MLBr_01399|M.leprae_Br4923 TASDETAQTNSLT----